Last update
3/15/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 9 Researches
6.6
USERS' SCORE
Good
Based on 8 Reviews
8.1
Supplement Facts
Serving Size: 1 Spray (Approx. 0.41 ml)
Amount Per Serving
%DV
Vitamin B12(as Methylcobalamin from Saccharomyces cerevisiae)
500 mcg
20,833%
Certified Organic Food BlendOrganic Beet (root), Organic Carrot (root), Organic Spinach (leaf), Organic Broccoli (flower & stem), Organic Tomato (fruit), Organic Kale (leaf), Organic Cabbage (leaf), Organic Parsley (leaf), Organic Brussels Sprout (leaf), Organic Green Bell Pepper (fruit), Organic Cucumber (gourd), Organic Celery (stalk), Organic Garlic (bulb), Organic Ginger (root), Organic Onion (root), Organic Cauliflower (flower & stem), Organic Asparagus (flower & stem), Organic Strawberry (fruit), Organic Cherry (fruit), Organic Blackberry (fruit), Organic Blueberry (fruit), Organic Raspberry (fruit)
2 mg
+
Top Medical Research Studies
0
Vitamin B12 ineffective for CFS
We explored the effectiveness of high-dose vitamin B12 injections on chronic fatigue syndrome (CFS) through two case reports that utilized N of 1 trials. This approach allowed us to make tailored treatment decisions based on individual responses to the therapy.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
Read More
8
We investigated the use of vitamin B12 nasal drops in adults with chronic fatigue syndrome (CFS) over three months. A total of 51 patients participated, and we measured their vitamin B12 levels alongside physical activity and fatigue scores.
Remarkably, two-thirds of the participants experienced positive results, including increased activity and better overall scores on fatigue measures. While responders showed significant improvements, the non-responders had only minor increases in vitamin B12 levels.
This indicates that vitamin B12 nasal drops could be a beneficial alternative to injections for many CFS patients.
Remarkably, two-thirds of the participants experienced positive results, including increased activity and better overall scores on fatigue measures. While responders showed significant improvements, the non-responders had only minor increases in vitamin B12 levels.
This indicates that vitamin B12 nasal drops could be a beneficial alternative to injections for many CFS patients.
Read More
8
We evaluated the impact of B12 injections combined with folic acid on patients with chronic fatigue syndrome, also known as myalgic encephalomyelitis (ME). In our survey of 38 patients, we identified two groups based on their response: Good and Mild responders. Good responders received more frequent and higher doses of B12, leading to significant improvements in their symptoms.
However, Mild responders, many of whom took pain medications, reported minimal progress. Overall, while some patients showed benefits, the effectiveness of B12 treatment varies widely, and further research is needed to understand optimal dosages and drug interactions.
However, Mild responders, many of whom took pain medications, reported minimal progress. Overall, while some patients showed benefits, the effectiveness of B12 treatment varies widely, and further research is needed to understand optimal dosages and drug interactions.
Read More
Most Useful Reviews
7.5
Fatigue reduction
3 people found this helpful
My vitamin B12 levels have been borderline for years, leading to fatigue and irritability. I searched for an easy-to-use supplement and opted for this convenient spray. After two weeks, my fatigue began to diminish. I look forward to retesting my levels in a month, as I previously had slightly low results.
Read More
7.5
Increased energy
1 people found this helpful
We are a vegetarian family, and this product effectively addresses our B12 deficiency. My levels were critically low, causing chronic fatigue syndrome and other issues. I found this spray preferable to injections. After a month, my B12 levels improved, enhancing our overall energy and well-being.
