' 
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Organic Turmeric BlendOrganic Turmeric Root Extract standardized to 95% curcuminoids, Organic Fermented Turmeric Root (blend yielding 100 mg curcuminoids)
553 mg
+
Organic Fermented Ginger Root
50 mg
+
Organic Black Pepper Fruit Extract
7 mg
+
Probiotic Blend Bifidobacterium lactis Bl-04Lactobacillus acidophilus La-14
4 mg
+
The product is found useful for the following medical conditions
Knee Pain
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.7
USERS' SCORE
Good
Based on 48 Reviews
8.9
9
Curcumin alleviates knee osteoarthritis pain
An Investigation into the Effects of a Curcumin Extract (Curcugen) on Osteoarthritis Pain of the Knee: A Randomised, Double-Blind, Placebo-Controlled Study.
Most Relevant Research
In a well-structured study involving 101 adults suffering from knee osteoarthritis, we explored the effects of curcumin, a compound derived from turmeric, on knee pain. Participants were randomly assigned to receive either 500 mg of a standardized curcumin extract, Curcugen, twice daily, or a placebo for eight weeks, allowing for a clear comparison of its effectiveness.
Our findings revealed promising results. Curcumin significantly reduced knee pain scores and overall pain ratings compared to the placebo. We also noticed that participants taking curcumin showed greater improvements in various physical tests, like the timed up-and-go and six-minute walk tests, indicating enhanced mobility.
Interestingly, 37% of those on curcumin reduced their pain medications, which highlights the potential for curcumin to provide relief and improve quality of life for those with this condition. While the study didn’t explore longer treatment durations or different dosages, these initial results support curcumin's role as a feasible option for managing osteoarthritis pain in the knee.
Our findings revealed promising results. Curcumin significantly reduced knee pain scores and overall pain ratings compared to the placebo. We also noticed that participants taking curcumin showed greater improvements in various physical tests, like the timed up-and-go and six-minute walk tests, indicating enhanced mobility.
Interestingly, 37% of those on curcumin reduced their pain medications, which highlights the potential for curcumin to provide relief and improve quality of life for those with this condition. While the study didn’t explore longer treatment durations or different dosages, these initial results support curcumin's role as a feasible option for managing osteoarthritis pain in the knee.
9.5
Pain-free result
Most Useful Review
The inflammation in my knees has disappeared! After switching from CVS brand to this, I was no longer limping after only a week. I had previously taken Glucosamine, but it ceased to work. I'm thrilled to be free from knee pain and wish I'd discovered this remedy sooner.
Arthritis
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.3
USERS' SCORE
Good
Based on 36 Reviews
8.8
9
Curcumin reduces osteoarthritis severity
Curcumin alleviates osteoarthritis in mice by suppressing osteoclastogenesis in subchondral bone via inhibiting NF-κB/JNK signaling pathway.
Most Relevant Research
We investigated how curcumin, the active compound in turmeric, impacts osteoarthritis (OA) by focusing on its role in reducing the formation of bone-destroying cells called osteoclasts. In our research, we used a mouse model designed to mimic OA by destabilizing the medial meniscus, allowing us to measure the effects of curcumin on joint health.
Our study included three groups of male mice: those who received a vehicle treatment after their surgery, those with OA but also receiving the vehicle, and those with OA that were treated with curcumin. Over the course of eight weeks, we monitored the mice's cartilage and bone structure, looking for any changes.
We found that curcumin significantly suppressed osteoclast formation and bone resorption without harming the cells, suggesting it may be a promising treatment to alleviate arthritis symptoms. Specifically, curcumin inhibited the activation of important signaling pathways that promote osteoclast formation and cartilage degradation. This suggests a new and exciting approach for treating osteoarthritis, offering hope for better management of this chronic condition.
Our study included three groups of male mice: those who received a vehicle treatment after their surgery, those with OA but also receiving the vehicle, and those with OA that were treated with curcumin. Over the course of eight weeks, we monitored the mice's cartilage and bone structure, looking for any changes.
We found that curcumin significantly suppressed osteoclast formation and bone resorption without harming the cells, suggesting it may be a promising treatment to alleviate arthritis symptoms. Specifically, curcumin inhibited the activation of important signaling pathways that promote osteoclast formation and cartilage degradation. This suggests a new and exciting approach for treating osteoarthritis, offering hope for better management of this chronic condition.
10
Pain GONE quickly
Most Useful Review
I can't believe how fast this worked! My doctor advised me to take turmeric and glucosamine for crippling knee pain that the arthritis gel did not alleviate. After trying various options, I started this supplement and within 2-3 days, my pain was GONE! It’s truly been life-changing.
Autoimmune Disorder
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
USERS' SCORE
Good
Based on 17 Reviews
8.8
9
Curcumin improves rheumatoid arthritis symptoms
The efficacy of curcumin supplementation on serum total antioxidant capacity, malondialdehyde, and disease activity in women with rheumatoid arthritis: A randomized, double-blind, placebo-controlled clinical trial.
Most Relevant Research
We conducted a clinical trial to explore how curcumin, a compound found in turmeric, affects women with rheumatoid arthritis (RA). Over the course of eight weeks, 48 participants took either a daily curcumin capsule or a placebo. This double-blind, placebo-controlled design ensured that neither the participants nor the researchers knew who was receiving the actual treatment, which adds credibility to our findings.
At the end of the study, we observed some encouraging results. Women who took curcumin showed a significant increase in their serum total antioxidant capacity (TAC), indicating improved antioxidant levels in their bodies. Additionally, these participants experienced a notable decrease in symptoms like tender and swollen joints, pain intensity, and overall disease activity, as measured by the Disease Activity Score in 28 joints (DAS-28).
