We delved into the relationship between magnesium levels and gouty arthritis, a condition known for causing painful flare-ups and damaging joint function. Our research focused on measuring serum ionized magnesium levels in a group of 769 patients and assessing how these levels relate to bone erosion, a serious complication of gout.
Our findings revealed that patients experiencing bone erosion had significantly lower magnesium levels compared to those without erosion. When we categorized magnesium levels into quartiles, the data showed that those in the lowest quartile (Q1) were more likely to have bone erosion compared to patients in higher quartiles. In fact, the prevalence of erosion in the lowest magnesium group was much higher, illustrating a clear connection.
Through detailed analysis, we concluded that higher levels of serum ionized magnesium may serve as a protective factor against bone erosion in gouty arthritis. This suggests that magnesium supplementation could be a promising strategy for individuals suffering from this debilitating condition, potentially helping to slow down or prevent further joint damage.
We explored how magnesium (Mg) supplementation impacts rheumatoid arthritis (RA) by analyzing the effects on specific tissues in mice. In our study, we observed that mice with KRN serum-induced arthritis were given either a high magnesium diet or a regular diet for 15 days. After this period, we analyzed the gene activity in their spleens and joint tissues.
Our findings revealed significant changes in the expression of genes associated with RA and biological processes like oxidative stress and senescence—key factors involved in the disease's progression. Specifically, we noted that high magnesium intake led to higher expression levels of certain genes, while others were suppressed.
This supports the idea that increased magnesium can modify the way our body responds to the stresses associated with arthritis. Overall, our research adds to the evidence that suggests that magnesium supplementation might be a promising approach to managing RA and helps pave the way for new treatment options for autoimmune and inflammatory diseases.
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9
Magnesium chloride alleviates arthritis
Systemic and local antiinflammatory effect of magnesium chloride in experimental arthritis.
We delved into the potential of magnesium chloride (MgCl) as a treatment for arthritis, particularly looking at its anti-inflammatory effects. In our study, we used a model of acute arthritis where mice were injected with zymosan to induce inflammation in their knees. To evaluate the impact of magnesium, we administered it both orally and directly into the joint, comparing its effects to a control group that received a saline solution.
The results were promising! We observed that magnesium chloride treatment lowered inflammation, reduced pain levels, and decreased the presence of certain inflammatory cells and cytokines, specifically interleukin-1. Both systemic and local administrations of MgCl significantly improved the conditions in the mice compared to the saline group.
Importantly, one of the mechanisms behind these benefits seems to involve the suppression of a key inflammatory pathway known as NFκB. This study marks a significant step forward, as it is the first to show how magnesium chloride can effectively reduce signs of arthritis in a live model, leading to decreased inflammation and relief from pain.
Read More
Most Useful Reviews
9
Reduced arthritis pain
5 people found this helpful
I stopped using calcium and now use Magnesium Citrate instead, which was recommended by a friend. My arthritis feels significantly better since I made the switch.
Read More
10
Salvation for arthritis
This is my cure for rheumatoid arthritis! It has made a significant difference in my daily life.
Read More
9
Helpful for arthritis
This Magnesium is effective and easy to swallow, and it has been very beneficial for my arthritis. The price is good too.
We explored how magnesium (Mg) supplementation impacts rheumatoid arthritis (RA) by analyzing the effects on specific tissues in mice. In our study, we observed that mice with KRN serum-induced arthritis were given either a high magnesium diet or a regular diet for 15 days. After this period, we analyzed the gene activity in their spleens and joint tissues.
Our findings revealed significant changes in the expression of genes associated with RA and biological processes like oxidative stress and senescence—key factors involved in the disease's progression. Specifically, we noted that high magnesium intake led to higher expression levels of certain genes, while others were suppressed.
This supports the idea that increased magnesium can modify the way our body responds to the stresses associated with arthritis. Overall, our research adds to the evidence that suggests that magnesium supplementation might be a promising approach to managing RA and helps pave the way for new treatment options for autoimmune and inflammatory diseases.
Read More
9
Magnesium potentially alleviates OA
Engineered MgO nanoparticles for cartilage-bone synergistic therapy.
We explored how magnesium affects arthritis, particularly osteoarthritis (OA), focusing on its role in both cartilage and bone health. By studying the protective effects of magnesium at the cellular and animal levels, we sought to understand how it interacts with joint tissues to potentially alleviate symptoms of OA.
