We explored how Bifidobacterium bifidum TMC3115 could help infants with cow's milk protein allergy (CMPA). In our controlled trial with 256 infants, half received B. bifidum while the other half received a placebo.
Over six months, we observed significant reductions in allergic scores and improvements in anti-inflammatory responses among those taking B. bifidum. We also found changes in gut microbiota, increasing beneficial bacteria and decreasing potentially harmful ones.
Though promising, these interventions indicate that managing CMPA may benefit from focusing on gut health.
Read More
7
Lactobacillus salivarius lowers allergy symptoms
Effect of probiotics on allergic rhinitis in Df, Dp or dust-sensitive children: a randomized double blind controlled trial.
We explored the impact of Lactobacillus salivarius on allergic rhinitis symptoms in children through a double-blind, randomized controlled trial. Over 12 weeks, children either received the probiotic or a placebo.
Results showed a decrease in rhinitis symptoms and medication usage in those treated with the probiotic. However, there were no significant changes in immunological or blood cell measures when comparing the two groups.
Overall, Lactobacillus salivarius may be beneficial for reducing symptoms of allergic rhinitis in children.
Read More
9
Lactobacillus KBL409 reduces atopic dermatitis
Lactobacillus acidophilus KBL409 Ameliorates Atopic Dermatitis in a Mouse Model.
We explored the effects of Lactobacillus acidophilus KBL409 on atopic dermatitis (AD) using a house dust mite-induced mouse model. The treatment notably lowered dermatitis symptoms and reduced immune cell infiltration in the skin. Additionally, it decreased levels of specific immune markers and increased anti-inflammatory responses.
L. acidophilus KBL409 also positively influenced gut microbiota and certain metabolites. The findings suggest that this probiotic may offer a promising approach to managing AD through immune system modulation and gut health improvement.
Read More
Most Useful Reviews
9
No colic or allergies
2 people found this helpful
I began taking these probiotics to minimise the risk of lactostasis whilst breastfeeding. They suit me well, especially since my stomach is sensitive. Notably, I've observed that my child has had no allergies or colic occurrences — thank goodness!
Read More
9
Avoided allergy signs
1 people found this helpful
Perfect for pregnancy and breastfeeding, these high-quality probiotics are free from harmful ingredients. They contain scientifically-backed probiotic strains beneficial for pregnancy and breastfeeding. I consumed them during my pregnancy and breastfeeding to prevent allergies in my second child (my first had a milk protein allergy), and it seems to have worked as he shows no signs of allergies so far. The small capsules have a neutral flavour, making them ideal.
Read More
7.5
No allergies noted
1 people found this helpful
Great, very good! I took probiotics during both of my pregnancies and experienced no bloating or abdominal pain. I believe my daughters are free from allergies and rashes thanks to this product, even though they are a bit pricey — £9 for five cans per month.
We sought to understand if Bifiform Kids, a probiotic, could help prevent respiratory infections in children with recurrent infections and gastrointestinal allergy symptoms. In our controlled trial with 92 children aged 4 to 5, those taking the probiotic showed a significant 3-fold reduction in respiratory infections compared to the control group.
After 21 days, there were notable immune system improvements, including an increase in protective IgA levels and a decrease in allergic IgE. These findings suggest that Bifiform Kids is effective for preventing respiratory infections in children facing allergic issues.
Read More
9
Lactobacillus KBL409 reduces atopic dermatitis
Lactobacillus acidophilus KBL409 Ameliorates Atopic Dermatitis in a Mouse Model.
We explored the effects of Lactobacillus acidophilus KBL409 on atopic dermatitis (AD) using a house dust mite-induced mouse model. The treatment notably lowered dermatitis symptoms and reduced immune cell infiltration in the skin. Additionally, it decreased levels of specific immune markers and increased anti-inflammatory responses.
L. acidophilus KBL409 also positively influenced gut microbiota and certain metabolites. The findings suggest that this probiotic may offer a promising approach to managing AD through immune system modulation and gut health improvement.
Read More
9
Lactobacillus Acidophilus shows promise
The Effect of Lactobacillus actobacillus Peptidoglycan on Bovine β-Lactoglobulin-Sensitized Mice via TLR2/NF-κB Pathway.
We investigated the effects of Lactobacillus acidophilus on allergies, particularly its peptidoglycan derived from dairy. In a mouse model of β-lactoglobulin allergy, we discovered that this peptidoglycan helped lower IgE production and promoted a healthier immune response. It also appeared to influence specific immune signaling pathways that help manage allergic reactions.
However, while the results showed promise, they were conducted in a controlled lab setting and further studies are needed to understand how these effects translate to humans.
Read More
9
Lactobacillus L-92 shows promise
Efficacy of prolonged ingestion of Lactobacillus acidophilus L-92 in adult patients with atopic dermatitis.
We conducted a thorough investigation to see how Lactobacillus acidophilus L-92 affects skin symptoms in adults with atopic dermatitis. In this double-blind study involving 50 participants, we compared this probiotic against a placebo over 24 weeks.