While levels of malondialdehyde (MDA)—a marker of oxidative stress—decreased in the curcumin group, the change wasn't significantly different when compared to the placebo group. Overall, our findings support the idea that curcumin can be beneficial for women with RA, particularly in reducing disease activity and enhancing antioxidant levels.
At the end of the study, we observed some encouraging results. Women who took curcumin showed a significant increase in their serum total antioxidant capacity (TAC), indicating improved antioxidant levels in their bodies. Additionally, these participants experienced a notable decrease in symptoms like tender and swollen joints, pain intensity, and overall disease activity, as measured by the Disease Activity Score in 28 joints (DAS-28).
While levels of malondialdehyde (MDA)—a marker of oxidative stress—decreased in the curcumin group, the change wasn't significantly different when compared to the placebo group. Overall, our findings support the idea that curcumin can be beneficial for women with RA, particularly in reducing disease activity and enhancing antioxidant levels.
9.5
Alleviates symptoms
Most Useful Review
After taking one daily capsule of curcumin, my trigger finger symptoms vanished within a month. It remarkably improved inflammation and roughness in my knee. I've taken this turmeric pill for nearly a year without stomach side effects. I’ll continue to use it daily, as it's become essential for treating my autoimmune disorder.
Liver Disease
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.2
USERS' SCORE
Good
Based on 18 Reviews
8.8
9
Turmeric shows promise for NAFLD
"Evaluation of Curcuma zedoaria Rosc. in the management of non-alcoholic fatty liver Disease: A Randomized, single blind, controlled trial".
Most Relevant Research
In a recent clinical trial, we explored the effectiveness of Curcuma zedoaria Rosc., commonly known as turmeric, in treating non-alcoholic fatty liver disease (NAFLD). This condition is alarmingly widespread, affecting a significant portion of the global population. Over the course of 60 days, we compared turmeric with vitamin E, a standard treatment, to see which had better results.
Our study involved 68 patients with mild to moderate NAFLD, who were divided into two groups. One group received turmeric in capsule form, while the other took vitamin E. We looked at various outcomes, including improvements in liver function, symptoms like digestive issues and malaise, and ultrasound assessments of liver size.
The findings were compelling. We observed that turmeric outperformed vitamin E in alleviating subjective symptoms, such as discomfort in the upper right abdomen, and issues with appetite and digestion. Notably, there were no significant adverse effects reported with turmeric, making it a promising alternative for managing NAFLD.
Overall, our research highlights turmeric as a viable option for those seeking treatment for liver disease, offering benefits that may surpass those of conventional therapies.
Our study involved 68 patients with mild to moderate NAFLD, who were divided into two groups. One group received turmeric in capsule form, while the other took vitamin E. We looked at various outcomes, including improvements in liver function, symptoms like digestive issues and malaise, and ultrasound assessments of liver size.
The findings were compelling. We observed that turmeric outperformed vitamin E in alleviating subjective symptoms, such as discomfort in the upper right abdomen, and issues with appetite and digestion. Notably, there were no significant adverse effects reported with turmeric, making it a promising alternative for managing NAFLD.
Overall, our research highlights turmeric as a viable option for those seeking treatment for liver disease, offering benefits that may surpass those of conventional therapies.
9.5
Pelvic pain relief
Most Useful Review
It works! I've been struggling with lower stomach discomfort and pains linked to liver disease caused by uterine fibroids. Typically, I drink green tea for relief, but I've been too busy recently. This product provided almost immediate relief from my pelvic pain. I'm hoping it also reduces my fibroid size since turmeric is known for its anti-inflammatory properties. It has worked well for me, but I recommend consulting a doctor before using it.
Pelvic Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 7 Reviews
8.8
9.5
Pelvic pain relieved
Most Useful Review
It works! I have discomfort and sometimes pain in my lower abdomen due to uterine fibroids. Typically, I drink three cups of green tea daily for relief, but recently I've been too busy. This product showed results almost right away, and by day three, my pelvic pain had vanished! I hope it also helps reduce my fibroid size, as turmeric and ginger are traditionally used for inflammation in my culture. This product has worked for me, but consult your doctor before trying it.
Gout
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.2
USERS' SCORE
Good
Based on 6 Reviews
8.7
9
Curcumin nanoparticles effectively combat gout
Anti-gouty arthritis and anti-inflammatory effects of curcumin nanoparticles in monosodium urate crystals induced Balb/C mice.
Most Relevant Research
We explored the potential of curcumin nanoparticles (CNPs) as a treatment for gout, a condition caused by the buildup of urate crystals in the joints. To investigate this, researchers induced gout-like symptoms in mice by injecting monosodium urate crystals. This led to joint swelling and increased levels of uric acid in the bloodstream.
The study involved administering various concentrations of CNPs, alongside a commonly used medication, allopurinol. The results were promising, showing that CNPs not only lowered uric acid levels and reduced swelling but also decreased inflammation in the affected mice. Interestingly, the application of CNPs increased beneficial substances like high-density lipoprotein and interleukin-10, further supporting their potential health benefits.
Overall, our findings indicate that curcumin nanoparticles present a viable and effective anti-gout treatment with minimal side effects compared to traditional pharmaceuticals. This opens exciting possibilities for developing natural therapies to manage gout and improve patient quality of life.
The study involved administering various concentrations of CNPs, alongside a commonly used medication, allopurinol. The results were promising, showing that CNPs not only lowered uric acid levels and reduced swelling but also decreased inflammation in the affected mice. Interestingly, the application of CNPs increased beneficial substances like high-density lipoprotein and interleukin-10, further supporting their potential health benefits.
Overall, our findings indicate that curcumin nanoparticles present a viable and effective anti-gout treatment with minimal side effects compared to traditional pharmaceuticals. This opens exciting possibilities for developing natural therapies to manage gout and improve patient quality of life.
