Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.2
USERS' SCORE
Good
Based on 6 Reviews
8.3
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Organic Turmeric BlendOrganic Turmeric Root Extract standardized to 95% curcuminoids, Organic Fermented Turmeric Root (blend yielding 100 mg curcuminoids)
553 mg
+
Organic Fermented Ginger Root
50 mg
+
Organic Black Pepper Fruit Extract
7 mg
+
Probiotic Blend Bifidobacterium lactis Bl-04Lactobacillus acidophilus La-14
4 mg
+
Top Medical Research Studies
9
We explored the potential of curcumin nanoparticles (CNPs) as a treatment for gout, a condition caused by the buildup of urate crystals in the joints. To investigate this, researchers induced gout-like symptoms in mice by injecting monosodium urate crystals. This led to joint swelling and increased levels of uric acid in the bloodstream.
The study involved administering various concentrations of CNPs, alongside a commonly used medication, allopurinol. The results were promising, showing that CNPs not only lowered uric acid levels and reduced swelling but also decreased inflammation in the affected mice. Interestingly, the application of CNPs increased beneficial substances like high-density lipoprotein and interleukin-10, further supporting their potential health benefits.
Overall, our findings indicate that curcumin nanoparticles present a viable and effective anti-gout treatment with minimal side effects compared to traditional pharmaceuticals. This opens exciting possibilities for developing natural therapies to manage gout and improve patient quality of life.
The study involved administering various concentrations of CNPs, alongside a commonly used medication, allopurinol. The results were promising, showing that CNPs not only lowered uric acid levels and reduced swelling but also decreased inflammation in the affected mice. Interestingly, the application of CNPs increased beneficial substances like high-density lipoprotein and interleukin-10, further supporting their potential health benefits.
Overall, our findings indicate that curcumin nanoparticles present a viable and effective anti-gout treatment with minimal side effects compared to traditional pharmaceuticals. This opens exciting possibilities for developing natural therapies to manage gout and improve patient quality of life.
Read More
9
We investigated how curcumin, a natural compound found in turmeric, impacts inflammation caused by monosodium urate (MSU) crystals, which are responsible for gouty arthritis. Our approach involved pre-treating macrophage cells with curcumin before exposing them to MSU crystals and measuring various inflammatory responses.
Through our research, we observed that curcumin significantly reduced inflammation by preventing the breakdown of a molecule called IκBα and curbing the activation of a key inflammatory pathway known as NF-κB. Notably, this compound also appeared to protect mitochondria—the powerhouse of the cells—from damage and inhibited the activity of the NLRP3 inflammasome, which plays a crucial role in inflammatory responses.
Additionally, we tested curcumin in mouse models of acute gout, where we saw improvements in joint swelling and reduced signs of inflammation. These findings suggest that curcumin could be a promising strategy to mitigate acute gout flares. Overall, our results highlight curcumin's potential as an effective natural treatment for managing gout-related inflammation.
Through our research, we observed that curcumin significantly reduced inflammation by preventing the breakdown of a molecule called IκBα and curbing the activation of a key inflammatory pathway known as NF-κB. Notably, this compound also appeared to protect mitochondria—the powerhouse of the cells—from damage and inhibited the activity of the NLRP3 inflammasome, which plays a crucial role in inflammatory responses.
Additionally, we tested curcumin in mouse models of acute gout, where we saw improvements in joint swelling and reduced signs of inflammation. These findings suggest that curcumin could be a promising strategy to mitigate acute gout flares. Overall, our results highlight curcumin's potential as an effective natural treatment for managing gout-related inflammation.
Read More
9
We explored the potential of turmeric as a treatment for gout, utilizing modern nanoparticle technology to enhance its effects. By developing turmeric nanoparticles (T-NPs), we aimed to determine their impact on acute and chronic gout-related symptoms.
The T-NPs were successfully created and characterized, revealing a small size of about 46 nanometers, alongside qualities such as a positive charge which could enhance their interaction with biological systems. We applied the T-NPs to a group of mice that had induced gout, observing the effects of varying doses (5, 10, and 20 ppm) administered orally.
Excitingly, our findings showed that, following treatment, the mice experienced significant reductions in uric acid levels, joint swelling, and improvements in important biochemical parameters related to overall health. This suggests that turmeric nanoparticles could emerge as a promising solution in managing gout with minimal side effects. Overall, we found that T-NPs not only maintain the beneficial properties of turmeric but potentially enhance its effectiveness against gout.
The T-NPs were successfully created and characterized, revealing a small size of about 46 nanometers, alongside qualities such as a positive charge which could enhance their interaction with biological systems. We applied the T-NPs to a group of mice that had induced gout, observing the effects of varying doses (5, 10, and 20 ppm) administered orally.
