Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.1
USERS' SCORE
Good
Based on 6 Reviews
8.7
Supplement Facts
Serving Size: 1 Vegetarian Tablet
Amount Per Serving
%DV
Vitamin C (as Ester-C® Calcium Ascorbate)
1,000 mg (1 g)
1,111%
Calcium (as Ester-C® Calcium Ascorbate)
110 mg
8%
Citrus Bioflavonoids ComplexCitrus Bioflavonoids (Citrus sinensis) (fruit), Sweet Orange, Tangerine, Lime, Lemon, Acerola, Rutin, Hesperidin Complex (Citrus spp.) (fruit), Naturally Occurring Vitamin C Metabolites
200 mg
**
Top Medical Research Studies
9.5
We conducted a double-blind trial involving sixteen individuals with chronic foot ulcers to see how vitamin C impacts their healing. Half of the participants received 500 mg of vitamin C, while the others got a placebo.
After eight weeks, those taking vitamin C showed significant improvement—ulcer healing was much better compared to the placebo group. Notably, everyone who received vitamin C healed without needing amputation, while 44% of the control group did not see any healing.
Our findings suggest vitamin C may be a beneficial treatment for chronic foot ulcers, given its accessibility and low cost.
After eight weeks, those taking vitamin C showed significant improvement—ulcer healing was much better compared to the placebo group. Notably, everyone who received vitamin C healed without needing amputation, while 44% of the control group did not see any healing.
Our findings suggest vitamin C may be a beneficial treatment for chronic foot ulcers, given its accessibility and low cost.
Read More
8
We explored the effects of vitamin C on two men suffering from necrotic ulcers in their lower limbs linked to scurvy. Both had undetectable vitamin C levels and exhibited progressive ulceration. After starting vitamin C supplementation, we noticed a significant improvement in the condition of their ulcers.
This study makes it clear that while diagnosing scurvy can be tricky, it’s crucial, especially in at-risk groups. Addressing vitamin C deficiency early may enhance patient outcomes and resolve atypical ulcerations that don’t respond to typical treatments.
This study makes it clear that while diagnosing scurvy can be tricky, it’s crucial, especially in at-risk groups. Addressing vitamin C deficiency early may enhance patient outcomes and resolve atypical ulcerations that don’t respond to typical treatments.
Read More
9
In our study, we looked into how a culture supernatant from Lactobacillus acidophilus and vitamin C can combat ileal ulcer formation in rats treated with a nonsteroidal anti-inflammatory drug. We found that while other antioxidants didn’t improve ulcer prevention, ascorbic acid stood out as the most effective.
It significantly reduced the formation of ulcers and harmful substances linked to oxidative stress in the ileal mucosa. This suggests that vitamin C plays a key role in reducing ulcer risk by combating oxidative damage and altering gut bacteria effectively.
It significantly reduced the formation of ulcers and harmful substances linked to oxidative stress in the ileal mucosa. This suggests that vitamin C plays a key role in reducing ulcer risk by combating oxidative damage and altering gut bacteria effectively.
Read More
Most Useful Reviews
9
No side effects
1 people found this helpful
Vitamin C in its Ester form is gentle on the stomach, which is important for those with ulcers. I've experienced no side effects from this variant.
Read More
9
Gentle on stomach
1 people found this helpful
These capsules work well with my body. I find some vitamin Cs troublesome, but not this one. It doesn't irritate my stomach at all, which is essential as I have ulcerative colitis. Although the pills are a bit large, they are manageable for me.
Read More
9
Quick recovery
This is the best form of vitamin C. It includes bioflavonoids and doesn't irritate the stomach, making it safe for those with ulcers. I take two tablets three times daily at the onset of symptoms, leading to a remarkable recovery.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.1
- All Researches
9.5
We conducted a double-blind trial involving sixteen individuals with chronic foot ulcers to see how vitamin C impacts their healing. Half of the participants received 500 mg of vitamin C, while the others got a placebo.
After eight weeks, those taking vitamin C showed significant improvement—ulcer healing was much better compared to the placebo group. Notably, everyone who received vitamin C healed without needing amputation, while 44% of the control group did not see any healing.
Our findings suggest vitamin C may be a beneficial treatment for chronic foot ulcers, given its accessibility and low cost.
After eight weeks, those taking vitamin C showed significant improvement—ulcer healing was much better compared to the placebo group. Notably, everyone who received vitamin C healed without needing amputation, while 44% of the control group did not see any healing.
Our findings suggest vitamin C may be a beneficial treatment for chronic foot ulcers, given its accessibility and low cost.
