We aimed to understand the role of vitamin C in heart disease and its potential cardioprotective effects. Vitamin C is renowned for its antioxidant properties, which means it fights off harmful substances in our body, potentially reducing the risk of heart issues.
Our analysis revealed that vitamin C could play a meaningful role in supporting cardiovascular health. While the evidence is promising, it is important to be cautious, as clinical studies have shown mixed results regarding its effectiveness.
So, while vitamin C might contribute positively to heart health, more solid evidence is required to fully confirm these effects. Overall, we learned that while there are positive indicators, we should be careful about over-relying on vitamin C as a sole preventive measure for heart disease.
Read More
8
Nutrition's role in heart health
Maternal high-fat diet alters Tet-mediated epigenetic regulation during heart development.
We observed how a mother’s diet during pregnancy, particularly a high-fat diet (HFD), can significantly impact the heart development of her offspring. In our exploration, we found that pregnant mice exposed to HFD suffered metabolic changes, leading to issues like non-compaction cardiomyopathy (NCC) in their embryos. This was marked by low levels of a molecule called 5-hydroxymethylcytosine (5hmC) and changes in chromatin accessibility in the heart tissues of the embryos.
Interestingly, we discovered that when we supplemented these mice with vitamin C, it helped to reduce the harmful effects linked to HFD. This seems to work by restoring iron levels in a form that helps certain enzymes, known as Tet enzymes, function better. Through our genetic investigations, we confirmed that vitamin C boosts Tet activity, a crucial factor for heart health, particularly under stress from a poor diet.
Our findings emphasize the critical importance of balanced maternal nutrition. They show how choices like including vitamin C can play a protective role in heart development, especially when faced with the challenges of a high-fat diet.
Read More
8
Vitamin C's role in heart health
Role of ascorbic acid in cardiac allograft vasculopathy.
We explored how ascorbic acid, commonly known as vitamin C, plays a role in cardiac allograft vasculopathy (CAV), a condition that can develop after heart transplants. CAV is characterized by progressive damage to the heart's blood vessels, leading to serious complications.
Recent studies, particularly on rodent models, have shown exciting findings. Ascorbic acid appears to boost the activity of an enzyme called TET2, which helps reduce the death of vascular smooth muscle cells and the thickening of blood vessel walls. This is important because when TET2 is suppressed, as can occur with interferon γ during CAV, it can contribute to the disease's progression.
Ascorbic acid doesn't just stop there; it also helps improve the overall health of the endothelium— the thin layer of cells lining the blood vessels. By decreasing harmful reactive oxygen species and preventing excessive growth of smooth muscle cells, vitamin C shows promise in tackling the adverse effects of CAV.
However, while initial findings, including a small clinical trial, suggest potential benefits, much more research is needed. We must see larger, controlled studies to truly understand how effective ascorbic acid can be in managing heart transplant recipients' long-term health.
Read More
Most Useful Reviews
6
Gums stopped bleeding
5 people found this helpful
It's unfortunate that dentists often overlook the role of Vitamin C in treating heart disease and periodontal issues. After increasing my intake, my gums have ceased bleeding, which is a significant improvement. Reducing the dosage leads to bleeding again, so I notice a direct correlation to the Vitamin C. I appreciate Linus Pauling's advice, even if it causes some digestive discomfort.
Read More
9
Normal heart results
3 people found this helpful
Linus Pauling's theory may be valid; after consuming three 3-pound packages, my health hasn't suffered. It may even be aiding in clearing my arteries. After three years, my nuclear stress test results indicate normal heart function.
Read More
7.5
Eased Covid symptoms
I ordered this Vitamin C alongside collagen, believing it would enhance absorption. Unfortunately, my family contracted Covid-19, but I believe the Vitamin C aided our recovery. It tastes pleasant, dissolves well in water, and we managed to cope with the illness quite easily.
We investigated the effects of Vitamin C on heart disease, particularly in the context of sepsis-induced cardiac injury. In a carefully designed study, we utilized a rat model, dividing thirty female Sprague-Dawley rats into several groups to evaluate the individual and combined impacts of Vitamin C and Coenzyme Q10. Each group received oral treatments for ten days before we induced polymicrobial sepsis through cecal ligation and puncture.
After we euthanized the animals and analyzed the specimens, we found that the combination of Vitamin C and Coenzyme Q10 significantly reduced oxidative stress markers and improved antioxidative parameters. Notably, the treatments also led to a decrease in pro-inflammatory cytokines and improved cardiac indicators, suggesting that Vitamin C has a beneficial role when paired with Coenzyme Q10 in mitigating cardiac injury during sepsis.