Our findings showed that those taking L-92 experienced significant improvements in skin condition compared to the placebo group. There were reductions in symptoms and overall severity, with no adverse effects reported. This suggests that L-92 may help manage inflammation linked to allergies.
Read More
9
Lactobacillus acidophilus may reduce allergies
Probiotic Dahi containing Lactobacillus acidophilus and Bifidobacterium bifidum modulates immunoglobulin levels and cytokines expression in whey proteins sensitised mice.
Our study assessed how Lactobacillus acidophilus in probiotic Dahi affects allergies, particularly cow milk allergy in mice. Mice were given two types of probiotic Dahi before being exposed to whey proteins.
The results were promising; we found that the probiotic treatment reduced allergy-related immune responses. Specifically, it lowered certain IgE levels and shifted the immune response from a Th2-type to a Th1-type, which is generally more protective against allergens.
While further research is needed, these findings suggest that probiotics could be a potential avenue for managing food allergies.
I began taking these probiotics to minimise the risk of lactostasis whilst breastfeeding. They suit me well, especially since my stomach is sensitive. Notably, I've observed that my child has had no allergies or colic occurrences — thank goodness!
Read More
9
Avoided allergy signs
1 people found this helpful
Perfect for pregnancy and breastfeeding, these high-quality probiotics are free from harmful ingredients. They contain scientifically-backed probiotic strains beneficial for pregnancy and breastfeeding. I consumed them during my pregnancy and breastfeeding to prevent allergies in my second child (my first had a milk protein allergy), and it seems to have worked as he shows no signs of allergies so far. The small capsules have a neutral flavour, making them ideal.
Read More
7.5
No allergies noted
1 people found this helpful
Great, very good! I took probiotics during both of my pregnancies and experienced no bloating or abdominal pain. I believe my daughters are free from allergies and rashes thanks to this product, even though they are a bit pricey — £9 for five cans per month.
Read More
9
Healthy pregnancy
I had these during pregnancy. So far, I've been taking them weekly and my baby is healthy with no allergies.
Read More
7.5
Reduces baby allergies
Easy to swallow and feels good, these probiotics can significantly reduce allergies in babies.
Allergies are the body's immune system responses to substances known as allergens, which can be harmless in most individuals. When a person with allergies encounters these allergens, their immune system mistakenly identifies them as a threat and launches a response. This can lead to symptoms ranging from mild, such as sneezing, itching, and rashes, to severe reactions known as anaphylaxis, which can be life-threatening. Common allergens include pollen, pet dander, certain foods like nuts and shellfish, insect stings, and medications.
Managing allergies often involves avoiding known allergens and using medications such as antihistamines or corticosteroids to alleviate symptoms. In some cases, doctors might recommend allergy shots or immunotherapy to help patients build tolerance over time. If you suspect you have allergies, consulting with a healthcare professional for proper diagnosis and treatment options is crucial. Understanding your triggers and how to live with allergies can significantly improve your quality of life.
Pre and post-natal formulas are specialized dietary supplements designed to support the nutritional needs of women during pregnancy and postpartum recovery. Pre-natal formulas typically include a combination of essential vitamins and minerals, such as folic acid, iron, and calcium, to promote the health of both mother and developing baby. These nutrients are crucial for fetal development, reducing the risk of complications, and supporting the overall well-being of expectant mothers.
Post-natal formulas, on the other hand, focus on replenishing nutrients that may have been depleted during pregnancy and childbirth and enhancing recovery after delivery. They often contain additional nutrients to support breastfeeding, such as DHA and omega-3 fatty acids, which are important for infant brain development. Both types of formulas aim to ensure that mothers have the necessary nutrients for their health and their babies' development, making them an essential part of pre and post-natal care.
When taking pre or post-natal formulas specifically designed to address allergies, the timeline for seeing results can vary significantly from person to person. Generally, most users report noticing improvements in their symptoms within a few days to a couple of weeks. This timeframe can depend on various factors, including the severity of your allergies, the specific ingredients in the formula, and your body's individual response to the supplements. It’s essential to give your body time to adjust to any new regimen while remaining consistent with your intake.
However, if you don’t see any noticeable changes after a couple of weeks, it might be worth reevaluating your choice of supplement or consulting with a healthcare professional. They can help ensure that the formula you’re using is appropriate for your specific needs and potentially recommend additional or alternative treatments. Remember that while dietary supplements can play a role in managing allergies, they are most effective when used as part of a comprehensive approach that may include avoiding allergens and other lifestyle modifications.
Scientific research indicates that various probiotic supplements, particularly those containing Lactobacillus acidophilus and Bifidobacterium species, may be beneficial in managing certain types of allergies. For instance, studies have demonstrated that Lactobacillus acidophilus, when administered in mice, can reduce allergic inflammation by affecting immune pathways associated with allergies, such as the TLR4/NF-κB signaling pathway [3]. Additionally, a combination of probiotics and prebiotics showed significant improvements in symptoms associated with birch pollen allergies among participants exposed to allergens in a controlled setting, supporting the notion that these supplements may alleviate allergic rhinitis [4].
