We evaluated how vitamin C, also known as ascorbic acid, can help protect the liver during procedures that temporarily cut off blood flow—a process known as ischaemia followed by reperfusion. In this study, we used thirty-six male Wistar rats, split into control groups and experimental ones. Each group received the same total dose of vitamin C, administered at different times: either before the ischaemia, before the reperfusion, or both.
Our findings showed that the animals given vitamin C before both the ischaemia and reperfusion had improved outcomes. They had lower levels of liver enzymes, indicating less liver damage, and showed reduced inflammation. Additionally, their portal blood flow was better when compared to the other groups. Overall, our results suggest that administering vitamin C at specific times can significantly reduce liver injury associated with ischaemia-reperfusion.
This study highlights the potential of vitamin C as a protective agent in situations where liver damage is a concern during surgeries or treatments involving blood flow disruption.
Read More
9
L-AP mitigates liver injury
L-AP Alleviates Liver Injury in Septic Mice by Inhibiting Macrophage Activation via Suppressing NF-κB and NLRP3 Inflammasome/Caspase-1 Signal Pathways.
This study investigated how L-ascorbic acid 6-palmitate (L-AP), a derivative of vitamin C, could affect liver injury during sepsis. We focused on understanding its potential to alleviate liver damage caused by an overactive immune response. Through a series of experiments, including the cecal ligation and puncture method in mice, we observed that L-AP significantly increased the survival rates of these animals.
We found that L-AP treatment also reduced liver inflammation, which was evidenced by improved liver tissue health, less liver cell death, and lower levels of liver enzymes in the blood. Interestingly, the effects of L-AP were similar to the results seen in mice that lacked the NLRP3 inflammasome, a key player in inflammation.
Moreover, L-AP appeared to dampen the hyper-inflammatory response characteristic of sepsis. In both the liver tissues and cultured macrophages, we noted a decrease in inflammatory markers linked to the NLRP3 inflammasome pathway. This included lower expression levels of specific inflammatory proteins and less macrophage activation, promoting a more anti-inflammatory response instead.
Overall, our findings reveal that L-AP may help protect the liver during severe bacterial infections by mitigating the harmful effects of macrophage activation and the resultant inflammation. While this study points toward the possible benefits of an ascorbic acid derivative in treating septic liver damage, further investigation is necessary to fully unravel its mechanisms and potential therapeutic applications.
Read More
8
Vitamin C may protect liver health
Targeting Oxidative Stress: The Potential of Vitamin C in Protecting against Liver Damage after Electron Beam Therapy.
We investigated whether vitamin C could help protect the liver from damage caused by electron beam therapy, a treatment often used for cancers in the abdomen. Our study involved male Wistar rats, which were divided into four groups: one received electron irradiation, one was pre-treated with vitamin C, another received vitamin C alone, and the last group served as a control.
Through detailed analyses, we looked at various markers of liver health, such as liver enzymes and inflammatory cytokines. We also examined the liver tissues of the rats over 90 days to assess any changes. What we found was quite revealing; the group exposed to radiation showed significant liver damage, increased liver enzymes, inflammation, and signs of oxidative stress.
Interestingly, those rats pre-treated with vitamin C experienced milder liver damage and lower levels of oxidative stress and inflammation. This suggests that vitamin C may help maintain a better balance between liver cell growth and cell death, which is crucial after radiation exposure. Overall, our results indicate that vitamin C has potential as a protective agent against radiation-induced liver injury.
Still, while our findings are promising, further research is needed to fully understand the long-term benefits of vitamin C in this context.
Read More
Most Useful Reviews
8
Effective cold remedy
6 people found this helpful
I have been using the wonderful properties of vitamin C for a year now, and it truly works! I fell ill recently with ARVI, and at the most inconvenient time, I ran out of vitamin C. This vitamin is a strong antioxidant, supporting my body's cells so they can better resist unfavourable conditions while providing energy and promoting recovery. Despite claims that using high doses of vitamin C is ineffective, I find it helps me. For prevention, when sick individuals are around or I feel early symptoms, I take one tablet a day for three days, and all signs of the cold vanish. When I felt my throat sore again, I repeated the course, and it helped once more. I no longer doubt the efficacy of vitamin C.
