5/30/2025
Last update
5/30/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.5
USERS' SCORE
Good
Based on 2 Reviews
8.6
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Vitamin C (from culture of S. cerevisiae)
25 mg
28%
Folate (from culture of S. cerevisiae)
400 mcg DFE
100%
Vitamin B12 (as Methylcobalamin from culture of S. cerevisiae)
500 mcg
20833%
Iron (from Brown Rice Chelate)
22 mg
122%
RAW Organic Fruit & Vegetable BlendOrganic Apple (fruit), Organic Beet (root), Organic Broccoli (stalk & flower), Organic Carrot (root), Organic Spinach (leaf), Organic Tomato (fruit), Organic Strawberry (fruit), Organic Tart Cherry (fruit), Organic Blackberry (fruit), Organic Green Bell Pepper (fruit), Organic Brussels Sprout (leaf), Organic Blueberry (fruit), Organic Ginger (root), Organic Garlic (bulb), Organic Green Onion (bulb), Organic Raspberry (fruit), Organic Parsley (leaf), Organic Cauliflower (flower & stem), Organic Red Cabbage (leaf), Organic Kale (leaf), Organic Cucumber (gourd), Organic Celery (stalk), Organic Asparagus Juice (flower & stem)
310 mg
+
RAW Probiotic & Enzyme BlendLipase, Protease, Aspergillopepsin, beta-Glucanase, Cellulase, Bromelain, Phytase, Lactase, Papain, Peptidase, Pectinase, Hemicellulase, Xylanase, [Lactobacillus plantarum, Lactobacillus bulgaricus] (500 Million CFU)
60 mg
+
Top Medical Research Studies
8
We investigated how dihydroporphyrin iron (DH-Fe) acts as a plant growth regulator, particularly in enhancing cold tolerance. Our research focused on plants that are usually sensitive to low temperatures, finding that DH-Fe plays a vital role in helping these plants cope with cold stress by using different concentrations of this treatment.
Through our study, we applied varying levels of DH-Fe to see how it impacts carbon and nitrogen metabolism, as well as oxidative stress responses, when plants were exposed to low temperatures. Notably, we observed that DH-Fe significantly reduces oxidative stress and other harmful effects associated with cold exposure. For instance, it reduced certain sugars while simultaneously boosting the activity of enzymes crucial for sugar breakdown and nitrogen assimilation.
Among the various findings, we noted that a concentration of 20 μg·L of DH-Fe was particularly effective, improving the overall health and resilience of the plants against low temperatures. This suggests that by applying the right amount of iron, we can potentially mitigate the negative effects of cold weather on sensitive plant species, providing a fresh perspective on how to enhance cold tolerance through nutrient management.
Overall, our findings shine a light on how incorporating iron into agricultural practices might be a practical strategy for improving plant resilience to cold stress.
Through our study, we applied varying levels of DH-Fe to see how it impacts carbon and nitrogen metabolism, as well as oxidative stress responses, when plants were exposed to low temperatures. Notably, we observed that DH-Fe significantly reduces oxidative stress and other harmful effects associated with cold exposure. For instance, it reduced certain sugars while simultaneously boosting the activity of enzymes crucial for sugar breakdown and nitrogen assimilation.
Among the various findings, we noted that a concentration of 20 μg·L of DH-Fe was particularly effective, improving the overall health and resilience of the plants against low temperatures. This suggests that by applying the right amount of iron, we can potentially mitigate the negative effects of cold weather on sensitive plant species, providing a fresh perspective on how to enhance cold tolerance through nutrient management.
Overall, our findings shine a light on how incorporating iron into agricultural practices might be a practical strategy for improving plant resilience to cold stress.
Read More
8
We explored the intriguing case of a patient battling severe anemia after a COVID-19 infection. This patient exhibited both cold agglutinin and cryoglobulin, revealing some interesting findings when we examined their direct antiglobulin test results.
We noted that the test showed C3d positivity while being immunoglobulin G negative, indicating that the patient did not have evident hemolytic anemia or thrombosis. Interestingly, there was no clinically significant IgM monoclonal gammopathy reported, which suggests that the situation might not be as dire as it seems at first glance.
