We examined a case involving an 11-year-old male who experienced adverse effects from taking oral ferrous sulfate tablets to treat iron deficiency anemia. Over two months of treatment, he developed gastritis, which was confirmed through histological analysis during an endoscopy.
The findings revealed iron deposits in the stomach lining, prompting a reassessment of his iron supplementation strategy. We switched him from tablets to a liquid form of iron, which seemed to be gentler on his system.
After four months, a repeat endoscopy indicated a remarkable improvement, with the histological signs of gastritis resolving. This case illustrates that while iron is necessary for treating anemia, the form in which it's administered can significantly impact side effects like gastritis.
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We observed a case involving a 20-year-old woman with Type 1 diabetes experiencing persistent gastrointestinal issues, including diarrhea and nausea. Her medical journey led her to be diagnosed with autoimmune gastritis, an uncommon but important condition.
In the course of her treatment, we noticed her Vitamin B12 levels were not deficient, which is traditionally expected with autoimmune gastritis. Despite this, she was given parenteral Vitamin B12 therapy due to her neurological symptoms.
This case highlights that even when Vitamin B12 deficiency isn’t present, administration of Vitamin B12 can still provide significant relief from symptoms related to autoimmune gastritis. We learned that prompt treatment can prevent further neurological damage and improve overall quality of life for patients with autoimmune conditions.
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We explored the effects of vitamin B12 treatment alongside folic acid supplements in patients suffering from chronic atrophic gastritis (CAG). In a study involving 96 patients, we compared three treatment groups: those receiving weifuchun (a traditional treatment), those given weifuchun and folic acid, and those who had weifuchun, folic acid, and vitamin B12.
Although the presence of vitamin B12 in the treatment regimen was assessed, its isolated impact on gastritis cannot be conclusively determined due to the combination with other treatments. Mainly, we noted that the overall improvement in atrophic lesions was attributed to the combination of treatments rather than specifically to vitamin B12 alone.
The results showed a significant improvement in gastric atrophy, especially for those who received 5 mg of folic acid daily. However, we did not find separate evidence of a notable benefit from vitamin B12 treatment alone. This reveals the complexity of treating gastritis and the need for further research to validate the role of vitamin B12 independently.
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Folic acid in gastritis treatmentEfficacy analysis of folic acid in chronic atrophic gastritis with Helicobacter pylori infection: a systematic review and meta-analysis.
Combination treatment complicates evaluation
We explored the potential of folic acid in treating chronic atrophic gastritis (CAG), particularly in patients with Helicobacter pylori infection. Our analysis combined data from randomized controlled trials, clinical reports, and various databases, giving us a comprehensive view of the existing evidence.
Throughout our review, we found that the combination of anti-H. pylori treatment and folic acid supplementation can enhance treatment outcomes for those suffering from CAG. Early intervention with both therapies is recommended, as it may lead to more effective management of the condition. Moreover, the use of gastric mucosal protective agents can further improve patient outcomes, with adjustments based on individual tolerance and side effects.
However, while our findings support the potential benefits of folic acid in CAG treatment, further studies are needed to fully understand its effectiveness across different populations and regions. We believe this lays a foundation for better clinical practices, promoting a more holistic approach to managing chronic gastritis.
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Folate improves gastric healthEffects of folic acid supplementation on chronic atrophic gastritis based on MTHFR C677T polymorphism.
Study restricted by treatment combinations
We explored how folate supplements can affect patients with chronic atrophic gastritis (CAG), particularly focusing on those without Helicobacter pylori infection and considering their genetic background, specifically the MTHFR C677T genotype.
In a study involving 96 CAG patients aged 21 to 72, we observed that those who received a combination treatment of weifuchun (a traditional herbal remedy) and folate experienced notable improvements in their gastric health compared to those who received the herbal treatment alone. Specifically, 78.1% of patients taking both treatments showed improvement in atrophic lesions, compared to only 53.3% of those just on weifuchun.
Furthermore, we found that patients with the MTHFR 677TT genotype, who tend to have more severe gastric changes, benefited even more from the folate supplementation. This suggests that they may require quicker and more effective treatments than individuals with other genotypes, highlighting the importance of personalized approaches in treatment plans.
Overall, our findings underscore the potential of folate to play an essential role in supporting gastric health, particularly in patients with specific genetic predispositions.
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