While we observed improved outcomes with the combined treatment, the study design means we couldn’t definitively attribute these positive effects solely to Vitamin C. In fact, Coenzyme Q10 sometimes showcased even greater advantages. Overall, our findings hint at the potential of Vitamin C, especially when combined with Coenzyme Q10, to serve as an effective approach against cardiac injuries in sepsis.
Read More
8
Nutrition's role in heart health
Maternal high-fat diet alters Tet-mediated epigenetic regulation during heart development.
We observed how a mother’s diet during pregnancy, particularly a high-fat diet (HFD), can significantly impact the heart development of her offspring. In our exploration, we found that pregnant mice exposed to HFD suffered metabolic changes, leading to issues like non-compaction cardiomyopathy (NCC) in their embryos. This was marked by low levels of a molecule called 5-hydroxymethylcytosine (5hmC) and changes in chromatin accessibility in the heart tissues of the embryos.
Interestingly, we discovered that when we supplemented these mice with vitamin C, it helped to reduce the harmful effects linked to HFD. This seems to work by restoring iron levels in a form that helps certain enzymes, known as Tet enzymes, function better. Through our genetic investigations, we confirmed that vitamin C boosts Tet activity, a crucial factor for heart health, particularly under stress from a poor diet.
Our findings emphasize the critical importance of balanced maternal nutrition. They show how choices like including vitamin C can play a protective role in heart development, especially when faced with the challenges of a high-fat diet.
Read More
8
Combined antioxidants may benefit heart
Safety and Pharmacokinetics of a Combined Antioxidant Therapy against Myocardial Reperfusion Injury: A Phase 1 Randomized Clinical Trial in Healthy Humans.
We explored the potential of a combined antioxidant therapy that includes vitamin C to address myocardial reperfusion injury—a condition that can worsen heart damage after blood flow is restored following ischemia. In a Phase 1 clinical trial involving healthy participants, we tested whether this therapy could be safely administered while also examining the effects on oxidative stress, a key factor in heart injury.
Participants were randomly assigned to receive either the combined antioxidant therapy or a placebo. We provided two different doses of the therapy through an intravenous infusion lasting 90 minutes. Monitoring included collecting blood samples to measure levels of the antioxidants, including vitamin C, and assessing any adverse effects.
We observed that both doses of the antioxidant therapy significantly increased the concentration of the drugs in the bloodstream compared to placebo. Interestingly, while a few mild adverse events were reported, they were not serious, suggesting that the therapy is safe for human use. The therapy did show promise in boosting antioxidant levels in the blood.
However, it's essential to note that while vitamin C is part of this combined treatment, the study did not isolate its effects specifically. Thus, we can't draw definitive conclusions about vitamin C alone in treating heart disease. The findings suggest that this combined approach might hold potential for future therapies in managing acute myocardial infarction.
Read More
8
BM-164 shows heart-protective effects
Effects of HS-donor ascorbic acid derivative and ischemia/reperfusion-induced injury in isolated rat hearts.
We explored the effects of a novel water-soluble derivative of ascorbic acid, known as BM-164, on heart health under conditions of ischemia and reperfusion in rat hearts. This study aimed to combine the cardiovascular benefits of hydrogen sulfide (HS) with the antioxidant properties of ascorbic acid.
Through a series of tests, we found that BM-164 significantly reduced the incidence of harmful heart rhythms known as ventricular fibrillation from 79% to 31%. Moreover, the size of heart tissue damage, often referred to as infarct size, was decreased from 28% to 14% in the group treated with BM-164.
However, we also noted that while heart function improvements, such as coronary flow and heart rate, didn't show significant differences compared to a drug-free control group. Further analysis of cellular processes revealed increased levels of autophagy-related proteins, which could explain the heart-protective effects of BM-164, while markers of apoptosis didn’t show notable changes.
In conclusion, BM-164 showcases considerable potential in providing cardiac protection during injury caused by ischemia and reperfusion, showing advantages over untreated and simply ascorbic acid-treated hearts.
Read More
8
Vitamin C's role in heart health
Role of ascorbic acid in cardiac allograft vasculopathy.
We explored how ascorbic acid, commonly known as vitamin C, plays a role in cardiac allograft vasculopathy (CAV), a condition that can develop after heart transplants. CAV is characterized by progressive damage to the heart's blood vessels, leading to serious complications.