Our investigation indicated that magnesium has significant benefits, especially when it comes to the interaction between cartilage and bone. We found that these positive effects are primarily influenced by the PI3K/AKT signaling pathway, a crucial mechanism in cell communication and response.
To make this treatment practical, we developed tiny microspheres made from poly(lactic-co-glycolic acid) (PLGA) that are loaded with nano-magnesium oxide, modified to enhance their effectiveness. These innovative microspheres, which can be injected directly into the joints, showed encouraging results in reducing OA symptoms in rat models.
Our findings highlight the potential of magnesium-based therapies, especially with this new delivery system, paving the way for exciting clinical applications in the future.
Read More
9
Magnesium chloride alleviates arthritis
Systemic and local antiinflammatory effect of magnesium chloride in experimental arthritis.
We delved into the potential of magnesium chloride (MgCl) as a treatment for arthritis, particularly looking at its anti-inflammatory effects. In our study, we used a model of acute arthritis where mice were injected with zymosan to induce inflammation in their knees. To evaluate the impact of magnesium, we administered it both orally and directly into the joint, comparing its effects to a control group that received a saline solution.
The results were promising! We observed that magnesium chloride treatment lowered inflammation, reduced pain levels, and decreased the presence of certain inflammatory cells and cytokines, specifically interleukin-1. Both systemic and local administrations of MgCl significantly improved the conditions in the mice compared to the saline group.
Importantly, one of the mechanisms behind these benefits seems to involve the suppression of a key inflammatory pathway known as NFκB. This study marks a significant step forward, as it is the first to show how magnesium chloride can effectively reduce signs of arthritis in a live model, leading to decreased inflammation and relief from pain.
Read More
9
Magnesium reduces arthritis severity
Magnesium increases numbers of Foxp3+ Treg cells and reduces arthritis severity and joint damage in an IL-10-dependent manner mediated by the intestinal microbiome.
We investigated how a high magnesium diet affects arthritis, focusing on its impact on inflammation and T cell development in two mouse models of rheumatoid arthritis. Our findings revealed that the mice receiving a diet rich in magnesium experienced less severe arthritis and reduced joint damage.
In this study, the magnesium-rich diet not only lowered the levels of inflammatory markers but also increased the numbers of beneficial immune cells known as Foxp3+ regulatory T cells. Moreover, we noticed that these immune cells produced more interleukin-10, a cytokine that plays a crucial role in controlling inflammation.
Interestingly, when we tested this in mice lacking interleukin-10, the protective effects of magnesium disappeared. This led us to further explore the role of the intestinal microbiome. By performing fecal material transplantation from mice on a high magnesium diet, we could replicate the beneficial immune responses observed in the original magnesium diet group.
The microbiome analyses revealed significant changes, including a decrease in specific bacteria linked to rheumatoid arthritis and an increase in those that promote health. These results suggest that magnesium might provide a novel approach to modifying the gut microbiome to help treat arthritis and potentially other autoimmune diseases.
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9
Magnesium's role in cartilage restoration
Hybrid composites with magnesium-containing glycosaminoglycans as a chondroconducive matrix for osteoarthritic cartilage repair.
We investigated how magnesium-containing glycosaminoglycans, or Mg-GAGs, might improve cartilage health and combat osteoarthritis (OA). The study highlighted that OA is largely characterized by the breakdown of key components in the extracellular matrix (ECM), including collagen and aggrecan. The objective was to find out if introducing Mg-GAGs could help restore this matrix and mitigate inflammation linked to OA.
Our findings were promising. We observed that Mg-GAGs not only encouraged chondrocyte (cartilage cell) growth but also helped activate genes important for cartilage formation while reducing inflammatory responses. In laboratory experiments, these glycosaminoglycans showed significant positive effects.
Furthermore, in an animal model of OA, Mg-GAGs eased synovial inflammation, lessened chondrocyte death, and helped protect the bone beneath cartilage. These outcomes suggest that Mg-GAGs might represent a new way to treat OA, focusing on ECM repair and addressing inflammation to improve joint health.
I stopped using calcium and now use Magnesium Citrate instead, which was recommended by a friend. My arthritis feels significantly better since I made the switch.
Read More
10
Salvation for arthritis
This is my cure for rheumatoid arthritis! It has made a significant difference in my daily life.
Read More
9
Helpful for arthritis
This Magnesium is effective and easy to swallow, and it has been very beneficial for my arthritis. The price is good too.
