Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.5
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.9
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Vitamin C (from culture of S. cerevisiae)
25 mg
28%
Folate (from culture of S. cerevisiae)
400 mcg DFE
100%
Vitamin B12 (as Methylcobalamin from culture of S. cerevisiae)
500 mcg
20833%
Iron (from Brown Rice Chelate)
22 mg
122%
RAW Organic Fruit & Vegetable BlendOrganic Apple (fruit), Organic Beet (root), Organic Broccoli (stalk & flower), Organic Carrot (root), Organic Spinach (leaf), Organic Tomato (fruit), Organic Strawberry (fruit), Organic Tart Cherry (fruit), Organic Blackberry (fruit), Organic Green Bell Pepper (fruit), Organic Brussels Sprout (leaf), Organic Blueberry (fruit), Organic Ginger (root), Organic Garlic (bulb), Organic Green Onion (bulb), Organic Raspberry (fruit), Organic Parsley (leaf), Organic Cauliflower (flower & stem), Organic Red Cabbage (leaf), Organic Kale (leaf), Organic Cucumber (gourd), Organic Celery (stalk), Organic Asparagus Juice (flower & stem)
310 mg
+
RAW Probiotic & Enzyme BlendLipase, Protease, Aspergillopepsin, beta-Glucanase, Cellulase, Bromelain, Phytase, Lactase, Papain, Peptidase, Pectinase, Hemicellulase, Xylanase, [Lactobacillus plantarum, Lactobacillus bulgaricus] (500 Million CFU)
60 mg
+
Top Medical Research Studies
9
We examined the effects of dietary folate intake on severe headaches by analyzing data from a large national health survey. The study involved nearly 10,000 participants over the age of 20, where individuals self-reported their experiences with severe headaches.
Through sophisticated analysis methods, including multivariate logistic regression, we discovered that higher dietary folate intake appears to be associated with a lower likelihood of experiencing severe headaches. Specifically, participants who consumed more folate had significantly reduced odds of reporting severe headaches, with the most substantial impact seen in those with the highest intake levels.
Interestingly, we found that women aged 20 to 50 exhibited a non-linear association between folate and headache severity, suggesting that they might benefit from being more mindful of their folate consumption.
This research underscores the potential for dietary folate to play a protective role against severe headaches, encouraging individuals to consider increasing their folate intake for headache prevention.
Through sophisticated analysis methods, including multivariate logistic regression, we discovered that higher dietary folate intake appears to be associated with a lower likelihood of experiencing severe headaches. Specifically, participants who consumed more folate had significantly reduced odds of reporting severe headaches, with the most substantial impact seen in those with the highest intake levels.
Interestingly, we found that women aged 20 to 50 exhibited a non-linear association between folate and headache severity, suggesting that they might benefit from being more mindful of their folate consumption.
This research underscores the potential for dietary folate to play a protective role against severe headaches, encouraging individuals to consider increasing their folate intake for headache prevention.
Read More
8
We explored how dietary folate intake might be linked to severe headaches or migraines through a comprehensive analysis of data from the National Health and Nutrition Examination Survey (NHANES) conducted from 1999 to 2004. By examining over 4,100 adults, we observed that around 17% reported experiencing severe headaches or migraines. Importantly, our study used advanced statistical methods to ensure accurate and meaningful results.
Our findings revealed a clear relationship: higher intake of dietary folate appeared to correlate with fewer headaches. Specifically, those with higher folate intake, measured in categorized segments, had significantly lower odds of experiencing severe headaches or migraines compared to those with lower intake levels. The results suggested that as folate intake increased, the likelihood of suffering from severe headaches decreased, supporting the idea of a beneficial relationship.
In summary, our study indicated a linear negative relationship between dietary folate and headache severity, suggesting that incorporating more folate-rich foods into our diets could potentially help reduce the occurrence of migraines. This research provides valuable insights into dietary interventions for managing headache symptoms.
Our findings revealed a clear relationship: higher intake of dietary folate appeared to correlate with fewer headaches. Specifically, those with higher folate intake, measured in categorized segments, had significantly lower odds of experiencing severe headaches or migraines compared to those with lower intake levels. The results suggested that as folate intake increased, the likelihood of suffering from severe headaches decreased, supporting the idea of a beneficial relationship.
In summary, our study indicated a linear negative relationship between dietary folate and headache severity, suggesting that incorporating more folate-rich foods into our diets could potentially help reduce the occurrence of migraines. This research provides valuable insights into dietary interventions for managing headache symptoms.
