MCT oil shows promise for NAFLDMedium chain triglycerides alleviate non-alcoholic fatty liver disease through bile acid-mediated FXR signaling pathway: A comparative study with common vegetable edible oils.
We investigated the effects of medium-chain triglycerides (MCTs) on non-alcoholic fatty liver disease (NAFLD) induced by obesity. By treating mice with various dietary fats over 16 weeks, we observed that MCTs significantly improved weight and blood lipid levels, and reduced liver fat more effectively than traditional vegetable oils. Significant changes in bile acid composition were also noted, with MCTs promoting beneficial FXR signaling. Overall, MCTs demonstrated a promising potential in managing NAFLD, offering a better option than common long-chain oils.
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MCT oil improves GSD-1 outcomesMedium-Chain Triglyceride Oil and Dietary Intervention Improved Body Composition and Metabolic Parameters in Children with Glycogen Storage Disease Type 1 in Jordan: A Clinical Trial.
We examined how medium-chain triglyceride (MCT) oil, combined with a specialized diet, influences children suffering from glycogen storage disease type 1 (GSD-1) in Jordan.
Over three months, we assessed 38 children and observed a dramatic reduction in hypoglycaemia, from nearly 95% to about 8%. There were also significant drops in triglycerides, cholesterol, and uric acid levels.
Importantly, we noted improvements in liver size and various growth parameters, indicating that MCT oil can positively impact metabolic health in this population.
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MCT reduces alcohol-related liver fatPreservation of hepatocyte nuclear factor-4α contributes to the beneficial effect of dietary medium chain triglyceride on alcohol-induced hepatic lipid dyshomeostasis in rats.
We examined the effects of medium chain triglycerides (MCT) on liver health, particularly in the context of alcohol consumption. Over eight weeks, male rats were fed diets containing control, alcohol, and MCT with alcohol.
The results showed that MCT reduced liver fat accumulation linked to alcohol while preserving critical liver proteins. MCT helped balance the fatty acid levels and normalized several liver genes affected by alcohol.
Ultimately, we found that MCT could offer liver protection from the harmful effects of alcohol by maintaining important cellular functions.
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MCT oil improves liver fatRapid reduction of liver steatosis in omega3-depleted rats injected with a novel lipid emulsion.
We examined the effects of a novel medium-chain triglyceride and fish oil emulsion on liver fat in omega-3-depleted rats. By injecting this emulsion, we found that liver cells significantly increased their omega-3 fatty acid content and experienced a noticeable reduction in fatty liver.
Our study suggests that bolus intravenous administration of this emulsion may quickly replenish omega-3s in liver cells, potentially correcting biochemical deficiencies. However, more research is needed to understand the full implications for liver disease treatment.
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MCT may improve liver functionMedium-chain TAG attenuate hepatic oxidative damage in intra-uterine growth-retarded weanling piglets by improving the metabolic efficiency of the glutathione redox cycle.
We explored the impact of medium-chain triglycerides (MCT) on liver health in piglets facing challenges due to intra-uterine growth retardation (IUGR). By comparing piglets on a conventional soy oil diet with those receiving a diet rich in MCT, we observed that the latter group showed improved daily growth and feed efficiency.
Additionally, the MCT diet enhanced the liver's ability to manage oxidative damage, indicated by higher glutathione levels and reduced cell death in the liver. Overall, our findings suggest that MCT might offer a supportive therapy for young animals with liver stress.
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