We conducted a randomized, double-blind clinical trial to explore the combined effects of resveratrol and vitamin C on oxidative stress in postmenopausal women. The study included forty-six women who faced insulin resistance and were divided into three groups: one received resveratrol alone, another received both resveratrol and vitamin C, and the third group got only vitamin C.
After the treatment, we observed notable results, particularly in the group that took the combination of resveratrol and vitamin C. This group exhibited a significant reduction in harmful oxidative stress markers. For instance, markers like lipohydroperoxides dropped by 33%. Additionally, malondialdehyde levels decreased by remarkable rates in all groups. Group B, which received both antioxidants, showed the most pronounced improvements, including a 39% decrease in protein damage.
While vitamin C showed benefits when combined with resveratrol, it’s crucial to note that the study did not reveal significant differences in insulin resistance among the groups. This finding suggests that while vitamin C may enhance antioxidant capacity and reduce oxidative stress, its isolated effects on menopause-related conditions were not conclusively established. Overall, our study highlights the potential of combining these antioxidants for managing oxidative stress in postmenopausal women.