Recent studies, particularly on rodent models, have shown exciting findings. Ascorbic acid appears to boost the activity of an enzyme called TET2, which helps reduce the death of vascular smooth muscle cells and the thickening of blood vessel walls. This is important because when TET2 is suppressed, as can occur with interferon γ during CAV, it can contribute to the disease's progression.
Ascorbic acid doesn't just stop there; it also helps improve the overall health of the endothelium— the thin layer of cells lining the blood vessels. By decreasing harmful reactive oxygen species and preventing excessive growth of smooth muscle cells, vitamin C shows promise in tackling the adverse effects of CAV.
However, while initial findings, including a small clinical trial, suggest potential benefits, much more research is needed. We must see larger, controlled studies to truly understand how effective ascorbic acid can be in managing heart transplant recipients' long-term health.
It's unfortunate that dentists often overlook the role of Vitamin C in treating heart disease and periodontal issues. After increasing my intake, my gums have ceased bleeding, which is a significant improvement. Reducing the dosage leads to bleeding again, so I notice a direct correlation to the Vitamin C. I appreciate Linus Pauling's advice, even if it causes some digestive discomfort.
Read More
9
Normal heart results
3 people found this helpful
Linus Pauling's theory may be valid; after consuming three 3-pound packages, my health hasn't suffered. It may even be aiding in clearing my arteries. After three years, my nuclear stress test results indicate normal heart function.
Read More
7.5
Eased Covid symptoms
I ordered this Vitamin C alongside collagen, believing it would enhance absorption. Unfortunately, my family contracted Covid-19, but I believe the Vitamin C aided our recovery. It tastes pleasant, dissolves well in water, and we managed to cope with the illness quite easily.
Read More
7.5
Healthy drink option
10 people found this helpful
Vitamin C powder has been beneficial in my efforts to treat heart disease. I use 1/4 teaspoon of this powder with a few drops of stevia in water, which makes for a healthy beverage. Adding herbal tea enhances the flavour as well!
Read More
6
Benefits heart and vessels
I started using this Vitamin C powder to incorporate more into my diet for heart disease and vascular health. It's straightforward to mix with water, making it easier to maintain my intake.
Read More
Frequently Asked Questions
Heart disease refers to a range of conditions that affect the heart's function and overall health. This umbrella term includes various cardiovascular issues such as coronary artery disease, which is caused by the buildup of plaque in the arteries; heart rhythm problems (arrhythmias); and heart defects present at birth (congenital heart defects). Additionally, heart disease encompasses conditions related to the heart muscle, such as cardiomyopathy, and the heart's valves, which might not open or close properly. The effects of heart disease can be significant, impacting not only physical health but also quality of life, making prevention and timely medical intervention crucial.
Several risk factors contribute to the development of heart disease, including high blood pressure, high cholesterol levels, diabetes, obesity, poor diet, physical inactivity, and smoking. Genetics also play a role, as heart disease can run in families. To mitigate the risks, healthcare professionals typically recommend lifestyle changes such as adopting a heart-healthy diet, engaging in regular physical activity, and avoiding tobacco use. For those already diagnosed with heart disease, treatment options can vary widely, ranging from lifestyle modifications to medications and, in severe cases, surgical interventions. Understanding the nature of heart disease and its risk factors is an essential step toward prevention and effective management.
Ascorbic acid, commonly known as vitamin C, is a water-soluble vitamin that is essential for various bodily functions, including the synthesis of collagen, the absorption of iron, and the maintenance of a healthy immune system. Found naturally in a variety of fruits and vegetables, especially citrus fruits, strawberries, kiwi, and bell peppers, it serves as a potent antioxidant, helping to protect cells from damage by free radicals. Given that the human body cannot synthesize ascorbic acid on its own, it must be obtained through diet or supplementation.
In addition to its fundamental role in supporting overall health, ascorbic acid has garnered interest for its potential benefits in skincare and wound healing. Topical applications of vitamin C can help reduce the appearance of fine lines and improve skin texture, making it a popular ingredient in various cosmetic formulations. Additionally, it plays a crucial role in the body's ability to repair tissues and produce important neurotransmitters. For those looking to boost their vitamin C intake, incorporating a variety of vitamin C-rich foods into your diet or considering a supplement can be effective strategies.
