SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.5
USERS' SCORE
Good
Based on 7 Reviews
8.6
Supplement Facts
Serving Size: 1 Capsule
Serving Per Container: 90
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol)
250 mcg(10,000 IU)
1250%
Top Medical Research Studies
9
Vitamin D3 modulates autoimmune response
Vitamin D3 attenuates autoimmune thyroiditis by regulating Th17/Treg cell differentiation via YAP/JAK1/STAT1 axis.
Study directly examines Vitamin D3
We explored how Vitamin D3 impacts autoimmune thyroiditis, a specific autoimmune disorder. In this study, researchers established a mouse model of experimental autoimmune thyroiditis (EAT) to see how Vitamin D3 could influence this condition. After eight weeks of treatment, they assessed thyroid health and immune response through various methods, including staining tissues and measuring hormone levels.
Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.
Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.
Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.
Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.
Read More
9.5
Vitamin D3 aids autoimmune thyroiditis
Supplementation with active vitamin D3 ameliorates experimental autoimmune thyroiditis in mice by modulating the differentiation and functionality of intrathyroidal T-cell subsets.
Highly relevant to autoimmune research
We observed that vitamin D3 supplementation may play a significant role in managing autoimmune thyroiditis, a condition often marked by thyroid inflammation. In this study, researchers induced autoimmune thyroiditis in female mice and administered vitamin D3 to evaluate its effects on the disease.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
Read More
9
Vitamin D3 mitigates autoimmune thyroiditis
Supplementation with active vitamin D3 ameliorates experimental autoimmune thyroiditis in mice by modulating the differentiation and functionality of intrathyroidal T-cell subsets.
High relevance to thyroiditis treatment
Our research aimed to understand how vitamin D3 affects autoimmune thyroiditis, particularly in the context of Hashimoto's thyroiditis, which is characterized by low levels of vitamin D3 in patients. We induced a model of autoimmune thyroiditis in female mice and treated them with vitamin D3 to see if it could alleviate the symptoms of this condition.
After 8 weeks of treatment, we observed that vitamin D3 significantly improved the condition of the thyroid in these mice. The inflammation that commonly accompanies autoimmune thyroiditis decreased, and levels of thyroid autoantibodies, which indicate the severity of the disorder, also dropped. Notably, the application of vitamin D3 inhibited the activity of harmful immune cells while promoting the function of protective cells, providing a better balance in the immune response.
Overall, our findings suggest that vitamin D3 supplementation could be a promising strategy to manage autoimmune thyroiditis by restoring immune balance and reducing inflammation. This not only enhances our understanding of the disease but also opens up potential avenues for treatment in humans facing similar issues with autoimmune disorders.
After 8 weeks of treatment, we observed that vitamin D3 significantly improved the condition of the thyroid in these mice. The inflammation that commonly accompanies autoimmune thyroiditis decreased, and levels of thyroid autoantibodies, which indicate the severity of the disorder, also dropped. Notably, the application of vitamin D3 inhibited the activity of harmful immune cells while promoting the function of protective cells, providing a better balance in the immune response.
Overall, our findings suggest that vitamin D3 supplementation could be a promising strategy to manage autoimmune thyroiditis by restoring immune balance and reducing inflammation. This not only enhances our understanding of the disease but also opens up potential avenues for treatment in humans facing similar issues with autoimmune disorders.
Read More
Most Useful Reviews
9.5
Restores normality
I chose the liposomal vitamin D for my mother due to her significant deficiency revealed by tests. After 1.5 months of taking 4-5 tablets weekly, she now falls just below the average range. I intend to order more to maintain her vitamin D levels. Hope this review helps!
Read More
9.5
Energy boost
This product is 100% effective, as confirmed by my tests; my vitamin D index rose from 11 to 70 in two months! I've gained energy, and the natural ingredients are vital for my health. I'll definitely order again, especially as the sun exposure increases. The capsules are easy to swallow too.
Read More
8.8
Effective vitamin D
Raised my 69-year-old mother's vitamin D level from 14 to 50 units in just a month. I immediately ordered four packs for the family as winter approached. Since taking liposomal vitamins, the absorption has significantly improved; previously, she took Aquadetrim for nine months, increasing her level by only 20 units. This fat-soluble vitamin works better than others I've tried. Considering the overall admission period, it might not even cost more in the long run, as it raises vitamin D levels more rapidly. Highly recommend!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.5
- All Researches
9.5
Vitamin D3 aids autoimmune thyroiditis
Supplementation with active vitamin D3 ameliorates experimental autoimmune thyroiditis in mice by modulating the differentiation and functionality of intrathyroidal T-cell subsets.
Highly relevant to autoimmune research
We observed that vitamin D3 supplementation may play a significant role in managing autoimmune thyroiditis, a condition often marked by thyroid inflammation. In this study, researchers induced autoimmune thyroiditis in female mice and administered vitamin D3 to evaluate its effects on the disease.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
Read More
9
Vitamin D3 mitigates autoimmune thyroiditis
Supplementation with active vitamin D3 ameliorates experimental autoimmune thyroiditis in mice by modulating the differentiation and functionality of intrathyroidal T-cell subsets.