However, the effectiveness of probiotics can vary significantly by strain and individual responses. While some studies report positive results, like reduced incidence of eczema and improved allergic symptoms in children [78], others suggest that further investigation is needed to determine optimal dosages and treatment durations, as well as the mechanisms behind these effects [2]. Consequently, while there is promising evidence that probiotics could support allergy management, it is essential to approach supplementation with caution and consider consulting healthcare professionals for personalized advice.
Based on user reviews, many individuals taking these probiotics have reported significant improvements in symptoms related to allergies and digestive concerns during pregnancy and breastfeeding. Users frequently mention that they experienced no bloating or abdominal pain while using these products, contributing to an overall sense of well-being Read Review. Additionally, several parents have expressed relief at observing their children showing no signs of allergies or colic, attributing these positive outcomes to the probiotics (review id='f1ce0a5e-efbb-46b5-870a-84d61d9490cc', review id='65af68f8-37bd-4836-8ddf-8ae724a5331e').
Moreover, users noted that taking probiotics during pregnancy may not only reduce the likelihood of allergies in their babies but also may assist in preventing conditions such as eczema Read Review. The anecdotal evidence suggests that while individual results can vary, many users find these probiotics beneficial in promoting both their own gut health and the allergy-preventive health of their children Read Review. Overall, these probiotics have been positively received by users looking to enhance their and their child's health during the crucial phases of pregnancy and early childhood.
Based on user reviews, many individuals have successfully combined these probiotics with other supplements to manage allergies, particularly during pregnancy and breastfeeding. Users frequently mention the effectiveness of these probiotics in reducing the risk of allergies in their infants. One user noted that after consuming the probiotics during pregnancy, their child exhibited no signs of allergies, which they attributed to the supplement Read Review. Another user observed similar benefits, claiming that these probiotics helped in preventing conditions like eczema in their child Read Review.
Additionally, many users highlighted that taking these probiotics seemed to enhance the overall efficacy of their allergy management strategies. Some cited a direct positive correlation, stating that these probiotics significantly contributed to healthier outcomes for their babies when taken alongside regular prenatal care or other nutritional supplements (review id='c7d2dbf3-a301-4227-b976-e41e8b16ca44', review id='6b740f01-abc3-45a2-a34a-48fb4eb93d65'). Overall, these user experiences indicate that combining these probiotics with other supplements can provide notable benefits in managing allergies.
Users report a consistent belief that probiotics taken during pregnancy and breastfeeding may help prevent allergies in infants. Many reviewers indicate they experienced positive outcomes, suggesting that the right dosage, while not explicitly detailed, is effective when the probiotics are consumed regularly throughout pregnancy and breastfeeding. For instance, one user noted that after taking probiotics during her pregnancy, her child showed no signs of allergies or colic occurrences Read Review. Similarly, another user highlighted the preventive nature of these probiotics, stating they took them during both pregnancies and saw their daughters remain free from allergies and rashes Read Review.
Overall, while specific dosages are not provided in the reviews, the common theme is that users found success with consistent usage of probiotics, often on a daily basis during pregnancy Read Review. This suggests that users advocate for a regular intake as a preventative measure against potential allergies in their infants, noting beneficial outcomes in their children’s health Read Review.
7.5
No allergies noted
1 people found this helpful
Great, very good! I took probiotics during both of my pregnancies and experienced no bloating or abdominal pain. I believe my daughters are free from allergies and rashes thanks to this product, even though they are a bit pricey — £9 for five cans per month.
7.5
Avoided eczema
Probiotics helped me avoid having a child with eczema. Research indicates that prebiotics can help reduce allergies in newborns.
7.5
Helps prevent allergies
1 people found this helpful
Taking probiotics during pregnancy may assist in preventing allergies in the baby.
9
Avoided allergy signs
1 people found this helpful
Perfect for pregnancy and breastfeeding, these high-quality probiotics are free from harmful ingredients. They contain scientifically-backed probiotic strains beneficial for pregnancy and breastfeeding. I consumed them during my pregnancy and breastfeeding to prevent allergies in my second child (my first had a milk protein allergy), and it seems to have worked as he shows no signs of allergies so far. The small capsules have a neutral flavour, making them ideal.
9
No colic or allergies
2 people found this helpful
I began taking these probiotics to minimise the risk of lactostasis whilst breastfeeding. They suit me well, especially since my stomach is sensitive. Notably, I've observed that my child has had no allergies or colic occurrences — thank goodness!
6
Hope to reduce allergies
I take these every day during pregnancy, hoping they will reduce my baby's allergies.
8
L. acidophilus impacts allergy inflammation
Lactobacillus acidophilus KLDS 1.0738 inhibits TLR4/NF-κB inflammatory pathway in β-lactoglobulin-induced macrophages via modulating miR-146a.
