Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 4 Researches
5.9
USERS' SCORE
Medium or Average
Based on 5 Reviews
6.8
Supplement Facts
Serving Size: 1 Spray (Approx. 0.41 ml)
Amount Per Serving
%DV
Vitamin B12(as Methylcobalamin from Saccharomyces cerevisiae)
500 mcg
20,833%
Certified Organic Food BlendOrganic Beet (root), Organic Carrot (root), Organic Spinach (leaf), Organic Broccoli (flower & stem), Organic Tomato (fruit), Organic Kale (leaf), Organic Cabbage (leaf), Organic Parsley (leaf), Organic Brussels Sprout (leaf), Organic Green Bell Pepper (fruit), Organic Cucumber (gourd), Organic Celery (stalk), Organic Garlic (bulb), Organic Ginger (root), Organic Onion (root), Organic Cauliflower (flower & stem), Organic Asparagus (flower & stem), Organic Strawberry (fruit), Organic Cherry (fruit), Organic Blackberry (fruit), Organic Blueberry (fruit), Organic Raspberry (fruit)
2 mg
+
Top Medical Research Studies
9.5
β-Glucan shows cardioprotective effects
We explored whether pretreatment with β-glucan, a compound from the yeast Saccharomyces cerevisiae, could shield against heart damage induced by isoprenaline in rats. Through a well-structured experiment involving control and treatment groups, we discovered that β-glucan significantly reduced heart strain by improving cardiac markers and minimizing harmful changes in heart tissue.
This suggests that β-glucan has the potential to aid in preventing damage from heart attacks. However, it’s essential to note that more research is needed to see if these promising results can translate to humans.
This suggests that β-glucan has the potential to aid in preventing damage from heart attacks. However, it’s essential to note that more research is needed to see if these promising results can translate to humans.
Read More
4
Vitamin B12 shows no heart attack benefit
In a recent study, we delved into the role of homocysteine thiolactone, a metabolite linked to heart disease, in predicting the risk of acute myocardial infarction (AMI). Conducted with a sizable group of 2049 patients suspected of having coronary artery disease (CAD), the trial was meticulously designed as a double-blind clinical intervention.
Participants were divided randomly into four distinct groups, receiving a combination of folic acid and other B vitamins or a placebo. Notably, we measured urinary levels of homocysteine thiolactone at different points throughout the study to draw correlations with heart attack incidents.
Our analysis revealed that while the homocysteine thiolactone/creatinine ratio was a significant predictor of AMI risk, there was no observable effect from the vitamin B treatments received by participants. This suggests that vitamin B12, when part of a group of B vitamins, did not independently influence the likelihood of having a heart attack.
Ultimately, we found that higher levels of homocysteine thiolactone correlated with a greater risk of AMI, but the combination of vitamin B treatments did not alter this outcome. This points to the potential of homocysteine thiolactone as an important marker in understanding cardiovascular health.
Participants were divided randomly into four distinct groups, receiving a combination of folic acid and other B vitamins or a placebo. Notably, we measured urinary levels of homocysteine thiolactone at different points throughout the study to draw correlations with heart attack incidents.
Our analysis revealed that while the homocysteine thiolactone/creatinine ratio was a significant predictor of AMI risk, there was no observable effect from the vitamin B treatments received by participants. This suggests that vitamin B12, when part of a group of B vitamins, did not independently influence the likelihood of having a heart attack.
Ultimately, we found that higher levels of homocysteine thiolactone correlated with a greater risk of AMI, but the combination of vitamin B treatments did not alter this outcome. This points to the potential of homocysteine thiolactone as an important marker in understanding cardiovascular health.
Read More
2
We explored the role of vitamin B12 in relation to heart attacks by examining the effects of a combination therapy including B-vitamins and folate in patients with coronary artery disease (CAD). In a large-scale study involving nearly 2,000 participants, the researchers monitored how these vitamins impacted fibrin clot characteristics and the risk of heart attack over several years.
Surprisingly, our findings indicated that vitamin B12 alone, as part of the combination therapy, did not significantly influence heart attack risk or outcomes. Instead, other factors like homocysteine thiolactone and plasma cysteine emerged as key players in determining clot properties and predicting adverse outcomes.
While we noted that baseline clot lysis time and maximum absorbance were associated with higher risks of acute myocardial infarction and mortality, the treatment with B-vitamins did not alter these markers significantly. Thus, the lack of efficacy from vitamin B12 in this context raises important questions about its effectiveness in preventing heart attacks when administered with other nutrients.
Surprisingly, our findings indicated that vitamin B12 alone, as part of the combination therapy, did not significantly influence heart attack risk or outcomes. Instead, other factors like homocysteine thiolactone and plasma cysteine emerged as key players in determining clot properties and predicting adverse outcomes.