Read More
9
Improved energy levels
I suffer from chronic fatigue and a constant feeling of tiredness, and this product really helped me. I appreciate that this spray is organic and contains only natural ingredients. I was pleasantly surprised by the raspberry flavour, which makes it nicer to consume. After a few days of use, I've noticed an improvement in my energy levels; I feel more energised and refreshed. My skin has also become healthier and smoother, which is a lovely bonus. I recommend this product to anyone who suffers from fatigue and wants to enhance their overall well-being. It is easily digestible and has a pleasant taste, making it ideal for daily use.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 9 Researches
6.6
- All Researches
8
We investigated the use of vitamin B12 nasal drops in adults with chronic fatigue syndrome (CFS) over three months. A total of 51 patients participated, and we measured their vitamin B12 levels alongside physical activity and fatigue scores.
Remarkably, two-thirds of the participants experienced positive results, including increased activity and better overall scores on fatigue measures. While responders showed significant improvements, the non-responders had only minor increases in vitamin B12 levels.
This indicates that vitamin B12 nasal drops could be a beneficial alternative to injections for many CFS patients.
Remarkably, two-thirds of the participants experienced positive results, including increased activity and better overall scores on fatigue measures. While responders showed significant improvements, the non-responders had only minor increases in vitamin B12 levels.
This indicates that vitamin B12 nasal drops could be a beneficial alternative to injections for many CFS patients.
Read More
8
We evaluated the impact of B12 injections combined with folic acid on patients with chronic fatigue syndrome, also known as myalgic encephalomyelitis (ME). In our survey of 38 patients, we identified two groups based on their response: Good and Mild responders. Good responders received more frequent and higher doses of B12, leading to significant improvements in their symptoms.
However, Mild responders, many of whom took pain medications, reported minimal progress. Overall, while some patients showed benefits, the effectiveness of B12 treatment varies widely, and further research is needed to understand optimal dosages and drug interactions.
However, Mild responders, many of whom took pain medications, reported minimal progress. Overall, while some patients showed benefits, the effectiveness of B12 treatment varies widely, and further research is needed to understand optimal dosages and drug interactions.
Read More
8
We recently came across an intriguing study that highlighted the potential benefits of a combination therapy involving lofepramine, L-phenylalanine, and vitamin B12 for patients suffering from multiple sclerosis (MS). Conducted as a randomized, placebo-controlled double-blind trial, the research aimed to evaluate how this combination could help alleviate various symptoms associated with MS and chronic pain.
While this study did address the role of vitamin B12, it was examined alongside lofepramine and phenylalanine. This makes it challenging for us to pinpoint the specific impact of vitamin B12 in the context of chronic fatigue syndrome on its own. The treatment showed effectiveness in improving symptoms within just two to four weeks, but due to the combination of treatments, we need more focused studies to assess vitamin B12's distinct role.
Overall, it's exciting to see a potential link between this therapy and symptom relief, yet we must remain cautious about attributing the benefits solely to vitamin B12, given the blended approach of the therapy used in the trial.
While this study did address the role of vitamin B12, it was examined alongside lofepramine and phenylalanine. This makes it challenging for us to pinpoint the specific impact of vitamin B12 in the context of chronic fatigue syndrome on its own. The treatment showed effectiveness in improving symptoms within just two to four weeks, but due to the combination of treatments, we need more focused studies to assess vitamin B12's distinct role.
Overall, it's exciting to see a potential link between this therapy and symptom relief, yet we must remain cautious about attributing the benefits solely to vitamin B12, given the blended approach of the therapy used in the trial.
Read More
7
Beta-glucan alleviates cognitive fatigue
We conducted a rigorous 36-week study with 65 patients diagnosed with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Participants were given either yeast-derived beta-glucan with vitamins or a placebo.
The results revealed that those taking beta-glucan showed notable improvements in cognitive fatigue compared to those on the placebo. This suggests that beta-glucan could be a promising nutritional supplement for easing cognitive symptoms associated with ME/CFS.
However, more research is needed to fully understand its benefits and mechanisms.
The results revealed that those taking beta-glucan showed notable improvements in cognitive fatigue compared to those on the placebo. This suggests that beta-glucan could be a promising nutritional supplement for easing cognitive symptoms associated with ME/CFS.