9.5
Pain relief
Most Useful Review
A mighty product. I had gout and, by chance, was eating this. I found the pain subsided and my symptoms improved. I highly recommend it.
Yeast Infection
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.3
USERS' SCORE
Good
Based on 3 Reviews
8.7
8
Curcumin shows antifungal promise
Efficacy of curcumin in the treatment of experimental vulvovaginal candidiasis.
Most Relevant Research
We explored the potential of curcumin, the active component of turmeric, in treating vulvovaginal candidiasis, a common yeast infection primarily caused by Candida albicans. Our investigation focused on the substance’s antifungal properties against various strains of Candida, comparing its effectiveness to traditional treatments.
The study involved several methods, including an in vitro assessment where curcumin’s ability to combat yeast was tested against eight different Candida strains. We also examined how curcumin interacts with ergosterol, a vital component of the yeast cell membrane, which could explain its antifungal action. Furthermore, we conducted an in vivo experiment using rats treated with estrogen to simulate conditions that might lead to yeast infections.
Results showed that curcumin had a minimum inhibitory concentration ranging from 125 to 1000μg/ml, with the most significant effect observed against the Candida glabrata strain. Additionally, in the rat model, treatment with curcumin successfully reduced the fungal load in infected subjects after a week. This demonstrates promising potential for curcumin as an effective antifungal agent in treating yeast infections.
The study involved several methods, including an in vitro assessment where curcumin’s ability to combat yeast was tested against eight different Candida strains. We also examined how curcumin interacts with ergosterol, a vital component of the yeast cell membrane, which could explain its antifungal action. Furthermore, we conducted an in vivo experiment using rats treated with estrogen to simulate conditions that might lead to yeast infections.
Results showed that curcumin had a minimum inhibitory concentration ranging from 125 to 1000μg/ml, with the most significant effect observed against the Candida glabrata strain. Additionally, in the rat model, treatment with curcumin successfully reduced the fungal load in infected subjects after a week. This demonstrates promising potential for curcumin as an effective antifungal agent in treating yeast infections.
9.5
Amazing results
Most Useful Review
I was struggling with yeast infections and warts, but now the results are astonishing. Thank you very much.
Back Pain
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.5
USERS' SCORE
Good
Based on 53 Reviews
8.6
9.5
Turmeric-Boswellia improves back pain
The effect of turmeric-Boswellia formulation (Rhuleave-K) in posture-related low back soreness and discomfort: A randomized double blinded placebo controlled trial.
Most Relevant Research
We investigated how a turmeric and Boswellia formulation, known as Rhuleave-K, helps manage low back pain related to poor posture. This study involved 52 participants, equally divided by gender, who had been experiencing discomfort for at least two to three weeks.
Using a randomized, placebo-controlled, and double-blinded approach, we carefully measured the pain intensity at the beginning and again at the end of the 15-day trial. The findings were promising; those taking Rhuleave-K experienced a dramatic reduction in pain—showing a reduction of up to 98.5% by the end of the trial. In comparison, the placebo group reported minimal improvement.
We also noted significant decreases in the Oswestry disability index, indicating that participants not only had less pain but also felt increasingly able to carry out daily activities. Overall, this study supports the idea that Rhuleave-K can be a safe and effective option for those looking to alleviate low back discomfort, specifically due to poor posture.
Using a randomized, placebo-controlled, and double-blinded approach, we carefully measured the pain intensity at the beginning and again at the end of the 15-day trial. The findings were promising; those taking Rhuleave-K experienced a dramatic reduction in pain—showing a reduction of up to 98.5% by the end of the trial. In comparison, the placebo group reported minimal improvement.
We also noted significant decreases in the Oswestry disability index, indicating that participants not only had less pain but also felt increasingly able to carry out daily activities. Overall, this study supports the idea that Rhuleave-K can be a safe and effective option for those looking to alleviate low back discomfort, specifically due to poor posture.
8.8
Inflammation control
Most Useful Review
Turmeric was a game changer for my back pain linked to Hashimoto's Disease. After experiencing painful attacks and being unable to take NSAIDs, I started taking Turmeric with black pepper. Within days, it significantly relieved my inflammation and spasms.
Chronic Cough
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.6
9.5
Reduced burning sensation
Most Useful Review
I will continue to buy this curcumin! I began taking it for my chronic cystitis, which I’ve suffered from for four years with no lasting relief from antibiotics. After starting curcumin, the burning sensation during urination gradually lessened, and since I'm not taking anything else for cystitis, it provides me with relief.
Chronic Fatigue Syndrome
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 13 Reviews
8.6
9
Curcumin alleviates fatigue symptoms
Curcumin, a polyphenolic antioxidant, attenuates chronic fatigue syndrome in murine water immersion stress model.
Most Relevant Research
We examined the connection between curcumin, a natural compound found in turmeric, and chronic fatigue syndrome in a mouse model. This model used purified lipopolysaccharide (LPS) and Brucella abortus (BA) antigens to induce symptoms of fatigue.
The study involved a water-immersion stress test conducted for 10 minutes each day over 19 days. Notably, the mice treated with LPS or BA showed increased immobility time and heightened sensitivity to pain, which are markers for fatigue. As expected, these mice also exhibited elevated levels of tumor necrosis factor-alpha (TNF-alpha), a sign of inflammation.
Upon administering curcumin during this period, we observed significant improvements. The treatment reduced both the immobility time and pain sensitivity in the mice. Additionally, curcumin helped to lower oxidative stress and the levels of TNF-alpha.
These findings suggest that curcumin could be a promising option for addressing chronic fatigue syndrome, especially related to inflammation and oxidative stress. As we continue to explore this natural remedy, we may uncover more about its potential role in managing this challenging condition.