Read More
9
Highly recommended product
This product is excellent! The quality, ingredients, size, and packaging are all top notch. It provides numerous benefits and notably helps with my arthritis. Everything about it is truly exceptional.
Read More
7.5
Excellent for arthritis
This product is of great quality, offers excellent value, and effectively helps with arthritis. I have noticed a significant improvement.
Arthritis is a general term that refers to inflammation of the joints, which can lead to pain, stiffness, and swelling. It encompasses over 100 different types, with osteoarthritis and rheumatoid arthritis being the most common. Osteoarthritis, often associated with aging, occurs when the cartilage that cushions the joints wears down over time. In contrast, rheumatoid arthritis is an autoimmune disorder where the body's immune system mistakenly attacks the joints, leading to chronic inflammation and potential disability if left untreated.
Symptoms of arthritis can vary widely depending on the type but typically include joint pain, swelling, reduced range of motion, and sometimes fatigue. Diagnosis usually involves a combination of physical exams, imaging tests, and blood tests. While there is currently no cure for arthritis, various treatments ranging from lifestyle modifications, physical therapy, and medications can help manage symptoms and improve quality of life. For those affected, seeking early diagnosis and intervention is crucial for slowing disease progression and preserving joint function.
Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a lightweight, silvery-white metal that is a member of the alkaline earth metals group. Often classified as one of the most abundant elements in the Earth's crust, magnesium plays a crucial role in various biological functions and is essential for living organisms. In nature, magnesium can be found in large quantities, primarily in minerals such as dolomite and magnesite, and it is also present in seawater.
In terms of health benefits, magnesium is vital for numerous metabolic processes, including energy production, DNA synthesis, and muscle function. It contributes to bone health, helps regulate blood pressure, and supports bone formation by promoting the effects of vitamin D. The recommended dietary allowance (RDA) for magnesium varies by age and gender, but it is generally important to include magnesium-rich foods like leafy greens, nuts, seeds, and whole grains in your diet to ensure adequate intake. For those who may not receive enough magnesium through their diet alone, supplements are also available; however, it is advisable to consult a healthcare professional before starting any supplementation.
Magnesium is an essential mineral that plays a role in various biological functions, including muscle and nerve function, blood pressure regulation, and immune system health. Some studies suggest that magnesium may have anti-inflammatory properties, which could potentially benefit individuals with arthritis. Chronic inflammation is a hallmark of arthritis, and increasing magnesium intake through diet or supplementation might help mitigate some of the inflammatory processes associated with the condition. Foods rich in magnesium, such as leafy greens, nuts, seeds, and whole grains, can be simple additions to an arthritis-friendly diet.
However, while there is some evidence pointing to the benefits of magnesium in reducing inflammation, more robust research specifically linking magnesium supplementation to significant improvements in arthritis symptoms is needed. It's essential for individuals with arthritis to consult with their healthcare provider before starting any new supplements, as they can provide personalized advice and ensure that magnesium supplementation won't interfere with existing treatments or medications. Ultimately, while magnesium may support joint health as part of a balanced diet, it shouldn't be viewed as a standalone solution for arthritis management.
Based on user reviews, it appears that results from taking Magnesium Citrate for arthritis can vary. Many users report significant improvements shortly after starting the supplement. For instance, one user mentioned feeling "significantly better" after switching to Magnesium Citrate from calcium Read Review. Another user emphasized that their rheumatoid arthritis has improved considerably, describing it as their "cure" Read Review.
However, the timeline for seeing noticeable changes can depend on individual circumstances and the dosage taken, with some users finding it beneficial after a consistent regimen. For example, one reviewer noted that taking the supplement three times a day has shown clear benefits Read Review. Overall, while some users may observe improvements within days, others may require a longer period of consistent use before experiencing significant relief.
Scientific research supports the potential role of magnesium supplementation in managing arthritis, particularly osteoarthritis (OA) and rheumatoid arthritis (RA). Studies indicate that magnesium can help reduce inflammation, support cartilage repair, and positively influence joint health. For instance, magnesium-infused microspheres have shown promise in alleviating inflammation and cartilage degeneration associated with OA, leading to significant improvements in joint conditions (see [1]). Other research highlights the anti-inflammatory effects of magnesium chloride, which has been found to lower pain levels and reduce inflammatory markers in animal models of arthritis ([8]).
