First off, let me say that I am prone to heart burn. I've had gerd and a hiatal hernia now for years and I do have to stick to a certain regiment if I want to stay acid reflux free. Unfortunately, this supplement exacerbated my reflux and I had to stop it. Didn't matter whether I took it with food or what the time of day I would wake up the next day with excess acid which pretty much lasted all day. I will say that in the short time I was able to take it (few days at a time) my BP did seem lower (is already low and got a bit too low for my comfort) and I possibly felt more clear and more energy. Could have been placebo, who knows. would recommend for people who do NOT have gerd, have a higher BP and maybe want something to strengthen immune system. I am still looking for something that will not give me gerd and won't lower my BP like many supplements do, am open to suggestions. recently ordered Grape seed extract, not sure about it