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SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.3
USERS' SCORE
Good
Based on 36 Reviews
8.8
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Organic Turmeric BlendOrganic Turmeric Root Extract standardized to 95% curcuminoids, Organic Fermented Turmeric Root (blend yielding 100 mg curcuminoids)
553 mg
+
Organic Fermented Ginger Root
50 mg
+
Organic Black Pepper Fruit Extract
7 mg
+
Probiotic Blend Bifidobacterium lactis Bl-04Lactobacillus acidophilus La-14
4 mg
+
Top Medical Research Studies
9
Curcumin reduces osteoarthritis severity
Curcumin alleviates osteoarthritis in mice by suppressing osteoclastogenesis in subchondral bone via inhibiting NF-κB/JNK signaling pathway.
Direct focus on OA treatment
We investigated how curcumin, the active compound in turmeric, impacts osteoarthritis (OA) by focusing on its role in reducing the formation of bone-destroying cells called osteoclasts. In our research, we used a mouse model designed to mimic OA by destabilizing the medial meniscus, allowing us to measure the effects of curcumin on joint health.
Our study included three groups of male mice: those who received a vehicle treatment after their surgery, those with OA but also receiving the vehicle, and those with OA that were treated with curcumin. Over the course of eight weeks, we monitored the mice's cartilage and bone structure, looking for any changes.
We found that curcumin significantly suppressed osteoclast formation and bone resorption without harming the cells, suggesting it may be a promising treatment to alleviate arthritis symptoms. Specifically, curcumin inhibited the activation of important signaling pathways that promote osteoclast formation and cartilage degradation. This suggests a new and exciting approach for treating osteoarthritis, offering hope for better management of this chronic condition.
Our study included three groups of male mice: those who received a vehicle treatment after their surgery, those with OA but also receiving the vehicle, and those with OA that were treated with curcumin. Over the course of eight weeks, we monitored the mice's cartilage and bone structure, looking for any changes.
We found that curcumin significantly suppressed osteoclast formation and bone resorption without harming the cells, suggesting it may be a promising treatment to alleviate arthritis symptoms. Specifically, curcumin inhibited the activation of important signaling pathways that promote osteoclast formation and cartilage degradation. This suggests a new and exciting approach for treating osteoarthritis, offering hope for better management of this chronic condition.
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7
Curcumin shows potential for arthritis
The Immunomodulatory Effects of Curcumin on Forkhead Box O1 and MicroRNA-873 in Patients with Osteoarthritis.
Directly assesses turmeric's effects
We conducted a study to see how curcumin, the key ingredient in turmeric, affects arthritis, particularly focusing on patients with knee osteoarthritis (OA). In this well-structured clinical trial, we recruited 30 female patients and randomly assigned them to receive either curcumin or a placebo over three months, ensuring a double-blind approach to keep the results unbiased.
Our findings were quite telling. We observed that the expression of the FOXO1 gene related to T helper 17 (Th17) cells significantly increased in the group that received curcumin. This is notable because FOXO1 plays a role in regulating inflammation. While we didn’t see a significant change in another important gene, FOXP3, the expression of HSA-MIR-873, a type of microRNA, did see a meaningful boost in the curcumin group.
Overall, our research suggests that curcumin has potential immunomodulatory effects that might help manage inflammation associated with arthritis, linking it closely to the FOXO1 and microRNA-873 genes. This addition to arthritis treatment could open new avenues for relief, especially for those suffering from this condition.
Our findings were quite telling. We observed that the expression of the FOXO1 gene related to T helper 17 (Th17) cells significantly increased in the group that received curcumin. This is notable because FOXO1 plays a role in regulating inflammation. While we didn’t see a significant change in another important gene, FOXP3, the expression of HSA-MIR-873, a type of microRNA, did see a meaningful boost in the curcumin group.
Overall, our research suggests that curcumin has potential immunomodulatory effects that might help manage inflammation associated with arthritis, linking it closely to the FOXO1 and microRNA-873 genes. This addition to arthritis treatment could open new avenues for relief, especially for those suffering from this condition.
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7
Curcumin influences arthritis immune response
Effects of Curcumin in Free and Phytosomal Forms on the Expression of T Helper1 and Regulatory T Cells' Transcription Factors in Collagen-Induced Arthritis.
Highly relevant to arthritis treatment
We explored how curcumin, a compound found in turmeric, can help manage arthritis by influencing immune responses. The study focused on understanding the effects of both free curcumin and its phytosomal form in a collagen-induced arthritis model. This involved isolating splenocytes, a type of immune cell, after inducing arthritis and then re-stimulating them with collagen in the presence of different doses of curcumin. We measured the expression of key transcription factors T-bet and Foxp3, which are important for regulating T helper cells and regulatory T cells.