Read More
9
In our study, we looked into how a culture supernatant from Lactobacillus acidophilus and vitamin C can combat ileal ulcer formation in rats treated with a nonsteroidal anti-inflammatory drug. We found that while other antioxidants didn’t improve ulcer prevention, ascorbic acid stood out as the most effective.
It significantly reduced the formation of ulcers and harmful substances linked to oxidative stress in the ileal mucosa. This suggests that vitamin C plays a key role in reducing ulcer risk by combating oxidative damage and altering gut bacteria effectively.
It significantly reduced the formation of ulcers and harmful substances linked to oxidative stress in the ileal mucosa. This suggests that vitamin C plays a key role in reducing ulcer risk by combating oxidative damage and altering gut bacteria effectively.
Read More
8
We conducted a thorough investigation into the protective effects of Vitamin C on gastric ulcers, especially in combination with metformin. Our study involved thirty rats divided into different groups to observe the ulcer-inducing effects of indomethacin and the potential healing properties of various treatments.
The findings were promising: both Vitamin C and metformin demonstrated significant improvements in gastric mucosal injury, helping to alleviate the damage caused by indomethacin. We noted that the combination of Vitamin C with metformin enhanced the effectiveness of antioxidant enzymes in the stomach, such as catalase and GPx, indicating a synergistic effect.
While Vitamin C showed positive results, it's important to recognize that these effects were observed in combination with metformin, making it difficult to isolate its specific benefits. Overall, our research suggests that the combination therapy could be a beneficial option for treating gastric ulcers linked to NSAID usage.
The findings were promising: both Vitamin C and metformin demonstrated significant improvements in gastric mucosal injury, helping to alleviate the damage caused by indomethacin. We noted that the combination of Vitamin C with metformin enhanced the effectiveness of antioxidant enzymes in the stomach, such as catalase and GPx, indicating a synergistic effect.
While Vitamin C showed positive results, it's important to recognize that these effects were observed in combination with metformin, making it difficult to isolate its specific benefits. Overall, our research suggests that the combination therapy could be a beneficial option for treating gastric ulcers linked to NSAID usage.
Read More
8
We observed the potential benefits of vitamin C in managing gastric ulcers under conditions of myocardial injury, which was induced using adrenaline in our study. Thirty Wistar rats were carefully divided into five groups, ensuring a control group for comparison.
The rats that received adrenaline alone showed increased gastric secretions and elevated markers related to heart injury. However, those pre-treated with vitamin C experienced a notable reduction in ulcer severity and excessive gastric secretions.
Interestingly, when we administered vitamin C before the adrenaline exposure, we found that it significantly decreased both the volume of gastric juice and total acidity, while also enhancing some protective factors. In essence, our research indicates that vitamin C may play a protective role in gastric health, particularly amid the stressful conditions created by adrenaline.
The rats that received adrenaline alone showed increased gastric secretions and elevated markers related to heart injury. However, those pre-treated with vitamin C experienced a notable reduction in ulcer severity and excessive gastric secretions.
Interestingly, when we administered vitamin C before the adrenaline exposure, we found that it significantly decreased both the volume of gastric juice and total acidity, while also enhancing some protective factors. In essence, our research indicates that vitamin C may play a protective role in gastric health, particularly amid the stressful conditions created by adrenaline.
Read More
8
We critically reviewed the effects of vitamin C supplementation on diabetic ulcers, particularly in patients who might benefit from this therapy. Current evidence suggests that vitamin C could play a role in supporting skin healing, which is vital for those suffering from diabetes-related complications like foot ulcers.
Through various studies, we noted that vitamin C might positively influence the healing process of ulcers. This was especially promising for individuals with diabetic foot ulcers, where effective management is crucial. While the evidence indicates potential benefits, it’s important to state that many of these studies have limitations, and we often see mixed results.
As we move forward, robust research focusing exclusively on vitamin C's effectiveness in treating ulcers is essential. Investigating different dosages and effects in diverse populations can help clarify its role and reliability as a supplementary treatment.
Through various studies, we noted that vitamin C might positively influence the healing process of ulcers. This was especially promising for individuals with diabetic foot ulcers, where effective management is crucial. While the evidence indicates potential benefits, it’s important to state that many of these studies have limitations, and we often see mixed results.
As we move forward, robust research focusing exclusively on vitamin C's effectiveness in treating ulcers is essential. Investigating different dosages and effects in diverse populations can help clarify its role and reliability as a supplementary treatment.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
No side effects
1 people found this helpful
Vitamin C in its Ester form is gentle on the stomach, which is important for those with ulcers. I've experienced no side effects from this variant.
