' 
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.8
USERS' SCORE
Good
Based on 10 Reviews
8.8
Top Medical Research Studies
8
Omega-3s and skin allergies
ω3 fatty acid metabolite, 12-hydroxyeicosapentaenoic acid, alleviates contact hypersensitivity by downregulation of CXCL1 and CXCL2 gene expression in keratinocytes via retinoid X receptor α.
Critical exploration of 12-HEPE
We uncovered intriguing insights into how eicosapentaenoic acid (EPA) and its metabolite, 12-hydroxyeicosapentaenoic acid (12-HEPE), play a role in managing allergic responses, particularly in the skin. Our study revealed that when mice consumed an omega-3 fatty acid-rich diet, 12-HEPE became a significant metabolite in their skin.
Interestingly, we observed that the enzymes responsible for producing 12-HEPE were more active in the skin compared to other organs. This effective metabolite appeared to reduce inflammation caused by contact hypersensitivity. Specifically, we found that applying 12-HEPE topically limited the influx of neutrophils, a type of white blood cell involved in inflammatory responses.
Taking our research a step further, we investigated the effects of 12-HEPE on human skin cells, or keratinocytes, in lab conditions. Our findings showed that 12-HEPE inhibited two specific genes that cause neutrophils to be attracted to the site of inflammation, showcasing its potential as a therapeutic agent for allergy management. Overall, we identified 12-HEPE as a potent metabolite in the skin, suggesting that dietary omega-3 fatty acids could be a beneficial strategy in controlling allergic reactions.
Interestingly, we observed that the enzymes responsible for producing 12-HEPE were more active in the skin compared to other organs. This effective metabolite appeared to reduce inflammation caused by contact hypersensitivity. Specifically, we found that applying 12-HEPE topically limited the influx of neutrophils, a type of white blood cell involved in inflammatory responses.
Taking our research a step further, we investigated the effects of 12-HEPE on human skin cells, or keratinocytes, in lab conditions. Our findings showed that 12-HEPE inhibited two specific genes that cause neutrophils to be attracted to the site of inflammation, showcasing its potential as a therapeutic agent for allergy management. Overall, we identified 12-HEPE as a potent metabolite in the skin, suggesting that dietary omega-3 fatty acids could be a beneficial strategy in controlling allergic reactions.
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9
Eicosapentaenoic acid benefits allergies
Evaluating the Effect of Eicosapentaenoic Acid in Children With Atopic Dermatitis: A Randomized Triple-Blind Clinical Trial.
Directly addresses EPA for allergies
We explored the impact of dietary eicosapentaenoic acid (EPA) in children suffering from atopic dermatitis, a common allergic skin condition. In a well-structured study, forty-eight children were divided into two groups: one received 250 mg of EPA twice daily, while the other was given a placebo for four weeks.
The study aimed to measure the effectiveness of EPA by examining improvements in the SCORing Atopic Dermatitis (SCORAD) index and the need for topical corticosteroids. What we found was quite promising—after just two weeks, the EPA group showed significant improvement in their SCORAD scores compared to the placebo group.
Additionally, by the end of four weeks, fewer children in the EPA group required corticosteroids, indicating a potential reduction in the severity of their condition. Overall, the results suggest that EPA supplementation is both effective and well-tolerated among young patients with atopic dermatitis, offering a supportive strategy for managing this allergy-related issue.
The study aimed to measure the effectiveness of EPA by examining improvements in the SCORing Atopic Dermatitis (SCORAD) index and the need for topical corticosteroids. What we found was quite promising—after just two weeks, the EPA group showed significant improvement in their SCORAD scores compared to the placebo group.
Additionally, by the end of four weeks, fewer children in the EPA group required corticosteroids, indicating a potential reduction in the severity of their condition. Overall, the results suggest that EPA supplementation is both effective and well-tolerated among young patients with atopic dermatitis, offering a supportive strategy for managing this allergy-related issue.
Read More
9
Eicosapentaenoic acid reduces inflammation
Effect of Omega-3 Polyunsaturated Fatty Acids Intake on Eosinophil Airway Inflammation in University Athletes.
Direct insight into EPA's effects
We assessed how eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, influences airway inflammation related to allergies in university athletes. In our study, we had 23 male participants divided into three groups based on their levels of airway inflammation, measured by fractional exhaled nitric oxide (FeNO).