Our findings revealed that curcumin did have a modulatory effect on the expression of T-bet, a crucial factor for Th1 cells. However, we observed that only the free-form curcumin increased the expression of Foxp3, which is indicative of regulatory T cells. This could be attributed to the lower bioavailability of the phytosomal form, meaning that the curcumin in this complex wasn't as effective at the same dosage. Thus, while curcumin shows promise in impacting immune responses in arthritis, its effectiveness may vary depending on its delivery form.
Our findings revealed that curcumin did have a modulatory effect on the expression of T-bet, a crucial factor for Th1 cells. However, we observed that only the free-form curcumin increased the expression of Foxp3, which is indicative of regulatory T cells. This could be attributed to the lower bioavailability of the phytosomal form, meaning that the curcumin in this complex wasn't as effective at the same dosage. Thus, while curcumin shows promise in impacting immune responses in arthritis, its effectiveness may vary depending on its delivery form.
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Most Useful Reviews
10
Pain GONE quickly
I can't believe how fast this worked! My doctor advised me to take turmeric and glucosamine for crippling knee pain that the arthritis gel did not alleviate. After trying various options, I started this supplement and within 2-3 days, my pain was GONE! It’s truly been life-changing.
Read More
9.5
Great for inflammation
I have Rheumatoid Arthritis, and this supplement has definitely assisted with the inflammation in my joints as well as relieving my daily pain. I love this brand and also take their women's daily vitamins and probiotics.
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10
Miraculous improvement
I am 20 years old with Crohn's disease and associated arthritis. Before taking this supplement, I was bedridden and in severe pain. Three days after taking turmeric, I felt miraculously better. It's been 15 days without any arthritis pain, which is the longest stretch I've experienced in months. This is a lifesaver!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.3
9
CUR-PDT shows promise in RA therapy
CUR-PDT induces ferroptosis of RA-FLS via the Nrf2/xCT/GPX4 pathway to inhibit proliferation in rheumatoid arthritis.
Curcumin's isolated effects noted
We delved into the effects of curcumin, particularly through a method called photodynamic therapy (CUR-PDT), in the context of rheumatoid arthritis. The research focused on how this treatment might trigger a specific type of cell death known as ferroptosis in fibroblast-like synoviocytes (FLSs), which are key players in arthritis inflammation.
Our study incorporated both in vivo and in vitro methods. In the animal model, we observed that CUR-PDT helped reduce joint swelling and associated inflammation. We also looked closely at how this treatment affected specific markers within FLSs, particularly focusing on the Nrf2/xCT/GPX4 signaling pathway. This pathway is crucial because it helps regulate responses to oxidative stress—something that can be detrimental in arthritis.
Through various tests, including measuring cell viability and cell responses to oxidative stress, we found that CUR-PDT effectively induced ferroptosis in the FLSs. This led to decreased cell proliferation and therefore suggests a potential avenue for treating rheumatoid arthritis more effectively. Although our findings show promising results regarding curcumin's role, it is important to emphasize that these effects stemmed more from the method of photodynamic therapy than solely from curcumin itself.
Overall, this research shines a light on the importance of understanding how curcumin, when utilized in specific therapeutic approaches, may contribute to better managing rheumatoid arthritis. However, the exact applications and benefits still require further exploration.
Our study incorporated both in vivo and in vitro methods. In the animal model, we observed that CUR-PDT helped reduce joint swelling and associated inflammation. We also looked closely at how this treatment affected specific markers within FLSs, particularly focusing on the Nrf2/xCT/GPX4 signaling pathway. This pathway is crucial because it helps regulate responses to oxidative stress—something that can be detrimental in arthritis.
Through various tests, including measuring cell viability and cell responses to oxidative stress, we found that CUR-PDT effectively induced ferroptosis in the FLSs. This led to decreased cell proliferation and therefore suggests a potential avenue for treating rheumatoid arthritis more effectively. Although our findings show promising results regarding curcumin's role, it is important to emphasize that these effects stemmed more from the method of photodynamic therapy than solely from curcumin itself.
Overall, this research shines a light on the importance of understanding how curcumin, when utilized in specific therapeutic approaches, may contribute to better managing rheumatoid arthritis. However, the exact applications and benefits still require further exploration.
Read More
9
Turmeric shows promise for RA
Effects of plant active substances in rheumatoid arthritis-a systematic review and network meta-analysis.