Read More
6
Supports liver function
1 people found this helpful
Vitamin C does not irritate the mucous membranes and must be continually obtained since it is not produced or stored in the human body. It is destroyed by heat, so Ester-C, a metabolite of vitamin C, is preferred as it maintains a neutral pH and does not harm the stomach. It regulates immune and nervous system functions and improves liver function. Ester-C is better absorbed, does not irritate, and does not interact with iron, which can create harmful free radicals. It also benefits stress management, skin properties, cardiovascular health, and protects against infections.
Read More
7
Faster recovery noted
2 people found this helpful
I take it twice daily at a good dosage, which includes bioflavonoids. I use it to maintain my immune system—one tablet per day—and when I feel a cold starting, I take up to four tablets. I notice a positive effect; I recover faster, or if I feel unwell, the illness does not escalate into a severe form. However, one downside is that the pill is large and not very convenient to swallow; a slightly smaller size would be ideal.
Case report: The efficacy of adding high doses of intravenous vitamin C to the combination therapy of atezolizumab and bevacizumab in unresectable HCC.
We observed an intriguing case involving a 68-year-old male patient diagnosed with unresectable hepatocellular carcinoma (HCC). This case focused on the potential benefits of incorporating high-dose intravenous vitamin C into the treatment regimen alongside atezolizumab and bevacizumab.
Initially, the patient underwent the combination therapy, but while the imaging showed stable disease, there was only a modest decline in alpha-fetoprotein (AFP) levels. Unfortunately, the patient's condition further declined. In response, a dose of 30 grams of intravenous vitamin C was added to the treatment plan.
Remarkably, this adjustment led to a swift and noteworthy reduction in AFP levels, normalization of liver function tests, and substantial improvement in overall symptoms. Four months later, imaging indicated significant tumor shrinkage and necrosis.
As of 30 months post-diagnosis, the patient benefits from the combined regimen, showing normal liver function and a dramatically reduced AFP level, all while maintaining an active lifestyle. This case demonstrates the potential synergistic effects of high-dose vitamin C in treating unresectable HCC alongside standard therapies, warranting further investigation into such combination approaches.
Read More
9
Vitamin C reduces liver injury
The Effect of Ascorbic Acid on Hepatic Ischaemia-Reperfusion Injury in Wistar Rats: An Experimental Study.
We evaluated how vitamin C, also known as ascorbic acid, can help protect the liver during procedures that temporarily cut off blood flow—a process known as ischaemia followed by reperfusion. In this study, we used thirty-six male Wistar rats, split into control groups and experimental ones. Each group received the same total dose of vitamin C, administered at different times: either before the ischaemia, before the reperfusion, or both.
Our findings showed that the animals given vitamin C before both the ischaemia and reperfusion had improved outcomes. They had lower levels of liver enzymes, indicating less liver damage, and showed reduced inflammation. Additionally, their portal blood flow was better when compared to the other groups. Overall, our results suggest that administering vitamin C at specific times can significantly reduce liver injury associated with ischaemia-reperfusion.
This study highlights the potential of vitamin C as a protective agent in situations where liver damage is a concern during surgeries or treatments involving blood flow disruption.
Read More
9
L-AP mitigates liver injury
L-AP Alleviates Liver Injury in Septic Mice by Inhibiting Macrophage Activation via Suppressing NF-κB and NLRP3 Inflammasome/Caspase-1 Signal Pathways.
This study investigated how L-ascorbic acid 6-palmitate (L-AP), a derivative of vitamin C, could affect liver injury during sepsis. We focused on understanding its potential to alleviate liver damage caused by an overactive immune response. Through a series of experiments, including the cecal ligation and puncture method in mice, we observed that L-AP significantly increased the survival rates of these animals.
We found that L-AP treatment also reduced liver inflammation, which was evidenced by improved liver tissue health, less liver cell death, and lower levels of liver enzymes in the blood. Interestingly, the effects of L-AP were similar to the results seen in mice that lacked the NLRP3 inflammasome, a key player in inflammation.
