Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 12 Researches
8.5
USERS' SCORE
Good
Based on 3 Reviews
8.5
Supplement Facts
Serving Size: 2 Gummies
Serving Per Container: 30
Amount Per Serving
%DV
Calories
20
Total Carbohydrate
5 g
2%**
Total Sugars
3 g
†
Includes 3 g Added Sugars
6%**
Vitamin C
45 mg
50%
Zinc
7.5 mg
68%
Sodium
15 mg
<1%
Organic Black Elderberry Concentrate (Sambucus nigra) (fruit) (65:1)
150 mg
†
Organic VitaBerry® Fruit BlendStrawberry, Raspberry, Blueberry, Tart Cherry, Elderberry, Cranberry Powders
25 mg
†
Bacillus coagulans (Lactospore®)
10 mg(1 Billion CFU)
†
Top Medical Research Studies
9
We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.
Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.
The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.
Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.
The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.
Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
Read More
9
We explored the potential of zinc to manage allergic responses by examining its effects on a specific type of immune cell called RBL-2H3. This research highlighted how zinc sulfate (ZnSO) treatment can prevent cell degranulation, which is a process crucial for allergic reactions, triggered by antigens and IgE stimulation.
Our findings showed that ZnSO not only inhibited cell degranulation but also reduced the expression of certain immune signaling molecules such as IL-4, IL-13, and COX-2. We observed that the increased levels of calcium inside the cells, which usually accompany these allergic reactions, were significantly lowered with zinc treatment.
Interestingly, while zinc did not interfere with the activation of several key proteins in the signaling pathway, it was effective at reducing the overall calcium influx associated with allergic responses. This suggests that zinc might be acting on calcium release-activated channels, offering a preventative advantage in allergic conditions.
Overall, we conclude that treating with zinc sulfate could be a valuable strategy for suppressing allergic responses, making it a topic worth considering for further research and application in allergy management.
Our findings showed that ZnSO not only inhibited cell degranulation but also reduced the expression of certain immune signaling molecules such as IL-4, IL-13, and COX-2. We observed that the increased levels of calcium inside the cells, which usually accompany these allergic reactions, were significantly lowered with zinc treatment.
Interestingly, while zinc did not interfere with the activation of several key proteins in the signaling pathway, it was effective at reducing the overall calcium influx associated with allergic responses. This suggests that zinc might be acting on calcium release-activated channels, offering a preventative advantage in allergic conditions.
Overall, we conclude that treating with zinc sulfate could be a valuable strategy for suppressing allergic responses, making it a topic worth considering for further research and application in allergy management.
Read More
9
We explored the effects of oral probiotics, specifically Bacillus subtilis and Bacillus coagulans, on dogs suffering from allergic contact dermatitis. In a study involving 20 healthy dogs, four groups were given either probiotics, cortisone, a combination, or no treatment for 30 days. The results revealed that the probiotics helped reduce allergy symptoms, accelerated wound healing, and boosted immune responses. Notably, they increased antibody levels and decreased harmful proteins in the dogs, showing promise as an alternative to traditional corticosteroid treatments.
Read More
Most Useful Reviews
9
Effective for allergies
Very good quality extract - convenient to take and much more effective than consuming grass. I trust the purity of the raw material, as it has no impurities. I use it myself and give it to my children for their allergies, which we have not recommended before.
Read More
9
Helps with allergies
Delicious for a child! I love this company; the price and quality are perfect. Elderberry is an excellent antioxidant, and this package lasts for a course. I've noticed fewer acute exacerbations of allergies in my baby. At the first signs of a viral infection, I increase the dosage immediately.
Read More
7.5
Good for allergies
I took the vitamins at a great price. In the autumn-winter period, a first aid kit is essential. I will purchase for the future, as they do not cause allergies and are well absorbed.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 12 Researches
8.5
- All Researches
9
We delved into the effectiveness of zinc treatment in managing allergic rhinitis, aided by a systematic review of clinical studies. Our exploration began with a thorough search of major databases, revealing insights from five clinical reports that met the necessary criteria for inclusion. These studies involved participants ranging from 40 to 180 individuals, providing a balanced mix of genders.