High relevance to thyroiditis treatment
Our research aimed to understand how vitamin D3 affects autoimmune thyroiditis, particularly in the context of Hashimoto's thyroiditis, which is characterized by low levels of vitamin D3 in patients. We induced a model of autoimmune thyroiditis in female mice and treated them with vitamin D3 to see if it could alleviate the symptoms of this condition.
After 8 weeks of treatment, we observed that vitamin D3 significantly improved the condition of the thyroid in these mice. The inflammation that commonly accompanies autoimmune thyroiditis decreased, and levels of thyroid autoantibodies, which indicate the severity of the disorder, also dropped. Notably, the application of vitamin D3 inhibited the activity of harmful immune cells while promoting the function of protective cells, providing a better balance in the immune response.
Overall, our findings suggest that vitamin D3 supplementation could be a promising strategy to manage autoimmune thyroiditis by restoring immune balance and reducing inflammation. This not only enhances our understanding of the disease but also opens up potential avenues for treatment in humans facing similar issues with autoimmune disorders.
After 8 weeks of treatment, we observed that vitamin D3 significantly improved the condition of the thyroid in these mice. The inflammation that commonly accompanies autoimmune thyroiditis decreased, and levels of thyroid autoantibodies, which indicate the severity of the disorder, also dropped. Notably, the application of vitamin D3 inhibited the activity of harmful immune cells while promoting the function of protective cells, providing a better balance in the immune response.
Overall, our findings suggest that vitamin D3 supplementation could be a promising strategy to manage autoimmune thyroiditis by restoring immune balance and reducing inflammation. This not only enhances our understanding of the disease but also opens up potential avenues for treatment in humans facing similar issues with autoimmune disorders.
Read More
9
IgG4-RD case report findings
IgG4-RD-Associated Mikulicz Syndrome Without Classic Systemic Involvement-A Case Report.
Vitamin D3 used with corticosteroids
We explored an intriguing instance of IgG4-related disease (IgG4-RD) manifesting as Mikulicz syndrome in an 85-year-old male patient. This condition usually involves significant systemic symptoms, yet our patient exhibited primarily local manifestations, specifically bilateral dacryoadenitis and orbital pseudotumor, without major organ complications.
Interestingly, despite normal serum IgG4 levels, which were below 135 mg/dL, the clinical and imaging findings strongly suggested the diagnosis of IgG4-RD. This scenario underscores the importance of undertaking a biopsy for accurate diagnosis. Histopathological examination revealed notable signs, such as a dense lymphoplasmacytic infiltrate and storiform fibrosis, with a considerable percentage of IgG4-positive cells, ultimately confirming our diagnosis.
We observed that treatment with prednisone, alongside azathioprine for long-term control, was effective. To mitigate the risk of glucocorticoid-induced osteoporosis, we added calcium and vitamin D3 supplementation. Remarkably, the patient showed significant clinical improvement within just 24 hours, with resolution of orbital and glandular symptoms over the following year. There was a complete recovery of vision and no relapses, with only minor dry eye as a long-term concern.
This case demonstrates the necessity of considering IgG4-RD even when serum IgG4 levels are normal and highlights the role of histopathology in diagnosis. Furthermore, it showcases the effectiveness of corticosteroids as a first-line treatment in managing this condition.
Interestingly, despite normal serum IgG4 levels, which were below 135 mg/dL, the clinical and imaging findings strongly suggested the diagnosis of IgG4-RD. This scenario underscores the importance of undertaking a biopsy for accurate diagnosis. Histopathological examination revealed notable signs, such as a dense lymphoplasmacytic infiltrate and storiform fibrosis, with a considerable percentage of IgG4-positive cells, ultimately confirming our diagnosis.
We observed that treatment with prednisone, alongside azathioprine for long-term control, was effective. To mitigate the risk of glucocorticoid-induced osteoporosis, we added calcium and vitamin D3 supplementation. Remarkably, the patient showed significant clinical improvement within just 24 hours, with resolution of orbital and glandular symptoms over the following year. There was a complete recovery of vision and no relapses, with only minor dry eye as a long-term concern.
This case demonstrates the necessity of considering IgG4-RD even when serum IgG4 levels are normal and highlights the role of histopathology in diagnosis. Furthermore, it showcases the effectiveness of corticosteroids as a first-line treatment in managing this condition.
Read More
9
Calcitriol improves immune regulation
Calcitriol Treated Mesenchymal Stem Cells Modulated Immune Response in Collagen-Induced Rheumatoid Arthritis in BALB/c Mice.
Study relevant to autoimmune therapy.
