Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.1
USERS' SCORE
Good
Based on 3 Reviews
8.4
Supplement Facts
Serving Size: 1 Vegetarian Tablet
Amount Per Serving
%DV
Vitamin C (as Ester-C® Calcium Ascorbate)
1,000 mg (1 g)
1,111%
Calcium (as Ester-C® Calcium Ascorbate)
108 mg
8%
Citrus Bioflavonoids ComplexCitrus Bioflavonoids (Citrus spp.) (fruit), Sweet Orange, Tangerine, Lime, Lemon, Acerola, Rutin, Hesperidin Complex (Citrus spp.) (fruit), Naturally Occurring Vitamin C Metabolites
200 mg
**
Top Medical Research Studies
9.5
We conducted a double-blind trial involving sixteen individuals with chronic foot ulcers to see how vitamin C impacts their healing. Half of the participants received 500 mg of vitamin C, while the others got a placebo.
After eight weeks, those taking vitamin C showed significant improvement—ulcer healing was much better compared to the placebo group. Notably, everyone who received vitamin C healed without needing amputation, while 44% of the control group did not see any healing.
Our findings suggest vitamin C may be a beneficial treatment for chronic foot ulcers, given its accessibility and low cost.
After eight weeks, those taking vitamin C showed significant improvement—ulcer healing was much better compared to the placebo group. Notably, everyone who received vitamin C healed without needing amputation, while 44% of the control group did not see any healing.
Our findings suggest vitamin C may be a beneficial treatment for chronic foot ulcers, given its accessibility and low cost.
Read More
8
We explored the effects of vitamin C on two men suffering from necrotic ulcers in their lower limbs linked to scurvy. Both had undetectable vitamin C levels and exhibited progressive ulceration. After starting vitamin C supplementation, we noticed a significant improvement in the condition of their ulcers.
This study makes it clear that while diagnosing scurvy can be tricky, it’s crucial, especially in at-risk groups. Addressing vitamin C deficiency early may enhance patient outcomes and resolve atypical ulcerations that don’t respond to typical treatments.
This study makes it clear that while diagnosing scurvy can be tricky, it’s crucial, especially in at-risk groups. Addressing vitamin C deficiency early may enhance patient outcomes and resolve atypical ulcerations that don’t respond to typical treatments.
Read More
9
In our study, we looked into how a culture supernatant from Lactobacillus acidophilus and vitamin C can combat ileal ulcer formation in rats treated with a nonsteroidal anti-inflammatory drug. We found that while other antioxidants didn’t improve ulcer prevention, ascorbic acid stood out as the most effective.
It significantly reduced the formation of ulcers and harmful substances linked to oxidative stress in the ileal mucosa. This suggests that vitamin C plays a key role in reducing ulcer risk by combating oxidative damage and altering gut bacteria effectively.
It significantly reduced the formation of ulcers and harmful substances linked to oxidative stress in the ileal mucosa. This suggests that vitamin C plays a key role in reducing ulcer risk by combating oxidative damage and altering gut bacteria effectively.
Read More
Most Useful Reviews
9
Safe for ulcers
Vitamin C is essential in my home, especially during cold and flu season. I previously experienced heartburn and stomach pain, but this new form is safe for my gastric mucosa and has not caused any unpleasant effects. It helps condition my iron deficiency anaemia and invigorates me without any issues related to ulcers.
Read More
7.5
Alleviates ulcers
I take Ester C with citrus biflavonoids, as it works well for my digestive system and doesn't cause mouth ulcers like other forms of vitamin C. Since I use it regularly, I seldom catch colds.
Read More
7.5
Helps with ulcers
I recommend this vitamin C for those with high acidity or ulcers, as it's gentle on the stomach. I take 500mg in the morning and evening for better absorption, and it works well for me.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.1
- All Researches
9.5
We conducted a double-blind trial involving sixteen individuals with chronic foot ulcers to see how vitamin C impacts their healing. Half of the participants received 500 mg of vitamin C, while the others got a placebo.
After eight weeks, those taking vitamin C showed significant improvement—ulcer healing was much better compared to the placebo group. Notably, everyone who received vitamin C healed without needing amputation, while 44% of the control group did not see any healing.