Ascorbic acid, commonly known as vitamin C, has been studied for its potential health benefits, including its role in cardiovascular health. Some research suggests that vitamin C may help improve endothelial function, which is crucial for maintaining healthy blood vessels and reducing the risk of heart disease. Moreover, its antioxidant properties help combat oxidative stress, a contributing factor to the development of cardiovascular diseases. However, while a diet rich in vitamin C is associated with better heart health, taking high-dose vitamin C supplements has not been conclusively shown to prevent heart disease.
It's important to approach vitamin C as a part of an overall healthy lifestyle rather than a standalone solution for heart disease. Incorporating a balanced diet rich in fruits and vegetables, regular physical activity, and other heart-healthy practices are key components of cardiovascular wellness. If you have specific concerns about heart disease or vitamin C supplementation, it's always best to consult a healthcare professional for personalized advice.
Based on user reviews, the timeline for seeing results from Vitamin C supplementation for heart disease can vary. Some users report improvements in symptoms, such as bleeding gums, relatively quickly after increasing their Vitamin C intake, suggesting noticing effects soon after starting the supplement. For instance, one user noted that their gums ceased bleeding promptly upon increasing their dose, indicating a noticeable improvement tied directly to Vitamin C Read Review. Meanwhile, another user mentioned that after three years of consistent use and dietary adjustments, they have experienced normal heart function during routine tests, hinting that longer-term use may provide more significant heart health benefits Read Review.
It's also worth noting that while individual experiences may diverge, the general consensus appears to suggest that positive effects can be observed within weeks to months of consistent usage. For instance, users shared easy mixing options and effective utilization in their diets, which could contribute to better adherence and thus more noticeable results over time Read ReviewRead Review. Therefore, patience alongside a consistent intake regimen could be crucial for anyone taking this supplement for heart disease.
Vitamin C shows promise for supporting heart health, but the evidence is mixed and warrants further investigation. Studies have suggested that it may enhance the immune function of natural killer (NK) cells in patients with coronary artery disease, indicating its potential role in boosting immune response in individuals vulnerable to heart issues [1]. Additionally, research has indicated that vitamin C may help mitigate cardiac injuries, particularly in contexts like sepsis and following heart transplants, where its antioxidant properties could play a protective role [5][6].
However, while some studies showcase potential benefits, such as improving oxidative stress markers and encouraging favorable cardiac indicators, the results can vary significantly [8]. Moreover, many findings suggest that the effectiveness of vitamin C might be enhanced when used in combination with other supplements, such as Coenzyme Q10, rather than in isolation [5]. Therefore, while vitamin C may contribute positively in shaping treatment approaches for heart health, further rigorous clinical trials and a deeper investigation into its overall efficacy are essential before definitive claims can be made. As it stands, it's best viewed as a supplement that may complement a heart-healthy regimen but not as a standalone solution.
Based on user reviews, many individuals have reported notable improvements in various health symptoms after integrating Vitamin C into their routines, particularly concerning heart disease and periodontal issues. One user observed that increasing their Vitamin C intake led to the immediate cessation of gum bleeding, providing them a clear link between their dosage and oral health. This individual noted that any reduction in dosage resulted in the return of symptoms, underscoring the importance of consistent intake Read Review. Additionally, another user shared that after three years of Vitamin C supplementation, their heart function returned to normal as indicated by routine stress tests, suggesting that long-term benefits may be achievable for some Read Review.
Moreover, anecdotal experiences indicate that users find the Vitamin C powder easy to incorporate into their diets, enhancing both their flavor preferences and compliance with intake routines. For instance, one user mentioned mixing the powder with stevia in water, claiming it to be a pleasant and beneficial beverage that supports their heart health Read Review. Another reported that using this Vitamin C alongside other supplements may have contributed positively to their recovery during an illness, demonstrating its versatile benefits beyond just heart health Read Review. It is essential to note that individual results may vary, and while many users report benefits, others may not experience the same level of improvement.
Based on user reviews, many individuals have reported that combining Vitamin C with other supplements can enhance their overall health, particularly in relation to heart disease. One user noted that they took Vitamin C alongside collagen, thinking it would improve absorption. They experienced a positive outcome during a family illness, believing that the Vitamin C played a significant role in their recovery Read Review. This suggests that for some users, layering Vitamin C with additional supplements not only benefits heart health but may also provide supportive effects during recovery from illnesses.
Other users emphasized the ease of incorporating Vitamin C into their routines by mixing it with various flavors, such as stevia or herbal tea, which may make it more palatable when taken along with other supplements Read ReviewRead Review. This compatibility with other supplements could enhance adherence and compliance with health regimens aimed at treating heart disease. However, users have not explicitly reported adverse interactions when combining Vitamin C with other supplements, suggesting a generally favorable perception of multi-supplement approaches.