The study involved a water-immersion stress test conducted for 10 minutes each day over 19 days. Notably, the mice treated with LPS or BA showed increased immobility time and heightened sensitivity to pain, which are markers for fatigue. As expected, these mice also exhibited elevated levels of tumor necrosis factor-alpha (TNF-alpha), a sign of inflammation.
Upon administering curcumin during this period, we observed significant improvements. The treatment reduced both the immobility time and pain sensitivity in the mice. Additionally, curcumin helped to lower oxidative stress and the levels of TNF-alpha.
These findings suggest that curcumin could be a promising option for addressing chronic fatigue syndrome, especially related to inflammation and oxidative stress. As we continue to explore this natural remedy, we may uncover more about its potential role in managing this challenging condition.
9.5
Pain relief
Most Useful Review
I will buy more! Since taking this curcumin for my chronic fatigue syndrome, my burning sensation during urination has gradually disappeared. I haven't taken anything else for it, so I'm certain curcumin is providing me with relief. I will continue to take it!
Cold Sores
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Curcumin and blue light therapy
Photodynamic Therapy Mediated by Curcumin and Blue Light for Recurrent Herpes Labialis: A Case Report.
Most Relevant Research
We explored the effectiveness of photodynamic therapy (PDT) using curcumin and blue light for treating recurrent cold sores, specifically herpes labialis. This innovative treatment approach was assessed based on its ability to accelerate the healing of lesions and reduce their recurrence.
Our findings suggest that PDT shows promise as a safe and cost-effective option for managing this troublesome condition. However, it is important to note that the study was primarily focused on the combined effect of curcumin with PDT, making it difficult to determine the isolated benefits of curcumin on its own for cold sore treatment.
Overall, our research highlights an exciting potential pathway for alleviating the symptoms associated with recurring herpes labialis, paving the way for future studies to further investigate its components and their individual effects.
Our findings suggest that PDT shows promise as a safe and cost-effective option for managing this troublesome condition. However, it is important to note that the study was primarily focused on the combined effect of curcumin with PDT, making it difficult to determine the isolated benefits of curcumin on its own for cold sore treatment.
Overall, our research highlights an exciting potential pathway for alleviating the symptoms associated with recurring herpes labialis, paving the way for future studies to further investigate its components and their individual effects.
9.5
Effective inflammation relief
Most Useful Review
I switched to this product after using curcumin for a long time, and it seems effective in alleviating inflammation. I caught a cold and had a sore throat and runny nose, but after two days of taking it like cold medicine, the symptoms vanished. Highly recommended for cold sores!
Common Cold
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 30 Reviews
8.6
9
Curcumin reduces cold symptoms
Effects of Highly Bioavailable Curcumin Supplementation on Common Cold Symptoms and Immune and Inflammatory Functions in Healthy Japanese Subjects: A Randomized Controlled Study.
Most Relevant Research
We embarked on an engaging investigation into how highly bioavailable curcumin, a key component of turmeric, affects common cold symptoms. Our study spanned 12 weeks, involving 99 healthy Japanese adults who were randomly divided into three groups. Two groups received different formulations of curcumin while the third group was given a placebo.
Each participant took four capsules daily, and we measured the cumulative days participants experienced cold symptoms. Interestingly, we discovered that those taking either curcumin formulation reported significantly fewer days with cold symptoms compared to the placebo group.
Additionally, we monitored various immune function markers, inflammatory parameters, and overall safety throughout the study. Notably, we observed no adverse effects from curcumin supplementation, making it a promising option for those looking to mitigate cold symptoms naturally.
Each participant took four capsules daily, and we measured the cumulative days participants experienced cold symptoms. Interestingly, we discovered that those taking either curcumin formulation reported significantly fewer days with cold symptoms compared to the placebo group.
Additionally, we monitored various immune function markers, inflammatory parameters, and overall safety throughout the study. Notably, we observed no adverse effects from curcumin supplementation, making it a promising option for those looking to mitigate cold symptoms naturally.
9.5
Powerful protection
Most Useful Review
Turmeric is incredibly beneficial, especially when paired with black pepper and ginger! This jar lasts four months! Though the capsules are large, I have no trouble swallowing them, and they have a mild taste. When I sensed a cold, I took a double dose along with honey and propolis and didn't fall ill. Turmeric is indeed powerful!
Food Poisoning
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.6
USERS' SCORE
Good
Based on 1 Review
8.6
8
Curcumin supports gut health during infection
Curcumin Mitigates Immune-Induced Epithelial Barrier Dysfunction by .
Most Relevant Research
We examined how curcumin, a natural compound found in turmeric, can help protect against food poisoning caused by harmful bacteria. This research focused on the effects of curcumin in preventing inflammation and damage to the gut barrier, especially during infections.
Using co-cultures of intestinal cells and immune cells, we looked at what happens when the cells are exposed to bacteria that typically cause gastrointestinal issues. Our findings showed that when these cells were infected, there was a noticeable decrease in their ability to maintain a tight barrier—this was measured through transepithelial electrical resistance.
When we treated the infected cells with curcumin, we saw a significant reduction in the permeability of these cells, meaning curcumin helped restore their barrier function. Furthermore, curcumin appeared to reduce apoptosis (cell death) and inflammation, indicated by lowered levels of certain immune response markers like TNF-α, IL-1β, and IL-6.
Our study suggests that curcumin could serve as a valuable ally against the adverse effects of foodborne pathogens, potentially supporting treatment strategies for maintaining gut health during such infections.
Using co-cultures of intestinal cells and immune cells, we looked at what happens when the cells are exposed to bacteria that typically cause gastrointestinal issues. Our findings showed that when these cells were infected, there was a noticeable decrease in their ability to maintain a tight barrier—this was measured through transepithelial electrical resistance.