These athletes took daily supplements containing 600 mg of EPA for three weeks. During this time, we tracked changes in their FeNO levels and other respiratory factors. Our findings revealed a significant drop in FeNO levels among athletes with eosinophilic airway inflammation, indicating a reduction in airway inflammation.
Notably, while the athletes with high FeNO levels benefited from the supplementation, those without eosinophilic characteristics saw no significant changes in their respiratory status. This suggests that EPA may be particularly effective for certain allergy-related conditions, rather than universally beneficial for all types of respiratory issues.
These athletes took daily supplements containing 600 mg of EPA for three weeks. During this time, we tracked changes in their FeNO levels and other respiratory factors. Our findings revealed a significant drop in FeNO levels among athletes with eosinophilic airway inflammation, indicating a reduction in airway inflammation.
Notably, while the athletes with high FeNO levels benefited from the supplementation, those without eosinophilic characteristics saw no significant changes in their respiratory status. This suggests that EPA may be particularly effective for certain allergy-related conditions, rather than universally beneficial for all types of respiratory issues.
Read More
Most Useful Reviews
9.5
Significant improvement
Cheap, effective way to help with sore and itchy dog paws. I saw a video of someone using this for her dog's sore and itchy paws, so I tried it for my dog, who has been plagued with allergies this summer. A few of her toes got sore and infected, and we fill a low plastic tub for her to step in. We give her some cream cheese as a distraction and manage to let her soak for 3-5 minutes several times daily, leading to a significant improvement. We previously tried Hydrogen Peroxide and Epsom Salts, which didn't help much and seemed to sting her.
Read More
8.8
Effective treatment solution
Outstanding product for the money. This large bottle of Iodine prep solution is high-quality and thicker than many lesser brands. It works well diluted to a light tea colour to treat my dog's skin allergies and infections. I also use it full strength on cuts and scrapes myself, and it effectively prevents infections.
Read More
9.5
Natural healing solution
My dog suffers from extreme allergies and chews her feet until they are wounded. I prefer natural remedies over medication, and diluting this iodine with water for soaking has worked wonders, promoting healing of her occasional wounds.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.8
- All Researches
9
Eicosapentaenoic acid benefits allergies
Evaluating the Effect of Eicosapentaenoic Acid in Children With Atopic Dermatitis: A Randomized Triple-Blind Clinical Trial.
Directly addresses EPA for allergies
We explored the impact of dietary eicosapentaenoic acid (EPA) in children suffering from atopic dermatitis, a common allergic skin condition. In a well-structured study, forty-eight children were divided into two groups: one received 250 mg of EPA twice daily, while the other was given a placebo for four weeks.
The study aimed to measure the effectiveness of EPA by examining improvements in the SCORing Atopic Dermatitis (SCORAD) index and the need for topical corticosteroids. What we found was quite promising—after just two weeks, the EPA group showed significant improvement in their SCORAD scores compared to the placebo group.
Additionally, by the end of four weeks, fewer children in the EPA group required corticosteroids, indicating a potential reduction in the severity of their condition. Overall, the results suggest that EPA supplementation is both effective and well-tolerated among young patients with atopic dermatitis, offering a supportive strategy for managing this allergy-related issue.
The study aimed to measure the effectiveness of EPA by examining improvements in the SCORing Atopic Dermatitis (SCORAD) index and the need for topical corticosteroids. What we found was quite promising—after just two weeks, the EPA group showed significant improvement in their SCORAD scores compared to the placebo group.
Additionally, by the end of four weeks, fewer children in the EPA group required corticosteroids, indicating a potential reduction in the severity of their condition. Overall, the results suggest that EPA supplementation is both effective and well-tolerated among young patients with atopic dermatitis, offering a supportive strategy for managing this allergy-related issue.
Read More
9
Eicosapentaenoic acid reduces inflammation
Effect of Omega-3 Polyunsaturated Fatty Acids Intake on Eosinophil Airway Inflammation in University Athletes.
Direct insight into EPA's effects
We assessed how eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, influences airway inflammation related to allergies in university athletes. In our study, we had 23 male participants divided into three groups based on their levels of airway inflammation, measured by fractional exhaled nitric oxide (FeNO).