Read More
9
Gentle on stomach
1 people found this helpful
These capsules work well with my body. I find some vitamin Cs troublesome, but not this one. It doesn't irritate my stomach at all, which is essential as I have ulcerative colitis. Although the pills are a bit large, they are manageable for me.
Read More
9
Quick recovery
This is the best form of vitamin C. It includes bioflavonoids and doesn't irritate the stomach, making it safe for those with ulcers. I take two tablets three times daily at the onset of symptoms, leading to a remarkable recovery.
Read More
9
Safe for stomach
This excellent vitamin C is a non-acidic form that’s safe for individuals with gastrointestinal issues or ulcers. I can even take it on an empty stomach, fulfilling my daily requirements with just one capsule.
Read More
9
Supports during colds
This vitamin C does not irritate my stomach lining, which is crucial for those with ulcers. It effectively boosts my immune system during cold season.
Read More
Frequently Asked Questions
9
Quick recovery
This is the best form of vitamin C. It includes bioflavonoids and doesn't irritate the stomach, making it safe for those with ulcers. I take two tablets three times daily at the onset of symptoms, leading to a remarkable recovery.
9
Strong immunity
I highly recommend this vitamin C for its good quality and low acidity, making it suitable for ulcers. The results are impressive when taken regularly.
9
Safe for stomach
This excellent vitamin C is a non-acidic form that’s safe for individuals with gastrointestinal issues or ulcers. I can even take it on an empty stomach, fulfilling my daily requirements with just one capsule.
9
No side effects
1 people found this helpful
Vitamin C in its Ester form is gentle on the stomach, which is important for those with ulcers. I've experienced no side effects from this variant.
9
Supports during colds
This vitamin C does not irritate my stomach lining, which is crucial for those with ulcers. It effectively boosts my immune system during cold season.
8
We conducted a thorough investigation into the protective effects of Vitamin C on gastric ulcers, especially in combination with metformin. Our study involved thirty rats divided into different groups to observe the ulcer-inducing effects of indomethacin and the potential healing properties of various treatments.
The findings were promising: both Vitamin C and metformin demonstrated significant improvements in gastric mucosal injury, helping to alleviate the damage caused by indomethacin. We noted that the combination of Vitamin C with metformin enhanced the effectiveness of antioxidant enzymes in the stomach, such as catalase and GPx, indicating a synergistic effect.
While Vitamin C showed positive results, it's important to recognize that these effects were observed in combination with metformin, making it difficult to isolate its specific benefits. Overall, our research suggests that the combination therapy could be a beneficial option for treating gastric ulcers linked to NSAID usage.
The findings were promising: both Vitamin C and metformin demonstrated significant improvements in gastric mucosal injury, helping to alleviate the damage caused by indomethacin. We noted that the combination of Vitamin C with metformin enhanced the effectiveness of antioxidant enzymes in the stomach, such as catalase and GPx, indicating a synergistic effect.
While Vitamin C showed positive results, it's important to recognize that these effects were observed in combination with metformin, making it difficult to isolate its specific benefits. Overall, our research suggests that the combination therapy could be a beneficial option for treating gastric ulcers linked to NSAID usage.
8
We observed the potential benefits of vitamin C in managing gastric ulcers under conditions of myocardial injury, which was induced using adrenaline in our study. Thirty Wistar rats were carefully divided into five groups, ensuring a control group for comparison.
The rats that received adrenaline alone showed increased gastric secretions and elevated markers related to heart injury. However, those pre-treated with vitamin C experienced a notable reduction in ulcer severity and excessive gastric secretions.
Interestingly, when we administered vitamin C before the adrenaline exposure, we found that it significantly decreased both the volume of gastric juice and total acidity, while also enhancing some protective factors. In essence, our research indicates that vitamin C may play a protective role in gastric health, particularly amid the stressful conditions created by adrenaline.
The rats that received adrenaline alone showed increased gastric secretions and elevated markers related to heart injury. However, those pre-treated with vitamin C experienced a notable reduction in ulcer severity and excessive gastric secretions.
Interestingly, when we administered vitamin C before the adrenaline exposure, we found that it significantly decreased both the volume of gastric juice and total acidity, while also enhancing some protective factors. In essence, our research indicates that vitamin C may play a protective role in gastric health, particularly amid the stressful conditions created by adrenaline.
