' 
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.5
USERS' SCORE
Good
Based on 2 Reviews
8.7
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Vitamin C (from culture of S. cerevisiae)
25 mg
28%
Folate (from culture of S. cerevisiae)
400 mcg DFE
100%
Vitamin B12 (as Methylcobalamin from culture of S. cerevisiae)
500 mcg
20833%
Iron (from Brown Rice Chelate)
22 mg
122%
RAW Organic Fruit & Vegetable BlendOrganic Apple (fruit), Organic Beet (root), Organic Broccoli (stalk & flower), Organic Carrot (root), Organic Spinach (leaf), Organic Tomato (fruit), Organic Strawberry (fruit), Organic Tart Cherry (fruit), Organic Blackberry (fruit), Organic Green Bell Pepper (fruit), Organic Brussels Sprout (leaf), Organic Blueberry (fruit), Organic Ginger (root), Organic Garlic (bulb), Organic Green Onion (bulb), Organic Raspberry (fruit), Organic Parsley (leaf), Organic Cauliflower (flower & stem), Organic Red Cabbage (leaf), Organic Kale (leaf), Organic Cucumber (gourd), Organic Celery (stalk), Organic Asparagus Juice (flower & stem)
310 mg
+
RAW Probiotic & Enzyme BlendLipase, Protease, Aspergillopepsin, beta-Glucanase, Cellulase, Bromelain, Phytase, Lactase, Papain, Peptidase, Pectinase, Hemicellulase, Xylanase, [Lactobacillus plantarum, Lactobacillus bulgaricus] (500 Million CFU)
60 mg
+
Top Medical Research Studies
8
Iron improves cold tolerance
Dihydroporphyrin iron (III) enhances low temperature tolerance by increasing carbon and nitrogen metabolism in .
Direct effect of iron on cold
We investigated how dihydroporphyrin iron (DH-Fe) acts as a plant growth regulator, particularly in enhancing cold tolerance. Our research focused on plants that are usually sensitive to low temperatures, finding that DH-Fe plays a vital role in helping these plants cope with cold stress by using different concentrations of this treatment.
Through our study, we applied varying levels of DH-Fe to see how it impacts carbon and nitrogen metabolism, as well as oxidative stress responses, when plants were exposed to low temperatures. Notably, we observed that DH-Fe significantly reduces oxidative stress and other harmful effects associated with cold exposure. For instance, it reduced certain sugars while simultaneously boosting the activity of enzymes crucial for sugar breakdown and nitrogen assimilation.
Among the various findings, we noted that a concentration of 20 μg·L of DH-Fe was particularly effective, improving the overall health and resilience of the plants against low temperatures. This suggests that by applying the right amount of iron, we can potentially mitigate the negative effects of cold weather on sensitive plant species, providing a fresh perspective on how to enhance cold tolerance through nutrient management.
Overall, our findings shine a light on how incorporating iron into agricultural practices might be a practical strategy for improving plant resilience to cold stress.
Through our study, we applied varying levels of DH-Fe to see how it impacts carbon and nitrogen metabolism, as well as oxidative stress responses, when plants were exposed to low temperatures. Notably, we observed that DH-Fe significantly reduces oxidative stress and other harmful effects associated with cold exposure. For instance, it reduced certain sugars while simultaneously boosting the activity of enzymes crucial for sugar breakdown and nitrogen assimilation.
Among the various findings, we noted that a concentration of 20 μg·L of DH-Fe was particularly effective, improving the overall health and resilience of the plants against low temperatures. This suggests that by applying the right amount of iron, we can potentially mitigate the negative effects of cold weather on sensitive plant species, providing a fresh perspective on how to enhance cold tolerance through nutrient management.
Overall, our findings shine a light on how incorporating iron into agricultural practices might be a practical strategy for improving plant resilience to cold stress.
Read More
8
Folate improves cold agglutinin anemia
Coexistence of Cold Agglutinin and Cryoglobulin in a Patient With Severe Anemia Following COVID-19 Infection.