These athletes took daily supplements containing 600 mg of EPA for three weeks. During this time, we tracked changes in their FeNO levels and other respiratory factors. Our findings revealed a significant drop in FeNO levels among athletes with eosinophilic airway inflammation, indicating a reduction in airway inflammation.
Notably, while the athletes with high FeNO levels benefited from the supplementation, those without eosinophilic characteristics saw no significant changes in their respiratory status. This suggests that EPA may be particularly effective for certain allergy-related conditions, rather than universally beneficial for all types of respiratory issues.
These athletes took daily supplements containing 600 mg of EPA for three weeks. During this time, we tracked changes in their FeNO levels and other respiratory factors. Our findings revealed a significant drop in FeNO levels among athletes with eosinophilic airway inflammation, indicating a reduction in airway inflammation.
Notably, while the athletes with high FeNO levels benefited from the supplementation, those without eosinophilic characteristics saw no significant changes in their respiratory status. This suggests that EPA may be particularly effective for certain allergy-related conditions, rather than universally beneficial for all types of respiratory issues.
Read More
9
Eicosapentaenoic acid and allergies
Long-Chain Polyunsaturated Fatty Acid Status at Birth and Development of Childhood Allergy: A Systematic Review.
Focused on EPA's allergy impact
We focused on understanding how the levels of eicosapentaenoic acid (EPA) at birth relate to allergies in children. Through a systematic review, we analyzed multiple studies, narrowing it down to 14 key articles that matched our criteria. The findings suggested that lower levels of EPA in cord blood were linked to a higher likelihood of allergic conditions later in childhood.
When we looked deeper, we discovered that not only high levels of EPA, but also docosahexaenoic acid (DHA) and total n-3 long-chain polyunsaturated fatty acids were associated with a significant drop—at least 38%—in the risk of developing allergies in various studies. Additionally, we noted that the higher the levels of EPA, DHA, and docosapentaenoic acid in cord blood, the lower the laboratory measurements indicating allergic traits.
This paints a promising picture for the potential of these fatty acids in managing allergy risks. Overall, our findings can guide recommendations for the fatty acid intake that pregnant women should consider for better health outcomes for their children.
When we looked deeper, we discovered that not only high levels of EPA, but also docosahexaenoic acid (DHA) and total n-3 long-chain polyunsaturated fatty acids were associated with a significant drop—at least 38%—in the risk of developing allergies in various studies. Additionally, we noted that the higher the levels of EPA, DHA, and docosapentaenoic acid in cord blood, the lower the laboratory measurements indicating allergic traits.
This paints a promising picture for the potential of these fatty acids in managing allergy risks. Overall, our findings can guide recommendations for the fatty acid intake that pregnant women should consider for better health outcomes for their children.
Read More
9
Eicosapentaenoic acid aids allergy treatment
17(),18()-epoxyeicosatetraenoic acid generated by cytochrome P450 BM-3 from inhibits the development of contact hypersensitivity via G-protein-coupled receptor 40-mediated neutrophil suppression.
High relevance to allergy impacts
We examined how eicosapentaenoic acid (EPA) could influence allergic reactions, particularly through its metabolite known as 17,18-epoxyeicosatetraenoic acid (17,18-EpETE). This metabolite is recognized for its strong anti-allergic and anti-inflammatory properties.
Our findings highlighted that 17,18-EpETE can alleviate skin contact hypersensitivity, a common allergic response. Notably, this effect was not shared by its enantiomer, 17(),18()-EpETE, indicating that the specific form of the metabolite makes a significant difference in efficacy.
We discovered that a specific enzyme, cytochrome P450 BM-3, was effective in converting EPA into the beneficial 17,18-EpETE. This conversion served to inhibit neutrophil migration, a key component of allergic reactions, through a mechanism involving G protein-coupled receptor 40.
These results suggest that utilizing this bacterial enzyme may pave the way for producing this important lipid mediator in larger quantities, which could be advantageous for developing new allergy treatments. Overall, our research underscores the potential of EPA in addressing allergic conditions and contributes to the growing understanding of how dietary components can affect health.