Read More
8
We conducted a case-control study to investigate the link between vitamin B12 serum levels and migraine, which affects so many people but lacks a fully understood cause. Our research included 90 individuals experiencing migraines—split into those with chronic migraines and those with episodic migraines—matched against 90 healthy participants.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
Read More
Most Useful Reviews
9
No pain experienced
2 people found this helpful
These are the best iron pills I've used. Most cause headaches or stomach pain, but this one doesn't. I can take it either on an empty stomach or with food without issues. Just remember not to take it with dairy, as it hampers iron absorption.
Read More
0
Caused headache
1 people found this helpful
I took this and ended up with a headache. I would not recommend it.
Read More
9
No headaches experienced
Unlike other brands, this iron supplement did not cause any headaches for me.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.5
- All Researches
9
We examined the connection between genetic differences in folate metabolism and migraine experiences in children aged 7 to 18. The study involved 54 children with migraine symptoms and a control group of 115 others without neurological issues.
Focusing on four specific genetic variants linked to folate metabolism, we found that children with migraines were more likely to have a certain rare genetic variant that may increase plasma homocysteine levels, potentially indicating a hidden folate deficiency. In addition to genetic testing, we looked at vitamin B levels and the effectiveness of Cortexin, a treatment administered to the children.
After a 10-day course of Cortexin, many children reported significant improvements in their migraine symptoms, such as less headache pain, reduced fatigue, and better emotional stability. This suggests that while there’s a genetic connection to migraine, the treatment with Cortexin also plays a critical role in alleviating symptoms.
Focusing on four specific genetic variants linked to folate metabolism, we found that children with migraines were more likely to have a certain rare genetic variant that may increase plasma homocysteine levels, potentially indicating a hidden folate deficiency. In addition to genetic testing, we looked at vitamin B levels and the effectiveness of Cortexin, a treatment administered to the children.
After a 10-day course of Cortexin, many children reported significant improvements in their migraine symptoms, such as less headache pain, reduced fatigue, and better emotional stability. This suggests that while there’s a genetic connection to migraine, the treatment with Cortexin also plays a critical role in alleviating symptoms.
Read More
9
We examined the effects of dietary folate intake on severe headaches by analyzing data from a large national health survey. The study involved nearly 10,000 participants over the age of 20, where individuals self-reported their experiences with severe headaches.
Through sophisticated analysis methods, including multivariate logistic regression, we discovered that higher dietary folate intake appears to be associated with a lower likelihood of experiencing severe headaches. Specifically, participants who consumed more folate had significantly reduced odds of reporting severe headaches, with the most substantial impact seen in those with the highest intake levels.
Interestingly, we found that women aged 20 to 50 exhibited a non-linear association between folate and headache severity, suggesting that they might benefit from being more mindful of their folate consumption.
This research underscores the potential for dietary folate to play a protective role against severe headaches, encouraging individuals to consider increasing their folate intake for headache prevention.
Through sophisticated analysis methods, including multivariate logistic regression, we discovered that higher dietary folate intake appears to be associated with a lower likelihood of experiencing severe headaches. Specifically, participants who consumed more folate had significantly reduced odds of reporting severe headaches, with the most substantial impact seen in those with the highest intake levels.
Interestingly, we found that women aged 20 to 50 exhibited a non-linear association between folate and headache severity, suggesting that they might benefit from being more mindful of their folate consumption.
This research underscores the potential for dietary folate to play a protective role against severe headaches, encouraging individuals to consider increasing their folate intake for headache prevention.
Read More
9
We explored the case of a 14-year-old girl who faced severe headaches and nausea due to cerebral venous thrombosis (CVT) and high levels of homocysteine. After thorough examinations, including brain imaging and genetic testing, she underwent treatment that included anticoagulants and supplementation with folate, as well as vitamins B12 and B6.
The patient showed significant improvement in her condition within a month. She experienced relief from headaches, and her intracranial pressure decreased considerably. While the study indicates that folate was part of a comprehensive treatment approach, the specific contribution of folate alone to the relief of her headaches remains unclear due to the combined nature of the treatments.
This case highlights a unique instance of loss of heterozygosity at the methylenetetrahydrofolate reductase (MTHFR) gene and suggests that analyzing this genetic factor could be important in patients with CVT and hyperhomocysteinemia. However, we must interpret the efficacy of folate cautiously, as its isolated impact on headache resolution wasn't specifically tested.