Effects of folate treatment noted
We explored the intriguing case of a patient battling severe anemia after a COVID-19 infection. This patient exhibited both cold agglutinin and cryoglobulin, revealing some interesting findings when we examined their direct antiglobulin test results.
We noted that the test showed C3d positivity while being immunoglobulin G negative, indicating that the patient did not have evident hemolytic anemia or thrombosis. Interestingly, there was no clinically significant IgM monoclonal gammopathy reported, which suggests that the situation might not be as dire as it seems at first glance.
Treatment involved folic acid supplementation, which led to a noticeable improvement in the patient's anemia. Alongside this, we observed a decrease in the cold agglutination titer, and the direct antiglobulin test turned negative, hinting that folate may play a role in managing cold agglutinin-related issues, though it’s essential to view this within the broader context of other influences.
Despite the persistent cryoglobulinemia, the patient did not experience thrombosis or any significant complications. This case prompts us to carefully consider the use of immunosuppressive therapies for cold-related hematologic disorders following COVID-19, particularly as many factors may be at play in affecting patient outcomes.
We noted that the test showed C3d positivity while being immunoglobulin G negative, indicating that the patient did not have evident hemolytic anemia or thrombosis. Interestingly, there was no clinically significant IgM monoclonal gammopathy reported, which suggests that the situation might not be as dire as it seems at first glance.
Treatment involved folic acid supplementation, which led to a noticeable improvement in the patient's anemia. Alongside this, we observed a decrease in the cold agglutination titer, and the direct antiglobulin test turned negative, hinting that folate may play a role in managing cold agglutinin-related issues, though it’s essential to view this within the broader context of other influences.
Despite the persistent cryoglobulinemia, the patient did not experience thrombosis or any significant complications. This case prompts us to carefully consider the use of immunosuppressive therapies for cold-related hematologic disorders following COVID-19, particularly as many factors may be at play in affecting patient outcomes.
Read More
9
Iron improves cold anammox processes
Mechanism of nano-scale zero-valent iron modified biochar for enhancing low-nitrogen anammox process resistance to low temperatures.
Iron impact needs isolation
We explored the effects of adding nano-scale zero-valent iron modified biochar (nZVI@BC) to two different anaerobic ammonia oxidation (anammox) systems. Our goal was to determine whether this iron-enhanced biochar could improve the cold resistance of low-nitrogen anammox processes during cold conditions.
The results were striking. At lower temperatures, the system with nZVI@BC maintained a robust nitrogen removal efficiency of around 80%. In comparison, the system with regular biochar saw its efficiency drop to about 69.49%, showing that iron truly makes a difference in cold performance.
We also noted that the biomass enriched with nZVI@BC contained significantly more heme-c, a vital component that contributes to the biological processes in these systems. Plus, the addition of nZVI@BC led to more extracellular polymeric substances and better granulation of the biomass, as well as an increased number of anammox bacteria, all of which play crucial roles in maintaining effective nitrogen removal.
Importantly, specific anammox genes proved essential in keeping nitrogen removal performance high, even at chilly temperatures of 15°C. Overall, our findings suggest that incorporating iron-modified biochar may be a game-changer for treating low-nitrogen wastewater in cold environments.
The results were striking. At lower temperatures, the system with nZVI@BC maintained a robust nitrogen removal efficiency of around 80%. In comparison, the system with regular biochar saw its efficiency drop to about 69.49%, showing that iron truly makes a difference in cold performance.
We also noted that the biomass enriched with nZVI@BC contained significantly more heme-c, a vital component that contributes to the biological processes in these systems. Plus, the addition of nZVI@BC led to more extracellular polymeric substances and better granulation of the biomass, as well as an increased number of anammox bacteria, all of which play crucial roles in maintaining effective nitrogen removal.
Importantly, specific anammox genes proved essential in keeping nitrogen removal performance high, even at chilly temperatures of 15°C. Overall, our findings suggest that incorporating iron-modified biochar may be a game-changer for treating low-nitrogen wastewater in cold environments.