While we noted that baseline clot lysis time and maximum absorbance were associated with higher risks of acute myocardial infarction and mortality, the treatment with B-vitamins did not alter these markers significantly. Thus, the lack of efficacy from vitamin B12 in this context raises important questions about its effectiveness in preventing heart attacks when administered with other nutrients.
Read More
Most Useful Reviews
0
Unsatisfactory effects
3 people found this helpful
It's difficult to identify the effect of this supplement. It has a pleasant taste and is easy to use, but I didn't feel any benefits. After a while, I began to experience heart prickling and dry palms. Upon stopping, those issues ceased. Renewing the intake led to the same heart prickling and dry palms again.
Read More
0
Caused heart palpitations
After three days of use, it caused heart palpitations, and I had to stop taking it immediately!
Read More
6
Positive heart support
11 people found this helpful
I previously bought this supplement in gelatin capsules, and it's difficult to immediately gauge the difference. I take it for heart support and find it effective. When I tried increasing the dosage, my heartbeat became erratic. I'm grateful to IHERB and the reviewers, as their insights really help in choosing supplements, given that doctors are not always knowledgeable, sadly.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 4 Researches
5.9
- All Researches
9.5
β-Glucan shows cardioprotective effects
We explored whether pretreatment with β-glucan, a compound from the yeast Saccharomyces cerevisiae, could shield against heart damage induced by isoprenaline in rats. Through a well-structured experiment involving control and treatment groups, we discovered that β-glucan significantly reduced heart strain by improving cardiac markers and minimizing harmful changes in heart tissue.
This suggests that β-glucan has the potential to aid in preventing damage from heart attacks. However, it’s essential to note that more research is needed to see if these promising results can translate to humans.
This suggests that β-glucan has the potential to aid in preventing damage from heart attacks. However, it’s essential to note that more research is needed to see if these promising results can translate to humans.
Read More
8
Trace metals may aid heart health
This study examined how trace metals like selenium yeast, chromium picolinate, and zinc sulfate can help the heart after a heart attack. We tested these metals on rats, comparing them to a control group. Results showed that selenium significantly improved heart function and reduced oxidative stress, though it didn’t address high cholesterol. Chromium helped with cholesterol levels, while zinc offered moderate support. Interestingly, combining these metals didn’t provide as much benefit as taking them individually. Overall, daily intake of these metals could be promising for heart health post heart attack.
Read More
4
Vitamin B12 shows no heart attack benefit
In a recent study, we delved into the role of homocysteine thiolactone, a metabolite linked to heart disease, in predicting the risk of acute myocardial infarction (AMI). Conducted with a sizable group of 2049 patients suspected of having coronary artery disease (CAD), the trial was meticulously designed as a double-blind clinical intervention.
Participants were divided randomly into four distinct groups, receiving a combination of folic acid and other B vitamins or a placebo. Notably, we measured urinary levels of homocysteine thiolactone at different points throughout the study to draw correlations with heart attack incidents.
Our analysis revealed that while the homocysteine thiolactone/creatinine ratio was a significant predictor of AMI risk, there was no observable effect from the vitamin B treatments received by participants. This suggests that vitamin B12, when part of a group of B vitamins, did not independently influence the likelihood of having a heart attack.
Ultimately, we found that higher levels of homocysteine thiolactone correlated with a greater risk of AMI, but the combination of vitamin B treatments did not alter this outcome. This points to the potential of homocysteine thiolactone as an important marker in understanding cardiovascular health.
Participants were divided randomly into four distinct groups, receiving a combination of folic acid and other B vitamins or a placebo. Notably, we measured urinary levels of homocysteine thiolactone at different points throughout the study to draw correlations with heart attack incidents.
Our analysis revealed that while the homocysteine thiolactone/creatinine ratio was a significant predictor of AMI risk, there was no observable effect from the vitamin B treatments received by participants. This suggests that vitamin B12, when part of a group of B vitamins, did not independently influence the likelihood of having a heart attack.
Ultimately, we found that higher levels of homocysteine thiolactone correlated with a greater risk of AMI, but the combination of vitamin B treatments did not alter this outcome. This points to the potential of homocysteine thiolactone as an important marker in understanding cardiovascular health.
Read More
2
We explored the role of vitamin B12 in relation to heart attacks by examining the effects of a combination therapy including B-vitamins and folate in patients with coronary artery disease (CAD). In a large-scale study involving nearly 2,000 participants, the researchers monitored how these vitamins impacted fibrin clot characteristics and the risk of heart attack over several years.
Surprisingly, our findings indicated that vitamin B12 alone, as part of the combination therapy, did not significantly influence heart attack risk or outcomes. Instead, other factors like homocysteine thiolactone and plasma cysteine emerged as key players in determining clot properties and predicting adverse outcomes.