The results spotlighted the positive impact of combining quail egg-based supplements (QES) with zinc. Notably, this combination significantly improved several key measures, such as peak nasal inspiratory flow and mucociliary transport time. We observed that patients experienced relief from troublesome symptoms like nasal congestion, rhinorrhea, and sneezing. Moreover, this combination seemed to reduce the need for standard allergy medications, offering an appealing alternative for those seeking symptom relief.
Importantly, zinc and QES were generally well tolerated, with few reported side effects, which were usually mild and temporary. However, it’s crucial to highlight that individuals with egg allergies should avoid these supplements. As such, while our findings suggest that zinc, particularly in conjunction with QES, can play a role in alleviating allergic rhinitis symptoms, further research is encouraged to solidify these promising results.
The results spotlighted the positive impact of combining quail egg-based supplements (QES) with zinc. Notably, this combination significantly improved several key measures, such as peak nasal inspiratory flow and mucociliary transport time. We observed that patients experienced relief from troublesome symptoms like nasal congestion, rhinorrhea, and sneezing. Moreover, this combination seemed to reduce the need for standard allergy medications, offering an appealing alternative for those seeking symptom relief.
Importantly, zinc and QES were generally well tolerated, with few reported side effects, which were usually mild and temporary. However, it’s crucial to highlight that individuals with egg allergies should avoid these supplements. As such, while our findings suggest that zinc, particularly in conjunction with QES, can play a role in alleviating allergic rhinitis symptoms, further research is encouraged to solidify these promising results.
Read More
9
We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.
Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.
The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.
Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.
The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.
Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
Read More
9
We explored the potential of zinc to manage allergic responses by examining its effects on a specific type of immune cell called RBL-2H3. This research highlighted how zinc sulfate (ZnSO) treatment can prevent cell degranulation, which is a process crucial for allergic reactions, triggered by antigens and IgE stimulation.
Our findings showed that ZnSO not only inhibited cell degranulation but also reduced the expression of certain immune signaling molecules such as IL-4, IL-13, and COX-2. We observed that the increased levels of calcium inside the cells, which usually accompany these allergic reactions, were significantly lowered with zinc treatment.
Interestingly, while zinc did not interfere with the activation of several key proteins in the signaling pathway, it was effective at reducing the overall calcium influx associated with allergic responses. This suggests that zinc might be acting on calcium release-activated channels, offering a preventative advantage in allergic conditions.
Overall, we conclude that treating with zinc sulfate could be a valuable strategy for suppressing allergic responses, making it a topic worth considering for further research and application in allergy management.
Our findings showed that ZnSO not only inhibited cell degranulation but also reduced the expression of certain immune signaling molecules such as IL-4, IL-13, and COX-2. We observed that the increased levels of calcium inside the cells, which usually accompany these allergic reactions, were significantly lowered with zinc treatment.
Interestingly, while zinc did not interfere with the activation of several key proteins in the signaling pathway, it was effective at reducing the overall calcium influx associated with allergic responses. This suggests that zinc might be acting on calcium release-activated channels, offering a preventative advantage in allergic conditions.
Overall, we conclude that treating with zinc sulfate could be a valuable strategy for suppressing allergic responses, making it a topic worth considering for further research and application in allergy management.
Read More
9
We investigated how zinc oxide nanoparticles (nZnO), commonly found in skin products like sunscreens, influence allergic reactions in the skin. Using a specific mouse model that simulates contact allergies, we wanted to understand whether applying nZnO during the sensitization or challenge phases would alter the immune response.
Our research showed that these nanoparticles, when applied during the allergic reaction, were able to suppress the immune response significantly. We noted a reduction in skin inflammation, with the strongest effects observed within 24 hours of exposure, and these effects lasted up to 28 days. Interestingly, while nZnO didn't hinder the initial allergy sensitization process, it did prevent the allergic reaction from fully developing when the allergen was introduced.
We found that the immunosuppressive properties of nZnO are tied to its ability to disrupt certain inflammatory signaling pathways. These findings suggest that nZnO could provide relief for people dealing with contact allergies, especially those using products containing these nanoparticles. Overall, our study sheds light on the potential benefits and mechanisms of nZnO in managing skin allergies.
