5/5/2025
Last update
5/5/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.7
USERS' SCORE
Moderately Good
Based on 1 Review
7.7
Top Medical Research Studies
8
We investigated the potential connection between vitamin D deficiency and allergic proctocolitis (AP) in infants. Our study involved a careful comparison of vitamin D levels in infants diagnosed with AP against those of healthy infants. This meticulous, prospective approach allows us to draw insightful conclusions about how vitamin D might be influencing allergic conditions.
We found that vitamin D levels were noticeably lower in infants suffering from AP compared to their healthy peers. Notably, a significant percentage of AP patients—34.7%—were found to be vitamin D deficient or insufficient. Furthermore, the study revealed that infants with vitamin D levels below 40.75 mcg/L were 3.5 times more likely to develop AP.
Our findings suggest an intriguing association between vitamin D deficiency and allergic proctocolitis, hinting that the rising rates of such allergies may be influenced by environmental factors. It appears crucial that we assess vitamin D levels in infants diagnosed with AP, as this could contribute to better understanding and management of the condition.
We found that vitamin D levels were noticeably lower in infants suffering from AP compared to their healthy peers. Notably, a significant percentage of AP patients—34.7%—were found to be vitamin D deficient or insufficient. Furthermore, the study revealed that infants with vitamin D levels below 40.75 mcg/L were 3.5 times more likely to develop AP.
Our findings suggest an intriguing association between vitamin D deficiency and allergic proctocolitis, hinting that the rising rates of such allergies may be influenced by environmental factors. It appears crucial that we assess vitamin D levels in infants diagnosed with AP, as this could contribute to better understanding and management of the condition.
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8
We examined the rise of hypersensitivity reactions (HRs) linked to iron agents, especially as their usage in treating iron deficiency has increased. In this study, we evaluated the clinical features of patients who experienced immediate hypersensitivity reactions (IHRs) to both oral and intravenous (IV) iron preparations.
Our analysis included the medical records of 96 patients with a history of these reactions. Among them, 47 had reactions to oral iron, while 49 reacted to IV iron. We conducted skin-prick tests with various iron salts, but found that these tests weren't very helpful for diagnosing IHRs. In fact, only a small percentage showed a positive reaction.
Interestingly, we noted that patients who were sensitive to IV iron experienced more severe reactions, including cases of anaphylaxis. Despite the challenges in diagnosing these allergies, we successfully conducted desensitization treatments for 15 patients needing iron, specifically using ferric carboxymaltose. This approach proved to be safe and effective, marking an important option for patients requiring iron therapy despite their hypersensitivity.
Our analysis included the medical records of 96 patients with a history of these reactions. Among them, 47 had reactions to oral iron, while 49 reacted to IV iron. We conducted skin-prick tests with various iron salts, but found that these tests weren't very helpful for diagnosing IHRs. In fact, only a small percentage showed a positive reaction.
Interestingly, we noted that patients who were sensitive to IV iron experienced more severe reactions, including cases of anaphylaxis. Despite the challenges in diagnosing these allergies, we successfully conducted desensitization treatments for 15 patients needing iron, specifically using ferric carboxymaltose. This approach proved to be safe and effective, marking an important option for patients requiring iron therapy despite their hypersensitivity.
Read More
9
Iron reduces allergenicity in milk
We explored the effects of iron-complexed hydrolyzed whey protein on cow's milk allergies. In this study, we created various treatments with different hydrolysis degrees and tested their allergenicity using specific IgE antibodies.
Our findings showed a significant reduction in allergenicity—up to 60% when combining iron with ascorbic acid. Although there was a clear improvement, the results suggest that these treatments may not eliminate allergenic responses entirely.
In essence, iron fortification could be a promising strategy for creating hypoallergenic dairy products.
Our findings showed a significant reduction in allergenicity—up to 60% when combining iron with ascorbic acid. Although there was a clear improvement, the results suggest that these treatments may not eliminate allergenic responses entirely.
In essence, iron fortification could be a promising strategy for creating hypoallergenic dairy products.
Read More
Most Useful Reviews
0
Dangerous ingredient changes
10 people found this helpful
I'm extremely upset after noticing significant changes in my vitamin's ingredients. After months of use, I discovered this batch now contains wheat and corn starch, which I am severely allergic to. There was no warning about this change, and I suffered gastrointestinal distress after consuming it. This kind of alteration is dangerous, especially for those with allergies like mine, and should have been clearly indicated to avoid harm.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.7
- All Researches
9
We explored the effects of vitamin D in combination with fluticasone propionate on allergy-related symptoms in children with bronchial asthma. In this study, we grouped participants into two treatment plans: one group received only fluticasone, while the other group received both fluticasone and vitamin D. By comparing their progress, we noted various health improvements related to asthma control.
The findings highlighted that the children who received the combination therapy experienced quicker relief from asthma symptoms, such as wheezing and shortness of breath. Their overall lung function also improved, as seen in measures like forced vital capacity and peak expiratory flow. Moreover, the kids taking vitamin D showed better immune responses, indicated by increased levels of specific immunoglobulins and lymphocytes important for fighting off infections.
