Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.7
USERS' SCORE
Good
Based on 11 Reviews
8.1
Supplement Facts
Serving Size: 1 Vegetarian Tablet
Amount Per Serving
%DV
Vitamin C (as Ester-C® Calcium Ascorbate)
1,000 mg (1 g)
1,111%
Calcium (as Ester-C® Calcium Ascorbate)
110 mg
8%
Citrus Bioflavonoids ComplexCitrus Bioflavonoids (Citrus sinensis) (fruit), Sweet Orange, Tangerine, Lime, Lemon, Acerola, Rutin, Hesperidin Complex (Citrus spp.) (fruit), Naturally Occurring Vitamin C Metabolites
200 mg
**
Top Medical Research Studies
8
We aimed to discover how vitamin C supplementation affects oxidative stress in individuals diagnosed with chronic gastritis. In this study, we looked at 244 Japanese patients suffering from atrophic gastritis. They were randomly assigned to receive either 50 mg or 500 mg of vitamin C every day for five years.
After analyzing the results, we found notable differences between the two groups. The high-dose group experienced a significant decrease in reactive oxygen species (ROS), suggesting that vitamin C may help reduce oxidative stress associated with chronic gastritis. In contrast, the low-dose group reported an increase in ROS levels. These findings prompt further interest in how vitamin C can protect against oxidative stress in similar conditions.
Overall, our study supports the idea that higher doses of vitamin C could have a beneficial effect on oxidative stress, particularly in those dealing with gastritis. This insight opens avenues for considering vitamin C as a potential supportive treatment for managing oxidative stress-related issues in digestive health.
After analyzing the results, we found notable differences between the two groups. The high-dose group experienced a significant decrease in reactive oxygen species (ROS), suggesting that vitamin C may help reduce oxidative stress associated with chronic gastritis. In contrast, the low-dose group reported an increase in ROS levels. These findings prompt further interest in how vitamin C can protect against oxidative stress in similar conditions.
Overall, our study supports the idea that higher doses of vitamin C could have a beneficial effect on oxidative stress, particularly in those dealing with gastritis. This insight opens avenues for considering vitamin C as a potential supportive treatment for managing oxidative stress-related issues in digestive health.
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2
We explored the potential benefits of vitamin C supplementation for individuals suffering from atrophic gastritis. Conducted as a double-blind, randomized controlled trial in Japan, this study involved participants living in a region known for high rates of stomach cancer. Over five years, volunteers were assigned to receive daily doses of either 50 mg or 500 mg of vitamin C.
The results were intriguing: while those in the high-dose group had higher levels of serum vitamin C, the levels of two important inflammatory markers—C-reactive protein (CRP) and serum amyloid A (SAA)—showed no significant difference between the low- and high-dosage groups. Both biomarkers remained fairly constant, indicating that vitamin C supplementation did not effectively reduce inflammation or infection risk among these individuals with atrophic gastritis.
Overall, our findings suggest that high doses of vitamin C may not provide the hoped-for relief from inflammation in this patient group. Thus, it appears that vitamin C supplementation alone is insufficient in managing or alleviating gastritis-related inflammation.
The results were intriguing: while those in the high-dose group had higher levels of serum vitamin C, the levels of two important inflammatory markers—C-reactive protein (CRP) and serum amyloid A (SAA)—showed no significant difference between the low- and high-dosage groups. Both biomarkers remained fairly constant, indicating that vitamin C supplementation did not effectively reduce inflammation or infection risk among these individuals with atrophic gastritis.
Overall, our findings suggest that high doses of vitamin C may not provide the hoped-for relief from inflammation in this patient group. Thus, it appears that vitamin C supplementation alone is insufficient in managing or alleviating gastritis-related inflammation.
Read More
9
We investigated how vitamin C might help improve chronic atrophic gastritis (CAG), a condition characterized by gastric mucosal damage and inflammation. Our research utilized data from a well-known dataset, focusing on changes in gene expression related to CAG. Notably, we pinpointed IGFBP7 as a central gene that appeared to be strongly associated with this condition.
In our study, we treated CAG patients with vitamin C and observed significant improvements in blood parameters and the overall health of their gastric mucosa. Moreover, when we looked at gastric cells in the lab, vitamin C not only boosted cell viability but also reduced inflammation and cell death caused by a harmful compound known as MNNG. These effects included lowering the levels of inflammatory markers and apoptosis-related proteins.