However, more research is needed to fully understand its benefits and mechanisms.
Read More
7
Potential benefits of yeast supplements
We explored the impact of "Nagipol," a supplement made from beer yeasts, on chronic fatigue syndrome (CFS). Our clinical study indicated that "Nagipol" could improve the clinical status of CFS patients. It appears to help enhance cognitive functions and stabilize emotional symptoms while also normalizing certain blood parameters.
While these findings are promising, it’s important to note that further research is needed to fully confirm these benefits, especially regarding its role in diet therapy for individuals dealing with CFS.
While these findings are promising, it’s important to note that further research is needed to fully confirm these benefits, especially regarding its role in diet therapy for individuals dealing with CFS.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Fatigue reduction
3 people found this helpful
My vitamin B12 levels have been borderline for years, leading to fatigue and irritability. I searched for an easy-to-use supplement and opted for this convenient spray. After two weeks, my fatigue began to diminish. I look forward to retesting my levels in a month, as I previously had slightly low results.
Read More
7.5
Increased energy
1 people found this helpful
We are a vegetarian family, and this product effectively addresses our B12 deficiency. My levels were critically low, causing chronic fatigue syndrome and other issues. I found this spray preferable to injections. After a month, my B12 levels improved, enhancing our overall energy and well-being.
Read More
9
Improved energy levels
I suffer from chronic fatigue and a constant feeling of tiredness, and this product really helped me. I appreciate that this spray is organic and contains only natural ingredients. I was pleasantly surprised by the raspberry flavour, which makes it nicer to consume. After a few days of use, I've noticed an improvement in my energy levels; I feel more energised and refreshed. My skin has also become healthier and smoother, which is a lovely bonus. I recommend this product to anyone who suffers from fatigue and wants to enhance their overall well-being. It is easily digestible and has a pleasant taste, making it ideal for daily use.
Read More
9
Chronic fatigue disappeared
I have been on a plant-based diet for six years. Some believe B12 is only in meat and milk, but that's not accurate. It's produced by bacteria in the soil and water. I discovered a slight deficiency and tried various B12 capsules without any noticeable improvement. Recently, I ordered this organic spray from Garden of Life, and I immediately felt the effects! I take two puffs under my tongue separately from other vitamins. My chronic fatigue has vanished, and my mood and memory have improved. I recommend it to all vegans; don’t be deterred by the price—it’s worth it.
Read More
7.5
Energy boost
This spray is of excellent quality and effectively relieves my chronic fatigue syndrome. It boosts my energy levels and has a pleasant raspberry taste that isn’t overly sweet. I recommend it to anyone seeking improvement.
Read More
Frequently Asked Questions
7.5
Fatigue reduction
3 people found this helpful
My vitamin B12 levels have been borderline for years, leading to fatigue and irritability. I searched for an easy-to-use supplement and opted for this convenient spray. After two weeks, my fatigue began to diminish. I look forward to retesting my levels in a month, as I previously had slightly low results.
7.5
Increased energy
1 people found this helpful
We are a vegetarian family, and this product effectively addresses our B12 deficiency. My levels were critically low, causing chronic fatigue syndrome and other issues. I found this spray preferable to injections. After a month, my B12 levels improved, enhancing our overall energy and well-being.
8
We investigated the use of vitamin B12 nasal drops in adults with chronic fatigue syndrome (CFS) over three months. A total of 51 patients participated, and we measured their vitamin B12 levels alongside physical activity and fatigue scores.
Remarkably, two-thirds of the participants experienced positive results, including increased activity and better overall scores on fatigue measures. While responders showed significant improvements, the non-responders had only minor increases in vitamin B12 levels.
This indicates that vitamin B12 nasal drops could be a beneficial alternative to injections for many CFS patients.
Remarkably, two-thirds of the participants experienced positive results, including increased activity and better overall scores on fatigue measures. While responders showed significant improvements, the non-responders had only minor increases in vitamin B12 levels.