Treatment involved folic acid supplementation, which led to a noticeable improvement in the patient's anemia. Alongside this, we observed a decrease in the cold agglutination titer, and the direct antiglobulin test turned negative, hinting that folate may play a role in managing cold agglutinin-related issues, though it’s essential to view this within the broader context of other influences.
Despite the persistent cryoglobulinemia, the patient did not experience thrombosis or any significant complications. This case prompts us to carefully consider the use of immunosuppressive therapies for cold-related hematologic disorders following COVID-19, particularly as many factors may be at play in affecting patient outcomes.
We noted that the test showed C3d positivity while being immunoglobulin G negative, indicating that the patient did not have evident hemolytic anemia or thrombosis. Interestingly, there was no clinically significant IgM monoclonal gammopathy reported, which suggests that the situation might not be as dire as it seems at first glance.
Treatment involved folic acid supplementation, which led to a noticeable improvement in the patient's anemia. Alongside this, we observed a decrease in the cold agglutination titer, and the direct antiglobulin test turned negative, hinting that folate may play a role in managing cold agglutinin-related issues, though it’s essential to view this within the broader context of other influences.
Despite the persistent cryoglobulinemia, the patient did not experience thrombosis or any significant complications. This case prompts us to carefully consider the use of immunosuppressive therapies for cold-related hematologic disorders following COVID-19, particularly as many factors may be at play in affecting patient outcomes.
Read More
9
We explored the effects of adding nano-scale zero-valent iron modified biochar (nZVI@BC) to two different anaerobic ammonia oxidation (anammox) systems. Our goal was to determine whether this iron-enhanced biochar could improve the cold resistance of low-nitrogen anammox processes during cold conditions.
The results were striking. At lower temperatures, the system with nZVI@BC maintained a robust nitrogen removal efficiency of around 80%. In comparison, the system with regular biochar saw its efficiency drop to about 69.49%, showing that iron truly makes a difference in cold performance.
We also noted that the biomass enriched with nZVI@BC contained significantly more heme-c, a vital component that contributes to the biological processes in these systems. Plus, the addition of nZVI@BC led to more extracellular polymeric substances and better granulation of the biomass, as well as an increased number of anammox bacteria, all of which play crucial roles in maintaining effective nitrogen removal.
Importantly, specific anammox genes proved essential in keeping nitrogen removal performance high, even at chilly temperatures of 15°C. Overall, our findings suggest that incorporating iron-modified biochar may be a game-changer for treating low-nitrogen wastewater in cold environments.
The results were striking. At lower temperatures, the system with nZVI@BC maintained a robust nitrogen removal efficiency of around 80%. In comparison, the system with regular biochar saw its efficiency drop to about 69.49%, showing that iron truly makes a difference in cold performance.
We also noted that the biomass enriched with nZVI@BC contained significantly more heme-c, a vital component that contributes to the biological processes in these systems. Plus, the addition of nZVI@BC led to more extracellular polymeric substances and better granulation of the biomass, as well as an increased number of anammox bacteria, all of which play crucial roles in maintaining effective nitrogen removal.
Importantly, specific anammox genes proved essential in keeping nitrogen removal performance high, even at chilly temperatures of 15°C. Overall, our findings suggest that incorporating iron-modified biochar may be a game-changer for treating low-nitrogen wastewater in cold environments.
Read More
Most Useful Reviews
9
Cold symptom relief
4 people found this helpful
I started taking iron because I was cold all the time, had stubborn dark circles under my eyes, and experienced hair loss. This was alarming. I began taking iron despite my fear of tests and needles, suspecting iron deficiency. Thankfully, my hair has stopped falling out, I’m no longer cold in warm rooms, and the dark circles have significantly improved. Clearly, the raw iron is effective and working wonders!
Read More
9
Cold symptoms reduced
2 people found this helpful
This really works! I have been anaemic for years and dislike taking iron pills due to constipation side effects. After almost a month on these iron supplements, I've noticed a big difference. I'm not as cold as I was previously, and my iron levels improved from 8-9 to 11 after a recent check-up. I appreciate that these do not cause constipation, especially when taken with orange juice on an empty stomach. I'm ordering more today!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.5
- All Researches
9
We explored the effects of adding nano-scale zero-valent iron modified biochar (nZVI@BC) to two different anaerobic ammonia oxidation (anammox) systems. Our goal was to determine whether this iron-enhanced biochar could improve the cold resistance of low-nitrogen anammox processes during cold conditions.