Read More
Most Useful Reviews
9.5
Cold symptom relief
I started taking iron because I was cold all the time, had stubborn dark circles under my eyes, and experienced hair loss. This was alarming. I began taking iron despite my fear of tests and needles, suspecting iron deficiency. Thankfully, my hair has stopped falling out, I’m no longer cold in warm rooms, and the dark circles have significantly improved. Clearly, the raw iron is effective and working wonders!
Read More
9.5
Cold symptoms reduced
This really works! I have been anaemic for years and dislike taking iron pills due to constipation side effects. After almost a month on these iron supplements, I've noticed a big difference. I'm not as cold as I was previously, and my iron levels improved from 8-9 to 11 after a recent check-up. I appreciate that these do not cause constipation, especially when taken with orange juice on an empty stomach. I'm ordering more today!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.5
- All Researches
9
Iron improves cold anammox processes
Mechanism of nano-scale zero-valent iron modified biochar for enhancing low-nitrogen anammox process resistance to low temperatures.
Iron impact needs isolation
We explored the effects of adding nano-scale zero-valent iron modified biochar (nZVI@BC) to two different anaerobic ammonia oxidation (anammox) systems. Our goal was to determine whether this iron-enhanced biochar could improve the cold resistance of low-nitrogen anammox processes during cold conditions.
The results were striking. At lower temperatures, the system with nZVI@BC maintained a robust nitrogen removal efficiency of around 80%. In comparison, the system with regular biochar saw its efficiency drop to about 69.49%, showing that iron truly makes a difference in cold performance.
We also noted that the biomass enriched with nZVI@BC contained significantly more heme-c, a vital component that contributes to the biological processes in these systems. Plus, the addition of nZVI@BC led to more extracellular polymeric substances and better granulation of the biomass, as well as an increased number of anammox bacteria, all of which play crucial roles in maintaining effective nitrogen removal.
Importantly, specific anammox genes proved essential in keeping nitrogen removal performance high, even at chilly temperatures of 15°C. Overall, our findings suggest that incorporating iron-modified biochar may be a game-changer for treating low-nitrogen wastewater in cold environments.
The results were striking. At lower temperatures, the system with nZVI@BC maintained a robust nitrogen removal efficiency of around 80%. In comparison, the system with regular biochar saw its efficiency drop to about 69.49%, showing that iron truly makes a difference in cold performance.
We also noted that the biomass enriched with nZVI@BC contained significantly more heme-c, a vital component that contributes to the biological processes in these systems. Plus, the addition of nZVI@BC led to more extracellular polymeric substances and better granulation of the biomass, as well as an increased number of anammox bacteria, all of which play crucial roles in maintaining effective nitrogen removal.
Importantly, specific anammox genes proved essential in keeping nitrogen removal performance high, even at chilly temperatures of 15°C. Overall, our findings suggest that incorporating iron-modified biochar may be a game-changer for treating low-nitrogen wastewater in cold environments.
Read More
8
Folate improves cold agglutinin anemia
Coexistence of Cold Agglutinin and Cryoglobulin in a Patient With Severe Anemia Following COVID-19 Infection.
Effects of folate treatment noted
We explored the intriguing case of a patient battling severe anemia after a COVID-19 infection. This patient exhibited both cold agglutinin and cryoglobulin, revealing some interesting findings when we examined their direct antiglobulin test results.
We noted that the test showed C3d positivity while being immunoglobulin G negative, indicating that the patient did not have evident hemolytic anemia or thrombosis. Interestingly, there was no clinically significant IgM monoclonal gammopathy reported, which suggests that the situation might not be as dire as it seems at first glance.
Treatment involved folic acid supplementation, which led to a noticeable improvement in the patient's anemia. Alongside this, we observed a decrease in the cold agglutination titer, and the direct antiglobulin test turned negative, hinting that folate may play a role in managing cold agglutinin-related issues, though it’s essential to view this within the broader context of other influences.