Our findings suggest vitamin C may be a beneficial treatment for chronic foot ulcers, given its accessibility and low cost.
After eight weeks, those taking vitamin C showed significant improvement—ulcer healing was much better compared to the placebo group. Notably, everyone who received vitamin C healed without needing amputation, while 44% of the control group did not see any healing.
Our findings suggest vitamin C may be a beneficial treatment for chronic foot ulcers, given its accessibility and low cost.
Read More
9
In our study, we looked into how a culture supernatant from Lactobacillus acidophilus and vitamin C can combat ileal ulcer formation in rats treated with a nonsteroidal anti-inflammatory drug. We found that while other antioxidants didn’t improve ulcer prevention, ascorbic acid stood out as the most effective.
It significantly reduced the formation of ulcers and harmful substances linked to oxidative stress in the ileal mucosa. This suggests that vitamin C plays a key role in reducing ulcer risk by combating oxidative damage and altering gut bacteria effectively.
It significantly reduced the formation of ulcers and harmful substances linked to oxidative stress in the ileal mucosa. This suggests that vitamin C plays a key role in reducing ulcer risk by combating oxidative damage and altering gut bacteria effectively.
Read More
8
We conducted a thorough investigation into the protective effects of Vitamin C on gastric ulcers, especially in combination with metformin. Our study involved thirty rats divided into different groups to observe the ulcer-inducing effects of indomethacin and the potential healing properties of various treatments.
The findings were promising: both Vitamin C and metformin demonstrated significant improvements in gastric mucosal injury, helping to alleviate the damage caused by indomethacin. We noted that the combination of Vitamin C with metformin enhanced the effectiveness of antioxidant enzymes in the stomach, such as catalase and GPx, indicating a synergistic effect.
While Vitamin C showed positive results, it's important to recognize that these effects were observed in combination with metformin, making it difficult to isolate its specific benefits. Overall, our research suggests that the combination therapy could be a beneficial option for treating gastric ulcers linked to NSAID usage.
The findings were promising: both Vitamin C and metformin demonstrated significant improvements in gastric mucosal injury, helping to alleviate the damage caused by indomethacin. We noted that the combination of Vitamin C with metformin enhanced the effectiveness of antioxidant enzymes in the stomach, such as catalase and GPx, indicating a synergistic effect.
While Vitamin C showed positive results, it's important to recognize that these effects were observed in combination with metformin, making it difficult to isolate its specific benefits. Overall, our research suggests that the combination therapy could be a beneficial option for treating gastric ulcers linked to NSAID usage.
Read More
8
We observed the potential benefits of vitamin C in managing gastric ulcers under conditions of myocardial injury, which was induced using adrenaline in our study. Thirty Wistar rats were carefully divided into five groups, ensuring a control group for comparison.
The rats that received adrenaline alone showed increased gastric secretions and elevated markers related to heart injury. However, those pre-treated with vitamin C experienced a notable reduction in ulcer severity and excessive gastric secretions.
Interestingly, when we administered vitamin C before the adrenaline exposure, we found that it significantly decreased both the volume of gastric juice and total acidity, while also enhancing some protective factors. In essence, our research indicates that vitamin C may play a protective role in gastric health, particularly amid the stressful conditions created by adrenaline.
The rats that received adrenaline alone showed increased gastric secretions and elevated markers related to heart injury. However, those pre-treated with vitamin C experienced a notable reduction in ulcer severity and excessive gastric secretions.
Interestingly, when we administered vitamin C before the adrenaline exposure, we found that it significantly decreased both the volume of gastric juice and total acidity, while also enhancing some protective factors. In essence, our research indicates that vitamin C may play a protective role in gastric health, particularly amid the stressful conditions created by adrenaline.
Read More
8
We critically reviewed the effects of vitamin C supplementation on diabetic ulcers, particularly in patients who might benefit from this therapy. Current evidence suggests that vitamin C could play a role in supporting skin healing, which is vital for those suffering from diabetes-related complications like foot ulcers.
Through various studies, we noted that vitamin C might positively influence the healing process of ulcers. This was especially promising for individuals with diabetic foot ulcers, where effective management is crucial. While the evidence indicates potential benefits, it’s important to state that many of these studies have limitations, and we often see mixed results.