The patient showed significant improvement in her condition within a month. She experienced relief from headaches, and her intracranial pressure decreased considerably. While the study indicates that folate was part of a comprehensive treatment approach, the specific contribution of folate alone to the relief of her headaches remains unclear due to the combined nature of the treatments.
This case highlights a unique instance of loss of heterozygosity at the methylenetetrahydrofolate reductase (MTHFR) gene and suggests that analyzing this genetic factor could be important in patients with CVT and hyperhomocysteinemia. However, we must interpret the efficacy of folate cautiously, as its isolated impact on headache resolution wasn't specifically tested.
Read More
8
We explored how dietary folate intake might be linked to severe headaches or migraines through a comprehensive analysis of data from the National Health and Nutrition Examination Survey (NHANES) conducted from 1999 to 2004. By examining over 4,100 adults, we observed that around 17% reported experiencing severe headaches or migraines. Importantly, our study used advanced statistical methods to ensure accurate and meaningful results.
Our findings revealed a clear relationship: higher intake of dietary folate appeared to correlate with fewer headaches. Specifically, those with higher folate intake, measured in categorized segments, had significantly lower odds of experiencing severe headaches or migraines compared to those with lower intake levels. The results suggested that as folate intake increased, the likelihood of suffering from severe headaches decreased, supporting the idea of a beneficial relationship.
In summary, our study indicated a linear negative relationship between dietary folate and headache severity, suggesting that incorporating more folate-rich foods into our diets could potentially help reduce the occurrence of migraines. This research provides valuable insights into dietary interventions for managing headache symptoms.
Our findings revealed a clear relationship: higher intake of dietary folate appeared to correlate with fewer headaches. Specifically, those with higher folate intake, measured in categorized segments, had significantly lower odds of experiencing severe headaches or migraines compared to those with lower intake levels. The results suggested that as folate intake increased, the likelihood of suffering from severe headaches decreased, supporting the idea of a beneficial relationship.
In summary, our study indicated a linear negative relationship between dietary folate and headache severity, suggesting that incorporating more folate-rich foods into our diets could potentially help reduce the occurrence of migraines. This research provides valuable insights into dietary interventions for managing headache symptoms.
Read More
8
We examined how folate and vitamin B can affect the occurrence of migraines, drawing from data collected in a large survey of adults in the United States. Our analysis focused on the dietary intake of these nutrients and their relationship with headaches.
The study involved over 7,000 participants, with about 1,350 reporting migraines. Interestingly, we found that higher intakes of both folate and vitamin B were associated with a reduced risk of experiencing severe headaches or migraines. Specifically, those who consumed sufficient amounts—2.39 mg/day of vitamin B and 502.01 µg/day of folate—enjoyed even more significant benefits.
Moreover, we observed a synergistic effect when both nutrients were consumed in higher amounts together, indicating they may work better as a team in preventing migraines. These findings suggest that ensuring adequate folate intake, along with vitamin B, could be a simple strategy for those who suffer from severe headaches.
The study involved over 7,000 participants, with about 1,350 reporting migraines. Interestingly, we found that higher intakes of both folate and vitamin B were associated with a reduced risk of experiencing severe headaches or migraines. Specifically, those who consumed sufficient amounts—2.39 mg/day of vitamin B and 502.01 µg/day of folate—enjoyed even more significant benefits.
Moreover, we observed a synergistic effect when both nutrients were consumed in higher amounts together, indicating they may work better as a team in preventing migraines. These findings suggest that ensuring adequate folate intake, along with vitamin B, could be a simple strategy for those who suffer from severe headaches.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
9
No pain experienced
2 people found this helpful
These are the best iron pills I've used. Most cause headaches or stomach pain, but this one doesn't. I can take it either on an empty stomach or with food without issues. Just remember not to take it with dairy, as it hampers iron absorption.
Read More
0
Caused headache
1 people found this helpful
I took this and ended up with a headache. I would not recommend it.
Read More
9
No headaches experienced
Unlike other brands, this iron supplement did not cause any headaches for me.
Read More
9
Headaches resolved
3 people found this helpful
I've been using this product repeatedly and it has completely eradicated my headaches during menstruation. Unlike other iron supplements that upset my stomach, this plant-derived one is gentle. I take it daily, particularly five days before my period begins, and it has significantly improved my physical condition.
Read More
7.5
Fewer headaches experienced
1 people found this helpful
I struggle to take vitamins, but this brand agrees with me. I've noticed improvements in my restless leg syndrome, a decrease in headache frequency, and I feel more alert while following my specific diet.