Our research showed that these nanoparticles, when applied during the allergic reaction, were able to suppress the immune response significantly. We noted a reduction in skin inflammation, with the strongest effects observed within 24 hours of exposure, and these effects lasted up to 28 days. Interestingly, while nZnO didn't hinder the initial allergy sensitization process, it did prevent the allergic reaction from fully developing when the allergen was introduced.
We found that the immunosuppressive properties of nZnO are tied to its ability to disrupt certain inflammatory signaling pathways. These findings suggest that nZnO could provide relief for people dealing with contact allergies, especially those using products containing these nanoparticles. Overall, our study sheds light on the potential benefits and mechanisms of nZnO in managing skin allergies.
Read More
9
We explored the effects of oral probiotics, specifically Bacillus subtilis and Bacillus coagulans, on dogs suffering from allergic contact dermatitis. In a study involving 20 healthy dogs, four groups were given either probiotics, cortisone, a combination, or no treatment for 30 days. The results revealed that the probiotics helped reduce allergy symptoms, accelerated wound healing, and boosted immune responses. Notably, they increased antibody levels and decreased harmful proteins in the dogs, showing promise as an alternative to traditional corticosteroid treatments.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective for allergies
Very good quality extract - convenient to take and much more effective than consuming grass. I trust the purity of the raw material, as it has no impurities. I use it myself and give it to my children for their allergies, which we have not recommended before.
Read More
9
Helps with allergies
Delicious for a child! I love this company; the price and quality are perfect. Elderberry is an excellent antioxidant, and this package lasts for a course. I've noticed fewer acute exacerbations of allergies in my baby. At the first signs of a viral infection, I increase the dosage immediately.
Read More
7.5
Good for allergies
I took the vitamins at a great price. In the autumn-winter period, a first aid kit is essential. I will purchase for the future, as they do not cause allergies and are well absorbed.
Read More
Frequently Asked Questions
9
Helps with allergies
Delicious for a child! I love this company; the price and quality are perfect. Elderberry is an excellent antioxidant, and this package lasts for a course. I've noticed fewer acute exacerbations of allergies in my baby. At the first signs of a viral infection, I increase the dosage immediately.
9
Effective for allergies
Very good quality extract - convenient to take and much more effective than consuming grass. I trust the purity of the raw material, as it has no impurities. I use it myself and give it to my children for their allergies, which we have not recommended before.
7.5
Good for allergies
I took the vitamins at a great price. In the autumn-winter period, a first aid kit is essential. I will purchase for the future, as they do not cause allergies and are well absorbed.
9
We delved into the effectiveness of zinc treatment in managing allergic rhinitis, aided by a systematic review of clinical studies. Our exploration began with a thorough search of major databases, revealing insights from five clinical reports that met the necessary criteria for inclusion. These studies involved participants ranging from 40 to 180 individuals, providing a balanced mix of genders.
The results spotlighted the positive impact of combining quail egg-based supplements (QES) with zinc. Notably, this combination significantly improved several key measures, such as peak nasal inspiratory flow and mucociliary transport time. We observed that patients experienced relief from troublesome symptoms like nasal congestion, rhinorrhea, and sneezing. Moreover, this combination seemed to reduce the need for standard allergy medications, offering an appealing alternative for those seeking symptom relief.
Importantly, zinc and QES were generally well tolerated, with few reported side effects, which were usually mild and temporary. However, it’s crucial to highlight that individuals with egg allergies should avoid these supplements. As such, while our findings suggest that zinc, particularly in conjunction with QES, can play a role in alleviating allergic rhinitis symptoms, further research is encouraged to solidify these promising results.
The results spotlighted the positive impact of combining quail egg-based supplements (QES) with zinc. Notably, this combination significantly improved several key measures, such as peak nasal inspiratory flow and mucociliary transport time. We observed that patients experienced relief from troublesome symptoms like nasal congestion, rhinorrhea, and sneezing. Moreover, this combination seemed to reduce the need for standard allergy medications, offering an appealing alternative for those seeking symptom relief.