Additionally, dietary magnesium intake has been linked to lower risk factors in RA and OA. Higher magnesium consumption is associated with fewer symptoms and improved overall wellness in people with knee OA, potentially enhancing their quality of life ([14]). Moreover, the connection between magnesium levels and adverse conditions like bone erosion in gouty arthritis suggests that magnesium supplementation could serve as a protective factor against joint damage ([4]). Overall, these findings advocate for further exploration of magnesium as a supplementary treatment for various types of arthritis.
Based on user reviews, many individuals have reported a variety of improvements in their arthritis symptoms after using Magnesium Citrate. A notable testimony comes from a user who switched from calcium to Magnesium Citrate, stating that their arthritis felt "significantly better" following the change Read Review. Another reviewer even referred to it as their "cure" for rheumatoid arthritis, emphasizing the substantial difference it has made in their daily life Read Review.
Additionally, users expressed satisfaction with both the effectiveness and the easy consumption of the capsules, noting that they have felt "very beneficial" effects on their arthritis Read Review. A reviewer remarked on the overall exceptional quality of the product, while confirming its significant benefits for arthritis Read Review. Overall, while results can vary from person to person, many users have observed substantial improvements in their arthritis symptoms, particularly with consistent use of the supplement.
Based on user reviews, many individuals have found that combining Magnesium Citrate with other supplements can enhance its effectiveness in managing arthritis symptoms. One user mentioned taking Magnesium as an adjunct to their arthritis treatment regimen, noting that it "clearly helps" when taken thrice a day and even suggested that increasing the dosage at nighttime might yield further benefits Read Review. Additionally, another user reported taking magnesium alongside vitamins as part of their strategy to improve rheumatoid arthritis without the need for medication, indicating that pairing supplements may indeed provide complementary effects Read Review.
Overall, users seem to endorse the idea of combining Magnesium Citrate with other supplements or treatments for better arthritis management. They appreciate the supplement not only for its quality and value but also for its significant positive impact on their condition, suggesting that a multi-supplement approach could potentially lead to enhanced relief from arthritis symptoms Read Review. As always, it's advisable for individuals to consult with a healthcare provider before making any changes to their supplement routine.
Based on user reviews, many individuals report positive experiences with magnesium supplementation for arthritis management, indicating that it can significantly alleviate symptoms. For example, one user noted that switching from calcium to magnesium citrate resulted in a notable improvement in their arthritis discomfort Read Review. Others have found that taking magnesium regularly has enhanced their daily functionality, leading them to regard it as a "cure" for rheumatoid arthritis Read Review.
The dosage frequency varies among users, with one mentioning they take it thrice a day but are considering adjusting their regimen to include more at night Read Review. This suggests a level of experimentation among users to determine the right dose that maximizes benefits for arthritis relief. Overall, while the user reviews don't specify an exact dosage, they emphasize the effectiveness and ease of incorporating magnesium, contributing to a better quality of life for those managing arthritis.
9
Reduced arthritis pain
5 people found this helpful
I stopped using calcium and now use Magnesium Citrate instead, which was recommended by a friend. My arthritis feels significantly better since I made the switch.
10
Salvation for arthritis
This is my cure for rheumatoid arthritis! It has made a significant difference in my daily life.
7.5
Supports arthritis treatment
Recently, I started taking Magnesium as an adjunct to my arthritis treatment. It clearly helps, and while I take it thrice a day as directed, I wonder if taking two capsules at night could be beneficial.
9
Helpful for arthritis
This Magnesium is effective and easy to swallow, and it has been very beneficial for my arthritis. The price is good too.
9
Highly recommended product
This product is excellent! The quality, ingredients, size, and packaging are all top notch. It provides numerous benefits and notably helps with my arthritis. Everything about it is truly exceptional.
7.5
Hopes for improvement
After reading Dr. Fujikawa's book, I'm taking magnesium with vitamins to enhance my rheumatoid arthritis condition without medication. While some say the American supplements are large, you can get used to them with time.
8
Magnesium benefits for osteoarthritis
Injectable Chondroitin Sulfate Microspheres with Gallic Acid-Magnesium MOF for Anti-Inflammatory and Cartilage Degeneration Alleviation in Osteoarthritis Treatment.
Our exploration focused on how magnesium can aid in treating the challenges associated with osteoarthritis, such as inflammation and cartilage degeneration. We synthesized a special carrier made from a combination of gallic acid and magnesium, designed to deliver a drug called puerarin effectively. This innovative approach involved forming hybrid microspheres that can be injected into the joint space.