Interestingly, our findings suggested that IGFBP7 plays a role in these protective effects of vitamin C. When we knocked down IGFBP7 in the lab tests, we noted changes in how vitamin C worked, suggesting a complex interaction.
Overall, our study highlights the potential of vitamin C and IGFBP7 as key players in managing chronic atrophic gastritis and enhancing gastric health, opening doors for new therapeutic approaches.
In our study, we treated CAG patients with vitamin C and observed significant improvements in blood parameters and the overall health of their gastric mucosa. Moreover, when we looked at gastric cells in the lab, vitamin C not only boosted cell viability but also reduced inflammation and cell death caused by a harmful compound known as MNNG. These effects included lowering the levels of inflammatory markers and apoptosis-related proteins.
Interestingly, our findings suggested that IGFBP7 plays a role in these protective effects of vitamin C. When we knocked down IGFBP7 in the lab tests, we noted changes in how vitamin C worked, suggesting a complex interaction.
Overall, our study highlights the potential of vitamin C and IGFBP7 as key players in managing chronic atrophic gastritis and enhancing gastric health, opening doors for new therapeutic approaches.
Read More
Most Useful Reviews
9
Gentle on stomach
3 people found this helpful
This vitamin C is my go-to remedy. It's high quality with 500 mg of vitamin C and bioflavonoids, making for an excellent combination. The non-acidic form is gentle on the stomach, suitable for gastritis sufferers. I take 2 capsules daily when ill, and it works wonders for my immune system.
Read More
9
Quick recovery from illness
The best vitamin C form I've found! With bioflavonoids, it doesn’t irritate my stomach, making it suitable for those with gastritis. At the first sign of ARVI, I take 2 tablets up to three times a day for quick recovery.
Read More
9
Universal vitamin C
For over 5 years, I've taken this vitamin C, which is not sour and can be consumed on an empty stomach, even with gastritis. I take 1000 mg daily in smaller doses for maximum effect. Since adjusting my diet, my daughter hasn’t experienced serious illnesses.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.7
- All Researches
9
We explored the effects of daily Ester-C supplementation combined with antioxidants on patients suffering from chronic atrophic gastritis over a year-long trial. This well-designed study involved a double-blind, placebo-controlled approach, ensuring reliable results.
The outcome was promising, as 61% of patients experienced a significant regression of gastric premalignant lesions. Additionally, there was a noticeable drop in abnormal enzyme activity within the gastric mucosa, indicating potential benefits for individuals with these conditions.
Overall, the combination of Ester-C and antioxidants appears to positively impact those with chronic atrophic gastritis.
The outcome was promising, as 61% of patients experienced a significant regression of gastric premalignant lesions. Additionally, there was a noticeable drop in abnormal enzyme activity within the gastric mucosa, indicating potential benefits for individuals with these conditions.
Overall, the combination of Ester-C and antioxidants appears to positively impact those with chronic atrophic gastritis.
Read More
9
We investigated how vitamin C might help improve chronic atrophic gastritis (CAG), a condition characterized by gastric mucosal damage and inflammation. Our research utilized data from a well-known dataset, focusing on changes in gene expression related to CAG. Notably, we pinpointed IGFBP7 as a central gene that appeared to be strongly associated with this condition.
In our study, we treated CAG patients with vitamin C and observed significant improvements in blood parameters and the overall health of their gastric mucosa. Moreover, when we looked at gastric cells in the lab, vitamin C not only boosted cell viability but also reduced inflammation and cell death caused by a harmful compound known as MNNG. These effects included lowering the levels of inflammatory markers and apoptosis-related proteins.
Interestingly, our findings suggested that IGFBP7 plays a role in these protective effects of vitamin C. When we knocked down IGFBP7 in the lab tests, we noted changes in how vitamin C worked, suggesting a complex interaction.
Overall, our study highlights the potential of vitamin C and IGFBP7 as key players in managing chronic atrophic gastritis and enhancing gastric health, opening doors for new therapeutic approaches.