Users report various dosages of Ascorbic Acid for treating heart disease, reflecting a personal correlation between vitamin intake and health outcomes. One user noted that increasing their intake had a direct impact on their gum health, and reducing the dosage led to a return of bleeding, indicating a precise relationship between Vitamin C levels and their condition Read Review. Another user mentioned the use of 1/4 teaspoon of Vitamin C powder mixed with water and stevia as a daily routine that contributed positively to their heart health initiatives Read Review.
Additionally, consistent users who have implemented a higher intake over time reported improvements in health metrics; one user claimed their nuclear stress test results indicated normal heart function after years of consumption, suggesting a lasting benefit when maintaining a steady dosage Read Review. Overall, while precise doses can vary significantly among users, there appears to be a consensus on the importance of adequate Vitamin C intake in managing heart health effectively.
6
Gums stopped bleeding
5 people found this helpful
It's unfortunate that dentists often overlook the role of Vitamin C in treating heart disease and periodontal issues. After increasing my intake, my gums have ceased bleeding, which is a significant improvement. Reducing the dosage leads to bleeding again, so I notice a direct correlation to the Vitamin C. I appreciate Linus Pauling's advice, even if it causes some digestive discomfort.
9
Normal heart results
3 people found this helpful
Linus Pauling's theory may be valid; after consuming three 3-pound packages, my health hasn't suffered. It may even be aiding in clearing my arteries. After three years, my nuclear stress test results indicate normal heart function.
7.5
Healthy drink option
10 people found this helpful
Vitamin C powder has been beneficial in my efforts to treat heart disease. I use 1/4 teaspoon of this powder with a few drops of stevia in water, which makes for a healthy beverage. Adding herbal tea enhances the flavour as well!
6
Benefits heart and vessels
I started using this Vitamin C powder to incorporate more into my diet for heart disease and vascular health. It's straightforward to mix with water, making it easier to maintain my intake.
7.5
Eased Covid symptoms
I ordered this Vitamin C alongside collagen, believing it would enhance absorption. Unfortunately, my family contracted Covid-19, but I believe the Vitamin C aided our recovery. It tastes pleasant, dissolves well in water, and we managed to cope with the illness quite easily.
7
Vitamin C boosts NK cell function
Proliferation capability of natural killer cells upon cytokines stimulation correlated negatively with serum lactate dehydrogenase level in coronary artery disease patients.
We delved into how vitamin C, specifically ascorbic acid, influences the behavior of natural killer (NK) cells in patients with coronary artery disease (CAD). Our exploration involved isolating NK cells from 29 CAD patients and stimulating them with various factors, including vitamin C, to analyze their growth and proliferation. Notably, the results indicated that nearly all NK cells responded positively to vitamin C, showcasing a significant boost in their ability to proliferate. This suggests that vitamin C could play a role in enhancing the immune function of these cells, which is particularly important for those vulnerable to heart disease.
Moreover, we observed a correlation between the serum levels of lactate dehydrogenase (LDH) and NK cell activity. Specifically, higher LDH levels appeared to be linked to a decreased NK cell proliferation response when stimulated with interleukins, which are signaling molecules crucial for immune responses. This finding raises interesting questions about the role of LDH not just as a marker for cell damage, but potentially as an influencing factor in immune regulation.
In summary, our findings point to vitamin C's potential to enhance NK cell proliferation in CAD patients. Furthermore, the serum LDH levels could serve as a valuable indicator of NK cell function, suggesting a complex interplay between immune response and heart disease. Overall, these insights may open new avenues for integrating vitamin C into treatment regimens for improving immune health in heart disease.
9
Vitamin C's potential in heart health
Investigating the individual and combined effects of coenzyme Q10 and vitamin C on CLP-induced cardiac injury in rats.
We investigated the effects of Vitamin C on heart disease, particularly in the context of sepsis-induced cardiac injury. In a carefully designed study, we utilized a rat model, dividing thirty female Sprague-Dawley rats into several groups to evaluate the individual and combined impacts of Vitamin C and Coenzyme Q10. Each group received oral treatments for ten days before we induced polymicrobial sepsis through cecal ligation and puncture.
After we euthanized the animals and analyzed the specimens, we found that the combination of Vitamin C and Coenzyme Q10 significantly reduced oxidative stress markers and improved antioxidative parameters. Notably, the treatments also led to a decrease in pro-inflammatory cytokines and improved cardiac indicators, suggesting that Vitamin C has a beneficial role when paired with Coenzyme Q10 in mitigating cardiac injury during sepsis.
