Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 10 Researches
6.2
USERS' SCORE
Moderately Good
Based on 5 Reviews
7.5
Supplement Facts
Serving Size: 1 Spray (Approx. 0.41 ml)
Amount Per Serving
%DV
Vitamin B12(as Methylcobalamin from Saccharomyces cerevisiae)
500 mcg
20,833%
Certified Organic Food BlendOrganic Beet (root), Organic Carrot (root), Organic Spinach (leaf), Organic Broccoli (flower & stem), Organic Tomato (fruit), Organic Kale (leaf), Organic Cabbage (leaf), Organic Parsley (leaf), Organic Brussels Sprout (leaf), Organic Green Bell Pepper (fruit), Organic Cucumber (gourd), Organic Celery (stalk), Organic Garlic (bulb), Organic Ginger (root), Organic Onion (root), Organic Cauliflower (flower & stem), Organic Asparagus (flower & stem), Organic Strawberry (fruit), Organic Cherry (fruit), Organic Blackberry (fruit), Organic Blueberry (fruit), Organic Raspberry (fruit)
2 mg
+
Top Medical Research Studies
8
We explored the potential of high doses of vitamin B12 to protect against heart damage caused by ischemia/reperfusion injury. By researching mice subjected to heart injury, we found that vitamin B12 showed promising effects in reducing oxidative stress and improving heart function.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
Read More
8
We investigated how a mixture of vitamins B6, B9, and B12 (VITB) affects heart health in mice with Marfan syndrome. Over 20 weeks, VITB treatment led to reduced heart rate and smaller aorta size in these mice. Notably, VITB helped restore important gene expressions and improved TGF-β signaling, which is crucial for collagen maturation in the aorta. While this study shows promise for VITB in managing heart disease related to Marfan syndrome, further research is needed to confirm its efficacy in humans.
Read More
7
Vitamin B12 may lower inflammation
We examined how vitamin B12 levels relate to heart disease risk by looking at inflammatory markers in 136 individuals at high risk. Our findings revealed that those with higher vitamin B12 had lower levels of IL-6 and CRP, both linked to inflammation.
To further validate our results, we studied aged mice and found similar trends. While these observations suggest vitamin B12 might help reduce inflammation, we indicate that further research is needed to fully understand its role in heart disease.
To further validate our results, we studied aged mice and found similar trends. While these observations suggest vitamin B12 might help reduce inflammation, we indicate that further research is needed to fully understand its role in heart disease.
Read More
Most Useful Reviews
0
Not effective
3 people found this helpful
I found it difficult to identify any effect. While it was tasty and easy to use, I did not feel the benefits. However, I began to experience heart prickling and dry palms after continued use. Upon stopping, these issues ceased, but they returned when I resumed the supplement.
Read More
0
Caused palpitations
After three days of use, I experienced heart palpitations and stopped taking it immediately!
Read More
9
Positive heart effects
3 people found this helpful
I chose this natural vitamin because of its pleasant raspberry taste. Taking it once a day under the tongue has positively affected my heart muscles, thyroid glands, immunity, and blood pressure, while providing antiallergenic, antitoxic, and antitumour benefits. Despite B12 being poorly absorbed, this form worked well for me, alleviating muscle aches and pains.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 10 Researches
6.2
- All Researches
8
We explored the potential of high doses of vitamin B12 to protect against heart damage caused by ischemia/reperfusion injury. By researching mice subjected to heart injury, we found that vitamin B12 showed promising effects in reducing oxidative stress and improving heart function.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
Read More
8
We investigated how cow’s milk intake influences the risk of coronary heart disease (CHD) in postmenopausal women. Analyzing data from the Korea National Health and Nutrition Examination Survey, we included 1,825 women aged 50–64.
Our findings indicated that those consuming cow’s milk more frequently (more than three times a week) had better levels of HDL cholesterol and lower CHD risk factors compared to those who did not consume milk.
This suggests that regular cow’s milk consumption could be beneficial for heart health in this group.
Our findings indicated that those consuming cow’s milk more frequently (more than three times a week) had better levels of HDL cholesterol and lower CHD risk factors compared to those who did not consume milk.
This suggests that regular cow’s milk consumption could be beneficial for heart health in this group.
Read More
8
We investigated how a mixture of vitamins B6, B9, and B12 (VITB) affects heart health in mice with Marfan syndrome. Over 20 weeks, VITB treatment led to reduced heart rate and smaller aorta size in these mice. Notably, VITB helped restore important gene expressions and improved TGF-β signaling, which is crucial for collagen maturation in the aorta. While this study shows promise for VITB in managing heart disease related to Marfan syndrome, further research is needed to confirm its efficacy in humans.