While we noted that baseline clot lysis time and maximum absorbance were associated with higher risks of acute myocardial infarction and mortality, the treatment with B-vitamins did not alter these markers significantly. Thus, the lack of efficacy from vitamin B12 in this context raises important questions about its effectiveness in preventing heart attacks when administered with other nutrients.
Surprisingly, our findings indicated that vitamin B12 alone, as part of the combination therapy, did not significantly influence heart attack risk or outcomes. Instead, other factors like homocysteine thiolactone and plasma cysteine emerged as key players in determining clot properties and predicting adverse outcomes.
While we noted that baseline clot lysis time and maximum absorbance were associated with higher risks of acute myocardial infarction and mortality, the treatment with B-vitamins did not alter these markers significantly. Thus, the lack of efficacy from vitamin B12 in this context raises important questions about its effectiveness in preventing heart attacks when administered with other nutrients.
Read More
User Reviews
USERS' SCORE
Medium or Average
Based on 5 Reviews
6.8
- All Reviews
- Positive Reviews
- Negative Reviews
0
Unsatisfactory effects
3 people found this helpful
It's difficult to identify the effect of this supplement. It has a pleasant taste and is easy to use, but I didn't feel any benefits. After a while, I began to experience heart prickling and dry palms. Upon stopping, those issues ceased. Renewing the intake led to the same heart prickling and dry palms again.
Read More
0
Caused heart palpitations
After three days of use, it caused heart palpitations, and I had to stop taking it immediately!
Read More
6
Positive heart support
11 people found this helpful
I previously bought this supplement in gelatin capsules, and it's difficult to immediately gauge the difference. I take it for heart support and find it effective. When I tried increasing the dosage, my heartbeat became erratic. I'm grateful to IHERB and the reviewers, as their insights really help in choosing supplements, given that doctors are not always knowledgeable, sadly.
Read More
0
Increased heart rate
2 people found this helpful
Every time I used this, my heart rate surged significantly for about half an hour to an hour. I felt extremely anxious and it was so distressing that I stopped taking it. I can't comment on its effect overall.
Read More
7.5
Prevents heart attack
1 people found this helpful
Vitamin B12 is essential as it helps alleviate pain and prevents pernicious anaemia, heart attack, and stroke. It can assist in treating nervous disorders, anaemia, depression, hypertension, and sclerosis. The quality is excellent, the ingredients are natural, and I appreciate the attractive packaging and health benefits, especially for the price. The benefits are remarkable, and the size is convenient with a pleasant taste.
Read More
Frequently Asked Questions
0
Unsatisfactory effects
3 people found this helpful
It's difficult to identify the effect of this supplement. It has a pleasant taste and is easy to use, but I didn't feel any benefits. After a while, I began to experience heart prickling and dry palms. Upon stopping, those issues ceased. Renewing the intake led to the same heart prickling and dry palms again.
6
Positive heart support
11 people found this helpful
I previously bought this supplement in gelatin capsules, and it's difficult to immediately gauge the difference. I take it for heart support and find it effective. When I tried increasing the dosage, my heartbeat became erratic. I'm grateful to IHERB and the reviewers, as their insights really help in choosing supplements, given that doctors are not always knowledgeable, sadly.
7.5
Prevents heart attack
1 people found this helpful
Vitamin B12 is essential as it helps alleviate pain and prevents pernicious anaemia, heart attack, and stroke. It can assist in treating nervous disorders, anaemia, depression, hypertension, and sclerosis. The quality is excellent, the ingredients are natural, and I appreciate the attractive packaging and health benefits, especially for the price. The benefits are remarkable, and the size is convenient with a pleasant taste.
0
Increased heart rate
2 people found this helpful
Every time I used this, my heart rate surged significantly for about half an hour to an hour. I felt extremely anxious and it was so distressing that I stopped taking it. I can't comment on its effect overall.
9.5
β-Glucan shows cardioprotective effects
We explored whether pretreatment with β-glucan, a compound from the yeast Saccharomyces cerevisiae, could shield against heart damage induced by isoprenaline in rats. Through a well-structured experiment involving control and treatment groups, we discovered that β-glucan significantly reduced heart strain by improving cardiac markers and minimizing harmful changes in heart tissue.
This suggests that β-glucan has the potential to aid in preventing damage from heart attacks. However, it’s essential to note that more research is needed to see if these promising results can translate to humans.
This suggests that β-glucan has the potential to aid in preventing damage from heart attacks. However, it’s essential to note that more research is needed to see if these promising results can translate to humans.