Moreover, L-AP appeared to dampen the hyper-inflammatory response characteristic of sepsis. In both the liver tissues and cultured macrophages, we noted a decrease in inflammatory markers linked to the NLRP3 inflammasome pathway. This included lower expression levels of specific inflammatory proteins and less macrophage activation, promoting a more anti-inflammatory response instead.
Overall, our findings reveal that L-AP may help protect the liver during severe bacterial infections by mitigating the harmful effects of macrophage activation and the resultant inflammation. While this study points toward the possible benefits of an ascorbic acid derivative in treating septic liver damage, further investigation is necessary to fully unravel its mechanisms and potential therapeutic applications.
Read More
8
Dietary antioxidants and liver health
Association between composite dietary antioxidant index and metabolic dysfunction-associated fatty liver disease: a cross-sectional study from NHANES.
In our exploration of the connection between dietary antioxidants and liver health, we analyzed data from the National Health and Nutrition Examination Survey (NHANES) from 2013 to 2020. A key focus was on the composite dietary antioxidant index (CDAI), which includes essential nutrients like vitamin C.
We found that higher CDAI scores were associated with a lower likelihood of developing metabolic dysfunction-associated fatty liver disease (MAFLD). For those in the highest quartile of CDAI, there was a noted 27% reduction in the chance of having MAFLD compared to those in the lowest quartile.
Importantly, changes in vitamin C intake were found to be linked to MAFLD, suggesting that this vitamin may play a role in liver health. Our subgroup analysis particularly highlighted those engaging in moderate-intensity physical activity, reinforcing the idea that a diet rich in antioxidants, including vitamin C, could be beneficial for liver function.
This study opens the door to exploring dietary interventions that potentially reduce the incidence of MAFLD, highlighting the importance of getting enough vitamin C in our diets.
Read More
8
Vitamin C may protect liver health
Targeting Oxidative Stress: The Potential of Vitamin C in Protecting against Liver Damage after Electron Beam Therapy.
We investigated whether vitamin C could help protect the liver from damage caused by electron beam therapy, a treatment often used for cancers in the abdomen. Our study involved male Wistar rats, which were divided into four groups: one received electron irradiation, one was pre-treated with vitamin C, another received vitamin C alone, and the last group served as a control.
Through detailed analyses, we looked at various markers of liver health, such as liver enzymes and inflammatory cytokines. We also examined the liver tissues of the rats over 90 days to assess any changes. What we found was quite revealing; the group exposed to radiation showed significant liver damage, increased liver enzymes, inflammation, and signs of oxidative stress.
Interestingly, those rats pre-treated with vitamin C experienced milder liver damage and lower levels of oxidative stress and inflammation. This suggests that vitamin C may help maintain a better balance between liver cell growth and cell death, which is crucial after radiation exposure. Overall, our results indicate that vitamin C has potential as a protective agent against radiation-induced liver injury.
Still, while our findings are promising, further research is needed to fully understand the long-term benefits of vitamin C in this context.
I have been using the wonderful properties of vitamin C for a year now, and it truly works! I fell ill recently with ARVI, and at the most inconvenient time, I ran out of vitamin C. This vitamin is a strong antioxidant, supporting my body's cells so they can better resist unfavourable conditions while providing energy and promoting recovery. Despite claims that using high doses of vitamin C is ineffective, I find it helps me. For prevention, when sick individuals are around or I feel early symptoms, I take one tablet a day for three days, and all signs of the cold vanish. When I felt my throat sore again, I repeated the course, and it helped once more. I no longer doubt the efficacy of vitamin C.
Read More
6
Supports liver function
1 people found this helpful
Vitamin C does not irritate the mucous membranes and must be continually obtained since it is not produced or stored in the human body. It is destroyed by heat, so Ester-C, a metabolite of vitamin C, is preferred as it maintains a neutral pH and does not harm the stomach. It regulates immune and nervous system functions and improves liver function. Ester-C is better absorbed, does not irritate, and does not interact with iron, which can create harmful free radicals. It also benefits stress management, skin properties, cardiovascular health, and protects against infections.