Importantly, zinc and QES were generally well tolerated, with few reported side effects, which were usually mild and temporary. However, it’s crucial to highlight that individuals with egg allergies should avoid these supplements. As such, while our findings suggest that zinc, particularly in conjunction with QES, can play a role in alleviating allergic rhinitis symptoms, further research is encouraged to solidify these promising results.
9
We explored the potential of zinc to manage allergic responses by examining its effects on a specific type of immune cell called RBL-2H3. This research highlighted how zinc sulfate (ZnSO) treatment can prevent cell degranulation, which is a process crucial for allergic reactions, triggered by antigens and IgE stimulation.
Our findings showed that ZnSO not only inhibited cell degranulation but also reduced the expression of certain immune signaling molecules such as IL-4, IL-13, and COX-2. We observed that the increased levels of calcium inside the cells, which usually accompany these allergic reactions, were significantly lowered with zinc treatment.
Interestingly, while zinc did not interfere with the activation of several key proteins in the signaling pathway, it was effective at reducing the overall calcium influx associated with allergic responses. This suggests that zinc might be acting on calcium release-activated channels, offering a preventative advantage in allergic conditions.
Overall, we conclude that treating with zinc sulfate could be a valuable strategy for suppressing allergic responses, making it a topic worth considering for further research and application in allergy management.
Our findings showed that ZnSO not only inhibited cell degranulation but also reduced the expression of certain immune signaling molecules such as IL-4, IL-13, and COX-2. We observed that the increased levels of calcium inside the cells, which usually accompany these allergic reactions, were significantly lowered with zinc treatment.
Interestingly, while zinc did not interfere with the activation of several key proteins in the signaling pathway, it was effective at reducing the overall calcium influx associated with allergic responses. This suggests that zinc might be acting on calcium release-activated channels, offering a preventative advantage in allergic conditions.
Overall, we conclude that treating with zinc sulfate could be a valuable strategy for suppressing allergic responses, making it a topic worth considering for further research and application in allergy management.
7
We examined the relationship between zinc levels and common allergic diseases like allergic asthma, atopic dermatitis, and allergic rhinitis. By leveraging Mendelian randomization analysis, we looked into how varying concentrations of zinc could influence the risk of these allergies.
Our findings suggest that higher zinc levels in the bloodstream may help lower the chances of developing allergic asthma and atopic dermatitis. However, we also observed that an increase in vitamin C could potentially raise the risk of atopic dermatitis, indicating a complex interaction among nutrients.
Additionally, it seems that zinc, alongside phosphorus, could play a role in reducing the risk of allergic rhinitis. While these results are promising, it's important to note that they don't fully isolate zinc’s effects from other micronutrients, which means more focused research could clarify its role in managing allergies.
Our findings suggest that higher zinc levels in the bloodstream may help lower the chances of developing allergic asthma and atopic dermatitis. However, we also observed that an increase in vitamin C could potentially raise the risk of atopic dermatitis, indicating a complex interaction among nutrients.
Additionally, it seems that zinc, alongside phosphorus, could play a role in reducing the risk of allergic rhinitis. While these results are promising, it's important to note that they don't fully isolate zinc’s effects from other micronutrients, which means more focused research could clarify its role in managing allergies.
8
Zinc supplementation may reduce allergies
We explored how zinc interacts with allergic diseases, which have been rising in prevalence worldwide, affecting both Western and developing nations. The question we aimed to answer was whether zinc deficiency contributes to these allergies and if zinc supplementation can help alleviate symptoms.
Our findings highlight that zinc is an essential trace element crucial for modulating our immune response. This was first noted over 60 years ago, and since then, we have continued to observe the connection between zinc levels and allergic reactions. Allergic conditions like asthma, allergic rhinitis, and skin allergies occur when the immune system overreacts to normally harmless substances, leading to chronic inflammation.
Notably, zinc deficiency can mimic some of the immune responses seen in these allergies, showing how intertwined our nutrition is with our immune health. We noted that while different clinical trials on zinc supplementation yield varied results due to factors like dosage and study design, the overall literature suggests that increasing zinc intake can positively influence immune function and help reduce allergic symptoms.
In conclusion, while further investigation is needed to fully understand the nuances, it appears that maintaining adequate zinc levels could be beneficial for those suffering from allergic diseases.