8
Trace metals may aid heart health
This study examined how trace metals like selenium yeast, chromium picolinate, and zinc sulfate can help the heart after a heart attack. We tested these metals on rats, comparing them to a control group. Results showed that selenium significantly improved heart function and reduced oxidative stress, though it didn’t address high cholesterol. Chromium helped with cholesterol levels, while zinc offered moderate support. Interestingly, combining these metals didn’t provide as much benefit as taking them individually. Overall, daily intake of these metals could be promising for heart health post heart attack.
2
We explored the role of vitamin B12 in relation to heart attacks by examining the effects of a combination therapy including B-vitamins and folate in patients with coronary artery disease (CAD). In a large-scale study involving nearly 2,000 participants, the researchers monitored how these vitamins impacted fibrin clot characteristics and the risk of heart attack over several years.
Surprisingly, our findings indicated that vitamin B12 alone, as part of the combination therapy, did not significantly influence heart attack risk or outcomes. Instead, other factors like homocysteine thiolactone and plasma cysteine emerged as key players in determining clot properties and predicting adverse outcomes.
While we noted that baseline clot lysis time and maximum absorbance were associated with higher risks of acute myocardial infarction and mortality, the treatment with B-vitamins did not alter these markers significantly. Thus, the lack of efficacy from vitamin B12 in this context raises important questions about its effectiveness in preventing heart attacks when administered with other nutrients.
Surprisingly, our findings indicated that vitamin B12 alone, as part of the combination therapy, did not significantly influence heart attack risk or outcomes. Instead, other factors like homocysteine thiolactone and plasma cysteine emerged as key players in determining clot properties and predicting adverse outcomes.
While we noted that baseline clot lysis time and maximum absorbance were associated with higher risks of acute myocardial infarction and mortality, the treatment with B-vitamins did not alter these markers significantly. Thus, the lack of efficacy from vitamin B12 in this context raises important questions about its effectiveness in preventing heart attacks when administered with other nutrients.
4
Vitamin B12 shows no heart attack benefit
In a recent study, we delved into the role of homocysteine thiolactone, a metabolite linked to heart disease, in predicting the risk of acute myocardial infarction (AMI). Conducted with a sizable group of 2049 patients suspected of having coronary artery disease (CAD), the trial was meticulously designed as a double-blind clinical intervention.
Participants were divided randomly into four distinct groups, receiving a combination of folic acid and other B vitamins or a placebo. Notably, we measured urinary levels of homocysteine thiolactone at different points throughout the study to draw correlations with heart attack incidents.
Our analysis revealed that while the homocysteine thiolactone/creatinine ratio was a significant predictor of AMI risk, there was no observable effect from the vitamin B treatments received by participants. This suggests that vitamin B12, when part of a group of B vitamins, did not independently influence the likelihood of having a heart attack.
Ultimately, we found that higher levels of homocysteine thiolactone correlated with a greater risk of AMI, but the combination of vitamin B treatments did not alter this outcome. This points to the potential of homocysteine thiolactone as an important marker in understanding cardiovascular health.
Participants were divided randomly into four distinct groups, receiving a combination of folic acid and other B vitamins or a placebo. Notably, we measured urinary levels of homocysteine thiolactone at different points throughout the study to draw correlations with heart attack incidents.
Our analysis revealed that while the homocysteine thiolactone/creatinine ratio was a significant predictor of AMI risk, there was no observable effect from the vitamin B treatments received by participants. This suggests that vitamin B12, when part of a group of B vitamins, did not independently influence the likelihood of having a heart attack.
Ultimately, we found that higher levels of homocysteine thiolactone correlated with a greater risk of AMI, but the combination of vitamin B treatments did not alter this outcome. This points to the potential of homocysteine thiolactone as an important marker in understanding cardiovascular health.
References
- Çetin E. Pretreatment with β-glucan attenuates isoprenaline-induced myocardial injury in rats. Exp Physiol. 2019;104:505. 10.1113/EP086739
- Al-Rasheed NM, Attia HA, Mohamed RA, Al-Rasheed NM, Al-Amin MA. Preventive effects of selenium yeast, chromium picolinate, zinc sulfate and their combination on oxidative stress, inflammation, impaired angiogenesis and atherogenesis in myocardial infarction in rats. J Pharm Pharm Sci. 2013;16:848.
- Sikora M, Skrzydlewski P, Perła-Kaján J, Jakubowski H. Homocysteine thiolactone contributes to the prognostic value of fibrin clot structure/function in coronary artery disease. PLoS One. 2022;17:e0275956. 10.1371/journal.pone.0275956
- Borowczyk K, Piechocka J, Głowacki R, Dhar I, Midtun Ø, et al. Urinary excretion of homocysteine thiolactone and the risk of acute myocardial infarction in coronary artery disease patients: the WENBIT trial. J Intern Med. 2019;285:232. 10.1111/joim.12834