Read More
Frequently Asked Questions
7.5
Significant improvement
4 people found this helpful
Good. Initially, I had worse iron deficiency anaemia. I often experienced headaches, but after starting this, I noticed my menstrual syndrome improved by over 80%. I used to struggle for a week, but now it's manageable. There are no issues with constipation, and I appreciate the convenience of taking just one capsule a day.
7.5
Relief from headaches
This supplement is a relief for my frequent headaches caused by anaemia. It includes organic vegetables and fruits, which is rare in Japan, making it genuinely helpful.
0
Caused headache
1 people found this helpful
I took this and ended up with a headache. I would not recommend it.
9
Headaches resolved
3 people found this helpful
I've been using this product repeatedly and it has completely eradicated my headaches during menstruation. Unlike other iron supplements that upset my stomach, this plant-derived one is gentle. I take it daily, particularly five days before my period begins, and it has significantly improved my physical condition.
9
No headaches experienced
Unlike other brands, this iron supplement did not cause any headaches for me.
9
No pain experienced
2 people found this helpful
These are the best iron pills I've used. Most cause headaches or stomach pain, but this one doesn't. I can take it either on an empty stomach or with food without issues. Just remember not to take it with dairy, as it hampers iron absorption.
8
We explored how dietary folate intake might be linked to severe headaches or migraines through a comprehensive analysis of data from the National Health and Nutrition Examination Survey (NHANES) conducted from 1999 to 2004. By examining over 4,100 adults, we observed that around 17% reported experiencing severe headaches or migraines. Importantly, our study used advanced statistical methods to ensure accurate and meaningful results.
Our findings revealed a clear relationship: higher intake of dietary folate appeared to correlate with fewer headaches. Specifically, those with higher folate intake, measured in categorized segments, had significantly lower odds of experiencing severe headaches or migraines compared to those with lower intake levels. The results suggested that as folate intake increased, the likelihood of suffering from severe headaches decreased, supporting the idea of a beneficial relationship.
In summary, our study indicated a linear negative relationship between dietary folate and headache severity, suggesting that incorporating more folate-rich foods into our diets could potentially help reduce the occurrence of migraines. This research provides valuable insights into dietary interventions for managing headache symptoms.
Our findings revealed a clear relationship: higher intake of dietary folate appeared to correlate with fewer headaches. Specifically, those with higher folate intake, measured in categorized segments, had significantly lower odds of experiencing severe headaches or migraines compared to those with lower intake levels. The results suggested that as folate intake increased, the likelihood of suffering from severe headaches decreased, supporting the idea of a beneficial relationship.
In summary, our study indicated a linear negative relationship between dietary folate and headache severity, suggesting that incorporating more folate-rich foods into our diets could potentially help reduce the occurrence of migraines. This research provides valuable insights into dietary interventions for managing headache symptoms.
7
We aimed to explore how serum folate levels might be connected to the occurrence of severe headaches and migraines. To do this, we analyzed data from the National Health and Nutrition Examination Survey, focusing on a large group of 13,351 participants. From this group, 2,742 individuals reported experiencing severe headaches or migraines in the past three months.
Our findings indicated that higher serum folate levels were associated with a lower likelihood of experiencing these types of headaches. Specifically, we calculated an odds ratio of 0.5, showing that as folate levels increased, the chances of suffering from migraines or severe headaches decreased. This pattern was particularly strong among women, people aged 20 to 50, and non-Hispanic White participants.
The results suggest that adequate folate levels could potentially play a role in reducing headache occurrences, though more research is needed to confirm these findings. Overall, our study points to the importance of serum folate not just as a nutritional measure, but also as a factor that might influence headache health.
Our findings indicated that higher serum folate levels were associated with a lower likelihood of experiencing these types of headaches. Specifically, we calculated an odds ratio of 0.5, showing that as folate levels increased, the chances of suffering from migraines or severe headaches decreased. This pattern was particularly strong among women, people aged 20 to 50, and non-Hispanic White participants.
The results suggest that adequate folate levels could potentially play a role in reducing headache occurrences, though more research is needed to confirm these findings. Overall, our study points to the importance of serum folate not just as a nutritional measure, but also as a factor that might influence headache health.
