Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 22 Researches
8.4
USERS' SCORE
Moderately Good
Based on 71 Reviews
7.8
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Selenium (from SelenoExcell® High Selenium Yeast) (Saccharomyces cerevisiae)
50 mcg
90%
Molybdenum (from molybdenum glycinate chelate)
50 mcg
110%
N-Acetylcysteine (NAC)
600 mg
†
Top Medical Research Studies
9.5
We explored the effects of modified β-glucan derivatives from Saccharomyces cerevisiae on lung cancer. The study revealed promising results for a sulfated derivative (SCGS), which showed strong anti-tumor and anti-metastatic properties.
In a mouse model, SCGS significantly inhibited lung metastasis, reducing tumor nodules by 86.7% and enhancing immune response. These findings suggest SCGS's potential not only as an effective treatment for metastasis but also for future cancer drug development.
In a mouse model, SCGS significantly inhibited lung metastasis, reducing tumor nodules by 86.7% and enhancing immune response. These findings suggest SCGS's potential not only as an effective treatment for metastasis but also for future cancer drug development.
Read More
9
We explored the effectiveness of a novel selenium nanocomposite, AANL-SeNPs, in treating lung cancer. This innovative compound, created from a natural ingredient, demonstrated significant inhibition of lung cancer cell growth in various cell lines, showing up to a 67% reduction in viability.
Furthermore, AANL-SeNPs slowed tumor growth in live models and appeared safe for normal cells. While promising, our findings indicate that although AANL-SeNPs upregulate the protein CLK2 and can enhance therapeutic response, further studies are needed to fully understand its potential.
Furthermore, AANL-SeNPs slowed tumor growth in live models and appeared safe for normal cells. While promising, our findings indicate that although AANL-SeNPs upregulate the protein CLK2 and can enhance therapeutic response, further studies are needed to fully understand its potential.
Read More
9
We isolated a unique exopolysaccharide (EPS) from the marine black yeast Hortaea werneckii, which shows promising anti-cancer effects. This EPS demonstrated significant anticancer activity against A549 human lung cancer cells, with an IC50 of just 22.9 μg/mL, making it quite effective.
Remarkably, it showed minimal toxicity to normal lung cells, indicating its potential safety for further development. Additionally, the EPS also displayed strong antiradical properties. These findings suggest that H. werneckii could be a valuable resource in the fight against lung cancer.
Remarkably, it showed minimal toxicity to normal lung cells, indicating its potential safety for further development. Additionally, the EPS also displayed strong antiradical properties. These findings suggest that H. werneckii could be a valuable resource in the fight against lung cancer.
Read More
Most Useful Reviews
9
Energises lungs
140 people found this helpful
NAC is a top-notch antioxidant, particularly beneficial for lung health. It effectively cleanses the lungs, especially for smokers or those with lung issues. I always take it on an empty stomach and feel revitalised afterward.
Read More
9
Promotes COVID recovery
91 people found this helpful
This NAC has significantly aided my recovery from COVID when paired with vitamins, leading to a quicker recuperation without lasting consequences! I wholeheartedly recommend drinking this NAC during challenging times like this pandemic. I wish everyone good health and positivity!
Read More
8
Normalises lung function
23 people found this helpful
After two years of consistent use, NAC has been nothing short of excellent for both my family and me, effectively alleviating mucus caused by allergies. It remarkably promotes detox, especially when combined with Spirulina and Chlorella, enhancing my oxygen levels and lung function. My continued adoration for this product has grown, particularly when taken with Msm.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 22 Researches
8.4
- All Researches
9.5
We explored the effects of modified β-glucan derivatives from Saccharomyces cerevisiae on lung cancer. The study revealed promising results for a sulfated derivative (SCGS), which showed strong anti-tumor and anti-metastatic properties.
In a mouse model, SCGS significantly inhibited lung metastasis, reducing tumor nodules by 86.7% and enhancing immune response. These findings suggest SCGS's potential not only as an effective treatment for metastasis but also for future cancer drug development.