Our findings highlight that zinc is an essential trace element crucial for modulating our immune response. This was first noted over 60 years ago, and since then, we have continued to observe the connection between zinc levels and allergic reactions. Allergic conditions like asthma, allergic rhinitis, and skin allergies occur when the immune system overreacts to normally harmless substances, leading to chronic inflammation.
Notably, zinc deficiency can mimic some of the immune responses seen in these allergies, showing how intertwined our nutrition is with our immune health. We noted that while different clinical trials on zinc supplementation yield varied results due to factors like dosage and study design, the overall literature suggests that increasing zinc intake can positively influence immune function and help reduce allergic symptoms.
In conclusion, while further investigation is needed to fully understand the nuances, it appears that maintaining adequate zinc levels could be beneficial for those suffering from allergic diseases.
References
- Jesenak M, Hrubisko M, Chudek J, Bystron J, Rennerova Z, et al. Beneficial effects of pleuran on asthma control and respiratory tract-infection frequency in children with perennial asthma. Sci Rep. 2025;15:7146. doi:10.1038/s41598-025-91830-2
- Antonelli M, Mazzoleni E, Donelli D. Quail Egg-Based Supplements in Allergic Rhinitis: A Systematic Review of Clinical Studies. Nutrients. 2025;17. doi:10.3390/nu17040712
- Xu H, Tong K, Iwasaki N, Ohgami N, Tazaki A, et al. Alleviating effect of intranasal zinc on symptoms of allergic rhinitis. J Allergy Clin Immunol Glob. 2025;4:100408. doi:10.1016/j.jacig.2025.100408
- Otsuka T, Sato K, Kamiya T, Tanaka H, Hara H. Zinc treatment prevents IgE-mediated Ca influx and allergic response in RBL-2H3 cells. Eur J Pharmacol. 2025;994:177391. doi:10.1016/j.ejphar.2025.177391
- Wang S, Ilves M, Mäenpää K, Zhao L, El-Nezami H, et al. ZnO Nanoparticles as Potent Inducers of Dermal Immunosuppression in Contact Hypersensitivity in Mice. ACS Nano. 2024;18:29479. doi:10.1021/acsnano.4c04270
- Changhai L, Zaichun W, Bo Y, Dan L, Shaohua W. Micronutrients and Allergic Diseases: A Mendelian Randomization Study. Int Arch Allergy Immunol. 2025;186:41. doi:10.1159/000540376
- Maywald M, Rink L. Zinc Deficiency and Zinc Supplementation in Allergic Diseases. Biomolecules. 2024;14. doi:10.3390/biom14070863
- Wei Y, Zhu X, Lin S, Yang W, Wang T, et al. Zinc gluconate improves atopic dermatitis by modulating CXCL10 release of keratinocytes via PPARα activation. Biomed Pharmacother. 2024;177:117129. doi:10.1016/j.biopha.2024.117129
- Tafrishi R, Ahanchian H, Jafari SA, Pahlevanloo A, Kianifar H, et al. Development and clinical assessment of a novel probiotic candy in the prevention of respiratory infections in asthmatic children. World Allergy Organ J. 2025;18:101023. doi:10.1016/j.waojou.2024.101023
- Khosravi M, Avizeh R, Zayerzadeh A, Gharibi D, Razijalali M. Effect of Bacillus subtilis and Bacillus coagulans spores on induced allergic contact dermatitis in dogs. Vet Med Sci. 2024;10:e1410. doi:10.1002/vms3.1410
- Fu L, Fu S, Wang C, Xie M, Wang Y. Yogurt-sourced probiotic bacteria alleviate shrimp tropomyosin-induced allergic mucosal disorders, potentially through microbiota and metabolism modifications. Allergol Int. 2019;68:506. doi:10.1016/j.alit.2019.05.013
- Fu L, Peng J, Zhao S, Zhang Y, Su X, et al. Lactic acid bacteria-specific induction of CD4Foxp3T cells ameliorates shrimp tropomyosin-induced allergic response in mice via suppression of mTOR signaling. Sci Rep. 2017;7:1987. doi:10.1038/s41598-017-02260-8