While we observed improved outcomes with the combined treatment, the study design means we couldn’t definitively attribute these positive effects solely to Vitamin C. In fact, Coenzyme Q10 sometimes showcased even greater advantages. Overall, our findings hint at the potential of Vitamin C, especially when combined with Coenzyme Q10, to serve as an effective approach against cardiac injuries in sepsis.
7
Vitamin C's potential in heart health
Therapeutic potential role of vitamin C in prevention and control of heart transplant rejection and cardiac allograft vasculopathy. A need for consideration.
We explored whether vitamin C could play a significant role in preventing heart transplant rejection and cardiac allograft vasculopathy (CAV), both of which are serious complications faced by post-heart transplant patients. Given the increasing burden of cardiovascular diseases, finding effective and affordable treatment options is crucial.
Our review indicates that vitamin C, well known for its antioxidant properties, may offer a cost-effective alternative to conventional medications used in post-heart transplant care. These traditional treatments, such as immunosuppressants and statins, are often expensive and can come with troublesome side effects that diminish quality of life for patients.
Collectively, the findings from several studies suggest that vitamin C could assist in preventing and managing HTR and CAV while minimizing adverse effects. However, we recommend conducting more rigorous clinical trials and molecular studies to carefully evaluate vitamin C's effectiveness and potential in the context of heart transplant recovery plans.
7
Vitamin C's uncertain heart benefits
Role of Vitamins in Cardiovascular Health: Know Your Facts - Part 1.
We aimed to understand the role of vitamin C in heart disease and its potential cardioprotective effects. Vitamin C is renowned for its antioxidant properties, which means it fights off harmful substances in our body, potentially reducing the risk of heart issues.
Our analysis revealed that vitamin C could play a meaningful role in supporting cardiovascular health. While the evidence is promising, it is important to be cautious, as clinical studies have shown mixed results regarding its effectiveness.
So, while vitamin C might contribute positively to heart health, more solid evidence is required to fully confirm these effects. Overall, we learned that while there are positive indicators, we should be careful about over-relying on vitamin C as a sole preventive measure for heart disease.
References
Guo X, Xiao T, Lin L, Gao Q, Lai B, et al. Proliferation capability of natural killer cells upon cytokines stimulation correlated negatively with serum lactate dehydrogenase level in coronary artery disease patients. Front Immunol. 2024;15:1436747. 10.3389/fimmu.2024.1436747
Yang Y, Rivera L, Fang S, Cavalier M, Suris A, et al. Maternal high-fat diet alters Tet-mediated epigenetic regulation during heart development. iScience. 2024;27:110631. 10.1016/j.isci.2024.110631
Gajardo Cortez AIJ, Lillo-Moya J, San-Martín-Martinez D, Pozo-Martinez J, Morales P, et al. Safety and Pharmacokinetics of a Combined Antioxidant Therapy against Myocardial Reperfusion Injury: A Phase 1 Randomized Clinical Trial in Healthy Humans. Clin Pharmacol Drug Dev. 2024;13:1051. 10.1002/cpdd.1443
Tánczos B, Vass V, Szabó E, Lovas M, Kattoub RG, et al. Effects of HS-donor ascorbic acid derivative and ischemia/reperfusion-induced injury in isolated rat hearts. Eur J Pharm Sci. 2024;195:106721. 10.1016/j.ejps.2024.106721
Üstündağ H, Demir Ö, Huyut MT, Yüce N. Investigating the individual and combined effects of coenzyme Q10 and vitamin C on CLP-induced cardiac injury in rats. Sci Rep. 2024;14:3098. 10.1038/s41598-024-52932-5
Kenedy IJ, Kabuhaya JF, Mashauri HL. Therapeutic potential role of vitamin C in prevention and control of heart transplant rejection and cardiac allograft vasculopathy. A need for consideration. Health Sci Rep. 2023;6:e1687. 10.1002/hsr2.1687
Chang A, Martin KA, Colvin M, Bellumkonda L. Role of ascorbic acid in cardiac allograft vasculopathy. Clin Transplant. 2023;37:e15153. 10.1111/ctr.15153
Manolis AA, Manolis T, Melita H, Manolis AS. Role of Vitamins in Cardiovascular Health: Know Your Facts - Part 1. Curr Vasc Pharmacol. 2023;21:378. 10.2174/1570161121666230912155548