In our study, we treated CAG patients with vitamin C and observed significant improvements in blood parameters and the overall health of their gastric mucosa. Moreover, when we looked at gastric cells in the lab, vitamin C not only boosted cell viability but also reduced inflammation and cell death caused by a harmful compound known as MNNG. These effects included lowering the levels of inflammatory markers and apoptosis-related proteins.
Interestingly, our findings suggested that IGFBP7 plays a role in these protective effects of vitamin C. When we knocked down IGFBP7 in the lab tests, we noted changes in how vitamin C worked, suggesting a complex interaction.
Overall, our study highlights the potential of vitamin C and IGFBP7 as key players in managing chronic atrophic gastritis and enhancing gastric health, opening doors for new therapeutic approaches.
Read More
9
We sought to understand how vitamin C affects the absorption of levothyroxine, a common medication for hypothyroidism, particularly in patients who also experience gastritis. Our study involved 31 patients, most of whom had poorly controlled hypothyroidism along with gastrointestinal issues.
Participants took levothyroxine alongside a solution that either contained or did not contain vitamin C, and we monitored their hormone levels over several months. Our findings revealed that vitamin C can actually improve levels of free T4 and T3, as well as TSH, suggesting it enhances the absorption of medication in these patients.
This is particularly significant because individuals dealing with both hypothyroidism and gastritis often struggle to maintain stable thyroid hormone levels. Our research indicates that incorporating vitamin C into their treatment regimen could serve as a beneficial strategy in managing their condition.
Participants took levothyroxine alongside a solution that either contained or did not contain vitamin C, and we monitored their hormone levels over several months. Our findings revealed that vitamin C can actually improve levels of free T4 and T3, as well as TSH, suggesting it enhances the absorption of medication in these patients.
This is particularly significant because individuals dealing with both hypothyroidism and gastritis often struggle to maintain stable thyroid hormone levels. Our research indicates that incorporating vitamin C into their treatment regimen could serve as a beneficial strategy in managing their condition.
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9
We explored how vitamin C, or ascorbic acid, plays a role in the development of gastritis, specifically focusing on acute gastric mucosal lesions induced by a compound known as C48/80 in rats. In our study, we injected fasted Wistar rats with C48/80 to trigger gastric lesions, followed by varying doses of oral vitamin C.
After assessing the severity of the lesions and measuring various biochemical markers in the gastric mucosa and serum, we found that lesions appeared 0.5 hours post treatment and continued to worsen over the next 3 hours. Notably, the administration of vitamin C right after the initial treatment appeared to significantly reduce the progression of these lesions. It also helped maintain the levels of various protective substances in the gastric lining and overall health indicators.
By the end of our study, it was clear that vitamin C has a crucial protective effect in this scenario. Our results suggest that timely vitamin C administration can prevent the worsening of gastritis caused by mast cell degranulation. This adds a promising angle to the conversation about dietary vitamins in managing gastric health.
After assessing the severity of the lesions and measuring various biochemical markers in the gastric mucosa and serum, we found that lesions appeared 0.5 hours post treatment and continued to worsen over the next 3 hours. Notably, the administration of vitamin C right after the initial treatment appeared to significantly reduce the progression of these lesions. It also helped maintain the levels of various protective substances in the gastric lining and overall health indicators.
By the end of our study, it was clear that vitamin C has a crucial protective effect in this scenario. Our results suggest that timely vitamin C administration can prevent the worsening of gastritis caused by mast cell degranulation. This adds a promising angle to the conversation about dietary vitamins in managing gastric health.
Read More
8
We explored the effects of Ascorbic Acid 2-Glucoside (AA2G), a stable form of Vitamin C, on human gastric epithelial cells infected with Helicobacter pylori, a common cause of gastritis and related stomach issues. In our research, we focused on understanding how AA2G could mitigate the damage caused by this bacterium on stomach cells.
Our findings revealed that AA2G significantly reduced oxidative stress—a harmful condition triggered by H. pylori that can damage cells. We observed that treatment with AA2G led to lower levels of harmful substances, such as reactive oxygen species, known to contribute to cell damage.
Notably, AA2G also helped restore the cells' mitochondrial function, which is often impaired during H. pylori infection. This improvement included an increase in ATP levels and enhanced mitochondrial membrane potential, both essential for cell energy production and health.