We investigated the potential of Lactobacillus acidophilus KLDS 1.0738 to alleviate allergic inflammation, focusing on its ability to influence a specific inflammatory pathway in macrophages. By treating β-lactoglobulin-induced macrophages with viable L. acidophilus, we found that it effectively reduced inflammation by inhibiting the TLR4/NF-κB signaling pathway. This strain outperformed other probiotics in its effectiveness. Additionally, it was linked to increased levels of miR-146a, a molecule that regulates inflammation. These findings suggest that probiotics could play a significant role in managing milk allergies, particularly in infants.
8
Probiotic supplement alleviates allergy symptoms
First evaluation of a symbiotic food supplement in an allergen exposure chamber in birch pollen allergic patients.
We investigated the use of a symbiotic food supplement, combining probiotics and prebiotics, in combatting birch pollen allergies. Conducted in a controlled allergen exposure chamber, our research monitored patients' symptoms over four months.
The results showed noticeable improvements in allergy symptoms and overall well-being after regular use of the supplement. This suggests such supplements can be a helpful addition to managing allergic rhinitis, with a strong safety record.
8
Probiotics reduce eczema incidence
Probiotics in late infancy reduce the incidence of eczema: A randomized controlled trial.
We conducted a double-blind, placebo-controlled trial to explore the effects of a combination of probiotics—specifically Lactobacillus rhamnosus and Bifidobacterium animalis subsp lactis—on allergies in infants.
After six months of treatment, we found that the incidence of eczema was significantly lower in the probiotic group (4.2%) compared to the placebo group (11.5%).
However, there were no differences in the rates of asthma, rhinitis, or conjunctivitis between the two groups. This highlights the specific benefit of probiotics in reducing eczema during late infancy.
8
Probiotics may help with dermatitis
Effects of probiotic supplementation in adult with atopic dermatitis: a systematic review with meta-analysis.
We aimed to assess how probiotic supplementation, particularly using Lactobacillus acidophilus, can help treat adult atopic dermatitis (AD). After analyzing nine studies, we found that specific probiotics, including L. acidophilus, provided some benefits, especially for those with moderate to severe AD.
However, changes in skin severity did not significantly improve patients’ quality of life. Importantly, the effectiveness of probiotics varied by strain, and there are still many unknowns about the best dosage and treatment duration.
References
Kim WK, Jang YJ, Park S, Min SG, Kwon H, et al. Lactobacillus acidophilus KBL409 Ameliorates Atopic Dermatitis in a Mouse Model. J Microbiol. 2024;62:91. 10.1007/s12275-024-00104-5
Husein-ElAhmed H, Steinhoff M. Effects of probiotic supplementation in adult with atopic dermatitis: a systematic review with meta-analysis. Clin Exp Dermatol. 2023;49:46. 10.1093/ced/llad318
Li A, Yang J, Zhang C, Chi H, Zhang C, et al. Lactobacillus acidophilus KLDS 1.0738 inhibits TLR4/NF-κB inflammatory pathway in β-lactoglobulin-induced macrophages via modulating miR-146a. J Food Biochem. 2021;45:e13662. 10.1111/jfbc.13662
Bergmann KC, Krause L, Hiller J, Becker S, Kugler S, et al. First evaluation of a symbiotic food supplement in an allergen exposure chamber in birch pollen allergic patients. World Allergy Organ J. 2021;14:100494. 10.1016/j.waojou.2020.100494
Tan-Lim CSC, Esteban-Ipac NAR, Mantaring JBV, Chan Shih Yen E, Recto MST, et al. Comparative effectiveness of probiotic strains for the treatment of pediatric atopic dermatitis: A systematic review and network meta-analysis. Pediatr Allergy Immunol. 2021;32:124. 10.1111/pai.13305
Ni WW, Zhang QM, Zhang X, Li Y, Yu SS, et al. Modulation effect of Lactobacillus acidophilus KLDS 1.0738 on gut microbiota and TLR4 expression in β-lactoglobulin-induced allergic mice model. Allergol Immunopathol (Madr). 2020;48:149. 10.1016/j.aller.2019.06.002
Wang JJ, Zhang QM, Ni WW, Zhang X, Li Y, et al. Modulatory effect of Lactobacillus acidophilus KLDS 1.0738 on intestinal short-chain fatty acids metabolism and GPR41/43 expression in β-lactoglobulin-sensitized mice. Microbiol Immunol. 2019;63:303. 10.1111/1348-0421.12723
Nakata J, Hirota T, Umemura H, Nakagawa T, Kando N, et al. Additive effect of L-92 on children with atopic dermatitis concomitant with food allergy. Asia Pac Allergy. 2019;9:e18. 10.5415/apallergy.2019.9.e18
Wang JJ, Li SH, Li AL, Zhang QM, Ni WW, et al. Effect of Lactobacillus acidophilus KLDS 1.0738 on miRNA expression in in vitro and in vivo models of β-lactoglobulin allergy. Biosci Biotechnol Biochem. 2018;82:1955. 10.1080/09168451.2018.1495551
Li AL, Sun YQ, Du P, Meng XC, Guo L, et al. The Effect of Lactobacillus actobacillus Peptidoglycan on Bovine β-Lactoglobulin-Sensitized Mice via TLR2/NF-κB Pathway. Iran J Allergy Asthma Immunol. 2017;16:147.