When we treated the infected cells with curcumin, we saw a significant reduction in the permeability of these cells, meaning curcumin helped restore their barrier function. Furthermore, curcumin appeared to reduce apoptosis (cell death) and inflammation, indicated by lowered levels of certain immune response markers like TNF-α, IL-1β, and IL-6.
Our study suggests that curcumin could serve as a valuable ally against the adverse effects of foodborne pathogens, potentially supporting treatment strategies for maintaining gut health during such infections.
9.5
Pelvic pain relief
Most Useful Review
It works! I've had discomfort and sometimes pain from uterine fibroids. I usually consume three cups of green tea daily for relief, but lately I've struggled to manage even one cup. This product showed results almost immediately; by day three, my pelvic pain had disappeared! I hope it also helps reduce the fibroid size, as turmeric and ginger are traditionally used for inflammation in my country. This product has been effective for me, but it's best to consult your doctor before using it.
High Cholesterol
SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8.5
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
Turmeric improves cholesterol levels
Effects of curcumin/turmeric supplementation on lipid profile: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials.
Most Relevant Research
We aimed to understand how turmeric, specifically its active compound curcumin, affects cholesterol levels in the body. After searching several online databases and analyzing 64 randomized clinical trials, we found that turmeric supplementation can lead to noticeable improvements in key cholesterol metrics.
Specifically, we observed significant reductions in total cholesterol, triglycerides, and low-density lipoprotein cholesterol (often referred to as "bad" cholesterol). Additionally, there was an increase in high-density lipoprotein cholesterol, known as "good" cholesterol. However, it's important to note that turmeric did not show considerable effects on related apolipoproteins, which are proteins that help carry cholesterol in the blood.
Although these results are promising, we must approach them with caution. The quality of evidence was assessed to be low and very low regarding these outcomes. This means that while turmeric supplementation does seem to help with certain cholesterol levels, more rigorous studies are needed to confirm these benefits and properly evaluate the overall efficacy.
Specifically, we observed significant reductions in total cholesterol, triglycerides, and low-density lipoprotein cholesterol (often referred to as "bad" cholesterol). Additionally, there was an increase in high-density lipoprotein cholesterol, known as "good" cholesterol. However, it's important to note that turmeric did not show considerable effects on related apolipoproteins, which are proteins that help carry cholesterol in the blood.
Although these results are promising, we must approach them with caution. The quality of evidence was assessed to be low and very low regarding these outcomes. This means that while turmeric supplementation does seem to help with certain cholesterol levels, more rigorous studies are needed to confirm these benefits and properly evaluate the overall efficacy.
9
Effective for memory
Most Useful Review
Curcumin is an extremely potent antioxidant, which I use for various complaints, including issues with high cholesterol. It enhances memory, concentration, and alleviates pain and inflammation. The brand is of excellent quality, and I noticed its effectiveness from the first dose. I recommend taking one tablet in the morning with fat-soluble vitamins for the best results.
Bursitis
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Inflammation reduced
Most Useful Review
This product has significantly diminished the inflammation in my hip due to bursitis. I wanted an organic, non-GMO alternative rather than opting for injections or medication. This really works for me!
Headache
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.8
USERS' SCORE
Good
Based on 1 Review
8.6
8
Curcumin improves migraine symptoms
Effects of Curcumin Supplementation on Clinical Features and Inflammation, in Migraine Patients: A Double-Blind Controlled, Placebo Randomized Clinical Trial.
Most Relevant Research
We conducted a thoughtful investigation into the effects of curcumin, a natural compound found in turmeric, on migraine sufferers. This study involved 44 women with migraines, who were randomly assigned to receive either 500 mg of curcumin twice a day or a placebo for eight weeks. The team measured various factors, including the severity, duration, and frequency of headaches, as well as specific inflammation markers in the body.
After the eight-week period, we observed noticeable improvements in the group receiving curcumin. Compared to the placebo, participants taking curcumin reported significant reductions in pain severity and headache duration. While there was a slight improvement in how often headaches struck, it didn't reach a level of statistical significance.
Moreover, curcumin supplementation also appeared to lower levels of two important inflammatory markers related to migraines: calcitonin gene-related peptide (CGRP) and interleukin-6 (IL-6). We didn't see any significant changes in body weight or composition between the groups, indicating that the effects were primarily linked to curcumin's properties rather than any other lifestyle changes.
Overall, our findings suggest that curcumin may serve as an effective, natural remedy for managing migraine symptoms, largely due to its anti-inflammatory benefits.
After the eight-week period, we observed noticeable improvements in the group receiving curcumin. Compared to the placebo, participants taking curcumin reported significant reductions in pain severity and headache duration. While there was a slight improvement in how often headaches struck, it didn't reach a level of statistical significance.
Moreover, curcumin supplementation also appeared to lower levels of two important inflammatory markers related to migraines: calcitonin gene-related peptide (CGRP) and interleukin-6 (IL-6). We didn't see any significant changes in body weight or composition between the groups, indicating that the effects were primarily linked to curcumin's properties rather than any other lifestyle changes.
Overall, our findings suggest that curcumin may serve as an effective, natural remedy for managing migraine symptoms, largely due to its anti-inflammatory benefits.
9.5
Natural alternative found
Most Useful Review
I've used these tablets almost daily for a year, effectively helping with headaches and inflammation. They keep me focused without the grogginess from other medications, making them a better choice for my liver.
Multiple Sclerosis
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.9
USERS' SCORE
Good
Based on 1 Review
8.6
9
Curcumin reduces MS-related inflammation
Curcumin and Its Semisynthetic Derivative F-Curcumin Ameliorate the Expression of Cytokines in Autoimmune Encephalomyelitis Mouse Models of Multiple Sclerosis.