Research highlights turmeric's efficacy
We delved into the effects of turmeric, specifically curcumin, on rheumatoid arthritis (RA) through a systematic network meta-analysis. By gathering data from several major databases, we aimed to determine how this plant-derived substance might alleviate symptoms associated with RA.
Our analysis revealed that curcumin stands out for its ability to reduce swollen and tender joint counts significantly compared to placebo treatments. Additionally, it helped decrease inflammatory markers, which are crucial in managing RA effectively.
We also found that other substances like quercetin and resveratrol showed notable benefits, with quercetin being effective in lowering pain levels and resveratrol improving overall disease activity scores.
While these findings are promising and suggest that patients could benefit from turmeric as part of their treatment plan, we highlight that further research is necessary to confirm these results and ensure safety in long-term use.
Our analysis revealed that curcumin stands out for its ability to reduce swollen and tender joint counts significantly compared to placebo treatments. Additionally, it helped decrease inflammatory markers, which are crucial in managing RA effectively.
We also found that other substances like quercetin and resveratrol showed notable benefits, with quercetin being effective in lowering pain levels and resveratrol improving overall disease activity scores.
While these findings are promising and suggest that patients could benefit from turmeric as part of their treatment plan, we highlight that further research is necessary to confirm these results and ensure safety in long-term use.
Read More
9
Curcumin and Vitamin D aid OA
Curcumin and Vitamin D Supplement Attenuates Knee Osteoarthritis Progression in ACLT + MMx Rat Model: Effect on Cartilage Protection and Pain Reduction.
Combination effects of supplements
We investigated the effects of curcumin, a natural compound found in turmeric, along with vitamin D, on knee osteoarthritis (OA) using a rat model. The study divided male Wistar rats into five groups: a control group, a group receiving curcumin, another getting vitamin D, one that received a combination of both, and a sham-operated group. Each supplement was given daily for 12 weeks to assess their impacts on pain and inflammation associated with OA.
Our findings reveal that curcumin and vitamin D worked well to reduce pain levels individually. Interestingly, when combined, they provided even better relief from pain. We also observed notable changes in inflammation markers; while pro-inflammatory cytokines were reduced, the anti-inflammatory cytokine interleukin-10 (IL-10) increased in the groups receiving the supplements. Additionally, curcumin and vitamin D demonstrated a beneficial effect on oxidative stress markers, leading to improved joint structure and cartilage health.
Histological analysis showed that the treated groups maintained better joint architecture, less inflammation of the synovium, and preserved cartilage integrity compared to the control group. Therefore, we recognize the potential of curcumin and vitamin D as natural agents that could play a role in managing knee osteoarthritis and associated pain. This research suggests they may offer valuable strategies for delaying OA progression and enhancing patient care in clinical settings.
Our findings reveal that curcumin and vitamin D worked well to reduce pain levels individually. Interestingly, when combined, they provided even better relief from pain. We also observed notable changes in inflammation markers; while pro-inflammatory cytokines were reduced, the anti-inflammatory cytokine interleukin-10 (IL-10) increased in the groups receiving the supplements. Additionally, curcumin and vitamin D demonstrated a beneficial effect on oxidative stress markers, leading to improved joint structure and cartilage health.
Histological analysis showed that the treated groups maintained better joint architecture, less inflammation of the synovium, and preserved cartilage integrity compared to the control group. Therefore, we recognize the potential of curcumin and vitamin D as natural agents that could play a role in managing knee osteoarthritis and associated pain. This research suggests they may offer valuable strategies for delaying OA progression and enhancing patient care in clinical settings.
Read More
9
Curcumin reduces inflammation in arthritis
Mechanism of action of curcumin targeting TRPM2/NLRP3 signaling axis to mediate cell death in the treatment of knee osteoarthritis.
High relevance to turmeric and arthritis
We explored how curcumin, a key compound in turmeric, might help alleviate symptoms of knee osteoarthritis. In our study, we focused on the inflammatory response in cartilage cells, known as chondrocytes, which can be triggered by interleukin IL-1β. To better understand curcumin’s role, we created chondrocytes that overexpress a protein called TRPM2, allowing us to investigate the underlying mechanisms more closely.
We conducted a series of experiments to assess how curcumin affects cell viability, reactive oxygen species (ROS) levels, and the release of inflammatory factors like TNF-α and IL-6. Our findings showed that curcumin effectively improved the inflammatory response in chondrocytes, protecting them against damage induced by IL-1β. Moreover, in tests conducted on a rat model of knee osteoarthritis, we observed that curcumin helped maintain cartilage integrity and reduced inflammation, confirming its potential as a therapeutic option.