Rø ADB, Simpson MR, Rø TB, Storrø O, Johnsen R, et al. Reduced Th22 cell proportion and prevention of atopic dermatitis in infants following maternal probiotic supplementation. Clin Exp Allergy. 2017;47:1014. 10.1111/cea.12930
Gelardi M, De Luca C, Taliente S, Fiorella ML, Quaranta N, et al. Adjuvant treatment with a symbiotic in patients with inflammatory non-allergic rhinitis. J Biol Regul Homeost Agents. 2017;31:201.
Shen X, Li M, Shi L, Ling N, He M, et al. [The Immunomodulatory and Anti-allergy Effects of Lactobacilli]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2016;47:192.
Yamamoto K, Yokoyama K, Matsukawa T, Kato S, Kato S, et al. Efficacy of prolonged ingestion of Lactobacillus acidophilus L-92 in adult patients with atopic dermatitis. J Dairy Sci. 2016;99:5039. 10.3168/jds.2015-10605
Shandilya UK, Sharma A, Kapila R, Kansal VK. Probiotic Dahi containing Lactobacillus acidophilus and Bifidobacterium bifidum modulates immunoglobulin levels and cytokines expression in whey proteins sensitised mice. J Sci Food Agric. 2016;96:3180. 10.1002/jsfa.7497
Simpson MR, Dotterud CK, Storrø O, Johnsen R, Øien T. Perinatal probiotic supplementation in the prevention of allergy related disease: 6 year follow up of a randomised controlled trial. BMC Dermatol. 2015;15:13. 10.1186/s12895-015-0030-1
Xu H, Duan X, Wang Y, Geng W. Amelioration Effect of ZW3 on Ovalbumin-Induced Allergic Symptoms in BALB/c Mice. Foods. 2024;14. 10.3390/foods14010016
Lungaro L, Malfa P, Manza F, Costanzini A, Valentini G, et al. Clinical Efficacy of Probiotics for Allergic Rhinitis: Results of an Exploratory Randomized Controlled Trial. Nutrients. 2024;16. 10.3390/nu16234173
Song S, Zhang H, Liu L, Li M, Wang X, et al. Probiotic DNA regulates intestinal Th2 polarization by inducing epithelial cells to produce PD-L1. Apoptosis. 2025;30:239. 10.1007/s10495-024-02043-3
Mennini M, Piccirillo M, Furio S, Valitutti F, Ferretti A, et al. Probiotics and other adjuvants in allergen-specific immunotherapy for food allergy: a comprehensive review. Front Allergy. 2024;5:1473352. 10.3389/falgy.2024.1473352
Malekiantaghi A, Ghanaati F, Shabani-Mirzaee H, Shariat M, Mojtahedi SY, et al. Helps to Reduce the Duration of Bleeding in Breastfed Infants with Allergic Proctocolitis. Breastfeed Med. 2025;20:59. 10.1089/bfm.2024.0185
Xue J, Liu Z, Xie B, Dong R, Wu J, et al. Probiotic nucleotides increase IL-10 expression in airway macrophages to mitigate airway allergy. Inflamm Res. 2024;73:1919. 10.1007/s00011-024-01940-2
Puisto R, Gómez-Gallego C, Collado MC, Turta O, Isolauri E, et al. The Role of Infant Gut Microbiota Modulation by Perinatal Maternal Probiotic Intervention in Atopic Eczema Risk Reduction. Neonatology. 2025;122:84. 10.1159/000540075
Uberos J, Garcia-Cuesta A, Carrasco-Solis M, Ruiz-López A, Fernandez-Marı N E, et al. Lacticaseibacillus rhamnosus and breastmilk are associated with a decreased risk of atopic dermatitis in very low birth weight premature infants. Benef Microbes. 2023;14:433. 10.1163/18762891-20220144
Shi J, Dong P, Liu C, Xu Y, Zheng M, et al. Probio-M9 alleviates OVA-sensitized food allergy through modulating gut microbiota and its metabolism. Food Funct. 2023;14:10784. 10.1039/d3fo03321j
Li L, Wen X, Gong Y, Chen Y, Xu J, et al. HMGN2 and Histone H1.2: potential targets of a novel probiotic mixture for seasonal allergic rhinitis. Front Microbiol. 2023;14:1202858. 10.3389/fmicb.2023.1202858
Vasconcelos JA, Mota AS, Olímpio F, Rosa PC, Damaceno-Rodrigues N, et al. Lactobacillus rhamnosus Modulates Lung Inflammation and Mitigates Gut Dysbiosis in a Murine Model of Asthma-COPD Overlap Syndrome. Probiotics Antimicrob Proteins. 2025;17:588. 10.1007/s12602-023-10167-2
Tan Lim CSC, Sajo MEJV, Orteza KEMP, Fernandez PBA, Vila MJC. Next-Gen biotherapeutics: A systematic review and network meta-analysis on postbiotics as treatment for pediatric atopic dermatitis. Pediatr Allergy Immunol. 2023;34:e14022. 10.1111/pai.14022