Excitingly, our findings showed that, following treatment, the mice experienced significant reductions in uric acid levels, joint swelling, and improvements in important biochemical parameters related to overall health. This suggests that turmeric nanoparticles could emerge as a promising solution in managing gout with minimal side effects. Overall, we found that T-NPs not only maintain the beneficial properties of turmeric but potentially enhance its effectiveness against gout.
Read More
Most Useful Reviews
9
Pain relief
7 people found this helpful
A mighty product. I had gout and, by chance, was eating this. I found the pain subsided and my symptoms improved. I highly recommend it.
Read More
9
Symptom relief
It effectively relieves symptoms of gout.
Read More
7.5
Effective treatment
Excellent! This is my preferred brand. I notice a difference when taking it; it helps reduce inflammation and pain significantly. My friend with gout also finds it beneficial, although I wish it were slightly cheaper.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.2
- All Researches
9
We explored the potential of curcumin nanoparticles (CNPs) as a treatment for gout, a condition caused by the buildup of urate crystals in the joints. To investigate this, researchers induced gout-like symptoms in mice by injecting monosodium urate crystals. This led to joint swelling and increased levels of uric acid in the bloodstream.
The study involved administering various concentrations of CNPs, alongside a commonly used medication, allopurinol. The results were promising, showing that CNPs not only lowered uric acid levels and reduced swelling but also decreased inflammation in the affected mice. Interestingly, the application of CNPs increased beneficial substances like high-density lipoprotein and interleukin-10, further supporting their potential health benefits.
Overall, our findings indicate that curcumin nanoparticles present a viable and effective anti-gout treatment with minimal side effects compared to traditional pharmaceuticals. This opens exciting possibilities for developing natural therapies to manage gout and improve patient quality of life.
The study involved administering various concentrations of CNPs, alongside a commonly used medication, allopurinol. The results were promising, showing that CNPs not only lowered uric acid levels and reduced swelling but also decreased inflammation in the affected mice. Interestingly, the application of CNPs increased beneficial substances like high-density lipoprotein and interleukin-10, further supporting their potential health benefits.
Overall, our findings indicate that curcumin nanoparticles present a viable and effective anti-gout treatment with minimal side effects compared to traditional pharmaceuticals. This opens exciting possibilities for developing natural therapies to manage gout and improve patient quality of life.
Read More
9
We explored the potential of curcumin, a natural anti-inflammatory compound found in turmeric, for treating gouty arthritis. Gout is a painful inflammatory condition, and managing inflammation is crucial for preventing flare-ups. Traditionally, colchicine has been used to treat gout, but it comes with significant side effects.
To enhance the effectiveness of curcumin, researchers developed a delivery system using tetrahedral framework nucleic acids (TFNAs). This innovation aimed to overcome curcumin's common issues, such as its rapid degradation and poor solubility in water, which limit its therapeutic use. With this new curcumin formulation, we observed improved drug stability, good compatibility with biological systems, and better uptake in the body compared to free curcumin.
Most notably, both laboratory tests and studies in living organisms demonstrated that curcumin-loaded TFNAs had a stronger anti-inflammatory effect than regular curcumin. By measuring inflammation-related proteins, the results showed promise in treatment effectiveness. Overall, the enhanced bioavailability and stability of curcumin through this innovative delivery method could lead to better prevention and management of gout and other inflammatory diseases.
To enhance the effectiveness of curcumin, researchers developed a delivery system using tetrahedral framework nucleic acids (TFNAs). This innovation aimed to overcome curcumin's common issues, such as its rapid degradation and poor solubility in water, which limit its therapeutic use. With this new curcumin formulation, we observed improved drug stability, good compatibility with biological systems, and better uptake in the body compared to free curcumin.
Most notably, both laboratory tests and studies in living organisms demonstrated that curcumin-loaded TFNAs had a stronger anti-inflammatory effect than regular curcumin. By measuring inflammation-related proteins, the results showed promise in treatment effectiveness. Overall, the enhanced bioavailability and stability of curcumin through this innovative delivery method could lead to better prevention and management of gout and other inflammatory diseases.
Read More
9
We investigated how curcumin, a natural compound found in turmeric, impacts inflammation caused by monosodium urate (MSU) crystals, which are responsible for gouty arthritis. Our approach involved pre-treating macrophage cells with curcumin before exposing them to MSU crystals and measuring various inflammatory responses.