Read More
7
Faster recovery noted
2 people found this helpful
I take it twice daily at a good dosage, which includes bioflavonoids. I use it to maintain my immune system—one tablet per day—and when I feel a cold starting, I take up to four tablets. I notice a positive effect; I recover faster, or if I feel unwell, the illness does not escalate into a severe form. However, one downside is that the pill is large and not very convenient to swallow; a slightly smaller size would be ideal.
Read More
Frequently Asked Questions
Liver disease encompasses a variety of conditions that affect the liver's ability to function effectively. The liver is a vital organ responsible for many important tasks, including metabolizing nutrients, detoxifying harmful substances, and producing bile for digestion. Common forms of liver disease include hepatitis, fatty liver disease, cirrhosis, and liver cancer. Each of these conditions can significantly impact liver function and overall health, leading to symptoms that range from fatigue and jaundice to more serious complications requiring urgent medical attention.
The causes of liver disease are diverse and can include chronic alcohol abuse, viral infections, autoimmune disorders, and metabolic conditions like obesity and diabetes. Early detection is key to managing liver disease effectively, often involving lifestyle changes, medications, and sometimes surgical interventions. Regular check-ups and liver function tests are recommended for individuals at higher risk, such as those with a family history of liver disease or those who lead certain lifestyle habits. Adopting a balanced diet and reducing alcohol intake can greatly aid in liver health and help prevent the onset of these conditions.
Ester-C is a patented form of vitamin C (ascorbic acid) that is known for its unique formulation, which includes calcium ascorbate. This makes Ester-C less acidic than standard vitamin C, making it gentler on the stomach for those who may experience gastrointestinal discomfort from regular vitamin C supplementation. One of the key features touted by manufacturers of Ester-C is that it is better absorbed by the body and stays in the immune system longer, although scientific research on these claims can be mixed.
In addition to its purported benefits, Ester-C is often marketed as a supplement that supports immune health, collagen production, and serves as an antioxidant, helping to combat free radicals and oxidative stress. It's available in various forms, including capsules, tablets, and powders, making it easy to incorporate into your daily routine. While some users report positive effects and tolerance of Ester-C, it's essential to consult with a healthcare professional before adding any new supplement to your regimen, especially if you have existing conditions or are taking other medications.
Vitamin C has shown potential benefits for liver health supported by various scientific studies, particularly concerning specific liver diseases. For instance, research indicated that higher dietary antioxidant intake, which includes vitamin C, may lower the risk of developing metabolic dysfunction-associated fatty liver disease (MAFLD) by 27%, underscoring the vitamin's role as a protective factor ([2]). Additionally, studies exploring vitamin C's impact in animal models have revealed that it may mitigate liver damage linked to chemotherapy drugs or oxidative stress, suggesting that adequate levels of this vitamin could help maintain liver function under various stressors ([4]; [6]).
Further investigations into vitamin C's protective role against liver injury have shown promising results in contexts such as radiation exposure and ischemia-reperfusion protocols, highlighting its capacity to reduce inflammation and oxidative stress in the liver ([3]; [7]). Moreover, studies have suggested that vitamin C could enhance the effectiveness of treatments for liver cancer when used in combination therapies ([5]). While the findings indicate a valuable role for vitamin C in liver health, more extensive clinical research is necessary to define its efficacy and establish comprehensive treatment guidelines for individuals with liver disease.
Users report notable improvements in their symptoms when using vitamin C, with many emphasizing its role in bolstering the immune system. For instance, one user noted that taking a tablet daily for three days effectively eliminated early cold symptoms, showcasing vitamin C's potential as a preventive measure during times of increased illness exposure Read Review. Another reviewer highlighted a regimen of increased dosage at the onset of illness, which helped them recover more quickly and prevent a cold from worsening Read Review.
Additionally, users appreciate the benefits of specific formulations like Ester-C, which are reported to be easier on the digestive system and potentially more effective due to better absorption Read Review. While many users have had positive experiences, individual results can vary significantly, and it is important to consider personal health conditions and consult with a healthcare provider for tailored advice.