Komulainen M, Saros L, Vahlberg T, Nermes M, Jartti T, et al. Maternal fish oil and/or probiotics intervention: Allergic diseases in children up to two years old. Pediatr Allergy Immunol. 2023;34:e14004. 10.1111/pai.14004
Hou Y, Zheng S, Zou F, Wang D, Da H, et al. Lactobacillus rhamnosus 76 alleviates airway inflammation in ovalbumin-allergic mice and improves mucus secretion by down-regulating STAT6/SPDEF pathway. Immunobiology. 2023;228:152712. 10.1016/j.imbio.2023.152712
Vorobieva OA, Shih EV, Drozdov VN, Shikh NV. [The results of the use of a combined probiotic ( and spp. ВB-12) in children with gastrointestinal and skin manifestations of food allergy]. Vopr Pitan. 2023;92:79. 10.33029/0042-8833-2023-92-3-79-86
Lee JY, Park JY, Jeong Y, Kang CH. Anti-Inflammatory Response in TNFα/IFNγ-Induced HaCaT Keratinocytes and Probiotic Properties of MG4644, MG4693, and MG5474. J Microbiol Biotechnol. 2023;33:1039. 10.4014/jmb.2301.01028
Lin TJ, Huang CC, Lee MC, Lee YP, Huang WC, et al. Effects of ssp. SA-03 Supplementation on Reversing Phthalate-Induced Asthma in Mice. Nutrients. 2024;16. 10.3390/nu16081160
Yang S, Peng Z, Hardie WJ, Huang T, Tang H, et al. Screening of probiotic Lactobacillus to reduce peanut allergy and with potential anti-allergic activity. J Sci Food Agric. 2024;104:2006. 10.1002/jsfa.13089
Uwaezuoke SN, Ayuk AC, Eze JN, Odimegwu CL, Ndiokwelu CO, et al. Postnatal probiotic supplementation can prevent and optimize treatment of childhood asthma and atopic disorders: A systematic review of randomized controlled trials. Front Pediatr. 2022;10:956141. 10.3389/fped.2022.956141
Holowacz S, Blondeau C, Guinobert I, Guilbot A, Hidalgo S, et al. Lactobacillus salivarius LA307 and Lactobacillus rhamnosus LA305 attenuate skin inflammation in mice. Benef Microbes. 2018;9:299. 10.3920/BM2017.0084
Nettis E, Di Leo E, Pastore A, Distaso M, Zaza I, et al. Probiotics and refractory chronic spontaneous urticaria. Eur Ann Allergy Clin Immunol. 2016;48:182.
Neau E, Delannoy J, Marion C, Cottart CH, Labellie C, et al. Three Novel Candidate Probiotic Strains with Prophylactic Properties in a Murine Model of Cow's Milk Allergy. Appl Environ Microbiol. 2016;82:1722. 10.1128/AEM.03440-15
Yun X, Shang Y, Li M. Effect of Lactobacillus salivarius on Th1/Th2 cytokines and the number of spleen CD4⁺ CD25⁺ Foxp3⁺ Treg in asthma Balb/c mouse. Int J Clin Exp Pathol. 2015;8:7661.
Drago L, De Vecchi E, Gabrieli A, De Grandi R, Toscano M. Immunomodulatory Effects of Lactobacillus salivarius LS01 and Bifidobacterium breve BR03, Alone and in Combination, on Peripheral Blood Mononuclear Cells of Allergic Asthmatics. Allergy Asthma Immunol Res. 2015;7:409. 10.4168/aair.2015.7.4.409
Drago L, De Vecchi E, Toscano M, Vassena C, Altomare G, et al. Treatment of atopic dermatitis eczema with a high concentration of Lactobacillus salivarius LS01 associated with an innovative gelling complex: a pilot study on adults. J Clin Gastroenterol. 2014;48 Suppl 1:S47. 10.1097/MCG.0000000000000249
Niccoli AA, Artesi AL, Candio F, Ceccarelli S, Cozzali R, et al. Preliminary results on clinical effects of probiotic Lactobacillus salivarius LS01 in children affected by atopic dermatitis. J Clin Gastroenterol. 2014;48 Suppl 1:S34. 10.1097/MCG.0000000000000233
Allen SJ, Jordan S, Storey M, Thornton CA, Gravenor MB, et al. Probiotics in the prevention of eczema: a randomised controlled trial. Arch Dis Child. 2014;99:1014. 10.1136/archdischild-2013-305799
Drago L, Toscano M, De Vecchi E, Piconi S, Iemoli E. Changing of fecal flora and clinical effect of L. salivarius LS01 in adults with atopic dermatitis. J Clin Gastroenterol. 2012;46 Suppl:S56. 10.1097/MCG.0b013e318265ef38
Iemoli E, Trabattoni D, Parisotto S, Borgonovo L, Toscano M, et al. Probiotics reduce gut microbial translocation and improve adult atopic dermatitis. J Clin Gastroenterol. 2012;46 Suppl:S33. 10.1097/MCG.0b013e31826a8468
Lin TY, Chen CJ, Chen LK, Wen SH, Jan RH. Effect of probiotics on allergic rhinitis in Df, Dp or dust-sensitive children: a randomized double blind controlled trial. Indian Pediatr. 2013;50:209.