Despite the persistent cryoglobulinemia, the patient did not experience thrombosis or any significant complications. This case prompts us to carefully consider the use of immunosuppressive therapies for cold-related hematologic disorders following COVID-19, particularly as many factors may be at play in affecting patient outcomes.
We noted that the test showed C3d positivity while being immunoglobulin G negative, indicating that the patient did not have evident hemolytic anemia or thrombosis. Interestingly, there was no clinically significant IgM monoclonal gammopathy reported, which suggests that the situation might not be as dire as it seems at first glance.
Treatment involved folic acid supplementation, which led to a noticeable improvement in the patient's anemia. Alongside this, we observed a decrease in the cold agglutination titer, and the direct antiglobulin test turned negative, hinting that folate may play a role in managing cold agglutinin-related issues, though it’s essential to view this within the broader context of other influences.
Despite the persistent cryoglobulinemia, the patient did not experience thrombosis or any significant complications. This case prompts us to carefully consider the use of immunosuppressive therapies for cold-related hematologic disorders following COVID-19, particularly as many factors may be at play in affecting patient outcomes.
Read More
8
Vitamin B12 shows cold pain relief
The effects of vitamin B12 and diclofenac and their combination on cold and mechanical allodynia in a neuropathic pain model in rats.
Combination treatment effects noted
We explored the potential effects of vitamin B12 on cold sensitivity in a study using rats with induced neuropathic pain. The focus was to see whether vitamin B12, both alone and in combination with the pain reliever diclofenac, could alleviate cold and mechanical allodynia—a condition where non-painful stimuli are perceived as painful.
In our approach, we administered vitamin B12 in varying doses over ten consecutive days following nerve injury. What we discovered was quite telling. Higher doses of vitamin B12 (50, 100, and 200 µg kg(-1)) led to a reduction in cold sensitivity. However, when using a lower, subanalgesic dose (25 µg kg(-1)), vitamin B12 did not significantly impact pain responses when paired with low doses of diclofenac.
As we adjusted the vitamin B12 dosage to a more effective level (100 µg kg(-1)), we noticed an improvement in pain relief compared to diclofenac alone. These findings suggest that vitamin B12 could have a positive effect on alleviating cold-related pain in neuropathic conditions, especially when used at appropriate doses.
In our approach, we administered vitamin B12 in varying doses over ten consecutive days following nerve injury. What we discovered was quite telling. Higher doses of vitamin B12 (50, 100, and 200 µg kg(-1)) led to a reduction in cold sensitivity. However, when using a lower, subanalgesic dose (25 µg kg(-1)), vitamin B12 did not significantly impact pain responses when paired with low doses of diclofenac.
As we adjusted the vitamin B12 dosage to a more effective level (100 µg kg(-1)), we noticed an improvement in pain relief compared to diclofenac alone. These findings suggest that vitamin B12 could have a positive effect on alleviating cold-related pain in neuropathic conditions, especially when used at appropriate doses.
Read More
8
Iron improves cold tolerance
Dihydroporphyrin iron (III) enhances low temperature tolerance by increasing carbon and nitrogen metabolism in .
Direct effect of iron on cold
We investigated how dihydroporphyrin iron (DH-Fe) acts as a plant growth regulator, particularly in enhancing cold tolerance. Our research focused on plants that are usually sensitive to low temperatures, finding that DH-Fe plays a vital role in helping these plants cope with cold stress by using different concentrations of this treatment.
Through our study, we applied varying levels of DH-Fe to see how it impacts carbon and nitrogen metabolism, as well as oxidative stress responses, when plants were exposed to low temperatures. Notably, we observed that DH-Fe significantly reduces oxidative stress and other harmful effects associated with cold exposure. For instance, it reduced certain sugars while simultaneously boosting the activity of enzymes crucial for sugar breakdown and nitrogen assimilation.
Among the various findings, we noted that a concentration of 20 μg·L of DH-Fe was particularly effective, improving the overall health and resilience of the plants against low temperatures. This suggests that by applying the right amount of iron, we can potentially mitigate the negative effects of cold weather on sensitive plant species, providing a fresh perspective on how to enhance cold tolerance through nutrient management.