Based on user reviews regarding the appropriate dosage of Ester C for treating liver disease, there seems to be a consensus on the benefits of regular and adequate intake. Users have reported that taking one tablet daily can be effective for maintaining immune health and improving liver function. One user noted that they take it twice daily as part of their routine, alongside bioflavonoids, and increase their dosage to up to four tablets at the onset of cold symptoms, suggesting that higher doses can yield quicker recovery and bolster the immune response Read Review.
Additionally, another review emphasizes the absorption and benefits of Ester-C, mentioning its favorable properties without causing irritation or interaction with other medications, making it a suitable choice for liver health Read Review. Users seem to agree that while the exact optimal dose may vary based on individual health needs, a regular intake of Ester C could potentially enhance liver function and overall wellness.
8
Effective cold remedy
6 people found this helpful
I have been using the wonderful properties of vitamin C for a year now, and it truly works! I fell ill recently with ARVI, and at the most inconvenient time, I ran out of vitamin C. This vitamin is a strong antioxidant, supporting my body's cells so they can better resist unfavourable conditions while providing energy and promoting recovery. Despite claims that using high doses of vitamin C is ineffective, I find it helps me. For prevention, when sick individuals are around or I feel early symptoms, I take one tablet a day for three days, and all signs of the cold vanish. When I felt my throat sore again, I repeated the course, and it helped once more. I no longer doubt the efficacy of vitamin C.
7
Faster recovery noted
2 people found this helpful
I take it twice daily at a good dosage, which includes bioflavonoids. I use it to maintain my immune system—one tablet per day—and when I feel a cold starting, I take up to four tablets. I notice a positive effect; I recover faster, or if I feel unwell, the illness does not escalate into a severe form. However, one downside is that the pill is large and not very convenient to swallow; a slightly smaller size would be ideal.
6
Supports liver function
1 people found this helpful
Vitamin C does not irritate the mucous membranes and must be continually obtained since it is not produced or stored in the human body. It is destroyed by heat, so Ester-C, a metabolite of vitamin C, is preferred as it maintains a neutral pH and does not harm the stomach. It regulates immune and nervous system functions and improves liver function. Ester-C is better absorbed, does not irritate, and does not interact with iron, which can create harmful free radicals. It also benefits stress management, skin properties, cardiovascular health, and protects against infections.
8
Dietary antioxidants and liver health
Association between composite dietary antioxidant index and metabolic dysfunction-associated fatty liver disease: a cross-sectional study from NHANES.
In our exploration of the connection between dietary antioxidants and liver health, we analyzed data from the National Health and Nutrition Examination Survey (NHANES) from 2013 to 2020. A key focus was on the composite dietary antioxidant index (CDAI), which includes essential nutrients like vitamin C.
We found that higher CDAI scores were associated with a lower likelihood of developing metabolic dysfunction-associated fatty liver disease (MAFLD). For those in the highest quartile of CDAI, there was a noted 27% reduction in the chance of having MAFLD compared to those in the lowest quartile.
Importantly, changes in vitamin C intake were found to be linked to MAFLD, suggesting that this vitamin may play a role in liver health. Our subgroup analysis particularly highlighted those engaging in moderate-intensity physical activity, reinforcing the idea that a diet rich in antioxidants, including vitamin C, could be beneficial for liver function.
This study opens the door to exploring dietary interventions that potentially reduce the incidence of MAFLD, highlighting the importance of getting enough vitamin C in our diets.
7
Vitamin C aids liver protection
Evaluation the effects of Omega-3 and vitamin C alone or in combination on Methotrexate-Induced hepatotoxicity (in mice).
We investigated the effects of vitamin C on liver health, particularly how it might help mitigate liver damage caused by methotrexate, a common chemotherapy drug. In our study, we observed Swiss albino mice divided into five groups, with one group receiving vitamin C along with omega-3 fatty acids.
The results were promising; pretreatment with both vitamin C and omega-3 showed a noteworthy ability to lessen liver damage. After assessing the levels of certain enzymes and antioxidants in the blood, we found that the combination treatment significantly reduced oxidative stress markers compared to those that received methotrexate alone.