Anania C, Matys V, Marra S, De Canditiis D, Olivero F, et al. Effect of Supplementation with a Specific Probiotic ( PRL2010) in Pregnancy for the Prevention of Atopic Dermatitis in Children: Preliminary Results of a Randomized Trial. Nutrients. 2025;17. 10.3390/nu17040673
Chan OM, Xu W, Cheng NS, Leung ASY, Ching JYL, et al. A novel infant microbiome formula (SIM03) improved eczema severity and quality of life in preschool children. Sci Rep. 2024;14:3168. 10.1038/s41598-024-53848-w
Jing W, Liu Q, Wang W. Bifidobacterium bifidum TMC3115 ameliorates milk protein allergy in by affecting gut microbiota: A randomized double-blind control trial. J Food Biochem. 2020;44:e13489. 10.1111/jfbc.13489
Cheng R, Guo J, Pu F, Wan C, Shi L, et al. Loading ceftriaxone, vancomycin, and Bifidobacteria bifidum TMC3115 to neonatal mice could differently and consequently affect intestinal microbiota and immunity in adulthood. Sci Rep. 2019;9:3254. 10.1038/s41598-018-35737-1
Suzuki S, Campos-Alberto E, Morita Y, Yamaguchi M, Toshimitsu T, et al. Low Interleukin 10 Production at Birth Is a Risk Factor for Atopic Dermatitis in Neonates with Bifidobacterium Colonization. Int Arch Allergy Immunol. 2018;177:342. 10.1159/000492130
Cheng RY, Yao JR, Wan Q, Guo JW, Pu FF, et al. Oral administration of Bifidobacterium bifidum TMC3115 to neonatal mice may alleviate IgE-mediated allergic risk in adulthood. Benef Microbes. 2018;9:815. 10.3920/BM2018.0005
Dennis-Wall JC, Culpepper T, Nieves C, Rowe CC, Burns AM, et al. Probiotics ( KS-13, G9-1, and MM-2) improve rhinoconjunctivitis-specific quality of life in individuals with seasonal allergies: a double-blind, placebo-controlled, randomized trial. Am J Clin Nutr. 2017;105:758. 10.3945/ajcn.116.140012
Kim HK, Rutten NB, Besseling-van der Vaart I, Niers LE, Choi YH, et al. Probiotic supplementation influences faecal short chain fatty acids in infants at high risk for eczema. Benef Microbes. 2015;6:783. 10.3920/BM2015.0056
Tsunemine S, Isa Y, Ohno H, Hagino S, Yamamura H, et al. Longitudinal study of effects of oral dosage of Bifidobacterium bifidum G9-1 on Japanese cedar pollen-induced allergic nasal symptoms in guinea pigs. Microbiol Immunol. 2015;59:690. 10.1111/1348-0421.12324
Moussu H, Van Overtvelt L, Horiot S, Tourdot S, Airouche S, et al. Bifidobacterium bifidum NCC 453 promotes tolerance induction in murine models of sublingual immunotherapy. Int Arch Allergy Immunol. 2012;158:35. 10.1159/000330101
López P, González-Rodríguez I, Sánchez B, Gueimonde M, Margolles A, et al. Treg-inducing membrane vesicles from Bifidobacterium bifidum LMG13195 as potential adjuvants in immunotherapy. Vaccine. 2012;30:825. 10.1016/j.vaccine.2011.11.115
Hosoki K, Nakamura A, Nagao M, Hiraguchi Y, Tokuda R, et al. Differential activation of eosinophils by 'probiotic' Bifidobacterium bifidum and 'pathogenic' Clostridium difficile. Int Arch Allergy Immunol. 2010;152 Suppl 1:83. 10.1159/000312131
Kim JY, Kwon JH, Ahn SH, Lee SI, Han YS, et al. Effect of probiotic mix (Bifidobacterium bifidum, Bifidobacterium lactis, Lactobacillus acidophilus) in the primary prevention of eczema: a double-blind, randomized, placebo-controlled trial. Pediatr Allergy Immunol. 2010;21:e386. 10.1111/j.1399-3038.2009.00958.x
Niers L, Martín R, Rijkers G, Sengers F, Timmerman H, et al. The effects of selected probiotic strains on the development of eczema (the PandA study). Allergy. 2009;64:1349. 10.1111/j.1398-9995.2009.02021.x
Li D, Sorkhabi S, Cruz I, Foley PL, Bellanti JA. Studies of methylated CpG ODN from subsp. in a murine model: Implications for treatment of human allergic disease. Allergy Asthma Proc. 2025;46:e13. 10.2500/aap.2025.46.240100
Jeong K, Jang SW, Jeon SA, Seo HJ, Kang SH, et al. Efficacy of and (NVP-1703) in Children With Allergic Rhinitis: A Randomized Controlled Trial. J Korean Med Sci. 2024;39:e266. 10.3346/jkms.2024.39.e266
