Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.2
USERS' SCORE
Moderately Good
Based on 8 Reviews
7.2
Supplement Facts
Serving Size: 1/4 Level Teaspoon (1.1 g)
Amount Per Serving
%DV
Vitamin C (Ascorbic Acid)
1.1 g (1,100 mg)
1222%
Top Medical Research Studies
9.5
We looked into how well ascorbic acid, or vitamin C, helps heal chronic foot ulcers. In a carefully designed trial, we compared the effects of vitamin C against a placebo on sixteen participants.
Over 8 weeks, those who received vitamin C showed significant healing improvements, with a median healing rate of 100%, compared to a negative healing rate in the placebo group.
Everyone in the vitamin C group avoided amputation, while almost half from the control group did not heal at all. This affordable and accessible treatment could greatly benefit those suffering from chronic foot ulcers.
Over 8 weeks, those who received vitamin C showed significant healing improvements, with a median healing rate of 100%, compared to a negative healing rate in the placebo group.
Everyone in the vitamin C group avoided amputation, while almost half from the control group did not heal at all. This affordable and accessible treatment could greatly benefit those suffering from chronic foot ulcers.
Read More
8
We examined the effects of ascorbic acid on two elderly patients suffering from severe ulcers on their lower limbs, attributed to scurvy—a condition caused by a lack of vitamin C. Both individuals showed undetectable vitamin C levels, and after receiving vitamin C supplementation, we noted a significant improvement in the ulcers.
This experience underscores the need to consider scurvy as a possible diagnosis in similar ulcer cases, especially for those with dietary deficiencies. Identifying this condition early can lead to better health outcomes for affected patients.
This experience underscores the need to consider scurvy as a possible diagnosis in similar ulcer cases, especially for those with dietary deficiencies. Identifying this condition early can lead to better health outcomes for affected patients.
Read More
9
We examined the effects of ascorbic acid on ileal ulcer formation in rats treated with a specific anti-inflammatory drug.
In our study, while some antioxidants didn’t reduce ulcer formation, ascorbic acid stood out as the most effective at inhibiting ulcers and decreasing harmful substances in the ileal mucosa.
We also noted that ascorbic acid helped maintain healthier gut bacteria levels. This suggests that ascorbic acid can be a helpful ally against ulcers by combatting oxidative stress and supporting gut health.
In our study, while some antioxidants didn’t reduce ulcer formation, ascorbic acid stood out as the most effective at inhibiting ulcers and decreasing harmful substances in the ileal mucosa.
We also noted that ascorbic acid helped maintain healthier gut bacteria levels. This suggests that ascorbic acid can be a helpful ally against ulcers by combatting oxidative stress and supporting gut health.
Read More
Most Useful Reviews
7.5
Cost-effective megadoses
This NOW Vitamin C is cost-effective and suitable for megadoses of over 10g daily. I've been doing megadoses for about 10 years, and it's crucial for managing my gastric and duodenal ulcers.
Read More
0
Buffered recommended
1 people found this helpful
Caution! It’s sour! I tried different vitamin C brands for my husband. Eventually, I opted for a sour, powdered form which I find convenient. But it caused my stomach ulcer to flare up, so I recommend a buffered form for those with gastrointestinal issues.
Read More
9
Suitable for gastritis
Sodium ascorbate is one of the best forms of vitamin C, ideal for those with gastritis and ulcers.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.2
- All Researches
9.5
We looked into how well ascorbic acid, or vitamin C, helps heal chronic foot ulcers. In a carefully designed trial, we compared the effects of vitamin C against a placebo on sixteen participants.
Over 8 weeks, those who received vitamin C showed significant healing improvements, with a median healing rate of 100%, compared to a negative healing rate in the placebo group.
Everyone in the vitamin C group avoided amputation, while almost half from the control group did not heal at all. This affordable and accessible treatment could greatly benefit those suffering from chronic foot ulcers.
Over 8 weeks, those who received vitamin C showed significant healing improvements, with a median healing rate of 100%, compared to a negative healing rate in the placebo group.
Everyone in the vitamin C group avoided amputation, while almost half from the control group did not heal at all. This affordable and accessible treatment could greatly benefit those suffering from chronic foot ulcers.
Read More
9
We examined the effects of ascorbic acid on ileal ulcer formation in rats treated with a specific anti-inflammatory drug.