We also observed significant improvements in well-being and quality of life for those in the combination group. However, it's essential to note that while vitamin D appears to offer additional benefits when taken alongside traditional asthma treatments, the study did not focus solely on vitamin D's effects. Overall, the data suggest that vitamin D could play a positive role in managing allergies associated with asthma, but further research is needed to isolate its effects conclusively.
The findings highlighted that the children who received the combination therapy experienced quicker relief from asthma symptoms, such as wheezing and shortness of breath. Their overall lung function also improved, as seen in measures like forced vital capacity and peak expiratory flow. Moreover, the kids taking vitamin D showed better immune responses, indicated by increased levels of specific immunoglobulins and lymphocytes important for fighting off infections.
We also observed significant improvements in well-being and quality of life for those in the combination group. However, it's essential to note that while vitamin D appears to offer additional benefits when taken alongside traditional asthma treatments, the study did not focus solely on vitamin D's effects. Overall, the data suggest that vitamin D could play a positive role in managing allergies associated with asthma, but further research is needed to isolate its effects conclusively.
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9
Vitamin D metabolites aid pulmonary health
We explored the impact of vitamin D metabolites on respiratory health, particularly in the context of hypersensitivity pneumonitis (HP). Our study focused on C57BL/6J mice that were placed on a diet severely lacking in vitamin D to induce deficiency. These mice were then exposed to an antigen linked to HP while inhaling either 25(OH)-vitamin D3 or 1,25(OH)2-vitamin D3.
Over the course of the experiment, we observed significant changes in the respiratory function of vitamin D-deficient mice. The metabolites of vitamin D we tested seemed to counteract many adverse effects associated with vitamin D deficiency. Inhalations of these compounds not only improved respiratory functions but also reduced inflammation and fibrosis that was exacerbated by the HP-causing antigen.
This research suggests that inhaling vitamin D metabolites may restore normal levels of active vitamin D in the lungs of deficient mice, providing a promising avenue for further exploration into how vitamin D may help manage respiratory conditions related to allergies and hypersensitivity.
Over the course of the experiment, we observed significant changes in the respiratory function of vitamin D-deficient mice. The metabolites of vitamin D we tested seemed to counteract many adverse effects associated with vitamin D deficiency. Inhalations of these compounds not only improved respiratory functions but also reduced inflammation and fibrosis that was exacerbated by the HP-causing antigen.
This research suggests that inhaling vitamin D metabolites may restore normal levels of active vitamin D in the lungs of deficient mice, providing a promising avenue for further exploration into how vitamin D may help manage respiratory conditions related to allergies and hypersensitivity.
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9
We explored the impact of ferric carboxymaltose (FCM) on individuals with hypersensitivity reactions to iron supplements. The study included patients identified through a retrospective analysis, focusing on those who displayed allergic reactions.
In our analysis, we administered different protocols to patients based on their risk profiles. For low-risk patients, a 4-step drug provocation test (DPT) was performed, while those at higher risk underwent an 11-step rapid drug desensitization (RDD) protocol.
The results were promising, showing that the majority of patients could successfully complete FCM treatments without severe allergic reactions. Out of 21 patients undergoing RDD, 95.2% completed the treatment successfully. While some experienced mild reactions, such as urticaria, serious complications were infrequent.
Additionally, 10 low-risk patients who underwent DPT also completed their iron therapy effectively, though a couple of them experienced mild symptoms afterward. Overall, we found that RDD is a reliable method for safely administering FCM and that DPT is beneficial for low-risk individuals.
In our analysis, we administered different protocols to patients based on their risk profiles. For low-risk patients, a 4-step drug provocation test (DPT) was performed, while those at higher risk underwent an 11-step rapid drug desensitization (RDD) protocol.
The results were promising, showing that the majority of patients could successfully complete FCM treatments without severe allergic reactions. Out of 21 patients undergoing RDD, 95.2% completed the treatment successfully. While some experienced mild reactions, such as urticaria, serious complications were infrequent.
Additionally, 10 low-risk patients who underwent DPT also completed their iron therapy effectively, though a couple of them experienced mild symptoms afterward. Overall, we found that RDD is a reliable method for safely administering FCM and that DPT is beneficial for low-risk individuals.
Read More
9
Iron reduces allergenicity in milk
We explored the effects of iron-complexed hydrolyzed whey protein on cow's milk allergies. In this study, we created various treatments with different hydrolysis degrees and tested their allergenicity using specific IgE antibodies.
Our findings showed a significant reduction in allergenicity—up to 60% when combining iron with ascorbic acid. Although there was a clear improvement, the results suggest that these treatments may not eliminate allergenic responses entirely.
In essence, iron fortification could be a promising strategy for creating hypoallergenic dairy products.
Our findings showed a significant reduction in allergenicity—up to 60% when combining iron with ascorbic acid. Although there was a clear improvement, the results suggest that these treatments may not eliminate allergenic responses entirely.
In essence, iron fortification could be a promising strategy for creating hypoallergenic dairy products.
Read More
9
We investigated how coke oven emissions (COEs) might worsen allergic asthma, especially when combined with house dust mites. In our mouse model, exposure to both COEs and allergens led to increased airway inflammation and worsening allergic reactions compared to individual exposures.