Niu X, Yin X, Wu X, Zhang Q, Jiang Y, et al. Heat-Killed BBMN68 in Pasteurized Yogurt Alleviates Mugwort Pollen-Induced Allergic Airway Responses through Gut Microbiota Modulation in a Murine Model. Foods. 2023;12. 10.3390/foods12102049
Feíto-Rodríguez M, Ramírez-Boscà A, Vidal-Asensi S, Fernández-Nieto D, Ros-Cervera G, et al. Randomized double-blind placebo-controlled clinical trial to evaluate the effect of a mixture of probiotic strains on symptom severity and use of corticosteroids in children and adolescents with atopic dermatitis. Clin Exp Dermatol. 2023;48:495. 10.1093/ced/llad007
Fang Z, Pan T, Li L, Wang H, Zhu J, et al. mediated tryptophan metabolism to improve atopic dermatitis via the gut-skin axis. Gut Microbes. 2022;14:2044723. 10.1080/19490976.2022.2044723
Santos SS, Miranda VC, Trindade LM, Cardoso VN, Reis DC, et al. Bifidobacterium longum subsp. longum 5 Attenuates Signs of Inflammation in a Murine Model of Food Allergy. Probiotics Antimicrob Proteins. 2023;15:63. 10.1007/s12602-021-09846-9
Pyclik MJ, Srutkova D, Razim A, Hermanova P, Svabova T, et al. Viability Status-Dependent Effect of ssp CCM 7952 on Prevention of Allergic Inflammation in Mouse Model. Front Immunol. 2021;12:707728. 10.3389/fimmu.2021.707728
Seppo AE, Bu K, Jumabaeva M, Thakar J, Choudhury RA, et al. Infant gut microbiome is enriched with Bifidobacterium longum ssp. infantis in Old Order Mennonites with traditional farming lifestyle. Allergy. 2021;76:3489. 10.1111/all.14877
Ribeiro WR, Queiroz AG, Mendes E, Casaro MB, Nascimento CM, et al. Preventive oral supplementation with 5 alleviates oxazolone-induced allergic contact dermatitis-like skin inflammation in mice. Benef Microbes. 2021;12:199. 10.3920/BM2020.0134
Li D, Cheng J, Zhu Z, Catalfamo M, Goerlitz D, et al. Treg-inducing capacity of genomic DNA of subsp. . Allergy Asthma Proc. 2020;41:372. 10.2500/aap.2020.41.200064
Wang H, He Y, Dang D, Feng L, Huang L, et al. subsp. CCFM1274 relieved allergic asthma symptoms by modifying intestinal tryptophan metabolism in mice. Food Funct. 2024;15:8810. 10.1039/d4fo01079e
Adjibade M, Vigneron L, Delvert R, Adel-Patient K, Divaret-Chauveau A, et al. Characteristics of infant formula consumed in the first months of life and allergy in the EDEN mother-child cohort. Matern Child Nutr. 2024;20:e13673. 10.1111/mcn.13673
Tian X, Liang X, He H, Cui Q, Liu Q, et al. Probiotics Alleviate Food Protein Allergy in Mice by Activating TLR4 Signaling Pathway. Mol Nutr Food Res. 2023;67:e2200579. 10.1002/mnfr.202200579
Bezruk VV, Godovanets OS, Buriak OH, Voytkevich NI, Makarova OV, et al. The use of hydrolyzed formulas as a method of correction of feeding and clinical rehabilitation of infants with atopy signs. J Med Life. 2022;15:1536. 10.25122/jml-2022-0254
Shikh EV, Drozdov VN, Vorobieva OA, Zhukova OV, Ermolaeva AS, et al. [The effectiveness of BIFIFORM KIDS in the prevention of the incidence of acute respiratory infections in children]. Vopr Pitan. 2022;91:97. 10.33029/0042-8833-2022-91-4-97-106
Anania C, Di Marino VP, Olivero F, De Canditiis D, Brindisi G, et al. Treatment with a Probiotic Mixture Containing Subsp. BB12 and L3 for the Prevention of Allergic Rhinitis Symptoms in Children: A Randomized Controlled Trial. Nutrients. 2021;13. 10.3390/nu13041315
Tan-Lim CSC, Esteban-Ipac NAR, Recto MST, Castor MAR, Casis-Hao RJ, et al. Comparative effectiveness of probiotic strains on the prevention of pediatric atopic dermatitis: A systematic review and network meta-analysis. Pediatr Allergy Immunol. 2021;32:1255. 10.1111/pai.13514
Schmidt RM, Pilmann Laursen R, Bruun S, Larnkjaer A, Mølgaard C, et al. Probiotics in late infancy reduce the incidence of eczema: A randomized controlled trial. Pediatr Allergy Immunol. 2019;30:335. 10.1111/pai.13018
Liu Q, Jing W, Wang W. Ameliorates the Risk of Food Allergy in Chinese Children by Affecting Relative Percentage of Treg and Th17 Cells. Can J Infect Dis Med Microbiol. 2018;2018:4561038. 10.1155/2018/4561038