Most Relevant Research
We set out to understand how curcumin, a compound found in turmeric, and its modified version, F-curcumin, impact cytokine levels in mouse models of multiple sclerosis (MS). In our research, we focused on autoimmune encephalomyelitis (EAE), a model that closely mimics MS, examining how these compounds affect various cytokines that play key roles in inflammation and immune responses in the central nervous system.
Our findings revealed that both curcumin and F-curcumin significantly reduced the severity and onset of EAE. Notably, these compounds led to a marked drop in the expression of several pro-inflammatory cytokines, such as IL-1, IFN-γ, and IL-17, while boosting the levels of anti-inflammatory cytokines like TGF-β and IL-10. This shift suggests a potential for curcumin and F-curcumin to balance the immune response, which is crucial in managing MS.
Interestingly, the effects were more pronounced with F-curcumin, indicating that our modified version may offer enhanced benefits for inflammatory conditions like MS. Overall, this study highlights the promise of curcumin and its derivatives as potential therapeutic agents in mitigating inflammation associated with multiple sclerosis.
Our findings revealed that both curcumin and F-curcumin significantly reduced the severity and onset of EAE. Notably, these compounds led to a marked drop in the expression of several pro-inflammatory cytokines, such as IL-1, IFN-γ, and IL-17, while boosting the levels of anti-inflammatory cytokines like TGF-β and IL-10. This shift suggests a potential for curcumin and F-curcumin to balance the immune response, which is crucial in managing MS.
Interestingly, the effects were more pronounced with F-curcumin, indicating that our modified version may offer enhanced benefits for inflammatory conditions like MS. Overall, this study highlights the promise of curcumin and its derivatives as potential therapeutic agents in mitigating inflammation associated with multiple sclerosis.
9.5
Pain relief success
Most Useful Review
I have multiple sclerosis and experience chronic pain. After taking this product for the first time, I woke up pain-free from plantar fasciitis for the first time in over a year. I was nearly in tears from the relief it provided.
Rheumatoid Arthritis
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Pain relief guaranteed
Most Useful Review
This product is fantastic for inflammation. I have rheumatoid arthritis and it has indeed helped reduce joint inflammation and relieve the pain I experience daily. I love this brand and also take their women's daily vitamins and probiotics.
Cardiovascular Disease
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.3
USERS' SCORE
Good
Based on 9 Reviews
8.5
9
Curcumin protects heart cells effectively
Curcumin pretreatment attenuates myocardial ischemia/reperfusion injury by inhibiting ferroptosis, autophagy and apoptosis via HES1.
Most Relevant Research
We explored how curcumin, a natural compound found in turmeric, can protect heart cells during events like myocardial ischemia/reperfusion injury (I/RI). This type of injury occurs when blood supply returns to the heart after a period of low oxygen, often leading to additional damage to heart tissue.
Through a series of experiments, we observed that curcumin has significant protective effects on heart cells exposed to anoxic stress. Our findings revealed that curcumin improves cell health by reducing cell death, lowering oxidative stress markers, and increasing the body’s antioxidant defenses. Specifically, we noted an increase in important proteins that help protect heart cells, such as HES1 and glutathione peroxidase 4.
Furthermore, curcumin appears to inhibit processes known to contribute to cell death, such as ferroptosis and excessive autophagy, while also reducing apoptosis, which is a form of programmed cell death. This multifaceted approach showcases curcumin's ability to enhance cell survival and maintain heart function during and after ischemic episodes.
Overall, our study supports the potential of turmeric-derived curcumin as a promising natural treatment for reducing the harmful effects of ischemia/reperfusion injury in cardiovascular disease.
Through a series of experiments, we observed that curcumin has significant protective effects on heart cells exposed to anoxic stress. Our findings revealed that curcumin improves cell health by reducing cell death, lowering oxidative stress markers, and increasing the body’s antioxidant defenses. Specifically, we noted an increase in important proteins that help protect heart cells, such as HES1 and glutathione peroxidase 4.
Furthermore, curcumin appears to inhibit processes known to contribute to cell death, such as ferroptosis and excessive autophagy, while also reducing apoptosis, which is a form of programmed cell death. This multifaceted approach showcases curcumin's ability to enhance cell survival and maintain heart function during and after ischemic episodes.
Overall, our study supports the potential of turmeric-derived curcumin as a promising natural treatment for reducing the harmful effects of ischemia/reperfusion injury in cardiovascular disease.
8.8
Reduces inflammation
Most Useful Review
Curcumin is exceptional! I sought a suitable curcumin for some time. Its benefits include reducing chronic inflammation, crucial for preventing metabolic disorders and cardiovascular disease. It also helps arthritis sufferers by alleviating joint swelling. I chose this one for its effective dosage and the presence of pepper and ginger, though the tablets are a bit large, they are still manageable to swallow.
Chest Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.5
9.5
Reduced pain
Most Useful Review
I have arthritis, and this product alleviates my pain and suffering effectively.
Urinary Tract Infection
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.2
USERS' SCORE
Good
Based on 2 Reviews
8.5
9
Curcumin inhibits UTI bacteria
Inhibition of biofilm development of uropathogens by curcumin - an anti-quorum sensing agent from Curcuma longa.
Most Relevant Research
We examined the potential of curcumin, the active ingredient in turmeric, to combat urinary tract infections (UTIs), which are often caused by bacteria forming biofilms. This study specifically looked at how curcumin could interfere with the quorum sensing (QS) systems of uropathogens like Escherichia coli and Pseudomonas aeruginosa.
Our research found that curcumin effectively inhibited the formation of biofilms by these bacteria and was even able to disrupt existing mature biofilms. Using light and confocal laser scanning microscopy, we observed these effects firsthand.