Through our research, we observed that curcumin significantly reduced inflammation by preventing the breakdown of a molecule called IκBα and curbing the activation of a key inflammatory pathway known as NF-κB. Notably, this compound also appeared to protect mitochondria—the powerhouse of the cells—from damage and inhibited the activity of the NLRP3 inflammasome, which plays a crucial role in inflammatory responses.
Additionally, we tested curcumin in mouse models of acute gout, where we saw improvements in joint swelling and reduced signs of inflammation. These findings suggest that curcumin could be a promising strategy to mitigate acute gout flares. Overall, our results highlight curcumin's potential as an effective natural treatment for managing gout-related inflammation.
Through our research, we observed that curcumin significantly reduced inflammation by preventing the breakdown of a molecule called IκBα and curbing the activation of a key inflammatory pathway known as NF-κB. Notably, this compound also appeared to protect mitochondria—the powerhouse of the cells—from damage and inhibited the activity of the NLRP3 inflammasome, which plays a crucial role in inflammatory responses.
Additionally, we tested curcumin in mouse models of acute gout, where we saw improvements in joint swelling and reduced signs of inflammation. These findings suggest that curcumin could be a promising strategy to mitigate acute gout flares. Overall, our results highlight curcumin's potential as an effective natural treatment for managing gout-related inflammation.
Read More
9
We explored the potential of turmeric as a treatment for gout, utilizing modern nanoparticle technology to enhance its effects. By developing turmeric nanoparticles (T-NPs), we aimed to determine their impact on acute and chronic gout-related symptoms.
The T-NPs were successfully created and characterized, revealing a small size of about 46 nanometers, alongside qualities such as a positive charge which could enhance their interaction with biological systems. We applied the T-NPs to a group of mice that had induced gout, observing the effects of varying doses (5, 10, and 20 ppm) administered orally.
Excitingly, our findings showed that, following treatment, the mice experienced significant reductions in uric acid levels, joint swelling, and improvements in important biochemical parameters related to overall health. This suggests that turmeric nanoparticles could emerge as a promising solution in managing gout with minimal side effects. Overall, we found that T-NPs not only maintain the beneficial properties of turmeric but potentially enhance its effectiveness against gout.
The T-NPs were successfully created and characterized, revealing a small size of about 46 nanometers, alongside qualities such as a positive charge which could enhance their interaction with biological systems. We applied the T-NPs to a group of mice that had induced gout, observing the effects of varying doses (5, 10, and 20 ppm) administered orally.
Excitingly, our findings showed that, following treatment, the mice experienced significant reductions in uric acid levels, joint swelling, and improvements in important biochemical parameters related to overall health. This suggests that turmeric nanoparticles could emerge as a promising solution in managing gout with minimal side effects. Overall, we found that T-NPs not only maintain the beneficial properties of turmeric but potentially enhance its effectiveness against gout.
Read More
9
We explored the impact of curcumin, a well-known ingredient found in turmeric, on gouty arthritis specifically triggered by monosodium urate (MSU) crystals. By focusing on both in vitro and in vivo models, we evaluated how curcumin influences inflammation caused by these crystals, which are a primary factor in the onset of gout.
To assess its effects, we examined cell viability in rat abdominal macrophages and analyzed the levels of inflammatory markers like interleukin (IL)-1β and tumor necrosis factor (TNF)-α after treating cells with curcumin. Our methods included techniques like enzyme-linked immunosorbent assay and Western blot analysis, which helped us understand how curcumin interacts with the NLRP3 inflammasome and nuclear factor-kappa B (NF-κB) signaling pathways.
Our findings indicate that curcumin does help alleviate the symptoms of MSU-induced gouty arthritis. We observed that it inhibits the inflammatory response through specific signaling pathways, suggesting that it could be a promising option for treating gout. This strengthens the case for curcumin not just as a culinary spice but as a potential therapeutic agent for gout.
To assess its effects, we examined cell viability in rat abdominal macrophages and analyzed the levels of inflammatory markers like interleukin (IL)-1β and tumor necrosis factor (TNF)-α after treating cells with curcumin. Our methods included techniques like enzyme-linked immunosorbent assay and Western blot analysis, which helped us understand how curcumin interacts with the NLRP3 inflammasome and nuclear factor-kappa B (NF-κB) signaling pathways.
Our findings indicate that curcumin does help alleviate the symptoms of MSU-induced gouty arthritis. We observed that it inhibits the inflammatory response through specific signaling pathways, suggesting that it could be a promising option for treating gout. This strengthens the case for curcumin not just as a culinary spice but as a potential therapeutic agent for gout.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Pain relief
7 people found this helpful
A mighty product. I had gout and, by chance, was eating this. I found the pain subsided and my symptoms improved. I highly recommend it.
