5/20/2025
Last update
5/20/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 1 Review
8.5
Top Medical Research Studies
8
We explored the effects of L-ascorbate, commonly known as Vitamin C, on chloride transport in sinonasal epithelial tissues. This research is particularly significant as it addresses the common condition of chronic rhinosinusitis (CRS) and its potential link to the function of the cystic fibrosis transmembrane conductance regulator (CFTR) — a key chloride ion channel.
During our investigation, we utilized freshly excised sinonasal tissues from both normal individuals and patients suffering from CRS. The tissues were carefully prepared and tested to understand how L-ascorbate influenced chloride secretion. Our findings revealed that the application of L-ascorbate notably enhanced chloride secretion in these tissues.
This is important because optimal chloride transport is essential for maintaining healthy mucosal surfaces and effective mucociliary clearance. Therefore, since decreased chloride secretion could lead to the worsening of sinus conditions, L-ascorbate presents a promising avenue for therapeutic intervention in improving mucociliary clearance for those affected by chronic sinus issues.
During our investigation, we utilized freshly excised sinonasal tissues from both normal individuals and patients suffering from CRS. The tissues were carefully prepared and tested to understand how L-ascorbate influenced chloride secretion. Our findings revealed that the application of L-ascorbate notably enhanced chloride secretion in these tissues.
This is important because optimal chloride transport is essential for maintaining healthy mucosal surfaces and effective mucociliary clearance. Therefore, since decreased chloride secretion could lead to the worsening of sinus conditions, L-ascorbate presents a promising avenue for therapeutic intervention in improving mucociliary clearance for those affected by chronic sinus issues.
Read More
8
We evaluated the impact of antioxidants, specifically vitamin C, on acute maxillary sinusitis treatment through a study involving different treatment approaches. Patients received a mix of dibunol and vitamin C, delivered into the sinuses, while others only had traditional treatments like ampicillin and hydrocortisone.
This study involved control groups that helped us compare the effectiveness of the antioxidant treatment. Stunningly, we found that those receiving the antioxidant mixture demonstrated substantial improvements, with shorter treatment times and fewer overall interventions compared to the control group.
Additionally, positive changes in certain blood markers indicated that the antioxidant approach markedly enhanced the body's response to infection. These findings underscore the potential benefits of including vitamin C as part of a sinusitis treatment plan, especially when dealing with acute flare-ups.
This study involved control groups that helped us compare the effectiveness of the antioxidant treatment. Stunningly, we found that those receiving the antioxidant mixture demonstrated substantial improvements, with shorter treatment times and fewer overall interventions compared to the control group.
Additionally, positive changes in certain blood markers indicated that the antioxidant approach markedly enhanced the body's response to infection. These findings underscore the potential benefits of including vitamin C as part of a sinusitis treatment plan, especially when dealing with acute flare-ups.
Read More
Most Useful Reviews
9
Rapid relief from sinusitis
1 people found this helpful
Works swiftly! I have had sinusitis for 3 years, often waking with clots. After taking this product for just 3 days, I could breathe and my sinuses were clear. This is remarkable; I live in an older house that affects breathing, but that’s improved too. This product is a lifesaver!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
- All Researches
8
We explored the effects of L-ascorbate, commonly known as Vitamin C, on chloride transport in sinonasal epithelial tissues. This research is particularly significant as it addresses the common condition of chronic rhinosinusitis (CRS) and its potential link to the function of the cystic fibrosis transmembrane conductance regulator (CFTR) — a key chloride ion channel.
During our investigation, we utilized freshly excised sinonasal tissues from both normal individuals and patients suffering from CRS. The tissues were carefully prepared and tested to understand how L-ascorbate influenced chloride secretion. Our findings revealed that the application of L-ascorbate notably enhanced chloride secretion in these tissues.
This is important because optimal chloride transport is essential for maintaining healthy mucosal surfaces and effective mucociliary clearance. Therefore, since decreased chloride secretion could lead to the worsening of sinus conditions, L-ascorbate presents a promising avenue for therapeutic intervention in improving mucociliary clearance for those affected by chronic sinus issues.
During our investigation, we utilized freshly excised sinonasal tissues from both normal individuals and patients suffering from CRS. The tissues were carefully prepared and tested to understand how L-ascorbate influenced chloride secretion. Our findings revealed that the application of L-ascorbate notably enhanced chloride secretion in these tissues.
This is important because optimal chloride transport is essential for maintaining healthy mucosal surfaces and effective mucociliary clearance. Therefore, since decreased chloride secretion could lead to the worsening of sinus conditions, L-ascorbate presents a promising avenue for therapeutic intervention in improving mucociliary clearance for those affected by chronic sinus issues.
Read More
8
We evaluated the impact of antioxidants, specifically vitamin C, on acute maxillary sinusitis treatment through a study involving different treatment approaches. Patients received a mix of dibunol and vitamin C, delivered into the sinuses, while others only had traditional treatments like ampicillin and hydrocortisone.
This study involved control groups that helped us compare the effectiveness of the antioxidant treatment. Stunningly, we found that those receiving the antioxidant mixture demonstrated substantial improvements, with shorter treatment times and fewer overall interventions compared to the control group.
Additionally, positive changes in certain blood markers indicated that the antioxidant approach markedly enhanced the body's response to infection. These findings underscore the potential benefits of including vitamin C as part of a sinusitis treatment plan, especially when dealing with acute flare-ups.
This study involved control groups that helped us compare the effectiveness of the antioxidant treatment. Stunningly, we found that those receiving the antioxidant mixture demonstrated substantial improvements, with shorter treatment times and fewer overall interventions compared to the control group.
Additionally, positive changes in certain blood markers indicated that the antioxidant approach markedly enhanced the body's response to infection. These findings underscore the potential benefits of including vitamin C as part of a sinusitis treatment plan, especially when dealing with acute flare-ups.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Rapid relief from sinusitis
1 people found this helpful
Works swiftly! I have had sinusitis for 3 years, often waking with clots. After taking this product for just 3 days, I could breathe and my sinuses were clear. This is remarkable; I live in an older house that affects breathing, but that’s improved too. This product is a lifesaver!
Read More
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References
- Cho DY, Hwang PH, Illek B. Effect of L-ascorbate on chloride transport in freshly excised sinonasal epithelia. Am J Rhinol Allergy. 2009;23:294. 10.2500/ajra.2009.23.3316
- Nikolaev MP, Logunov AI, Tsyrulńikova LG, Dzhalilov DS. [Clinical and biochemical aspects in the treatment of acute maxillary sinusitis with antioxidants]. Vestn Otorinolaringol. 1994.