As we move forward, robust research focusing exclusively on vitamin C's effectiveness in treating ulcers is essential. Investigating different dosages and effects in diverse populations can help clarify its role and reliability as a supplementary treatment.
Through various studies, we noted that vitamin C might positively influence the healing process of ulcers. This was especially promising for individuals with diabetic foot ulcers, where effective management is crucial. While the evidence indicates potential benefits, it’s important to state that many of these studies have limitations, and we often see mixed results.
As we move forward, robust research focusing exclusively on vitamin C's effectiveness in treating ulcers is essential. Investigating different dosages and effects in diverse populations can help clarify its role and reliability as a supplementary treatment.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Safe for ulcers
Vitamin C is essential in my home, especially during cold and flu season. I previously experienced heartburn and stomach pain, but this new form is safe for my gastric mucosa and has not caused any unpleasant effects. It helps condition my iron deficiency anaemia and invigorates me without any issues related to ulcers.
Read More
7.5
Alleviates ulcers
I take Ester C with citrus biflavonoids, as it works well for my digestive system and doesn't cause mouth ulcers like other forms of vitamin C. Since I use it regularly, I seldom catch colds.
Read More
7.5
Helps with ulcers
I recommend this vitamin C for those with high acidity or ulcers, as it's gentle on the stomach. I take 500mg in the morning and evening for better absorption, and it works well for me.
Read More
Frequently Asked Questions
9
Safe for ulcers
Vitamin C is essential in my home, especially during cold and flu season. I previously experienced heartburn and stomach pain, but this new form is safe for my gastric mucosa and has not caused any unpleasant effects. It helps condition my iron deficiency anaemia and invigorates me without any issues related to ulcers.
7.5
Alleviates ulcers
I take Ester C with citrus biflavonoids, as it works well for my digestive system and doesn't cause mouth ulcers like other forms of vitamin C. Since I use it regularly, I seldom catch colds.
8
We conducted a thorough investigation into the protective effects of Vitamin C on gastric ulcers, especially in combination with metformin. Our study involved thirty rats divided into different groups to observe the ulcer-inducing effects of indomethacin and the potential healing properties of various treatments.
The findings were promising: both Vitamin C and metformin demonstrated significant improvements in gastric mucosal injury, helping to alleviate the damage caused by indomethacin. We noted that the combination of Vitamin C with metformin enhanced the effectiveness of antioxidant enzymes in the stomach, such as catalase and GPx, indicating a synergistic effect.
While Vitamin C showed positive results, it's important to recognize that these effects were observed in combination with metformin, making it difficult to isolate its specific benefits. Overall, our research suggests that the combination therapy could be a beneficial option for treating gastric ulcers linked to NSAID usage.
The findings were promising: both Vitamin C and metformin demonstrated significant improvements in gastric mucosal injury, helping to alleviate the damage caused by indomethacin. We noted that the combination of Vitamin C with metformin enhanced the effectiveness of antioxidant enzymes in the stomach, such as catalase and GPx, indicating a synergistic effect.
While Vitamin C showed positive results, it's important to recognize that these effects were observed in combination with metformin, making it difficult to isolate its specific benefits. Overall, our research suggests that the combination therapy could be a beneficial option for treating gastric ulcers linked to NSAID usage.
8
We observed the potential benefits of vitamin C in managing gastric ulcers under conditions of myocardial injury, which was induced using adrenaline in our study. Thirty Wistar rats were carefully divided into five groups, ensuring a control group for comparison.
The rats that received adrenaline alone showed increased gastric secretions and elevated markers related to heart injury. However, those pre-treated with vitamin C experienced a notable reduction in ulcer severity and excessive gastric secretions.
Interestingly, when we administered vitamin C before the adrenaline exposure, we found that it significantly decreased both the volume of gastric juice and total acidity, while also enhancing some protective factors. In essence, our research indicates that vitamin C may play a protective role in gastric health, particularly amid the stressful conditions created by adrenaline.
The rats that received adrenaline alone showed increased gastric secretions and elevated markers related to heart injury. However, those pre-treated with vitamin C experienced a notable reduction in ulcer severity and excessive gastric secretions.