7
Vitamin C positively influences gut microbiome
We explored how vitamin C affects the gut microbiome of patients with ulcerative colitis (UC) in a study involving 49 outpatient subjects. The participants were evaluated between June and December 2021, and they were divided into groups based on whether they had contracted COVID-19 in the prior six months. Our primary focus was to assess not just the impact of vitamin C, but also to consider the effects of antibiotics, probiotics, and the history of COVID-19 on their gut health.
Interestingly, we observed that those who used vitamin C supplements had more beneficial elements in their gut microbiome compared to those who did not. The study found a significant difference, indicating that vitamin C users had better microbiome readings, suggesting a positive influence on their gut health. However, while vitamin C presented statistically significant results, we noted that other factors such as antibiotic use also played a crucial role.
Importantly, the use of antibiotics negatively impacted the gut microbiome, which raises questions about the interplay between different treatments. There was also no significant impact found regarding mild COVID-19 on patients’ gut microbiomes, adding another layer to our understanding of these interactions. Ultimately, while vitamin C showed promise, the overall picture suggests that it's part of a broader landscape of factors affecting ulcerative colitis.
Interestingly, we observed that those who used vitamin C supplements had more beneficial elements in their gut microbiome compared to those who did not. The study found a significant difference, indicating that vitamin C users had better microbiome readings, suggesting a positive influence on their gut health. However, while vitamin C presented statistically significant results, we noted that other factors such as antibiotic use also played a crucial role.
Importantly, the use of antibiotics negatively impacted the gut microbiome, which raises questions about the interplay between different treatments. There was also no significant impact found regarding mild COVID-19 on patients’ gut microbiomes, adding another layer to our understanding of these interactions. Ultimately, while vitamin C showed promise, the overall picture suggests that it's part of a broader landscape of factors affecting ulcerative colitis.
References
- Straume Z, Krūmiņa N, Elbere I, Rozenberga M, Erts R, et al. Impact of Vitamins, Antibiotics, Probiotics, and History of COVID-19 on the Gut Microbiome in Ulcerative Colitis Patients: A Cross-Sectional Study. Medicina (Kaunas). 2025;61. doi:10.3390/medicina61020284
- Khezri MR, Varzandeh R, Ghasemnejad-Berenji M. Concomitant Effects of Metformin and Vitamin C on Indomethacin-Induced Gastric Ulcer in Rats: Biochemical and Histopathological Approach. Drug Res (Stuttg). 2024;74:280. doi:10.1055/a-2317-7578
- Ezeani C, Beshel JA, Okon IA, Inyang EG, Owu DU. Vitamin C modulates adrenaline-augmented gastric injury via cardiac troponin/creatine kinase pathway in Wistar rats. Iran J Basic Med Sci. 2023;26:843. doi:10.22038/IJBMS.2023.68651.15019
- Mason SA, Parker L, van der Pligt P, Wadley GD. Vitamin C supplementation for diabetes management: A comprehensive narrative review. Free Radic Biol Med. 2023;194:255. doi:10.1016/j.freeradbiomed.2022.12.003
- Kurt Y, Özmen Ö. Effects of Vitamin C on the Oral-Nasal Mucosal Damage Caused by Favipiravir in Old and Young Rats. Cureus. 2022;14:e28796. doi:10.7759/cureus.28796
- Guellich A, Tella E, Mahé E. [Scurvy presenting with low-extremity necrotic and purpuric ulcers: Two cases]. Rev Med Interne. 2021;42:214. doi:10.1016/j.revmed.2020.10.382
- Gunton JE, Girgis CM, Lau T, Vicaretti M, Begg L, et al. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial. Br J Nutr. 2021;126:1451. doi:10.1017/S0007114520003815
- Galati EM, Mondello MR, Giuffrida D, Dugo G, Miceli N, et al. Chemical characterization and biological effects of Sicilian Opuntia ficus indica (L.) mill. Fruit juice: antioxidant and antiulcerogenic activity. J Agric Food Chem. 2003;51:4903.
- Bing SR, Kinouchi T, Kataoka K, Kuwahara T, Ohnishi Y. Protective effects of a culture supernatant of Lactobacillus acidophilus and antioxidants on ileal ulcer formation in rats treated with a nonsteroidal antiinflammatory drug. Microbiol Immunol. 1998;42:745.
- Vishniak GN, Kharlamova KE, Gurosheva GT, Zavernaia AM, Golovnia IA. [Amben and galascorbin in the combined treatment of ulcerative-necrotic lesions of the oral mucosa]. Stomatologiia (Mosk). 1993;72:24.