The results were striking. At lower temperatures, the system with nZVI@BC maintained a robust nitrogen removal efficiency of around 80%. In comparison, the system with regular biochar saw its efficiency drop to about 69.49%, showing that iron truly makes a difference in cold performance.
We also noted that the biomass enriched with nZVI@BC contained significantly more heme-c, a vital component that contributes to the biological processes in these systems. Plus, the addition of nZVI@BC led to more extracellular polymeric substances and better granulation of the biomass, as well as an increased number of anammox bacteria, all of which play crucial roles in maintaining effective nitrogen removal.
Importantly, specific anammox genes proved essential in keeping nitrogen removal performance high, even at chilly temperatures of 15°C. Overall, our findings suggest that incorporating iron-modified biochar may be a game-changer for treating low-nitrogen wastewater in cold environments.
The results were striking. At lower temperatures, the system with nZVI@BC maintained a robust nitrogen removal efficiency of around 80%. In comparison, the system with regular biochar saw its efficiency drop to about 69.49%, showing that iron truly makes a difference in cold performance.
We also noted that the biomass enriched with nZVI@BC contained significantly more heme-c, a vital component that contributes to the biological processes in these systems. Plus, the addition of nZVI@BC led to more extracellular polymeric substances and better granulation of the biomass, as well as an increased number of anammox bacteria, all of which play crucial roles in maintaining effective nitrogen removal.
Importantly, specific anammox genes proved essential in keeping nitrogen removal performance high, even at chilly temperatures of 15°C. Overall, our findings suggest that incorporating iron-modified biochar may be a game-changer for treating low-nitrogen wastewater in cold environments.
Read More
8
We investigated how dihydroporphyrin iron (DH-Fe) acts as a plant growth regulator, particularly in enhancing cold tolerance. Our research focused on plants that are usually sensitive to low temperatures, finding that DH-Fe plays a vital role in helping these plants cope with cold stress by using different concentrations of this treatment.
Through our study, we applied varying levels of DH-Fe to see how it impacts carbon and nitrogen metabolism, as well as oxidative stress responses, when plants were exposed to low temperatures. Notably, we observed that DH-Fe significantly reduces oxidative stress and other harmful effects associated with cold exposure. For instance, it reduced certain sugars while simultaneously boosting the activity of enzymes crucial for sugar breakdown and nitrogen assimilation.
Among the various findings, we noted that a concentration of 20 μg·L of DH-Fe was particularly effective, improving the overall health and resilience of the plants against low temperatures. This suggests that by applying the right amount of iron, we can potentially mitigate the negative effects of cold weather on sensitive plant species, providing a fresh perspective on how to enhance cold tolerance through nutrient management.
Overall, our findings shine a light on how incorporating iron into agricultural practices might be a practical strategy for improving plant resilience to cold stress.
Through our study, we applied varying levels of DH-Fe to see how it impacts carbon and nitrogen metabolism, as well as oxidative stress responses, when plants were exposed to low temperatures. Notably, we observed that DH-Fe significantly reduces oxidative stress and other harmful effects associated with cold exposure. For instance, it reduced certain sugars while simultaneously boosting the activity of enzymes crucial for sugar breakdown and nitrogen assimilation.
Among the various findings, we noted that a concentration of 20 μg·L of DH-Fe was particularly effective, improving the overall health and resilience of the plants against low temperatures. This suggests that by applying the right amount of iron, we can potentially mitigate the negative effects of cold weather on sensitive plant species, providing a fresh perspective on how to enhance cold tolerance through nutrient management.
Overall, our findings shine a light on how incorporating iron into agricultural practices might be a practical strategy for improving plant resilience to cold stress.
Read More
8
We investigated how selenium supports cucumber seedlings in coping with cold stress, with a surprising focus on iron. As we delved into this, we found that the levels of abscisic acid, a crucial plant hormone, changed significantly when selenite was applied during cold conditions. This suggested a noteworthy interaction between selenium and iron in improving the resilience of cucumber plants.