Read More
7
Vitamin B12 may lower inflammation
We examined how vitamin B12 levels relate to heart disease risk by looking at inflammatory markers in 136 individuals at high risk. Our findings revealed that those with higher vitamin B12 had lower levels of IL-6 and CRP, both linked to inflammation.
To further validate our results, we studied aged mice and found similar trends. While these observations suggest vitamin B12 might help reduce inflammation, we indicate that further research is needed to fully understand its role in heart disease.
To further validate our results, we studied aged mice and found similar trends. While these observations suggest vitamin B12 might help reduce inflammation, we indicate that further research is needed to fully understand its role in heart disease.
Read More
7
B-vitamins reduce mortality risk
We explored how using calcium channel blockers (CCBs) affects survival in patients with suspected stable angina and the potential role of B-vitamin treatment. A study with nearly 4,000 patients found that those who used CCBs without receiving B-vitamins had a higher mortality risk.
Conversely, patients treated with B-vitamins showed no significant increase in mortality rates related to CCB use. This suggests that B-vitamins may offer protective benefits for heart health, particularly for those on CCBs.
Conversely, patients treated with B-vitamins showed no significant increase in mortality rates related to CCB use. This suggests that B-vitamins may offer protective benefits for heart health, particularly for those on CCBs.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 5 Reviews
7.5
- All Reviews
- Positive Reviews
- Negative Reviews
0
Not effective
3 people found this helpful
I found it difficult to identify any effect. While it was tasty and easy to use, I did not feel the benefits. However, I began to experience heart prickling and dry palms after continued use. Upon stopping, these issues ceased, but they returned when I resumed the supplement.
Read More
0
Caused palpitations
After three days of use, I experienced heart palpitations and stopped taking it immediately!
Read More
9
Positive heart effects
3 people found this helpful
I chose this natural vitamin because of its pleasant raspberry taste. Taking it once a day under the tongue has positively affected my heart muscles, thyroid glands, immunity, and blood pressure, while providing antiallergenic, antitoxic, and antitumour benefits. Despite B12 being poorly absorbed, this form worked well for me, alleviating muscle aches and pains.
Read More
7.5
Supports heart health
19 people found this helpful
An excellent vitamin B12 for vegans. It helps keep homocysteine levels low, protecting against heart disease. B12 plays a vital role in the nervous system, aiding in the regeneration of myelin sheaths. This isolation of our nerves is crucial for touch and motor function, making it irreplaceable for our central nervous system. Additionally, it aids in synthesising neurotransmitters and hormones, impacting our mood and perception.
Read More
5
Boosts heart mood
Spray B12 is so convenient! One spray a day boosts my energy and supports my heart, bones, and mood. It makes taking B12 easy and effective in addressing heart disease.
Read More
Frequently Asked Questions
0
Caused palpitations
After three days of use, I experienced heart palpitations and stopped taking it immediately!
9
Positive heart effects
3 people found this helpful
I chose this natural vitamin because of its pleasant raspberry taste. Taking it once a day under the tongue has positively affected my heart muscles, thyroid glands, immunity, and blood pressure, while providing antiallergenic, antitoxic, and antitumour benefits. Despite B12 being poorly absorbed, this form worked well for me, alleviating muscle aches and pains.
5
Boosts heart mood
Spray B12 is so convenient! One spray a day boosts my energy and supports my heart, bones, and mood. It makes taking B12 easy and effective in addressing heart disease.
0
Not effective
3 people found this helpful
I found it difficult to identify any effect. While it was tasty and easy to use, I did not feel the benefits. However, I began to experience heart prickling and dry palms after continued use. Upon stopping, these issues ceased, but they returned when I resumed the supplement.
7.5
Supports heart health
19 people found this helpful
An excellent vitamin B12 for vegans. It helps keep homocysteine levels low, protecting against heart disease. B12 plays a vital role in the nervous system, aiding in the regeneration of myelin sheaths. This isolation of our nerves is crucial for touch and motor function, making it irreplaceable for our central nervous system. Additionally, it aids in synthesising neurotransmitters and hormones, impacting our mood and perception.
7
Vitamin B12 may lower inflammation
We examined how vitamin B12 levels relate to heart disease risk by looking at inflammatory markers in 136 individuals at high risk. Our findings revealed that those with higher vitamin B12 had lower levels of IL-6 and CRP, both linked to inflammation.