In a mouse model, SCGS significantly inhibited lung metastasis, reducing tumor nodules by 86.7% and enhancing immune response. These findings suggest SCGS's potential not only as an effective treatment for metastasis but also for future cancer drug development.
Read More
9.5
We examined the role of selenium (Se) in treating advanced non-small-cell lung cancer (NSCLC). Our research revealed that a lack of selenium leads to weakened immunity and faster tumor growth in mice. Interestingly, using selenium nanoparticles showed promising results.
These nanoparticles enhanced natural killer cell activity, boosting the immune response against cancer. In a clinical trial, patients receiving selenium nanoparticles alongside standard treatments had an impressive 83.3% response rate and complete disease control.
Overall, selenium shows potential to strengthen lung cancer therapy through immune enhancement.
These nanoparticles enhanced natural killer cell activity, boosting the immune response against cancer. In a clinical trial, patients receiving selenium nanoparticles alongside standard treatments had an impressive 83.3% response rate and complete disease control.
Overall, selenium shows potential to strengthen lung cancer therapy through immune enhancement.
Read More
9
We isolated a unique exopolysaccharide (EPS) from the marine black yeast Hortaea werneckii, which shows promising anti-cancer effects. This EPS demonstrated significant anticancer activity against A549 human lung cancer cells, with an IC50 of just 22.9 μg/mL, making it quite effective.
Remarkably, it showed minimal toxicity to normal lung cells, indicating its potential safety for further development. Additionally, the EPS also displayed strong antiradical properties. These findings suggest that H. werneckii could be a valuable resource in the fight against lung cancer.
Remarkably, it showed minimal toxicity to normal lung cells, indicating its potential safety for further development. Additionally, the EPS also displayed strong antiradical properties. These findings suggest that H. werneckii could be a valuable resource in the fight against lung cancer.
Read More
9
We investigated the production of a special ginsenoside, 3β,12β-Di-O-Glc-PPD, through engineered yeasts. This ginsenoside, derived from a new enzyme found in Bacillus subtilis, was shown to have notable anti-lung cancer effects.
While traditional methods for ginsenoside production are complex and costly, our approach offers a more efficient synthetic biology route. We found that this ginsenoside had better anti-cancer activity than one of the leading natural variants, promising a significant step forward in lung cancer treatment options.
While traditional methods for ginsenoside production are complex and costly, our approach offers a more efficient synthetic biology route. We found that this ginsenoside had better anti-cancer activity than one of the leading natural variants, promising a significant step forward in lung cancer treatment options.
Read More
9
Effective selenium treatment for lung cancer
We aimed to explore the potential of selenium nanoparticles synthesized from Epimedium brevicornum in combating lung cancer. Using various techniques, we characterized these nanoparticles and evaluated their effects in both lab and live models.
Although the nanoparticles were not harmful to healthy liver cells, they effectively triggered cell death in lung cancer cells, reducing tumor growth and suppressing migration.
Our findings suggest that these selenium nanoparticles could be a promising and safe avenue for lung cancer treatment.
Although the nanoparticles were not harmful to healthy liver cells, they effectively triggered cell death in lung cancer cells, reducing tumor growth and suppressing migration.
Our findings suggest that these selenium nanoparticles could be a promising and safe avenue for lung cancer treatment.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 71 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Energises lungs
140 people found this helpful
NAC is a top-notch antioxidant, particularly beneficial for lung health. It effectively cleanses the lungs, especially for smokers or those with lung issues. I always take it on an empty stomach and feel revitalised afterward.
Read More
9
Promotes COVID recovery
91 people found this helpful
This NAC has significantly aided my recovery from COVID when paired with vitamins, leading to a quicker recuperation without lasting consequences! I wholeheartedly recommend drinking this NAC during challenging times like this pandemic. I wish everyone good health and positivity!
Read More
8
Normalises lung function
23 people found this helpful
After two years of consistent use, NAC has been nothing short of excellent for both my family and me, effectively alleviating mucus caused by allergies. It remarkably promotes detox, especially when combined with Spirulina and Chlorella, enhancing my oxygen levels and lung function. My continued adoration for this product has grown, particularly when taken with Msm.