Read More
9
Symptom relief
It effectively relieves symptoms of gout.
Read More
7.5
Effective treatment
Excellent! This is my preferred brand. I notice a difference when taking it; it helps reduce inflammation and pain significantly. My friend with gout also finds it beneficial, although I wish it were slightly cheaper.
Read More
7.5
High-quality ingredients
While the price is high, the quality is excellent, especially for joint pain relief from gout. I appreciate the natural ingredients with no fillers—my go-to brand. I just wish it would be more affordable.
Read More
7.5
Arthritis support
It aids in managing arthritis and gout effectively!
Read More
Frequently Asked Questions
9
Pain relief
7 people found this helpful
A mighty product. I had gout and, by chance, was eating this. I found the pain subsided and my symptoms improved. I highly recommend it.
7.5
Arthritis support
It aids in managing arthritis and gout effectively!
7.5
Effective treatment
Excellent! This is my preferred brand. I notice a difference when taking it; it helps reduce inflammation and pain significantly. My friend with gout also finds it beneficial, although I wish it were slightly cheaper.
6
Inflammation reduction
The tablets are quite large and can be difficult to swallow, but they do alleviate inflammation from gout, so I'll endure the size!
7.5
High-quality ingredients
While the price is high, the quality is excellent, especially for joint pain relief from gout. I appreciate the natural ingredients with no fillers—my go-to brand. I just wish it would be more affordable.
9
We explored the potential of curcumin nanoparticles (CNPs) as a treatment for gout, a condition caused by the buildup of urate crystals in the joints. To investigate this, researchers induced gout-like symptoms in mice by injecting monosodium urate crystals. This led to joint swelling and increased levels of uric acid in the bloodstream.
The study involved administering various concentrations of CNPs, alongside a commonly used medication, allopurinol. The results were promising, showing that CNPs not only lowered uric acid levels and reduced swelling but also decreased inflammation in the affected mice. Interestingly, the application of CNPs increased beneficial substances like high-density lipoprotein and interleukin-10, further supporting their potential health benefits.
Overall, our findings indicate that curcumin nanoparticles present a viable and effective anti-gout treatment with minimal side effects compared to traditional pharmaceuticals. This opens exciting possibilities for developing natural therapies to manage gout and improve patient quality of life.
The study involved administering various concentrations of CNPs, alongside a commonly used medication, allopurinol. The results were promising, showing that CNPs not only lowered uric acid levels and reduced swelling but also decreased inflammation in the affected mice. Interestingly, the application of CNPs increased beneficial substances like high-density lipoprotein and interleukin-10, further supporting their potential health benefits.
Overall, our findings indicate that curcumin nanoparticles present a viable and effective anti-gout treatment with minimal side effects compared to traditional pharmaceuticals. This opens exciting possibilities for developing natural therapies to manage gout and improve patient quality of life.
9
We investigated how curcumin, a natural compound found in turmeric, impacts inflammation caused by monosodium urate (MSU) crystals, which are responsible for gouty arthritis. Our approach involved pre-treating macrophage cells with curcumin before exposing them to MSU crystals and measuring various inflammatory responses.
Through our research, we observed that curcumin significantly reduced inflammation by preventing the breakdown of a molecule called IκBα and curbing the activation of a key inflammatory pathway known as NF-κB. Notably, this compound also appeared to protect mitochondria—the powerhouse of the cells—from damage and inhibited the activity of the NLRP3 inflammasome, which plays a crucial role in inflammatory responses.
Additionally, we tested curcumin in mouse models of acute gout, where we saw improvements in joint swelling and reduced signs of inflammation. These findings suggest that curcumin could be a promising strategy to mitigate acute gout flares. Overall, our results highlight curcumin's potential as an effective natural treatment for managing gout-related inflammation.
Through our research, we observed that curcumin significantly reduced inflammation by preventing the breakdown of a molecule called IκBα and curbing the activation of a key inflammatory pathway known as NF-κB. Notably, this compound also appeared to protect mitochondria—the powerhouse of the cells—from damage and inhibited the activity of the NLRP3 inflammasome, which plays a crucial role in inflammatory responses.
Additionally, we tested curcumin in mouse models of acute gout, where we saw improvements in joint swelling and reduced signs of inflammation. These findings suggest that curcumin could be a promising strategy to mitigate acute gout flares. Overall, our results highlight curcumin's potential as an effective natural treatment for managing gout-related inflammation.
9
We explored the impact of curcumin, a well-known ingredient found in turmeric, on gouty arthritis specifically triggered by monosodium urate (MSU) crystals. By focusing on both in vitro and in vivo models, we evaluated how curcumin influences inflammation caused by these crystals, which are a primary factor in the onset of gout.