In our study, while some antioxidants didn’t reduce ulcer formation, ascorbic acid stood out as the most effective at inhibiting ulcers and decreasing harmful substances in the ileal mucosa.
We also noted that ascorbic acid helped maintain healthier gut bacteria levels. This suggests that ascorbic acid can be a helpful ally against ulcers by combatting oxidative stress and supporting gut health.
In our study, while some antioxidants didn’t reduce ulcer formation, ascorbic acid stood out as the most effective at inhibiting ulcers and decreasing harmful substances in the ileal mucosa.
We also noted that ascorbic acid helped maintain healthier gut bacteria levels. This suggests that ascorbic acid can be a helpful ally against ulcers by combatting oxidative stress and supporting gut health.
Read More
8
We examined the effects of ascorbic acid on two elderly patients suffering from severe ulcers on their lower limbs, attributed to scurvy—a condition caused by a lack of vitamin C. Both individuals showed undetectable vitamin C levels, and after receiving vitamin C supplementation, we noted a significant improvement in the ulcers.
This experience underscores the need to consider scurvy as a possible diagnosis in similar ulcer cases, especially for those with dietary deficiencies. Identifying this condition early can lead to better health outcomes for affected patients.
This experience underscores the need to consider scurvy as a possible diagnosis in similar ulcer cases, especially for those with dietary deficiencies. Identifying this condition early can lead to better health outcomes for affected patients.
Read More
8
We examined the juice from Sicilian prickly pear fruits to see how ascorbic acid and other components affect ulcers. The study involved testing the juice's ability to prevent ulcer formation caused by ethanol in rats.
We discovered that the juice increased mucus production and restored the normal structure of the stomach lining, suggesting it may offer protective benefits. Additionally, its antioxidant properties were highlighted, which could further contribute to overall health. However, our findings don't provide substantial evidence that ascorbic acid alone is a direct cure for ulcers.
We discovered that the juice increased mucus production and restored the normal structure of the stomach lining, suggesting it may offer protective benefits. Additionally, its antioxidant properties were highlighted, which could further contribute to overall health. However, our findings don't provide substantial evidence that ascorbic acid alone is a direct cure for ulcers.
Read More
8
We conducted a thorough investigation into the protective effects of Vitamin C on gastric ulcers, especially in combination with metformin. Our study involved thirty rats divided into different groups to observe the ulcer-inducing effects of indomethacin and the potential healing properties of various treatments.
The findings were promising: both Vitamin C and metformin demonstrated significant improvements in gastric mucosal injury, helping to alleviate the damage caused by indomethacin. We noted that the combination of Vitamin C with metformin enhanced the effectiveness of antioxidant enzymes in the stomach, such as catalase and GPx, indicating a synergistic effect.
While Vitamin C showed positive results, it's important to recognize that these effects were observed in combination with metformin, making it difficult to isolate its specific benefits. Overall, our research suggests that the combination therapy could be a beneficial option for treating gastric ulcers linked to NSAID usage.
The findings were promising: both Vitamin C and metformin demonstrated significant improvements in gastric mucosal injury, helping to alleviate the damage caused by indomethacin. We noted that the combination of Vitamin C with metformin enhanced the effectiveness of antioxidant enzymes in the stomach, such as catalase and GPx, indicating a synergistic effect.
While Vitamin C showed positive results, it's important to recognize that these effects were observed in combination with metformin, making it difficult to isolate its specific benefits. Overall, our research suggests that the combination therapy could be a beneficial option for treating gastric ulcers linked to NSAID usage.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 8 Reviews
7.2
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Cost-effective megadoses
This NOW Vitamin C is cost-effective and suitable for megadoses of over 10g daily. I've been doing megadoses for about 10 years, and it's crucial for managing my gastric and duodenal ulcers.
Read More
0
Buffered recommended
1 people found this helpful
Caution! It’s sour! I tried different vitamin C brands for my husband. Eventually, I opted for a sour, powdered form which I find convenient. But it caused my stomach ulcer to flare up, so I recommend a buffered form for those with gastrointestinal issues.
Read More
9
Suitable for gastritis
Sodium ascorbate is one of the best forms of vitamin C, ideal for those with gastritis and ulcers.
Read More
9
Effective for ulcers
This is highly effective for treating dysmenorrhea and oral ulcers. I have used it long-term.