8
We conducted a case-control study to investigate the link between vitamin B12 serum levels and migraine, which affects so many people but lacks a fully understood cause. Our research included 90 individuals experiencing migraines—split into those with chronic migraines and those with episodic migraines—matched against 90 healthy participants.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
4
We explored the potential impact of folate, alongside other vitamins, on headache management, particularly migraines. Our review included a comprehensive search for studies that investigated the effects of folate supplementation, both alone and in combination with vitamins B6 and B12, on individuals with migraine and other headache disorders.
Among the studies reviewed, we found that while there were some promising findings regarding the use of B6 in preventing migraine with aura, the benefits of folate supplementation were not as clear-cut. One randomized controlled trial suggested that folate alone did not show significant efficacy compared to a placebo.
Additionally, limited research involving a small number of participants sought to understand the effects of folate on migraine without aura. Sadly, the lack of robust data makes it difficult to draw any firm conclusions about folate's effectiveness for headache relief.
Overall, while folate is included in combinations that may show benefits, isolating its specific contributions to headache treatment remains challenging. Therefore, further high-quality studies are necessary to truly assess its role in headache management.
Among the studies reviewed, we found that while there were some promising findings regarding the use of B6 in preventing migraine with aura, the benefits of folate supplementation were not as clear-cut. One randomized controlled trial suggested that folate alone did not show significant efficacy compared to a placebo.
Additionally, limited research involving a small number of participants sought to understand the effects of folate on migraine without aura. Sadly, the lack of robust data makes it difficult to draw any firm conclusions about folate's effectiveness for headache relief.
Overall, while folate is included in combinations that may show benefits, isolating its specific contributions to headache treatment remains challenging. Therefore, further high-quality studies are necessary to truly assess its role in headache management.
References
- Singh RK, Kaushik RM, Goel D, Kaushik R. Association between iron deficiency anemia and chronic daily headache: A case-control study. Cephalalgia. 2023;43:3331024221143540. doi:10.1177/03331024221143540
- Strozenko LA, Ponomaryov VS, Sanina OO, Lobanov YF. [The role of genetic polymorphisms in folate metabolism genes in the manifestation of migraine in children]. Zh Nevrol Psikhiatr Im S S Korsakova. 2025;125:47. doi:10.17116/jnevro202512501147
- Zhao D, Long X, Wang J. Association between dietary folate intake and severe headache or migraine in adults: a cross-sectional study of the National Health and Nutrition Examination Survey. Front Nutr. 2024;11:1456502. doi:10.3389/fnut.2024.1456502
- Luwen H, Ping C, Qing-Rong O, Lei X, Linlin L, et al. Association between serum folate levels and migraine or severe headaches: A nationwide cross-sectional study. Medicine (Baltimore). 2024;103:e40458. doi:10.1097/MD.0000000000040458
- Tian S, Yu X, Wu L, Zheng H, Zhong X, et al. Vitamin B and folate intake are associated with lower risk of severe headache or migraine in adults: An analysis based on NHANES 1999-2004. Nutr Res. 2024;121:51. doi:10.1016/j.nutres.2023.11.008
- Tian S, Wu L, Zheng H, Zhong X, Liu M, et al. Association between dietary folate intake and severe headache among adults in the USA: a cross-sectional survey. Br J Nutr. 2024;131:438. doi:10.1017/S000711452300137X
- Zhang M, Shi B, Zhao M. Cerebral venous thrombosis with hyperhomocysteinemia due to loss of heterozygosity at methylenetetrahydrofolate reductase (MTHFR) locus: a case report. BMC Neurol. 2023;23:154. doi:10.1186/s12883-023-03200-y
- Lin SS, Fan IW, Chen CY, Su YJ. A nitrous oxide abuser presenting with cerebral venous thrombosis: A case report. Med Int (Lond). 2022;2:20. doi:10.3892/mi.2022.45
- Aydin H, Bucak IH, Geyik M. Vitamin B12 and folic acid levels in pediatric migraine patients. Acta Neurol Belg. 2021;121:1741. doi:10.1007/s13760-020-01491-3
- Liampas IN, Siokas V, Aloizou AM, Tsouris Z, Dastamani M, et al. Pyridoxine, folate and cobalamin for migraine: A systematic review. Acta Neurol Scand. 2020;142:108. doi:10.1111/ane.13251
- Abdelsadek SE, Tahoun SA, Mansour FM, Abdulsalam MF, Ahmed AM. The correlation between vitamin B12 serum levels and migraine: a case-control study. Neurol Res. 2025;47:195. doi:10.1080/01616412.2025.2462735