While each treatment alone played a role, it was the combination that truly stood out. Our findings suggest that vitamin C, especially when paired with omega-3, could offer protective benefits against liver toxicity induced by medications like methotrexate. This adds a dimension to the conversation on managing liver health during such treatments.
7
Vitamin C supports liver health
fruit extract as a potential antioxidant against liver injury by 2-Nitropropane induction in obese male mice model: pre-clinical study.
We investigated the effects of vitamin C in protecting against liver injury induced by 2-Nitropropane using a controlled laboratory study with obese male mice models. The research involved administering vitamin C alongside other treatments to assess its potential as an antioxidant in reducing oxidative stress on the liver.
During the study, we observed that the vitamin C treatment was effective in lowering the levels of various harmful indicators associated with liver damage, such as serum glutamic pyruvic transaminase (SGPT) and serum glutamic oxaloacetic transaminase (SGOT). These findings suggest that vitamin C can play a supportive role in liver health, particularly in conditions characterized by oxidative stress and liver insult.
Although the focus was also on a fruit extract, the results highlight vitamin C's potential benefits for maintaining liver function amid cellular damage. This encourages further exploration into how vitamin C might be incorporated into treatment strategies for managing liver disease more effectively. Overall, it seems that vitamin C may serve as a valuable ally in combating oxidative damage in the liver.
8
Vitamin C may protect liver health
Targeting Oxidative Stress: The Potential of Vitamin C in Protecting against Liver Damage after Electron Beam Therapy.
We investigated whether vitamin C could help protect the liver from damage caused by electron beam therapy, a treatment often used for cancers in the abdomen. Our study involved male Wistar rats, which were divided into four groups: one received electron irradiation, one was pre-treated with vitamin C, another received vitamin C alone, and the last group served as a control.
Through detailed analyses, we looked at various markers of liver health, such as liver enzymes and inflammatory cytokines. We also examined the liver tissues of the rats over 90 days to assess any changes. What we found was quite revealing; the group exposed to radiation showed significant liver damage, increased liver enzymes, inflammation, and signs of oxidative stress.
Interestingly, those rats pre-treated with vitamin C experienced milder liver damage and lower levels of oxidative stress and inflammation. This suggests that vitamin C may help maintain a better balance between liver cell growth and cell death, which is crucial after radiation exposure. Overall, our results indicate that vitamin C has potential as a protective agent against radiation-induced liver injury.
Still, while our findings are promising, further research is needed to fully understand the long-term benefits of vitamin C in this context.
9
Vitamin C reduces liver injury
The Effect of Ascorbic Acid on Hepatic Ischaemia-Reperfusion Injury in Wistar Rats: An Experimental Study.
We evaluated how vitamin C, also known as ascorbic acid, can help protect the liver during procedures that temporarily cut off blood flow—a process known as ischaemia followed by reperfusion. In this study, we used thirty-six male Wistar rats, split into control groups and experimental ones. Each group received the same total dose of vitamin C, administered at different times: either before the ischaemia, before the reperfusion, or both.
Our findings showed that the animals given vitamin C before both the ischaemia and reperfusion had improved outcomes. They had lower levels of liver enzymes, indicating less liver damage, and showed reduced inflammation. Additionally, their portal blood flow was better when compared to the other groups. Overall, our results suggest that administering vitamin C at specific times can significantly reduce liver injury associated with ischaemia-reperfusion.
This study highlights the potential of vitamin C as a protective agent in situations where liver damage is a concern during surgeries or treatments involving blood flow disruption.
9.5
Vitamin C enhances liver cancer treatment
Case report: The efficacy of adding high doses of intravenous vitamin C to the combination therapy of atezolizumab and bevacizumab in unresectable HCC.
We observed an intriguing case involving a 68-year-old male patient diagnosed with unresectable hepatocellular carcinoma (HCC). This case focused on the potential benefits of incorporating high-dose intravenous vitamin C into the treatment regimen alongside atezolizumab and bevacizumab.