To further validate our results, we studied aged mice and found similar trends. While these observations suggest vitamin B12 might help reduce inflammation, we indicate that further research is needed to fully understand its role in heart disease.
To further validate our results, we studied aged mice and found similar trends. While these observations suggest vitamin B12 might help reduce inflammation, we indicate that further research is needed to fully understand its role in heart disease.
8
We explored the potential of high doses of vitamin B12 to protect against heart damage caused by ischemia/reperfusion injury. By researching mice subjected to heart injury, we found that vitamin B12 showed promising effects in reducing oxidative stress and improving heart function.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
4
Trace elements influence heart disease
We aimed to uncover how trace elements affect our hearts. Utilizing advanced genetic analysis methods, we found both positive and negative connections between certain trace elements and cardiovascular disease.
Notably, vitamin B12 appeared to increase the risk of coronary artery disease and cardiovascular death, whereas potassium may lower the risk of ischemic heart disease. This means that not all trace elements are beneficial for heart health. Our findings help clarify the complex relationships between these elements and cardiovascular conditions.
Notably, vitamin B12 appeared to increase the risk of coronary artery disease and cardiovascular death, whereas potassium may lower the risk of ischemic heart disease. This means that not all trace elements are beneficial for heart health. Our findings help clarify the complex relationships between these elements and cardiovascular conditions.
References
- Chen B, Wang C, Li W. Genetic insights into the effect of trace elements on cardiovascular diseases: multi-omics Mendelian randomization combined with linkage disequilibrium score regression analysis. Front Immunol. 2024;15:1459465. 10.3389/fimmu.2024.1459465
- Domínguez-López I, Kovatcheva M, Casas R, Toledo E, Fitó M, et al. Higher circulating vitamin B12 is associated with lower levels of inflammatory markers in individuals at high cardiovascular risk and in naturally aged mice. J Sci Food Agric. 2024;104:875. 10.1002/jsfa.12976
- Qin Y, Shi Y, Yu Q, Yang S, Wang Y, et al. Vitamin B12 alleviates myocardial ischemia/reperfusion injury via the SIRT3/AMPK signaling pathway. Biomed Pharmacother. 2023;163:114761. 10.1016/j.biopha.2023.114761
- Dhar I, Svingen GF, Bjørnestad EØ, Ulvik A, Saeed S, et al. B-vitamin Treatment Modifies the Mortality Risk Associated with Calcium Channel Blockers in Patients with Suspected Stable Angina Pectoris: A Prospective Cohort Study. Am J Clin Nutr. 2023;118:77. 10.1016/j.ajcnut.2023.04.033
- Ha AW, Kim WK, Kim SH. Cow's Milk Intake and Risk of Coronary Heart Disease in Korean Postmenopausal Women. Nutrients. 2022;14. 10.3390/nu14051092
- Liu Y, Geng T, Wan Z, Lu Q, Zhang X, et al. Associations of Serum Folate and Vitamin B12 Levels With Cardiovascular Disease Mortality Among Patients With Type 2 Diabetes. JAMA Netw Open. 2022;5:e2146124. 10.1001/jamanetworkopen.2021.46124
- Huang TH, Chang HH, Guo YR, Chang WC, Chen YF. Vitamin B Mitigates Thoracic Aortic Dilation in Marfan Syndrome Mice by Restoring the Canonical TGF-β Pathway. Int J Mol Sci. 2021;22. 10.3390/ijms222111737
- Aggarwal P, Sinha SK, Khanra D, Razi M, Nath RK, et al. Hematinic deficiency in patients with heart failure with reduced ejection fraction (HFrEF). Ann Cardiol Angeiol (Paris). 2022;71:153. 10.1016/j.ancard.2021.09.014
- Hjalmarsson C, Backelin C, Thoren A, Bergh N, Sloan JL, et al. Severe heart failure in a unique case of cobalamin-C-deficiency resolved with LVAD implantation and subsequent heart transplantation. Mol Genet Metab Rep. 2024;39:101089. 10.1016/j.ymgmr.2024.101089
- Mohan A, Kumar R, Kumar V, Yadav M. Homocysteine, Vitamin B12 and Folate Level: Possible Risk Factors in the Progression of Chronic Heart and Kidney Disorders. Curr Cardiol Rev. 2023;19:e090223213539. 10.2174/1573403X19666230209111854