During our tests, we noted that these magnesium-infused microspheres not only helped to release the drug over a longer period— extending beyond two weeks but they also positively affected the joint environment by reducing inflammation and oxidative stress. This means that magnesium, when combined with other components, can support overall joint health and promote cartilage repair.
In our in vivo experiments, we saw significant reductions in osteophyte formation and noticeable improvements in cartilage conditions, leading to a delay in the progression of osteoarthritis. Overall, these findings suggest that this magnesium-based delivery system could be an exciting avenue for enhancing treatment options for those suffering from osteoarthritis.
9
Magnesium chloride alleviates arthritis
Systemic and local antiinflammatory effect of magnesium chloride in experimental arthritis.
We delved into the potential of magnesium chloride (MgCl) as a treatment for arthritis, particularly looking at its anti-inflammatory effects. In our study, we used a model of acute arthritis where mice were injected with zymosan to induce inflammation in their knees. To evaluate the impact of magnesium, we administered it both orally and directly into the joint, comparing its effects to a control group that received a saline solution.
The results were promising! We observed that magnesium chloride treatment lowered inflammation, reduced pain levels, and decreased the presence of certain inflammatory cells and cytokines, specifically interleukin-1. Both systemic and local administrations of MgCl significantly improved the conditions in the mice compared to the saline group.
Importantly, one of the mechanisms behind these benefits seems to involve the suppression of a key inflammatory pathway known as NFκB. This study marks a significant step forward, as it is the first to show how magnesium chloride can effectively reduce signs of arthritis in a live model, leading to decreased inflammation and relief from pain.
8
Magnesium intake improves knee OA
Associations of Dietary Macroelements with Knee Joint Structures, Symptoms, Quality of Life, and Comorbid Conditions in People with Symptomatic Knee Osteoarthritis.
We conducted a detailed examination of how dietary magnesium affects people suffering from knee osteoarthritis (OA). In this study, we analyzed data from a two-year trial that involved 392 participants dealing with this common joint issue. Our focus was on dietary macroelements, particularly magnesium, and their relationships with various aspects of OA, including symptoms, quality of life, and related health conditions.
The results were compelling. Higher magnesium intake was associated with fewer OA symptoms, improved quality of life, and less severe comorbid conditions, such as depressive symptoms and lower limb muscle weakness. We observed that people who consumed more magnesium reported feeling better overall, suggesting that this dietary change could support knee OA management.
This connection is crucial as osteoarthritis currently has no cure, making effective management strategies like dietary adjustments especially valuable. By emphasizing magnesium's potential benefits, we hope to pave the way for new avenues in managing knee OA that can enhance comfort and quality of life for those affected.
8
Magnesium protects against bone erosion
Serum ionized magnesium acts as an independent protective factor against bone erosion in patients with gouty arthritis: a cross-sectional study.
We delved into the relationship between magnesium levels and gouty arthritis, a condition known for causing painful flare-ups and damaging joint function. Our research focused on measuring serum ionized magnesium levels in a group of 769 patients and assessing how these levels relate to bone erosion, a serious complication of gout.
Our findings revealed that patients experiencing bone erosion had significantly lower magnesium levels compared to those without erosion. When we categorized magnesium levels into quartiles, the data showed that those in the lowest quartile (Q1) were more likely to have bone erosion compared to patients in higher quartiles. In fact, the prevalence of erosion in the lowest magnesium group was much higher, illustrating a clear connection.
Through detailed analysis, we concluded that higher levels of serum ionized magnesium may serve as a protective factor against bone erosion in gouty arthritis. This suggests that magnesium supplementation could be a promising strategy for individuals suffering from this debilitating condition, potentially helping to slow down or prevent further joint damage.