Read More
9
Joint pain relief
7 people found this helpful
I’m hesitant to share this review because this product has changed my life for the better. I started taking NAC during the pandemic for lung inflammation and noticed I had no joint pain after just a week. I’ve been using it for 15 months and feel fantastic.
Read More
9
Lung purification essential
5 people found this helpful
NAC is my go-to supplement for cleansing my lungs of phlegm and toxins. A daily pill before bed allows me to breathe easier, and it effectively detoxifies both my lungs and liver. This has been my most reliable choice for maintaining respiratory health.
Read More
Frequently Asked Questions
9
Good for smokers
1 people found this helpful
This is wonderful for lung health, especially if you're a smoker. I noticed the effects after just a few days and take it alongside vitamin C.
9
Joint pain relief
7 people found this helpful
I’m hesitant to share this review because this product has changed my life for the better. I started taking NAC during the pandemic for lung inflammation and noticed I had no joint pain after just a week. I’ve been using it for 15 months and feel fantastic.
9
Energises lungs
140 people found this helpful
NAC is a top-notch antioxidant, particularly beneficial for lung health. It effectively cleanses the lungs, especially for smokers or those with lung issues. I always take it on an empty stomach and feel revitalised afterward.
9
Lung purification essential
5 people found this helpful
NAC is my go-to supplement for cleansing my lungs of phlegm and toxins. A daily pill before bed allows me to breathe easier, and it effectively detoxifies both my lungs and liver. This has been my most reliable choice for maintaining respiratory health.
9
Promotes COVID recovery
91 people found this helpful
This NAC has significantly aided my recovery from COVID when paired with vitamins, leading to a quicker recuperation without lasting consequences! I wholeheartedly recommend drinking this NAC during challenging times like this pandemic. I wish everyone good health and positivity!
9
Improves asthma symptoms
2 people found this helpful
Since using NAC from January 2021, my lung function and seasonal allergy symptoms have notably improved. I typically need my inhaler frequently during spring, but it's been much less since taking NAC. Additionally, it has contributed significantly to my husband's lung recovery after a serious virus, and I am truly grateful for its positive effects.
8
Normalises lung function
23 people found this helpful
After two years of consistent use, NAC has been nothing short of excellent for both my family and me, effectively alleviating mucus caused by allergies. It remarkably promotes detox, especially when combined with Spirulina and Chlorella, enhancing my oxygen levels and lung function. My continued adoration for this product has grown, particularly when taken with Msm.
7
Improves organ health
8 people found this helpful
This high-quality supplement is phenomenal for liver and lung health. It promotes detoxification and is crucial for glutathione production, which maintains cell vitality. I recommend taking it to enhance overall wellness.
9.5
We explored the effects of modified β-glucan derivatives from Saccharomyces cerevisiae on lung cancer. The study revealed promising results for a sulfated derivative (SCGS), which showed strong anti-tumor and anti-metastatic properties.
In a mouse model, SCGS significantly inhibited lung metastasis, reducing tumor nodules by 86.7% and enhancing immune response. These findings suggest SCGS's potential not only as an effective treatment for metastasis but also for future cancer drug development.
In a mouse model, SCGS significantly inhibited lung metastasis, reducing tumor nodules by 86.7% and enhancing immune response. These findings suggest SCGS's potential not only as an effective treatment for metastasis but also for future cancer drug development.
9
We isolated a unique exopolysaccharide (EPS) from the marine black yeast Hortaea werneckii, which shows promising anti-cancer effects. This EPS demonstrated significant anticancer activity against A549 human lung cancer cells, with an IC50 of just 22.9 μg/mL, making it quite effective.
Remarkably, it showed minimal toxicity to normal lung cells, indicating its potential safety for further development. Additionally, the EPS also displayed strong antiradical properties. These findings suggest that H. werneckii could be a valuable resource in the fight against lung cancer.
Remarkably, it showed minimal toxicity to normal lung cells, indicating its potential safety for further development. Additionally, the EPS also displayed strong antiradical properties. These findings suggest that H. werneckii could be a valuable resource in the fight against lung cancer.