Additionally, we noted that treatment with curcumin reduced important QS-dependent activities in these bacteria, such as exopolysaccharide and alginate production, as well as their swimming and swarming abilities. Remarkably, curcumin also increased the effectiveness of standard antibiotics against these uropathogens, making it a promising option for enhancing current UTI treatments.
Our research found that curcumin effectively inhibited the formation of biofilms by these bacteria and was even able to disrupt existing mature biofilms. Using light and confocal laser scanning microscopy, we observed these effects firsthand.
Additionally, we noted that treatment with curcumin reduced important QS-dependent activities in these bacteria, such as exopolysaccharide and alginate production, as well as their swimming and swarming abilities. Remarkably, curcumin also increased the effectiveness of standard antibiotics against these uropathogens, making it a promising option for enhancing current UTI treatments.
8.8
Effective infection relief
Most Useful Review
A useful product that I have used several times; it helps combat urinary tract infections effectively. I find it to be high quality, packed with antioxidants. The packaging is excellent, and I have noticed inflammation decrease with usage. The taste is acceptable.
Diabetes
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Stabilises blood glucose
Most Useful Review
This product works for me. It is vegetable-based, so it is free from pesticides. Containing Curcumin, it alleviates various symptoms like arthritis and stomach issues. Having type 2 diabetes for over a decade, this product stabilises my blood glucose levels, reduces inflammation, boosts my immune system, balances my mood, and lessens depression. It also aids digestion, regulates cholesterol, and enhances heart health. My wife, a nurse, and my son, a physician's assistant, recommended it to me years ago, and I am grateful for that. I recommend it to my family and friends, believing that others can benefit too. I feel better with continuous use and experience no side effects.
Hives
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8
Chronic pain relief
Most Useful Review
This product alleviates some chronic pain and reduces my chances of waking up covered in hives. It's tastier than other solutions I’ve tried for my issues.
Leukemia
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Pain relief
Most Useful Review
Shocked at how well this worked. My grandma has arthritis and chronic leukemia. I didn't expect this to work as effectively as it did. While I lean towards natural remedies, she prefers clinical ones. I researched and decided to get this for her due to her shoulder pain, which made it difficult for her to move. The first day she took it, she seemed to feel better that night. Now, after a week, her shoulder only bothers her slightly, and she moves around well again.
Blood Clot
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.1
USERS' SCORE
Good
Based on 3 Reviews
8.4
9
Curcumin inhibits platelet activation
Curcumin Modulates Platelet Activation and ROS Production Induced by Amyloid Peptides: New Perspectives in Attenuating Prothrombotic Risk in Alzheimer's Disease Patients.
Most Relevant Research
We explored how curcumin, a natural compound found in turmeric, affects platelet activation specifically when stimulated by amyloid peptides associated with Alzheimer’s disease. The research aimed to determine if curcumin could help modulate these potentially harmful blood clotting responses.
Using isolated human platelets, we assessed how curcumin influences platelet aggregation and the production of reactive oxygen species. Our findings revealed that curcumin successfully suppressed platelet aggregation triggered by amyloid peptides. This suppression was linked to a decrease in critical signaling pathways involved in platelet activation.
Interestingly, while curcumin significantly inhibited responses to amyloid peptides, its effects on platelet activation induced by standard physiological triggers like thrombin and convulxin were less pronounced. Granule secretion, another aspect of platelet activation, was completely suppressed by curcumin only in response to the hemostatic stimuli, not in the presence of amyloid peptides.
Overall, it seems that curcumin may offer a targeted approach to mitigate the risk of blood clot formation in individuals suffering from Alzheimer’s disease, particularly concerning the pathological roles of amyloid peptides.
Using isolated human platelets, we assessed how curcumin influences platelet aggregation and the production of reactive oxygen species. Our findings revealed that curcumin successfully suppressed platelet aggregation triggered by amyloid peptides. This suppression was linked to a decrease in critical signaling pathways involved in platelet activation.
Interestingly, while curcumin significantly inhibited responses to amyloid peptides, its effects on platelet activation induced by standard physiological triggers like thrombin and convulxin were less pronounced. Granule secretion, another aspect of platelet activation, was completely suppressed by curcumin only in response to the hemostatic stimuli, not in the presence of amyloid peptides.
Overall, it seems that curcumin may offer a targeted approach to mitigate the risk of blood clot formation in individuals suffering from Alzheimer’s disease, particularly concerning the pathological roles of amyloid peptides.
9.5
Effective blood thinning
Most Useful Review
I wish to leave a genuine review of curcumin, six months after using it. I initially bought it for my father, who suffered severe varicose veins, and the doctors recommended surgery. We opted for curcumin instead, and he avoided surgery within a year! I took it during COVID-19 to thin my blood and noticed, after six months, that my blood thinned significantly. When I cut myself, I struggled to stop the blood from flowing for hours, which shows how effective curcumin is as a blood thinner. I even give it to my 3-year-old for colds.
Heart Disease
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
USERS' SCORE
Good
Based on 5 Reviews
8.3
8
Nano-curcumin improves heart health
Effect of nano-curcumin supplementation on angina status, and traditional and novel cardiovascular risk factors in overweight or obese patients with coronary slow flow phenomenon: a randomized double-blind placebo-controlled clinical trial.
Most Relevant Research
We conducted a double-blind, placebo-controlled trial to see how nano-curcumin, a supplement derived from turmeric, affects heart health in overweight or obese patients with a condition known as coronary slow flow phenomenon (CSFP). Our study involved 42 participants who received either 80 mg of nano-curcumin or a placebo daily for 12 weeks.
To measure how angina—a type of chest pain—improved, we used the Seattle angina questionnaire among other cardiovascular risk factors, including endocan, adropin, homocysteine levels, and various lipid profiles.