We examined the effects of calcitriol, an active form of vitamin D3, on mesenchymal stem cells (MSCs) in a model of rheumatoid arthritis. To do this, we induced arthritis in BALB/c mice and divided them into three groups: those without treatment, those treated with untreated MSCs, and those treated with calcitriol-exposed MSCs.
After conducting our experiments, we found that MSCs treated with calcitriol demonstrated improved regulatory functions and inhibited inflammatory responses more effectively than untreated MSCs. Specifically, we observed differences in the behavior of immune cells, with calcitriol-treated cells showing reduced levels of certain inflammatory cytokines, like INF-γ and IL-17, while increasing beneficial cytokines such as IL-4, IL-10, and TGF-β.
These findings suggest that vitamin D3 may play an important role in moderating the immune response in autoimmune conditions like rheumatoid arthritis, potentially offering a pathway for more effective treatment options.
After conducting our experiments, we found that MSCs treated with calcitriol demonstrated improved regulatory functions and inhibited inflammatory responses more effectively than untreated MSCs. Specifically, we observed differences in the behavior of immune cells, with calcitriol-treated cells showing reduced levels of certain inflammatory cytokines, like INF-γ and IL-17, while increasing beneficial cytokines such as IL-4, IL-10, and TGF-β.
These findings suggest that vitamin D3 may play an important role in moderating the immune response in autoimmune conditions like rheumatoid arthritis, potentially offering a pathway for more effective treatment options.
Read More
9
Vitamin D3 aids immune balance
1,25(OH)D-treated mouse bone marrow-derived dendritic cells alleviate autoimmune hepatitis in mice by improving TFR/TFH imbalance.
Directly investigates vitamin D3 effects
We aimed to understand how vitamin D3, specifically its active form 1,25(OH)D, affects autoimmune hepatitis (AIH), a complex autoimmune disease that causes liver damage. Researchers focused on the role of a special type of immune cell known as dendritic cells (DCs), which are influenced by vitamin D3 to promote a more balanced immune response.
Through our investigation using a mouse model, we observed that injecting these vitamin D3-modulated dendritic cells, which overexpress a molecule called PD-L1, significantly lessened liver injury and severity of autoimmune hepatitis. This treatment appeared to correct the imbalance between two types of T cells: regulatory T cells (TFR) and follicular helper T cells (TFH).
By increasing the TFR population and restoring their balance with TFH cells, vitamin D3 treatment helped regulate this immune response. Additionally, the infusion boosted the production of anti-inflammatory substances while decreasing those linked to inflammation, suggesting a potential new avenue for treating autoimmune hepatitis. Overall, these findings indicate that vitamin D3-modulated dendritic cells could be a promising strategy for managing autoimmune conditions like AIH.
Through our investigation using a mouse model, we observed that injecting these vitamin D3-modulated dendritic cells, which overexpress a molecule called PD-L1, significantly lessened liver injury and severity of autoimmune hepatitis. This treatment appeared to correct the imbalance between two types of T cells: regulatory T cells (TFR) and follicular helper T cells (TFH).
By increasing the TFR population and restoring their balance with TFH cells, vitamin D3 treatment helped regulate this immune response. Additionally, the infusion boosted the production of anti-inflammatory substances while decreasing those linked to inflammation, suggesting a potential new avenue for treating autoimmune hepatitis. Overall, these findings indicate that vitamin D3-modulated dendritic cells could be a promising strategy for managing autoimmune conditions like AIH.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Restores normality
I chose the liposomal vitamin D for my mother due to her significant deficiency revealed by tests. After 1.5 months of taking 4-5 tablets weekly, she now falls just below the average range. I intend to order more to maintain her vitamin D levels. Hope this review helps!
9.5
Energy boost
This product is 100% effective, as confirmed by my tests; my vitamin D index rose from 11 to 70 in two months! I've gained energy, and the natural ingredients are vital for my health. I'll definitely order again, especially as the sun exposure increases. The capsules are easy to swallow too.
Read More
8.8
Effective vitamin D
Raised my 69-year-old mother's vitamin D level from 14 to 50 units in just a month. I immediately ordered four packs for the family as winter approached. Since taking liposomal vitamins, the absorption has significantly improved; previously, she took Aquadetrim for nine months, increasing her level by only 20 units. This fat-soluble vitamin works better than others I've tried. Considering the overall admission period, it might not even cost more in the long run, as it raises vitamin D levels more rapidly. Highly recommend!
Read More
8.8
Great absorption
I ordered this after the regular version did not improve my levels. I suspect a leaky gut, hence poor absorption. After taking the liposomal vitamin, my levels increased from 14.60 to 36.50. I plan to continue using this form for better absorption of fat-soluble vitamins. Thank you!
8.8
Boosts energy
I've been using Dr. Mercola's products for quite a while. I began this high-dose vitamin D3 to promote hair growth, and I've observed improvements in both hair growth and reduced hair loss. My energy levels also increased while taking it, and I really felt the decline when I ran out. I've started ordering the 90 capsules bottle to keep my stock replenished at home!
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Frequently Asked Questions
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