8
Beta-glucan improves drug sensitivity
We investigated how yeast-derived beta-glucan might improve the effectiveness of etoposide, a key chemotherapy drug for lung cancer. By using the A549 lung cancer cell line, we discovered that beta-glucan reduced levels of the protein Nrf2, which is often involved in drug resistance. This led to a heightened sensitivity to etoposide.
Additionally, our research highlighted the importance of specific signaling pathways in this process. However, the results suggest that while beta-glucan shows promise as a supportive treatment for overcoming drug resistance, it may not entirely replace conventional therapies.
Additionally, our research highlighted the importance of specific signaling pathways in this process. However, the results suggest that while beta-glucan shows promise as a supportive treatment for overcoming drug resistance, it may not entirely replace conventional therapies.
9.5
We examined the role of selenium (Se) in treating advanced non-small-cell lung cancer (NSCLC). Our research revealed that a lack of selenium leads to weakened immunity and faster tumor growth in mice. Interestingly, using selenium nanoparticles showed promising results.
These nanoparticles enhanced natural killer cell activity, boosting the immune response against cancer. In a clinical trial, patients receiving selenium nanoparticles alongside standard treatments had an impressive 83.3% response rate and complete disease control.
Overall, selenium shows potential to strengthen lung cancer therapy through immune enhancement.
These nanoparticles enhanced natural killer cell activity, boosting the immune response against cancer. In a clinical trial, patients receiving selenium nanoparticles alongside standard treatments had an impressive 83.3% response rate and complete disease control.
Overall, selenium shows potential to strengthen lung cancer therapy through immune enhancement.
References
- Li J, Zheng M, Wang Z, Liu Y, Niu Q, et al. Anti-tumor and anti-metastasis of water-soluble sulfated β-glucan derivatives from Saccharomyces cerevisiae. Carbohydr Polym. 2024;344:122466. 10.1016/j.carbpol.2024.122466
- Zaghloul EH, Abdel-Latif HH, Elsayis A, Hassan SWM. Production and characterization of novel marine black yeast's exopolysaccharide with potential antiradical and anticancer prospects. Microb Cell Fact. 2024;23:60. 10.1186/s12934-024-02332-1
- Siswanto FM, Tamura A, Sakuma R, Imaoka S. Yeast -glucan Increases Etoposide Sensitivity in Lung Cancer Cell Line A549 by Suppressing Nuclear Factor Erythroid 2-Related Factor 2 via the Noncanonical Nuclear Factor Kappa B Pathway. Mol Pharmacol. 2022;101:257. 10.1124/molpharm.121.000475
- Fang Y, Luo M, Song X, Shen Y, Xiao H. Improving the production of squalene-type triterpenoid 2,3;22,23-squalene dioxide by optimizing the expression of CYP505D13 in Saccharomyces cerevisiae. J Biosci Bioeng. 2020;130:265. 10.1016/j.jbiosc.2020.04.005
- Zhou X, Ling K, Liu M, Zhang X, Ding J, et al. Targeted Delivery of Cisplatin-Derived Nanoprecursors via a Biomimetic Yeast Microcapsule for Tumor Therapy by the Oral Route. Theranostics. 2019;9:6568. 10.7150/thno.35353
- Liang H, Hu Z, Zhang T, Gong T, Chen J, et al. Production of a bioactive unnatural ginsenoside by metabolically engineered yeasts based on a new UDP-glycosyltransferase from Bacillus subtilis. Metab Eng. 2017;44:60. 10.1016/j.ymben.2017.07.008
- Fu G, Tong J. Synthesis of Epimedium extract selenium nanoparticles and evaluation their efficacy against lung cancer. Gen Physiol Biophys. 2025;44:123. 10.4149/gpb_2024046