This indicates that vitamin B12 nasal drops could be a beneficial alternative to injections for many CFS patients.
8
We evaluated the impact of B12 injections combined with folic acid on patients with chronic fatigue syndrome, also known as myalgic encephalomyelitis (ME). In our survey of 38 patients, we identified two groups based on their response: Good and Mild responders. Good responders received more frequent and higher doses of B12, leading to significant improvements in their symptoms.
However, Mild responders, many of whom took pain medications, reported minimal progress. Overall, while some patients showed benefits, the effectiveness of B12 treatment varies widely, and further research is needed to understand optimal dosages and drug interactions.
However, Mild responders, many of whom took pain medications, reported minimal progress. Overall, while some patients showed benefits, the effectiveness of B12 treatment varies widely, and further research is needed to understand optimal dosages and drug interactions.
7
Beta-glucan alleviates cognitive fatigue
We conducted a rigorous 36-week study with 65 patients diagnosed with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Participants were given either yeast-derived beta-glucan with vitamins or a placebo.
The results revealed that those taking beta-glucan showed notable improvements in cognitive fatigue compared to those on the placebo. This suggests that beta-glucan could be a promising nutritional supplement for easing cognitive symptoms associated with ME/CFS.
However, more research is needed to fully understand its benefits and mechanisms.
The results revealed that those taking beta-glucan showed notable improvements in cognitive fatigue compared to those on the placebo. This suggests that beta-glucan could be a promising nutritional supplement for easing cognitive symptoms associated with ME/CFS.
However, more research is needed to fully understand its benefits and mechanisms.
7
Potential benefits of yeast supplements
We explored the impact of "Nagipol," a supplement made from beer yeasts, on chronic fatigue syndrome (CFS). Our clinical study indicated that "Nagipol" could improve the clinical status of CFS patients. It appears to help enhance cognitive functions and stabilize emotional symptoms while also normalizing certain blood parameters.
While these findings are promising, it’s important to note that further research is needed to fully confirm these benefits, especially regarding its role in diet therapy for individuals dealing with CFS.
While these findings are promising, it’s important to note that further research is needed to fully confirm these benefits, especially regarding its role in diet therapy for individuals dealing with CFS.
References
- van Campen CLM, Riepma K, Visser FC. Open Trial of Vitamin B12 Nasal Drops in Adults With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Comparison of Responders and Non-Responders. Front Pharmacol. 2019;10:1102. 10.3389/fphar.2019.01102
- Regland B, Forsmark S, Halaouate L, Matousek M, Peilot B, et al. Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia. PLoS One. 2015;10:e0124648. 10.1371/journal.pone.0124648
- Lacasa M, Alegre-Martin J, Sentañes RS, Varela-Sende L, Jurek J, et al. Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2023;15. 10.3390/nu15214504
- Dotsenko VA, Mosiĭchuk LV, Paramonov AE. [Biologically active food additives for correction of the chronic fatigue syndrome]. Vopr Pitan. 2004;73:17. PubMed
- Loder C, Allawi J, Horrobin DF. Treatment of multiple sclerosis with lofepramine, L-phenylalanine and vitamin B(12): mechanism of action and clinical importance: roles of the locus coeruleus and central noradrenergic systems. Med Hypotheses. 2002;59:594. PubMed
- Devitt NF. Chronic fatigue syndrome. JAMA. 1998;279:432. PubMed
- Regland B, Andersson M, Abrahamsson L, Bagby J, Dyrehag LE, et al. Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome. Scand J Rheumatol. 1997;26:301. PubMed
- Wiebe E. N of 1 trials. Managing patients with chronic fatigue syndrome: two case reports. Can Fam Physician. 1996;42:2214. PubMed
- Demitrack MA, Engleberg NC. Chronic fatigue syndrome. Curr Ther Endocrinol Metab. 1994;5:135. PubMed
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