Overall, our study highlights the ability of curcumin to target the TRPM2/NLRP3 signaling pathway, leading to reduced cell death and inflammation in osteoarthritis. This suggests that incorporating curcumin could offer a natural approach to managing arthritis symptoms.
We conducted a series of experiments to assess how curcumin affects cell viability, reactive oxygen species (ROS) levels, and the release of inflammatory factors like TNF-α and IL-6. Our findings showed that curcumin effectively improved the inflammatory response in chondrocytes, protecting them against damage induced by IL-1β. Moreover, in tests conducted on a rat model of knee osteoarthritis, we observed that curcumin helped maintain cartilage integrity and reduced inflammation, confirming its potential as a therapeutic option.
Overall, our study highlights the ability of curcumin to target the TRPM2/NLRP3 signaling pathway, leading to reduced cell death and inflammation in osteoarthritis. This suggests that incorporating curcumin could offer a natural approach to managing arthritis symptoms.
Read More
9
Curcumin's role in arthritis treatment
Optimized co-delivery of curcumin and methylprednisolone using polyvinyl alcohol-coated CuO nanoparticles for synergistic rheumatoid arthritis treatment.
Study combines turmeric with steroids
We explored the potential of using curcumin, a compound commonly found in turmeric, alongside methylprednisolone to improve treatments for rheumatoid arthritis. By employing a model that induced arthritis in rats, we aimed to see how this combination could minimize the amount of steroids needed, potentially reducing side effects while maintaining effectiveness.
In our research, we used polyvinyl alcohol-coated copper oxide nanoparticles as a method of delivering these drugs in a controlled manner. The nanoparticles, created through ultrasound synthesis, showed a promising size and demonstrated good biocompatibility. This means they are safe for cell life, which is crucial in medical applications.
What stood out in our findings were the benefits of the nanoparticle delivery system. Both curcumin and methylprednisolone were released into the body more gradually, which can be advantageous. Moreover, the combined treatment significantly reduced swelling and clinical symptoms in the rats, along with lower levels of certain pro-inflammatory cytokines associated with pain and inflammation.
Overall, our findings suggest that curcumin, especially when paired with methylprednisolone and delivered through these nanoparticles, could provide a more effective therapy for those suffering from arthritis, bridging natural and pharmaceutical solutions for better health.
In our research, we used polyvinyl alcohol-coated copper oxide nanoparticles as a method of delivering these drugs in a controlled manner. The nanoparticles, created through ultrasound synthesis, showed a promising size and demonstrated good biocompatibility. This means they are safe for cell life, which is crucial in medical applications.
What stood out in our findings were the benefits of the nanoparticle delivery system. Both curcumin and methylprednisolone were released into the body more gradually, which can be advantageous. Moreover, the combined treatment significantly reduced swelling and clinical symptoms in the rats, along with lower levels of certain pro-inflammatory cytokines associated with pain and inflammation.
Overall, our findings suggest that curcumin, especially when paired with methylprednisolone and delivered through these nanoparticles, could provide a more effective therapy for those suffering from arthritis, bridging natural and pharmaceutical solutions for better health.
Read More
User Reviews
USERS' SCORE
Good
Based on 36 Reviews
8.8
10
Pain GONE quickly
I can't believe how fast this worked! My doctor advised me to take turmeric and glucosamine for crippling knee pain that the arthritis gel did not alleviate. After trying various options, I started this supplement and within 2-3 days, my pain was GONE! It’s truly been life-changing.
Read More
10
Miraculous improvement
I am 20 years old with Crohn's disease and associated arthritis. Before taking this supplement, I was bedridden and in severe pain. Three days after taking turmeric, I felt miraculously better. It's been 15 days without any arthritis pain, which is the longest stretch I've experienced in months. This is a lifesaver!
Read More
9.5
Improves joint mobility
Excellent composition! I drank this for a month due to my rheumatoid arthritis, and my SOE dropped significantly, leading to less pain and improved joint mobility. I almost forget my joint issues now!
9.5
Immediate pain relief
These help my husband's arthritis pain! He feels immediate relief in his knees and hands, and taking them with food prevents stomach upset. If he misses a dose, he quickly notices a difference.
9.5
Pain-free days
After using this product, my arthritis pain in my thumbs has significantly reduced. Most days, I'm pain-free. I increase my dosage slightly during flare-ups, and it works quickly. I appreciate that they're organic and gluten-free.