Read More
8
Cures oral ulcers
NOW Vitamin C is fantastic! I have used it for a long time; it helps treat oral ulcers, colds, and dysmenorrhea effectively!
Read More
Frequently Asked Questions
2
Not recommended
I do not recommend these vitamins for anyone with an ulcer or suspected ulcer. I take them after meals if I feel unwell, and they help me feel better overnight. They boost my energy for colds and general wellness.
4
Cramps persist
I use this daily. It is a little sour, but I can manage, and the price is excellent! After trying several vitamin C products, this is the best for me. I do experience cramps due to my stomach ulcer after using it but have this issue with all vitamin C products I've tried, even those aimed at sensitive stomachs.
7.5
Cost-effective megadoses
This NOW Vitamin C is cost-effective and suitable for megadoses of over 10g daily. I've been doing megadoses for about 10 years, and it's crucial for managing my gastric and duodenal ulcers.
6
Emergency aid
An essential product in my home. I use it as an emergency remedy at the onset of respiratory ailments for my family. I also take it with collagen. Those with an ulcer should use it cautiously, preferably after meals.
0
Buffered recommended
1 people found this helpful
Caution! It’s sour! I tried different vitamin C brands for my husband. Eventually, I opted for a sour, powdered form which I find convenient. But it caused my stomach ulcer to flare up, so I recommend a buffered form for those with gastrointestinal issues.
9
Effective for ulcers
This is highly effective for treating dysmenorrhea and oral ulcers. I have used it long-term.
9
Suitable for gastritis
Sodium ascorbate is one of the best forms of vitamin C, ideal for those with gastritis and ulcers.
8
We conducted a thorough investigation into the protective effects of Vitamin C on gastric ulcers, especially in combination with metformin. Our study involved thirty rats divided into different groups to observe the ulcer-inducing effects of indomethacin and the potential healing properties of various treatments.
The findings were promising: both Vitamin C and metformin demonstrated significant improvements in gastric mucosal injury, helping to alleviate the damage caused by indomethacin. We noted that the combination of Vitamin C with metformin enhanced the effectiveness of antioxidant enzymes in the stomach, such as catalase and GPx, indicating a synergistic effect.
While Vitamin C showed positive results, it's important to recognize that these effects were observed in combination with metformin, making it difficult to isolate its specific benefits. Overall, our research suggests that the combination therapy could be a beneficial option for treating gastric ulcers linked to NSAID usage.
The findings were promising: both Vitamin C and metformin demonstrated significant improvements in gastric mucosal injury, helping to alleviate the damage caused by indomethacin. We noted that the combination of Vitamin C with metformin enhanced the effectiveness of antioxidant enzymes in the stomach, such as catalase and GPx, indicating a synergistic effect.
While Vitamin C showed positive results, it's important to recognize that these effects were observed in combination with metformin, making it difficult to isolate its specific benefits. Overall, our research suggests that the combination therapy could be a beneficial option for treating gastric ulcers linked to NSAID usage.
8
We observed the potential benefits of vitamin C in managing gastric ulcers under conditions of myocardial injury, which was induced using adrenaline in our study. Thirty Wistar rats were carefully divided into five groups, ensuring a control group for comparison.
The rats that received adrenaline alone showed increased gastric secretions and elevated markers related to heart injury. However, those pre-treated with vitamin C experienced a notable reduction in ulcer severity and excessive gastric secretions.
Interestingly, when we administered vitamin C before the adrenaline exposure, we found that it significantly decreased both the volume of gastric juice and total acidity, while also enhancing some protective factors. In essence, our research indicates that vitamin C may play a protective role in gastric health, particularly amid the stressful conditions created by adrenaline.
The rats that received adrenaline alone showed increased gastric secretions and elevated markers related to heart injury. However, those pre-treated with vitamin C experienced a notable reduction in ulcer severity and excessive gastric secretions.
Interestingly, when we administered vitamin C before the adrenaline exposure, we found that it significantly decreased both the volume of gastric juice and total acidity, while also enhancing some protective factors. In essence, our research indicates that vitamin C may play a protective role in gastric health, particularly amid the stressful conditions created by adrenaline.
7
Vitamin C positively influences gut microbiome
We explored how vitamin C affects the gut microbiome of patients with ulcerative colitis (UC) in a study involving 49 outpatient subjects. The participants were evaluated between June and December 2021, and they were divided into groups based on whether they had contracted COVID-19 in the prior six months. Our primary focus was to assess not just the impact of vitamin C, but also to consider the effects of antibiotics, probiotics, and the history of COVID-19 on their gut health.