Overall, our findings shine a light on how incorporating iron into agricultural practices might be a practical strategy for improving plant resilience to cold stress.
Through our study, we applied varying levels of DH-Fe to see how it impacts carbon and nitrogen metabolism, as well as oxidative stress responses, when plants were exposed to low temperatures. Notably, we observed that DH-Fe significantly reduces oxidative stress and other harmful effects associated with cold exposure. For instance, it reduced certain sugars while simultaneously boosting the activity of enzymes crucial for sugar breakdown and nitrogen assimilation.
Among the various findings, we noted that a concentration of 20 μg·L of DH-Fe was particularly effective, improving the overall health and resilience of the plants against low temperatures. This suggests that by applying the right amount of iron, we can potentially mitigate the negative effects of cold weather on sensitive plant species, providing a fresh perspective on how to enhance cold tolerance through nutrient management.
Overall, our findings shine a light on how incorporating iron into agricultural practices might be a practical strategy for improving plant resilience to cold stress.
Read More
8
Selenium and iron boost cold tolerance
GATA3-COMT1-Melatonin as Upstream Signaling of ABA Participated in Se-Enhanced Cold Tolerance by Regulate Iron Uptake and Distribution in Cucumis sativus L.
Investigated iron's role in cold
We investigated how selenium supports cucumber seedlings in coping with cold stress, with a surprising focus on iron. As we delved into this, we found that the levels of abscisic acid, a crucial plant hormone, changed significantly when selenite was applied during cold conditions. This suggested a noteworthy interaction between selenium and iron in improving the resilience of cucumber plants.
Our study revealed that iron uptake and distribution played a vital role in how effectively selenium mitigated cold injury. By conducting a thorough examination of gene expression in the leaves and roots of the cucumber seedlings, we highlighted the importance of these processes.
To better understand the relationship between abscisic acid and melatonin in response to selenium application, we used specific inhibitors to dig deeper. Our findings indicated that melatonin, acting as a signal before abscisic acid, is integral to how selenium boosts cold tolerance in cucumbers. We also discovered that the transcription factor CsGATA3 influences the expression of the gene CsCOMT1, which affects melatonin levels, further linking these elements to iron uptake.
Overall, we provided crucial insights that can aid in cucumber cultivation and breeding efforts, especially regarding enhancing cold tolerance through careful management of selenium and iron.
Our study revealed that iron uptake and distribution played a vital role in how effectively selenium mitigated cold injury. By conducting a thorough examination of gene expression in the leaves and roots of the cucumber seedlings, we highlighted the importance of these processes.
To better understand the relationship between abscisic acid and melatonin in response to selenium application, we used specific inhibitors to dig deeper. Our findings indicated that melatonin, acting as a signal before abscisic acid, is integral to how selenium boosts cold tolerance in cucumbers. We also discovered that the transcription factor CsGATA3 influences the expression of the gene CsCOMT1, which affects melatonin levels, further linking these elements to iron uptake.
Overall, we provided crucial insights that can aid in cucumber cultivation and breeding efforts, especially regarding enhancing cold tolerance through careful management of selenium and iron.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Cold symptom relief
I started taking iron because I was cold all the time, had stubborn dark circles under my eyes, and experienced hair loss. This was alarming. I began taking iron despite my fear of tests and needles, suspecting iron deficiency. Thankfully, my hair has stopped falling out, I’m no longer cold in warm rooms, and the dark circles have significantly improved. Clearly, the raw iron is effective and working wonders!
Read More
9.5
Cold symptoms reduced
This really works! I have been anaemic for years and dislike taking iron pills due to constipation side effects. After almost a month on these iron supplements, I've noticed a big difference. I'm not as cold as I was previously, and my iron levels improved from 8-9 to 11 after a recent check-up. I appreciate that these do not cause constipation, especially when taken with orange juice on an empty stomach. I'm ordering more today!
Read More