Our findings highlighted that 17,18-EpETE can alleviate skin contact hypersensitivity, a common allergic response. Notably, this effect was not shared by its enantiomer, 17(),18()-EpETE, indicating that the specific form of the metabolite makes a significant difference in efficacy.
We discovered that a specific enzyme, cytochrome P450 BM-3, was effective in converting EPA into the beneficial 17,18-EpETE. This conversion served to inhibit neutrophil migration, a key component of allergic reactions, through a mechanism involving G protein-coupled receptor 40.
These results suggest that utilizing this bacterial enzyme may pave the way for producing this important lipid mediator in larger quantities, which could be advantageous for developing new allergy treatments. Overall, our research underscores the potential of EPA in addressing allergic conditions and contributes to the growing understanding of how dietary components can affect health.
Read More
8
Eicosapentaenoic acid and allergies
[Analysis of the effect of early subcutaneous specific immunotherapy on the levels of dust mite allergen-specific antibodies and polyunsaturated fatty acid metabolism].
Limited specific conclusions noted
We aimed to understand how eicosapentaenoic acid, a type of beneficial fat known as a polyunsaturated fatty acid, interacts with allergy treatments like subcutaneous immunotherapy (SCIT). In our study, we assessed the effects of SCIT on patients allergic to dust mites, focusing on changes in specific antibodies and fatty acid metabolism over 12 months.
Notably, after treatment, eicosapentaenoic acid levels were observed to decrease in certain patient groups. While this may seem discouraging at first, we also uncovered new connections between eicosapentaenoic acid and specific allergy-related immune responses. For instance, we found that higher levels of certain fatty acids, including eicosapentaenoic acid, positively correlated with increases in dust mite-specific antibodies, suggesting a complex interplay between nutrition and immune function during allergy treatment.
Despite the intricate relationships we uncovered, we did not find any significant standalone benefits of eicosapentaenoic acid treatment used independently for allergies. Our research remains pivotal in helping us explore potential ties between dietary fats and allergic reactions, setting the stage for future studies to delve deeper into these relationships.
Notably, after treatment, eicosapentaenoic acid levels were observed to decrease in certain patient groups. While this may seem discouraging at first, we also uncovered new connections between eicosapentaenoic acid and specific allergy-related immune responses. For instance, we found that higher levels of certain fatty acids, including eicosapentaenoic acid, positively correlated with increases in dust mite-specific antibodies, suggesting a complex interplay between nutrition and immune function during allergy treatment.
Despite the intricate relationships we uncovered, we did not find any significant standalone benefits of eicosapentaenoic acid treatment used independently for allergies. Our research remains pivotal in helping us explore potential ties between dietary fats and allergic reactions, setting the stage for future studies to delve deeper into these relationships.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.8
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Significant improvement
Cheap, effective way to help with sore and itchy dog paws. I saw a video of someone using this for her dog's sore and itchy paws, so I tried it for my dog, who has been plagued with allergies this summer. A few of her toes got sore and infected, and we fill a low plastic tub for her to step in. We give her some cream cheese as a distraction and manage to let her soak for 3-5 minutes several times daily, leading to a significant improvement. We previously tried Hydrogen Peroxide and Epsom Salts, which didn't help much and seemed to sting her.
Read More
8.8
Effective treatment solution
Outstanding product for the money. This large bottle of Iodine prep solution is high-quality and thicker than many lesser brands. It works well diluted to a light tea colour to treat my dog's skin allergies and infections. I also use it full strength on cuts and scrapes myself, and it effectively prevents infections.
Read More
9.5
Natural healing solution
My dog suffers from extreme allergies and chews her feet until they are wounded. I prefer natural remedies over medication, and diluting this iodine with water for soaking has worked wonders, promoting healing of her occasional wounds.
9.5
Must-have product
This product works well for my dog dealing with skin allergies. I started with a smaller bottle to test it, and it was effective, leading me to order a larger size. The price is fantastic compared to my local drugstore. It has become a definite "must" for my dog's treatment.
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9.5
Significant relief
I love this for my dog's skin allergies. I dilute it to a tea colour and rinse her skin with it several times, patting her dry without rinsing. This method has provided significant relief, especially for a severe hot spot, which improved with twice-daily applications despite keeping a cone on her head to prevent her from obsessing over it.
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