References
He J, Wu J, Zheng J, Xu Y, Li K, et al. Injectable Chondroitin Sulfate Microspheres with Gallic Acid-Magnesium MOF for Anti-Inflammatory and Cartilage Degeneration Alleviation in Osteoarthritis Treatment. ACS Appl Mater Interfaces. 2025;17:11898. doi:10.1021/acsami.4c22415
Chathoth BM, Helmholz H, Angrisani N, Wiese B, Reifenrath J, et al. Investigating the Potential of Magnesium Microparticles on Cartilage and Bone Regeneration Utilizing an In Vitro Osteoarthritis Model. J Biomed Mater Res A. 2025;113:e37862. doi:10.1002/jbm.a.37862
Laragione T, Harris C, Gulko PS. Magnesium Supplementation Modifies Arthritis Synovial and Splenic Transcriptomic Signatures Including Ferroptosis and Cell Senescence Biological Pathways. Nutrients. 2024;16. doi:10.3390/nu16234247
Li Y, Wang Y, Xu L, Liu C, Cui J, et al. Serum ionized magnesium acts as an independent protective factor against bone erosion in patients with gouty arthritis: a cross-sectional study. Front Endocrinol (Lausanne). 2024;15:1375871. doi:10.3389/fendo.2024.1375871
Mei S, Jiang F, Liu N, Feng Z, Zheng Y, et al. Sol-gel synthesis of magnesium oxide nanoparticles and their evaluation as a therapeutic agent for the treatment of osteoarthritis. Nanomedicine (Lond). 2024;19:1867. doi:10.1080/17435889.2024.2382421
Liu H, Zhang K, Xiong L. Dietary magnesium intake and rheumatoid arthritis patients' all-cause mortality: evidence from the NHANES database. J Health Popul Nutr. 2024;43:112. doi:10.1186/s41043-024-00597-1
Zheng L, Zhao S, Li Y, Xu J, Yan W, et al. Engineered MgO nanoparticles for cartilage-bone synergistic therapy. Sci Adv. 2024;10:eadk6084. doi:10.1126/sciadv.adk6084
Pinto ACMD, de Melo Nunes R, de Freitas Carvalho WV, Girão VCC, Rocha FAC. Systemic and local antiinflammatory effect of magnesium chloride in experimental arthritis. Adv Rheumatol. 2024;64:6. doi:10.1186/s42358-023-00346-8
Fu H, Guo Y, Fang W, Wang J, Hu P, et al. Anti-Acidification and Immune Regulation by Nano-Ceria-Loaded Mg-Al Layered Double Hydroxide for Rheumatoid Arthritis Therapy. Adv Sci (Weinh). 2024;11:e2307094. doi:10.1002/advs.202307094
Yilmaz E, Ünver S. Investigation of the relationship between magnesium level and vitamin D, bone mineral density, and chronic diseases in patients with knee osteoarthritis. Magnes Res. 2023;36:40. doi:10.1684/mrh.2023.0515
Fang J, Cao T, Liu C, Wang D, Zhang H, et al. Association between magnesium, copper, and potassium intakes with risk of rheumatoid arthritis: a cross-sectional study from National Health and Nutrition Examination Survey (NHANES). BMC Public Health. 2023;23:2085. doi:10.1186/s12889-023-16906-y
Zheng Z, Luo H, Xu W, Shi L, Wang F, et al. Association between Elevated Magnesium Intake and Reduced Risk of Recurrent Falls and Frailty in Osteoarthritis: Data from the Osteoarthritis Initiative. J Nutr Health Aging. 2023;27:775. doi:10.1007/s12603-023-1979-9
Laragione T, Harris C, Azizgolshani N, Beeton C, Bongers G, et al. Magnesium increases numbers of Foxp3+ Treg cells and reduces arthritis severity and joint damage in an IL-10-dependent manner mediated by the intestinal microbiome. EBioMedicine. 2023;92:104603. doi:10.1016/j.ebiom.2023.104603
Zhang Y, Chen T, Luo P, Li S, Zhu J, et al. Associations of Dietary Macroelements with Knee Joint Structures, Symptoms, Quality of Life, and Comorbid Conditions in People with Symptomatic Knee Osteoarthritis. Nutrients. 2022;14. doi:10.3390/nu14173576
Chen R, Li X, Sun Z, Yin J, Hu X, et al. Intra-bone marrow injection of magnesium isoglyrrhizinate inhibits inflammation and delays osteoarthritis progression through the NF-κB pathway. J Orthop Surg Res. 2022;17:400. doi:10.1186/s13018-022-03294-z
Wu G, Ma F, Liu Z, Liu J, Xue Y, et al. Hybrid composites with magnesium-containing glycosaminoglycans as a chondroconducive matrix for osteoarthritic cartilage repair. Int J Biol Macromol. 2022;220:1104. doi:10.1016/j.ijbiomac.2022.08.071
Ma R, Zhang C, Liu J, Ren J, Huang H, et al. Associations of magnesium depletion score with the incidence and mortality of osteoarthritis: a nationwide study. Front Immunol. 2025;16:1512293. doi:10.3389/fimmu.2025.1512293