To assess its effects, we examined cell viability in rat abdominal macrophages and analyzed the levels of inflammatory markers like interleukin (IL)-1β and tumor necrosis factor (TNF)-α after treating cells with curcumin. Our methods included techniques like enzyme-linked immunosorbent assay and Western blot analysis, which helped us understand how curcumin interacts with the NLRP3 inflammasome and nuclear factor-kappa B (NF-κB) signaling pathways.
Our findings indicate that curcumin does help alleviate the symptoms of MSU-induced gouty arthritis. We observed that it inhibits the inflammatory response through specific signaling pathways, suggesting that it could be a promising option for treating gout. This strengthens the case for curcumin not just as a culinary spice but as a potential therapeutic agent for gout.
To assess its effects, we examined cell viability in rat abdominal macrophages and analyzed the levels of inflammatory markers like interleukin (IL)-1β and tumor necrosis factor (TNF)-α after treating cells with curcumin. Our methods included techniques like enzyme-linked immunosorbent assay and Western blot analysis, which helped us understand how curcumin interacts with the NLRP3 inflammasome and nuclear factor-kappa B (NF-κB) signaling pathways.
Our findings indicate that curcumin does help alleviate the symptoms of MSU-induced gouty arthritis. We observed that it inhibits the inflammatory response through specific signaling pathways, suggesting that it could be a promising option for treating gout. This strengthens the case for curcumin not just as a culinary spice but as a potential therapeutic agent for gout.
4
We explored the effects of curcumin, a natural compound from turmeric, on gouty arthritis—a painful condition triggered by the accumulation of urate crystals in the joints. Through a thorough literature search across ten different databases, we gathered studies that specifically focused on how curcumin might help alleviate the symptoms associated with gout.
Our findings highlighted that curcumin shows promise through its ability to inhibit xanthine oxidase, reduce uric acid levels, and offer both antioxidant and anti-inflammatory benefits. However, not every piece of research we examined found significant reductions in uric acid levels, which is crucial for gout management.
Despite the interesting results, we believe further well-structured studies are necessary to fully validate curcumin's effectiveness as a treatment for gout. We emphasized the potential of this compound, but it is clear that more research is needed before we can confidently recommend curcumin for gout treatment.
Our findings highlighted that curcumin shows promise through its ability to inhibit xanthine oxidase, reduce uric acid levels, and offer both antioxidant and anti-inflammatory benefits. However, not every piece of research we examined found significant reductions in uric acid levels, which is crucial for gout management.
Despite the interesting results, we believe further well-structured studies are necessary to fully validate curcumin's effectiveness as a treatment for gout. We emphasized the potential of this compound, but it is clear that more research is needed before we can confidently recommend curcumin for gout treatment.
References
- Javed C, Noreen R, Niazi SG, Kiyani MM, Ul Ain Q. Anti-gouty arthritis and anti-inflammatory effects of curcumin nanoparticles in monosodium urate crystals induced Balb/C mice. Inflammopharmacology. 2024;32:1929. doi:10.1007/s10787-024-01450-x
- Jafari-Nozad AM, Jafari A, Yousefi S, Bakhshi H, Farkhondeh T, et al. Anti-gout and Urate-lowering Potentials of Curcumin: A Review from Bench to Beside. Curr Med Chem. 2024;31:3715. doi:10.2174/0929867331666230721154653
- Zhang M, Zhang X, Tian T, Zhang Q, Wen Y, et al. Anti-inflammatory activity of curcumin-loaded tetrahedral framework nucleic acids on acute gouty arthritis. Bioact Mater. 2022;8:368. doi:10.1016/j.bioactmat.2021.06.003
- Chen B, Li H, Ou G, Ren L, Yang X, et al. Curcumin attenuates MSU crystal-induced inflammation by inhibiting the degradation of IκBα and blocking mitochondrial damage. Arthritis Res Ther. 2019;21:193. doi:10.1186/s13075-019-1974-z
- Kiyani MM, Sohail MF, Shahnaz G, Rehman H, Akhtar MF, et al. Evaluation of Turmeric Nanoparticles as Anti-Gout Agent: Modernization of a Traditional Drug. Medicina (Kaunas). 2019;55. doi:10.3390/medicina55010010
- Li X, Xu DQ, Sun DY, Zhang T, He X, et al. Curcumin ameliorates monosodium urate-induced gouty arthritis through Nod-like receptor 3 inflammasome mediation via inhibiting nuclear factor-kappa B signaling. J Cell Biochem. 2019;120:6718. doi:10.1002/jcb.27969