Initially, the patient underwent the combination therapy, but while the imaging showed stable disease, there was only a modest decline in alpha-fetoprotein (AFP) levels. Unfortunately, the patient's condition further declined. In response, a dose of 30 grams of intravenous vitamin C was added to the treatment plan.
Remarkably, this adjustment led to a swift and noteworthy reduction in AFP levels, normalization of liver function tests, and substantial improvement in overall symptoms. Four months later, imaging indicated significant tumor shrinkage and necrosis.
As of 30 months post-diagnosis, the patient benefits from the combined regimen, showing normal liver function and a dramatically reduced AFP level, all while maintaining an active lifestyle. This case demonstrates the potential synergistic effects of high-dose vitamin C in treating unresectable HCC alongside standard therapies, warranting further investigation into such combination approaches.
References
Pedersen K, Poojari A, Colberg SF, Mechernsee SM, Iversen JF, et al. A Guinea Pig Model of Pediatric Metabolic Dysfunction-Associated Steatohepatitis: Poor Vitamin C Status May Advance Disease. Nutrients. 2025;17. 10.3390/nu17020291
Dong JX, Jiang LL, Liu YP, Zheng AX. Association between composite dietary antioxidant index and metabolic dysfunction-associated fatty liver disease: a cross-sectional study from NHANES. BMC Gastroenterol. 2024;24:465. 10.1186/s12876-024-03556-6
Demyashkin G, Parshenkov M, Koryakin S, Skovorodko P, Shchekin V, et al. Targeting Oxidative Stress: The Potential of Vitamin C in Protecting against Liver Damage after Electron Beam Therapy. Biomedicines. 2024;12. 10.3390/biomedicines12102195
Mohammed D, Al-Gareeb AM. Evaluation the effects of Omega-3 and vitamin C alone or in combination on Methotrexate-Induced hepatotoxicity (in mice). J Pak Med Assoc. 2024;74:S414. 10.47391/JPMA-BAGH-16-94
Kian W, Remilah AA, Shatat C, Spector M, Roisman LC, et al. Case report: The efficacy of adding high doses of intravenous vitamin C to the combination therapy of atezolizumab and bevacizumab in unresectable HCC. Front Med (Lausanne). 2024;11:1461127. 10.3389/fmed.2024.1461127
Thadeus MS, Susantiningsih T, Muktamiroh H, Fauziah C, Citrawati M, et al. fruit extract as a potential antioxidant against liver injury by 2-Nitropropane induction in obese male mice model: pre-clinical study. F1000Res. 2023;12:300. 10.12688/f1000research.121695.2
Ximenes JLS, Rocha-Filho JA, Galvão FHF, Lanchotte C, Kubrusly MS, et al. The Effect of Ascorbic Acid on Hepatic Ischaemia-Reperfusion Injury in Wistar Rats: An Experimental Study. Int J Mol Sci. 2024;25. 10.3390/ijms25168833
Chen HK, Lan QW, Li YJ, Xin Q, Luo RQ, et al. Association between Dietary Potassium Intake and Nonalcoholic Fatty Liver Disease and Advanced Hepatic Fibrosis in U.S. Adults. Int J Endocrinol. 2024;2024:5588104. 10.1155/2024/5588104
Jaffey JA, Chamberlin T, Hu J. Acute manganese toxicosis related to joint health supplement ingestion in two dogs. Top Companion Anim Med. 2024;61:100877. 10.1016/j.tcam.2024.100877
Liu XH, Chen HK, Luo J, He XP, Zhang WL, et al. Potassium affects the association between dietary intake of vitamin C and NAFLD among adults in the United States. PLoS One. 2024;19:e0295986. 10.1371/journal.pone.0295986
Liu L, Lin L, Wang Y, Yan X, Li R, et al. L-AP Alleviates Liver Injury in Septic Mice by Inhibiting Macrophage Activation via Suppressing NF-κB and NLRP3 Inflammasome/Caspase-1 Signal Pathways. J Agric Food Chem. 2024;72:8460. 10.1021/acs.jafc.3c02781