- Yu Y, Xie B, Wang J, Luo W, Yang M, et al. Translational Selenium Nanoparticles Promotes Clinical Non-small-cell Lung Cancer Chemotherapy via Activating Selenoprotein-driven Immune Manipulation. Adv Mater. 2025. 10.1002/adma.202415818
- Shehata NS, Elwakil BH, Elshewemi SS, Ghareeb DA, Olama ZA. In vitro and in vivo studies of selenium nanoparticles coated bacterial polysaccharide as anti-lung cancer agents. Microb Cell Fact. 2024;23:339. 10.1186/s12934-024-02601-z
- Chen Y, Jin Y, Wang W, Zhang Y, Sun H, et al. Preparation and antitumor activity of selenium nanocomposite stabilized by AAGL from Agerocybe aegerita. Int J Biol Macromol. 2024;282:137002. 10.1016/j.ijbiomac.2024.137002
- Chen Y, Zhu F, Ou J, Chen J, Liu X, et al. Mitochondrion-targeted selenium nanoparticles stabilized by Sargassum fusiforme polysaccharides increase reactive oxygen species-mediated antitumour activity. Int J Biol Macromol. 2024;281:136545. 10.1016/j.ijbiomac.2024.136545
- Luo X, Wang J, Wang R, Lian J, Guo M, et al. SLL-1A-16 suppresses proliferation and induces autophagy in non-small-cell lung cancer cells the AKT/mTOR signaling pathway. RSC Med Chem. 2024;15:3460. 10.1039/d4md00405a
- Ohlinger J, Vordermark D, Ostheimer C, Bache M, Tzschoppe T, et al. Change in the serum selenium level of patients with non-metastatic and metastatic non-small cell lung cancer (NSCLC) during radiotherapy as a predictive factor for survival. Strahlenther Onkol. 2024. 10.1007/s00066-024-02276-w
- Shi H, Wang B, Ma H, Li Y, Du J, et al. Preparation of Biomimetic Selenium-Baicalein Nanoparticles and Their Targeted Therapeutic Application in Nonsmall Cell Lung Cancer. Mol Pharm. 2024;21:4476. 10.1021/acs.molpharmaceut.4c00390
- Cui B, Cheng X, Zhang X, Chen L, Pang W, et al. Anti-cancer activity and mechanism of flurbiprofen organoselenium compound RY-1-92 in non-small cell lung cancer. RSC Med Chem. 2024;15:1737. 10.1039/d4md00058g
- Zhang Y, Chen Y, Wang B, Cai Y, Zhang M, et al. A novel selenium nanocomposite modified by AANL inhibits tumor growth by upregulating CLK2 in lung cancer. Bioorg Chem. 2024;148:107459. 10.1016/j.bioorg.2024.107459
- Chen Y, Zhu F, Chen J, Liu X, Li R, et al. Selenium nanoparticles stabilized by Sargassum fusiforme polysaccharides: Synthesis, characterization and bioactivity. Int J Biol Macromol. 2024;269:132073. 10.1016/j.ijbiomac.2024.132073
- Shehata NS, Elwakil BH, Elshewemi SS, Ghareeb DA, Olama ZA. Selenium nanoparticles coated bacterial polysaccharide with potent antimicrobial and anti-lung cancer activities. Sci Rep. 2023;13:21871. 10.1038/s41598-023-48921-9
- Shen J, Xia H, Zhou X, Zhang L, Gao Q, et al. Selenium enhances photodynamic therapy of C-phycocyanin against lung cancer via dual regulation of cytotoxicity and antioxidant activity. Acta Biochim Biophys Sin (Shanghai). 2023;55:1925. 10.3724/abbs.2023159
- Zhang K, Zhu T, Quan X, Qian Y, Liu Y, et al. Association between blood heavy metals and lung cancer risk: A case-control study in China. Chemosphere. 2023;343:140200. 10.1016/j.chemosphere.2023.140200
- Zhu Y, Pu Q, Zhang Q, Liu Y, Ma Y, et al. Selenium-binding protein 1 inhibits malignant progression and induces apoptosis via distinct mechanisms in non-small cell lung cancer. Cancer Med. 2023;12:17149. 10.1002/cam4.6309
- Lubiński J, Lener MR, Marciniak W, Pietrzak S, Derkacz R, et al. Serum Essential Elements and Survival after Cancer Diagnosis. Nutrients. 2023;15. 10.3390/nu15112611