Ultimately, we found that AA2G effectively reduces the apoptosis (or programmed cell death) that results from H. pylori infection, suggesting that it provides a protective effect on gastric epithelial cells. Our research supports the potential use of AA2G as a beneficial intervention for combatting the adverse effects of H. pylori infection on gastritis.
Our findings revealed that AA2G significantly reduced oxidative stress—a harmful condition triggered by H. pylori that can damage cells. We observed that treatment with AA2G led to lower levels of harmful substances, such as reactive oxygen species, known to contribute to cell damage.
Notably, AA2G also helped restore the cells' mitochondrial function, which is often impaired during H. pylori infection. This improvement included an increase in ATP levels and enhanced mitochondrial membrane potential, both essential for cell energy production and health.
Ultimately, we found that AA2G effectively reduces the apoptosis (or programmed cell death) that results from H. pylori infection, suggesting that it provides a protective effect on gastric epithelial cells. Our research supports the potential use of AA2G as a beneficial intervention for combatting the adverse effects of H. pylori infection on gastritis.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Gentle on stomach
3 people found this helpful
This vitamin C is my go-to remedy. It's high quality with 500 mg of vitamin C and bioflavonoids, making for an excellent combination. The non-acidic form is gentle on the stomach, suitable for gastritis sufferers. I take 2 capsules daily when ill, and it works wonders for my immune system.
Read More
9
Quick recovery from illness
The best vitamin C form I've found! With bioflavonoids, it doesn’t irritate my stomach, making it suitable for those with gastritis. At the first sign of ARVI, I take 2 tablets up to three times a day for quick recovery.
Read More
9
Universal vitamin C
For over 5 years, I've taken this vitamin C, which is not sour and can be consumed on an empty stomach, even with gastritis. I take 1000 mg daily in smaller doses for maximum effect. Since adjusting my diet, my daughter hasn’t experienced serious illnesses.
Read More
9
Perfect for gastritis
Excellent quality! This supplement has no acidity, which is perfect for me as a gastritis sufferer.
Read More
9
Good for sensitive stomachs
A reputable brand! Everyone seems to buy it up quickly. It’s vitamin C that doesn’t irritate the stomach, perfect for those with gastritis or ulcers.
Read More
Frequently Asked Questions
9
Quick recovery from illness
The best vitamin C form I've found! With bioflavonoids, it doesn’t irritate my stomach, making it suitable for those with gastritis. At the first sign of ARVI, I take 2 tablets up to three times a day for quick recovery.
9
Universal vitamin C
For over 5 years, I've taken this vitamin C, which is not sour and can be consumed on an empty stomach, even with gastritis. I take 1000 mg daily in smaller doses for maximum effect. Since adjusting my diet, my daughter hasn’t experienced serious illnesses.
9
Suitable for sensitive stomachs
I've taken this soft drug for two months. It does not upset my stomach, which is essential as I have gastritis. I even managed to increase my dosage without any reaction.
9
Gentle on stomach
3 people found this helpful
This vitamin C is my go-to remedy. It's high quality with 500 mg of vitamin C and bioflavonoids, making for an excellent combination. The non-acidic form is gentle on the stomach, suitable for gastritis sufferers. I take 2 capsules daily when ill, and it works wonders for my immune system.
7.5
Supports gastritis well
106 people found this helpful
ORGANIC vitamin C is the world's only organic formula of this vitamin. It contains no harmful chemicals and is sold in Russian pharmacies. Unlike other types, it is effective for up to 8 hours and is gentle on the stomach, which is great for those with gastritis. It significantly boosts the immune system during cold seasons. Be healthy!
9
We investigated how vitamin C might help improve chronic atrophic gastritis (CAG), a condition characterized by gastric mucosal damage and inflammation. Our research utilized data from a well-known dataset, focusing on changes in gene expression related to CAG. Notably, we pinpointed IGFBP7 as a central gene that appeared to be strongly associated with this condition.
In our study, we treated CAG patients with vitamin C and observed significant improvements in blood parameters and the overall health of their gastric mucosa. Moreover, when we looked at gastric cells in the lab, vitamin C not only boosted cell viability but also reduced inflammation and cell death caused by a harmful compound known as MNNG. These effects included lowering the levels of inflammatory markers and apoptosis-related proteins.