Our study revealed that iron uptake and distribution played a vital role in how effectively selenium mitigated cold injury. By conducting a thorough examination of gene expression in the leaves and roots of the cucumber seedlings, we highlighted the importance of these processes.
To better understand the relationship between abscisic acid and melatonin in response to selenium application, we used specific inhibitors to dig deeper. Our findings indicated that melatonin, acting as a signal before abscisic acid, is integral to how selenium boosts cold tolerance in cucumbers. We also discovered that the transcription factor CsGATA3 influences the expression of the gene CsCOMT1, which affects melatonin levels, further linking these elements to iron uptake.
Overall, we provided crucial insights that can aid in cucumber cultivation and breeding efforts, especially regarding enhancing cold tolerance through careful management of selenium and iron.
Our study revealed that iron uptake and distribution played a vital role in how effectively selenium mitigated cold injury. By conducting a thorough examination of gene expression in the leaves and roots of the cucumber seedlings, we highlighted the importance of these processes.
To better understand the relationship between abscisic acid and melatonin in response to selenium application, we used specific inhibitors to dig deeper. Our findings indicated that melatonin, acting as a signal before abscisic acid, is integral to how selenium boosts cold tolerance in cucumbers. We also discovered that the transcription factor CsGATA3 influences the expression of the gene CsCOMT1, which affects melatonin levels, further linking these elements to iron uptake.
Overall, we provided crucial insights that can aid in cucumber cultivation and breeding efforts, especially regarding enhancing cold tolerance through careful management of selenium and iron.
Read More
8
In this study, we explored how cold deformation and heat treatments affect the microstructure and mechanical properties of Fe-15Cr-25Ni superalloys. By investigating varying processing methods, we sought to understand the relationship between these treatments and the strength and durability of the material.
We observed that cold drawing enhances tensile and yield strength, primarily due to increased grain refinement and dislocation density. However, this process comes with a trade-off, leading to reduced elongation or ductility. After undergoing solid-solution treatment, we noted a significant number of particles dissolving into the matrix, which decreased dislocation density and, consequently, the strength of the material while improving plasticity.
Following aging, the presence of a substantial amount of γ' phase contributed to enhanced strength through the combined effects of dislocation and second-phase strengthening. Interestingly, the alloy's strength in the aged state was found to surpass that of the cold-drawn state due to these strengthening mechanisms working together.
Overall, our findings provide valuable insights for the industrial production of Fe-15Cr-25Ni superalloys, highlighting the delicate balance between strength and ductility during processing.
We observed that cold drawing enhances tensile and yield strength, primarily due to increased grain refinement and dislocation density. However, this process comes with a trade-off, leading to reduced elongation or ductility. After undergoing solid-solution treatment, we noted a significant number of particles dissolving into the matrix, which decreased dislocation density and, consequently, the strength of the material while improving plasticity.
Following aging, the presence of a substantial amount of γ' phase contributed to enhanced strength through the combined effects of dislocation and second-phase strengthening. Interestingly, the alloy's strength in the aged state was found to surpass that of the cold-drawn state due to these strengthening mechanisms working together.
Overall, our findings provide valuable insights for the industrial production of Fe-15Cr-25Ni superalloys, highlighting the delicate balance between strength and ductility during processing.
Read More
8
We explored the intriguing case of a patient battling severe anemia after a COVID-19 infection. This patient exhibited both cold agglutinin and cryoglobulin, revealing some interesting findings when we examined their direct antiglobulin test results.
We noted that the test showed C3d positivity while being immunoglobulin G negative, indicating that the patient did not have evident hemolytic anemia or thrombosis. Interestingly, there was no clinically significant IgM monoclonal gammopathy reported, which suggests that the situation might not be as dire as it seems at first glance.
Treatment involved folic acid supplementation, which led to a noticeable improvement in the patient's anemia. Alongside this, we observed a decrease in the cold agglutination titer, and the direct antiglobulin test turned negative, hinting that folate may play a role in managing cold agglutinin-related issues, though it’s essential to view this within the broader context of other influences.