At the end of the study, we observed that those taking nano-curcumin reported significant improvements in their angina status and some cardiovascular factors, compared to their baseline measures. While some improvements were also seen in traditional and novel risk factors, more research will be needed to understand these changes in depth and whether they offer any real-world benefits for heart health.
To measure how angina—a type of chest pain—improved, we used the Seattle angina questionnaire among other cardiovascular risk factors, including endocan, adropin, homocysteine levels, and various lipid profiles.
At the end of the study, we observed that those taking nano-curcumin reported significant improvements in their angina status and some cardiovascular factors, compared to their baseline measures. While some improvements were also seen in traditional and novel risk factors, more research will be needed to understand these changes in depth and whether they offer any real-world benefits for heart health.
9.5
Effective for heart disease
Most Useful Review
Curcumin is a powerful antioxidant that I use for various ailments, including liver issues, heart disease, and joint pain. I've noticed improvements in memory and concentration. The high-quality brand shows effectiveness from the first doses. It's convenient to take one tablet daily, preferably in the morning with fat-soluble vitamins. I sincerely recommend purchasing it for positive results!
Bloating
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 1 Review
7.8
1.3
Caused bloating issues
Most Useful Review
This product did not work for me. Though potent, it caused stomach irritation and bloating without alleviating my inflammation. I would prefer a simpler product containing just turmeric and black pepper extract, as I believe this one has too many ingredients causing side effects. Unfortunately, it is non-returnable, so if you have existing stomach issues, you might want to consider another turmeric brand.
Anxiety
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.6
USERS' SCORE
Moderately Good
Based on 1 Review
7.7
9
Curcumin shows promise for anxiety
Effect of curcumin supplementation on symptoms of anxiety: A systematic review and meta-analysis of randomized controlled trials.
Most Relevant Research
We explored the potential of curcumin, a natural compound found in turmeric, as a treatment for anxiety. Through a thorough analysis of eight randomized controlled trials that included 567 participants, we aimed to determine whether curcumin could effectively alleviate anxiety symptoms.
The results were promising. The analysis indicated a significant improvement in anxiety symptoms among those who took curcumin, with a standardized mean difference of -1.56. This suggests that curcumin may lead to a noticeable reduction in anxiety levels. However, it’s important to note that the studies included were limited in number, and the variety in their designs contributed to considerable variation in outcomes.
While we found indications that curcumin may offer benefits for individuals dealing with anxiety, we also recognize the need for further high-quality research to solidify these findings. Until more comprehensive studies are conducted, it's crucial to approach curcumin as a potential supplementary treatment, rather than a standalone solution for anxiety disorders.
The results were promising. The analysis indicated a significant improvement in anxiety symptoms among those who took curcumin, with a standardized mean difference of -1.56. This suggests that curcumin may lead to a noticeable reduction in anxiety levels. However, it’s important to note that the studies included were limited in number, and the variety in their designs contributed to considerable variation in outcomes.
While we found indications that curcumin may offer benefits for individuals dealing with anxiety, we also recognize the need for further high-quality research to solidify these findings. Until more comprehensive studies are conducted, it's crucial to approach curcumin as a potential supplementary treatment, rather than a standalone solution for anxiety disorders.
0
Increased anxiety experienced
Most Useful Review
Caused irritation and increased anxiety. After 7 days without smoking, I attempted this supplement to ease nicotine withdrawal. Unfortunately, I experienced a spike in anxiety and agitation after taking it. It kept me up all night with extreme anxiety. I suspect the fermentation process in manufacturing caused this unfortunate reaction, making it unsuitable for anyone with sensitivities. I recommend seeking a lower strength product instead.
Diarrhea
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.8
USERS' SCORE
Moderately Good
Based on 1 Review
7.7
9
Curcumin alleviates diarrhea inflammation
Protective effects of curcumin against rat intestinal inflammation‑related motility disorders.
Most Relevant Research
In a recent study, we examined how curcumin, a component from the ginger family known for its anti-inflammatory properties, affects diarrhea in rats facing intestinal inflammation. We utilized a model involving Sprague-Dawley rats to induce conditions resembling diarrhea through the instillation of acetic acid.
Our findings highlighted that curcumin played a significant role in reversing the increase of pro-inflammatory cytokines, such as IL-1β and TNF-α, through the inhibition of the NF-κB pathway. Notably, we observed that curcumin effectively reduced myosin light chain (MLC) phosphorylation in the jejunum of rats experiencing diarrhea. This reduction was closely linked to improved motility in the context of inflammation.
Additionally, the study revealed that curcumin not only mitigated hypermotility related to diarrhea but also positively influenced inflammatory responses. This indicates that curcumin may hold therapeutic potential for managing intestinal inflammation-related motility disorders like diarrhea. Overall, our research suggests that incorporating curcumin could offer an effective strategy for those struggling with this condition.
Our findings highlighted that curcumin played a significant role in reversing the increase of pro-inflammatory cytokines, such as IL-1β and TNF-α, through the inhibition of the NF-κB pathway. Notably, we observed that curcumin effectively reduced myosin light chain (MLC) phosphorylation in the jejunum of rats experiencing diarrhea. This reduction was closely linked to improved motility in the context of inflammation.
Additionally, the study revealed that curcumin not only mitigated hypermotility related to diarrhea but also positively influenced inflammatory responses. This indicates that curcumin may hold therapeutic potential for managing intestinal inflammation-related motility disorders like diarrhea. Overall, our research suggests that incorporating curcumin could offer an effective strategy for those struggling with this condition.
0
Diarrhea issue
Most Useful Review
Caused diarrhoea, and I cannot return it! I purchased it based on positive reviews and after taking just one pill in the morning, I experienced diarrhoea by the afternoon. Now I have to discard the entire bottle since it is non-returnable. Twenty-two dollars wasted.