Interestingly, we observed that those who used vitamin C supplements had more beneficial elements in their gut microbiome compared to those who did not. The study found a significant difference, indicating that vitamin C users had better microbiome readings, suggesting a positive influence on their gut health. However, while vitamin C presented statistically significant results, we noted that other factors such as antibiotic use also played a crucial role.
Importantly, the use of antibiotics negatively impacted the gut microbiome, which raises questions about the interplay between different treatments. There was also no significant impact found regarding mild COVID-19 on patients’ gut microbiomes, adding another layer to our understanding of these interactions. Ultimately, while vitamin C showed promise, the overall picture suggests that it's part of a broader landscape of factors affecting ulcerative colitis.
Interestingly, we observed that those who used vitamin C supplements had more beneficial elements in their gut microbiome compared to those who did not. The study found a significant difference, indicating that vitamin C users had better microbiome readings, suggesting a positive influence on their gut health. However, while vitamin C presented statistically significant results, we noted that other factors such as antibiotic use also played a crucial role.
Importantly, the use of antibiotics negatively impacted the gut microbiome, which raises questions about the interplay between different treatments. There was also no significant impact found regarding mild COVID-19 on patients’ gut microbiomes, adding another layer to our understanding of these interactions. Ultimately, while vitamin C showed promise, the overall picture suggests that it's part of a broader landscape of factors affecting ulcerative colitis.
References
- Guellich A, Tella E, Mahé E. [Scurvy presenting with low-extremity necrotic and purpuric ulcers: Two cases]. Rev Med Interne. 2021;42:214. doi:10.1016/j.revmed.2020.10.382
- Gunton JE, Girgis CM, Lau T, Vicaretti M, Begg L, et al. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial. Br J Nutr. 2021;126:1451. doi:10.1017/S0007114520003815
- Galati EM, Mondello MR, Giuffrida D, Dugo G, Miceli N, et al. Chemical characterization and biological effects of Sicilian Opuntia ficus indica (L.) mill. Fruit juice: antioxidant and antiulcerogenic activity. J Agric Food Chem. 2003;51:4903.
- Bing SR, Kinouchi T, Kataoka K, Kuwahara T, Ohnishi Y. Protective effects of a culture supernatant of Lactobacillus acidophilus and antioxidants on ileal ulcer formation in rats treated with a nonsteroidal antiinflammatory drug. Microbiol Immunol. 1998;42:745.
- Straume Z, Krūmiņa N, Elbere I, Rozenberga M, Erts R, et al. Impact of Vitamins, Antibiotics, Probiotics, and History of COVID-19 on the Gut Microbiome in Ulcerative Colitis Patients: A Cross-Sectional Study. Medicina (Kaunas). 2025;61. doi:10.3390/medicina61020284
- Khezri MR, Varzandeh R, Ghasemnejad-Berenji M. Concomitant Effects of Metformin and Vitamin C on Indomethacin-Induced Gastric Ulcer in Rats: Biochemical and Histopathological Approach. Drug Res (Stuttg). 2024;74:280. doi:10.1055/a-2317-7578
- Ezeani C, Beshel JA, Okon IA, Inyang EG, Owu DU. Vitamin C modulates adrenaline-augmented gastric injury via cardiac troponin/creatine kinase pathway in Wistar rats. Iran J Basic Med Sci. 2023;26:843. doi:10.22038/IJBMS.2023.68651.15019
- Mason SA, Parker L, van der Pligt P, Wadley GD. Vitamin C supplementation for diabetes management: A comprehensive narrative review. Free Radic Biol Med. 2023;194:255. doi:10.1016/j.freeradbiomed.2022.12.003
- Kurt Y, Özmen Ö. Effects of Vitamin C on the Oral-Nasal Mucosal Damage Caused by Favipiravir in Old and Young Rats. Cureus. 2022;14:e28796. doi:10.7759/cureus.28796
- Vishniak GN, Kharlamova KE, Gurosheva GT, Zavernaia AM, Golovnia IA. [Amben and galascorbin in the combined treatment of ulcerative-necrotic lesions of the oral mucosa]. Stomatologiia (Mosk). 1993;72:24.