Interestingly, our findings suggested that IGFBP7 plays a role in these protective effects of vitamin C. When we knocked down IGFBP7 in the lab tests, we noted changes in how vitamin C worked, suggesting a complex interaction.
Overall, our study highlights the potential of vitamin C and IGFBP7 as key players in managing chronic atrophic gastritis and enhancing gastric health, opening doors for new therapeutic approaches.
In our study, we treated CAG patients with vitamin C and observed significant improvements in blood parameters and the overall health of their gastric mucosa. Moreover, when we looked at gastric cells in the lab, vitamin C not only boosted cell viability but also reduced inflammation and cell death caused by a harmful compound known as MNNG. These effects included lowering the levels of inflammatory markers and apoptosis-related proteins.
Interestingly, our findings suggested that IGFBP7 plays a role in these protective effects of vitamin C. When we knocked down IGFBP7 in the lab tests, we noted changes in how vitamin C worked, suggesting a complex interaction.
Overall, our study highlights the potential of vitamin C and IGFBP7 as key players in managing chronic atrophic gastritis and enhancing gastric health, opening doors for new therapeutic approaches.
8
We explored the effects of Ascorbic Acid 2-Glucoside (AA2G), a stable form of Vitamin C, on human gastric epithelial cells infected with Helicobacter pylori, a common cause of gastritis and related stomach issues. In our research, we focused on understanding how AA2G could mitigate the damage caused by this bacterium on stomach cells.
Our findings revealed that AA2G significantly reduced oxidative stress—a harmful condition triggered by H. pylori that can damage cells. We observed that treatment with AA2G led to lower levels of harmful substances, such as reactive oxygen species, known to contribute to cell damage.
Notably, AA2G also helped restore the cells' mitochondrial function, which is often impaired during H. pylori infection. This improvement included an increase in ATP levels and enhanced mitochondrial membrane potential, both essential for cell energy production and health.
Ultimately, we found that AA2G effectively reduces the apoptosis (or programmed cell death) that results from H. pylori infection, suggesting that it provides a protective effect on gastric epithelial cells. Our research supports the potential use of AA2G as a beneficial intervention for combatting the adverse effects of H. pylori infection on gastritis.
Our findings revealed that AA2G significantly reduced oxidative stress—a harmful condition triggered by H. pylori that can damage cells. We observed that treatment with AA2G led to lower levels of harmful substances, such as reactive oxygen species, known to contribute to cell damage.
Notably, AA2G also helped restore the cells' mitochondrial function, which is often impaired during H. pylori infection. This improvement included an increase in ATP levels and enhanced mitochondrial membrane potential, both essential for cell energy production and health.
Ultimately, we found that AA2G effectively reduces the apoptosis (or programmed cell death) that results from H. pylori infection, suggesting that it provides a protective effect on gastric epithelial cells. Our research supports the potential use of AA2G as a beneficial intervention for combatting the adverse effects of H. pylori infection on gastritis.
9
We explored the effects of daily Ester-C supplementation combined with antioxidants on patients suffering from chronic atrophic gastritis over a year-long trial. This well-designed study involved a double-blind, placebo-controlled approach, ensuring reliable results.
The outcome was promising, as 61% of patients experienced a significant regression of gastric premalignant lesions. Additionally, there was a noticeable drop in abnormal enzyme activity within the gastric mucosa, indicating potential benefits for individuals with these conditions.
Overall, the combination of Ester-C and antioxidants appears to positively impact those with chronic atrophic gastritis.
The outcome was promising, as 61% of patients experienced a significant regression of gastric premalignant lesions. Additionally, there was a noticeable drop in abnormal enzyme activity within the gastric mucosa, indicating potential benefits for individuals with these conditions.
Overall, the combination of Ester-C and antioxidants appears to positively impact those with chronic atrophic gastritis.
7
We explored the effects of vitamin C on gastritis through a study involving 51 patients who had multifocal atrophic gastritis (MAG) and 92 matched individuals with dyspeptic symptoms. The goal was to see how well vitamin C worked alongside the eradication of Helicobacter pylori, a bacteria often linked to gastritis.