We found that higher levels of iron were present in the combined exposure group, and when we used an iron-binding agent, it effectively reduced ferroptosis—a process damaging cells—in this context.
Our results suggest a potential new treatment avenue for asthma related to occupational COE exposure.
We found that higher levels of iron were present in the combined exposure group, and when we used an iron-binding agent, it effectively reduced ferroptosis—a process damaging cells—in this context.
Our results suggest a potential new treatment avenue for asthma related to occupational COE exposure.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 1 Review
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
0
Dangerous ingredient changes
10 people found this helpful
I'm extremely upset after noticing significant changes in my vitamin's ingredients. After months of use, I discovered this batch now contains wheat and corn starch, which I am severely allergic to. There was no warning about this change, and I suffered gastrointestinal distress after consuming it. This kind of alteration is dangerous, especially for those with allergies like mine, and should have been clearly indicated to avoid harm.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Jesenak M, Hrubisko M, Chudek J, Bystron J, Rennerova Z, et al. Beneficial effects of pleuran on asthma control and respiratory tract-infection frequency in children with perennial asthma. Sci Rep. 2025;15:7146. 10.1038/s41598-025-91830-2
- Kawada K, Sato C, Ishida T, Nagao Y, Yamamoto T, et al. Vitamin D Supplementation and Allergic Rhinitis: A Systematic Review and Meta-Analysis. Medicina (Kaunas). 2025;61. 10.3390/medicina61020355
- Molatefi R, Fouladi N, Asghariazar V, Samemaleki S, Golizadeh M, et al. The evaluation of the serum levels of vitamin D and interleukin-33 in children with atopic dermatitis and its association with diseases severity. Arch Dermatol Res. 2025;317:182. 10.1007/s00403-024-03709-3
- Akbulut O, Köksal BT, Aydın B, Oznacar T, Haberal A, et al. Does vitamin D deficiency predispose to allergic proctocolitis?. Nutrition. 2025;131:112659. 10.1016/j.nut.2024.112659
- Nielsen AY, Høj S, Thomsen SF, Meteran H. Vitamin D Supplementation for Treating Atopic Dermatitis in Children and Adults: A Systematic Review and Meta-Analysis. Nutrients. 2024;16. 10.3390/nu16234128
- Wu D, Wang J, Wei Y, Zhang X, Hou Z. Correlation Analysis of Serum 25-Hydroxyvitamin D Levels With Immune Function and Calcium-Phosphate Metabolism in Patients With Bronchial Asthma Treated With Combination Therapy. Physiol Res. 2024;73:841.
- Lemieszek MK, Chojnacki M, Paśnik I, Gawryś W, Wilczyńska A, et al. Beneficial Impact of Inhaled 25(OH)-Vitamin D3 and 1,25(OH)2-Vitamin D3 on Pulmonary Response in the Murine Model of Hypersensitivity Pneumonitis. Int J Mol Sci. 2024;25. 10.3390/ijms251910289
- Stichova J, Slanina P, Chovancova Z, Baros J, Litzman M, et al. Low CD46 expression on activated CD4 T cells predict improved Th1 cell reactivity to calcitriol in majority of patients with allergic eosinophilic asthma and healthy donors. Front Allergy. 2024;5:1462579. 10.3389/falgy.2024.1462579
- Aslan AF, Demir S, Toprak ID, Korkmaz P, Karabacak DE, et al. From diagnosis to desensitization in immediate hypersensitivity reactions to both oral and parenteral iron salts. Allergy Asthma Proc. 2025;46:152. 10.2500/aap.2025.46.240114
- Dindar Çelik F, Aksu K, Akkale Ö, Çelik Tuğlu H, Yağdıran M, et al. The experiences of ferric carboxymaltose desensitization and provocation. World Allergy Organ J. 2025;18:101025. 10.1016/j.waojou.2024.101025
- Lukose SJ, Divya MP, Beena AK, Rajakumar SN, Babu PS. Reduced allergenicity of hydrolysed whey protein concentrate complexed with iron: the effect of different enzymes, degree of hydrolysis and ascorbic acid. J Food Sci Technol. 2025;62:940. 10.1007/s13197-024-06085-y
- Afolabi BB, Babah OA, Adeyemo TA, Balogun M, Banke-Thomas A, et al. Intravenous versus oral iron for anaemia among pregnant women in Nigeria (IVON): an open-label, randomised controlled trial. Lancet Glob Health. 2024;12:e1649. 10.1016/S2214-109X(24)00239-0
- Chen X, Chen H, Zhang P, Ju Q, Wu Z, et al. Coke oven emissions exacerbate allergic asthma by promoting ferroptosis in airway epithelial cells. J Hazard Mater. 2024;478:135542. 10.1016/j.jhazmat.2024.135542
- Watanabe H, Honda A, Ichinose T, Ishikawa R, Miyasaka N, et al. Ferruginous components of particulate matters in subway environments, α-FeO or FeO, exacerbates allergies. Environ Pollut. 2024;355:124195. 10.1016/j.envpol.2024.124195