Interestingly, when we administered vitamin C before the adrenaline exposure, we found that it significantly decreased both the volume of gastric juice and total acidity, while also enhancing some protective factors. In essence, our research indicates that vitamin C may play a protective role in gastric health, particularly amid the stressful conditions created by adrenaline.
8
We critically reviewed the effects of vitamin C supplementation on diabetic ulcers, particularly in patients who might benefit from this therapy. Current evidence suggests that vitamin C could play a role in supporting skin healing, which is vital for those suffering from diabetes-related complications like foot ulcers.
Through various studies, we noted that vitamin C might positively influence the healing process of ulcers. This was especially promising for individuals with diabetic foot ulcers, where effective management is crucial. While the evidence indicates potential benefits, it’s important to state that many of these studies have limitations, and we often see mixed results.
As we move forward, robust research focusing exclusively on vitamin C's effectiveness in treating ulcers is essential. Investigating different dosages and effects in diverse populations can help clarify its role and reliability as a supplementary treatment.
Through various studies, we noted that vitamin C might positively influence the healing process of ulcers. This was especially promising for individuals with diabetic foot ulcers, where effective management is crucial. While the evidence indicates potential benefits, it’s important to state that many of these studies have limitations, and we often see mixed results.
As we move forward, robust research focusing exclusively on vitamin C's effectiveness in treating ulcers is essential. Investigating different dosages and effects in diverse populations can help clarify its role and reliability as a supplementary treatment.
References
- Straume Z, Krūmiņa N, Elbere I, Rozenberga M, Erts R, et al. Impact of Vitamins, Antibiotics, Probiotics, and History of COVID-19 on the Gut Microbiome in Ulcerative Colitis Patients: A Cross-Sectional Study. Medicina (Kaunas). 2025;61. doi:10.3390/medicina61020284
- Khezri MR, Varzandeh R, Ghasemnejad-Berenji M. Concomitant Effects of Metformin and Vitamin C on Indomethacin-Induced Gastric Ulcer in Rats: Biochemical and Histopathological Approach. Drug Res (Stuttg). 2024;74:280. doi:10.1055/a-2317-7578
- Ezeani C, Beshel JA, Okon IA, Inyang EG, Owu DU. Vitamin C modulates adrenaline-augmented gastric injury via cardiac troponin/creatine kinase pathway in Wistar rats. Iran J Basic Med Sci. 2023;26:843. doi:10.22038/IJBMS.2023.68651.15019
- Mason SA, Parker L, van der Pligt P, Wadley GD. Vitamin C supplementation for diabetes management: A comprehensive narrative review. Free Radic Biol Med. 2023;194:255. doi:10.1016/j.freeradbiomed.2022.12.003
- Kurt Y, Özmen Ö. Effects of Vitamin C on the Oral-Nasal Mucosal Damage Caused by Favipiravir in Old and Young Rats. Cureus. 2022;14:e28796. doi:10.7759/cureus.28796
- Guellich A, Tella E, Mahé E. [Scurvy presenting with low-extremity necrotic and purpuric ulcers: Two cases]. Rev Med Interne. 2021;42:214. doi:10.1016/j.revmed.2020.10.382
- Gunton JE, Girgis CM, Lau T, Vicaretti M, Begg L, et al. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial. Br J Nutr. 2021;126:1451. doi:10.1017/S0007114520003815
- Galati EM, Mondello MR, Giuffrida D, Dugo G, Miceli N, et al. Chemical characterization and biological effects of Sicilian Opuntia ficus indica (L.) mill. Fruit juice: antioxidant and antiulcerogenic activity. J Agric Food Chem. 2003;51:4903.
- Bing SR, Kinouchi T, Kataoka K, Kuwahara T, Ohnishi Y. Protective effects of a culture supernatant of Lactobacillus acidophilus and antioxidants on ileal ulcer formation in rats treated with a nonsteroidal antiinflammatory drug. Microbiol Immunol. 1998;42:745.
- Vishniak GN, Kharlamova KE, Gurosheva GT, Zavernaia AM, Golovnia IA. [Amben and galascorbin in the combined treatment of ulcerative-necrotic lesions of the oral mucosa]. Stomatologiia (Mosk). 1993;72:24.