Despite the persistent cryoglobulinemia, the patient did not experience thrombosis or any significant complications. This case prompts us to carefully consider the use of immunosuppressive therapies for cold-related hematologic disorders following COVID-19, particularly as many factors may be at play in affecting patient outcomes.
We noted that the test showed C3d positivity while being immunoglobulin G negative, indicating that the patient did not have evident hemolytic anemia or thrombosis. Interestingly, there was no clinically significant IgM monoclonal gammopathy reported, which suggests that the situation might not be as dire as it seems at first glance.
Treatment involved folic acid supplementation, which led to a noticeable improvement in the patient's anemia. Alongside this, we observed a decrease in the cold agglutination titer, and the direct antiglobulin test turned negative, hinting that folate may play a role in managing cold agglutinin-related issues, though it’s essential to view this within the broader context of other influences.
Despite the persistent cryoglobulinemia, the patient did not experience thrombosis or any significant complications. This case prompts us to carefully consider the use of immunosuppressive therapies for cold-related hematologic disorders following COVID-19, particularly as many factors may be at play in affecting patient outcomes.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Cold symptom relief
4 people found this helpful
I started taking iron because I was cold all the time, had stubborn dark circles under my eyes, and experienced hair loss. This was alarming. I began taking iron despite my fear of tests and needles, suspecting iron deficiency. Thankfully, my hair has stopped falling out, I’m no longer cold in warm rooms, and the dark circles have significantly improved. Clearly, the raw iron is effective and working wonders!
Read More
9
Cold symptoms reduced
2 people found this helpful
This really works! I have been anaemic for years and dislike taking iron pills due to constipation side effects. After almost a month on these iron supplements, I've noticed a big difference. I'm not as cold as I was previously, and my iron levels improved from 8-9 to 11 after a recent check-up. I appreciate that these do not cause constipation, especially when taken with orange juice on an empty stomach. I'm ordering more today!
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Jian SF, Huang YF, Chen DL, Zhong C. Dihydroporphyrin iron (III) enhances low temperature tolerance by increasing carbon and nitrogen metabolism in . Front Plant Sci. 2024;15:1522481. 10.3389/fpls.2024.1522481
- Wen D, Yang N, Zhang W, Wang X, Zhang J, et al. GATA3-COMT1-Melatonin as Upstream Signaling of ABA Participated in Se-Enhanced Cold Tolerance by Regulate Iron Uptake and Distribution in Cucumis sativus L. J Pineal Res. 2025;77:e70028. 10.1111/jpi.70028
- Zhang Y, Zhang Z, Sun Z, Zhao Y, Cui Y, et al. Effects of Cold Deformation and Heat Treatments on the Microstructure and Properties of Fe-15Cr-25Ni Superalloy Cold-Drawn Bars. Nanomaterials (Basel). 2024;14. 10.3390/nano14231949
- Chen W, Zhang L, Liu Z, Liu W, Lu B, et al. Mechanism of nano-scale zero-valent iron modified biochar for enhancing low-nitrogen anammox process resistance to low temperatures. J Environ Sci (China). 2025;152:442. 10.1016/j.jes.2024.05.049
- Suo W, Li L, Zheng Y, Pan S, Niu Y, et al. Effect of seed priming with zinc, iron and selenium on the low temperature tolerance of Nicotiana tabacum L. during seed germination. Biochem Biophys Res Commun. 2024;735:150806. 10.1016/j.bbrc.2024.150806
- Kaneko M, Masuda Y, Ishikawa K, Shikata H. Coexistence of Cold Agglutinin and Cryoglobulin in a Patient With Severe Anemia Following COVID-19 Infection. Cureus. 2024;16:e75257. 10.7759/cureus.75257
- Tamaddonfard E, Samadi F, Egdami K. The effects of vitamin B12 and diclofenac and their combination on cold and mechanical allodynia in a neuropathic pain model in rats. Vet Res Forum. 2013;4:19.
- Kopruszinski CM, Reis RC, Chichorro JG. B vitamins relieve neuropathic pain behaviors induced by infraorbital nerve constriction in rats. Life Sci. 2012;91:1187. 10.1016/j.lfs.2012.08.025