Our findings revealed that while vitamin C, taken in large doses for three months, along with H. pylori treatment didn't reverse the histological damage to the gastric lining, it did improve the functional capabilities of the affected stomach. Specifically, we observed better gastric acid and gastrin levels, reduced expression of certain premalignant markers, and an increase in growth factors.
These results suggest that vitamin C can enhance some aspects of gastric health in patients with MAG, but it is not a standalone cure. The study emphasizes that gastritis is influenced by various environmental and biological factors, and while vitamin C shows promise, it needs to be part of a comprehensive treatment strategy.
Our findings revealed that while vitamin C, taken in large doses for three months, along with H. pylori treatment didn't reverse the histological damage to the gastric lining, it did improve the functional capabilities of the affected stomach. Specifically, we observed better gastric acid and gastrin levels, reduced expression of certain premalignant markers, and an increase in growth factors.
These results suggest that vitamin C can enhance some aspects of gastric health in patients with MAG, but it is not a standalone cure. The study emphasizes that gastritis is influenced by various environmental and biological factors, and while vitamin C shows promise, it needs to be part of a comprehensive treatment strategy.
References
- Draudin-Krylenko VA, Petukhov AB, Kuvshinov IuP, Levchuk AA, Bukin IuV. [Effect of antioxidant use in dietary therapy in patients with chronic athrofic hastritis]. Vopr Pitan. 2006;75:53.
- Cheng X, Gu H, Chong Y, Li F, Bei S, et al. Vitamin C Mediates IGFBP7 to Alleviate Chronic Atrophic Gastritis via the HIF-1α/VEGF Pathway. J Cell Mol Med. 2025;29:e70392. doi:10.1111/jcmm.70392
- Mei H, Tu H. Vitamin C and Infection: Current Knowledge and Future Prospects. Front Physiol. 2018;9:1103. doi:10.3389/fphys.2018.01103
- Chen X, Liu R, Liu X, Xu C, Wang X. L-ascorbic Acid-2-Glucoside inhibits Helicobacter pylori-induced apoptosis through mitochondrial pathway in Gastric Epithelial cells. Biomed Pharmacother. 2018;97:75. doi:10.1016/j.biopha.2017.10.030
- Jubiz W, Ramirez M. Effect of vitamin C on the absorption of levothyroxine in patients with hypothyroidism and gastritis. J Clin Endocrinol Metab. 2014;99:E1031. doi:10.1210/jc.2013-4360
- Ma E, Sasazuki S, Sasaki S, Tsubono Y, Okubo S, et al. Vitamin C supplementation in relation to inflammation in individuals with atrophic gastritis: a randomised controlled trial in Japan. Br J Nutr. 2013;109:1089. doi:10.1017/S0007114512002954
- Aditi A, Graham DY. Vitamin C, gastritis, and gastric disease: a historical review and update. Dig Dis Sci. 2012;57:2504. doi:10.1007/s10620-012-2203-7
- Sezikli M, Çetinkaya ZA, Güzelbulut F, Çimen B, Özcan Ö, et al. Effects of alpha tocopherol and ascorbic acid on Helicobacter pylori colonization and the severity of gastric inflammation. Helicobacter. 2012;17:127. doi:10.1111/j.1523-5378.2011.00925.x
- Kohler JE, Blass AL, Liu J, Tai K, Soybel DI. Antioxidant pre-treatment prevents omeprazole-induced toxicity in an in vitro model of infectious gastritis. Free Radic Biol Med. 2010;49:786. doi:10.1016/j.freeradbiomed.2010.05.034
- Sasazuki S, Hayashi T, Nakachi K, Sasaki S, Tsubono Y, et al. Protective effect of vitamin C on oxidative stress: a randomized controlled trial. Int J Vitam Nutr Res. 2008;78:121. doi:10.1024/0300-9831.78.3.121
- Rembiasz K, Budzynski A, Karcz D, Konturek PC, Konturek SJ, et al. Multifocal atrophic gastritis: pathogenesis and therapeutic implications. Eur J Gastroenterol Hepatol. 2005;17:857.
- Kamiya Y, Ohta Y, Imai Y, Arisawa T, Nakano H. A critical role of gastric mucosal ascorbic acid in the progression of acute gastric mucosal lesions induced by compound 48/80 in rats. World J Gastroenterol. 2005;11:1324.
