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SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.6
USERS' SCORE
Good
Based on 9 Reviews
8.3
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Vitamin C (from culture of S. cerevisiae)
25 mg
28%
Folate (from culture of S. cerevisiae)
400 mcg DFE
100%
Vitamin B12 (as Methylcobalamin from culture of S. cerevisiae)
500 mcg
20833%
Iron (from Brown Rice Chelate)
22 mg
122%
RAW Organic Fruit & Vegetable BlendOrganic Apple (fruit), Organic Beet (root), Organic Broccoli (stalk & flower), Organic Carrot (root), Organic Spinach (leaf), Organic Tomato (fruit), Organic Strawberry (fruit), Organic Tart Cherry (fruit), Organic Blackberry (fruit), Organic Green Bell Pepper (fruit), Organic Brussels Sprout (leaf), Organic Blueberry (fruit), Organic Ginger (root), Organic Garlic (bulb), Organic Green Onion (bulb), Organic Raspberry (fruit), Organic Parsley (leaf), Organic Cauliflower (flower & stem), Organic Red Cabbage (leaf), Organic Kale (leaf), Organic Cucumber (gourd), Organic Celery (stalk), Organic Asparagus Juice (flower & stem)
310 mg
+
RAW Probiotic & Enzyme BlendLipase, Protease, Aspergillopepsin, beta-Glucanase, Cellulase, Bromelain, Phytase, Lactase, Papain, Peptidase, Pectinase, Hemicellulase, Xylanase, [Lactobacillus plantarum, Lactobacillus bulgaricus] (500 Million CFU)
60 mg
+
Top Medical Research Studies
9
Folate intake may reduce headaches
Association between dietary folate intake and severe headache among adults in the USA: a cross-sectional survey.
Study directly examines folate effects
We examined the effects of dietary folate intake on severe headaches by analyzing data from a large national health survey. The study involved nearly 10,000 participants over the age of 20, where individuals self-reported their experiences with severe headaches.
Through sophisticated analysis methods, including multivariate logistic regression, we discovered that higher dietary folate intake appears to be associated with a lower likelihood of experiencing severe headaches. Specifically, participants who consumed more folate had significantly reduced odds of reporting severe headaches, with the most substantial impact seen in those with the highest intake levels.
Interestingly, we found that women aged 20 to 50 exhibited a non-linear association between folate and headache severity, suggesting that they might benefit from being more mindful of their folate consumption.
This research underscores the potential for dietary folate to play a protective role against severe headaches, encouraging individuals to consider increasing their folate intake for headache prevention.
Through sophisticated analysis methods, including multivariate logistic regression, we discovered that higher dietary folate intake appears to be associated with a lower likelihood of experiencing severe headaches. Specifically, participants who consumed more folate had significantly reduced odds of reporting severe headaches, with the most substantial impact seen in those with the highest intake levels.
Interestingly, we found that women aged 20 to 50 exhibited a non-linear association between folate and headache severity, suggesting that they might benefit from being more mindful of their folate consumption.
This research underscores the potential for dietary folate to play a protective role against severe headaches, encouraging individuals to consider increasing their folate intake for headache prevention.
Read More
8
Folate intake decreases migraine severity
Association between dietary folate intake and severe headache or migraine in adults: a cross-sectional study of the National Health and Nutrition Examination Survey.
Directly evaluates folate effects
We explored how dietary folate intake might be linked to severe headaches or migraines through a comprehensive analysis of data from the National Health and Nutrition Examination Survey (NHANES) conducted from 1999 to 2004. By examining over 4,100 adults, we observed that around 17% reported experiencing severe headaches or migraines. Importantly, our study used advanced statistical methods to ensure accurate and meaningful results.
Our findings revealed a clear relationship: higher intake of dietary folate appeared to correlate with fewer headaches. Specifically, those with higher folate intake, measured in categorized segments, had significantly lower odds of experiencing severe headaches or migraines compared to those with lower intake levels. The results suggested that as folate intake increased, the likelihood of suffering from severe headaches decreased, supporting the idea of a beneficial relationship.
In summary, our study indicated a linear negative relationship between dietary folate and headache severity, suggesting that incorporating more folate-rich foods into our diets could potentially help reduce the occurrence of migraines. This research provides valuable insights into dietary interventions for managing headache symptoms.
Our findings revealed a clear relationship: higher intake of dietary folate appeared to correlate with fewer headaches. Specifically, those with higher folate intake, measured in categorized segments, had significantly lower odds of experiencing severe headaches or migraines compared to those with lower intake levels. The results suggested that as folate intake increased, the likelihood of suffering from severe headaches decreased, supporting the idea of a beneficial relationship.
In summary, our study indicated a linear negative relationship between dietary folate and headache severity, suggesting that incorporating more folate-rich foods into our diets could potentially help reduce the occurrence of migraines. This research provides valuable insights into dietary interventions for managing headache symptoms.
Read More
8
Vitamin B12 deficiency linked to migraines
The correlation between vitamin B12 serum levels and migraine: a case-control study.
Direct investigation of B12 effects
We conducted a case-control study to investigate the link between vitamin B12 serum levels and migraine, which affects so many people but lacks a fully understood cause. Our research included 90 individuals experiencing migraines—split into those with chronic migraines and those with episodic migraines—matched against 90 healthy participants.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
Read More
Most Useful Reviews
9.5
No pain experienced
These are the best iron pills I've used. Most cause headaches or stomach pain, but this one doesn't. I can take it either on an empty stomach or with food without issues. Just remember not to take it with dairy, as it hampers iron absorption.
Read More
0
Caused headache
I took this and ended up with a headache. I would not recommend it.
Read More
8.3
No headaches experienced
Unlike other brands, this iron supplement did not cause any headaches for me.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.6
9
Migraine linked to folate genetics
[The role of genetic polymorphisms in folate metabolism genes in the manifestation of migraine in children].
Folate's role in headache relief
We examined the connection between genetic differences in folate metabolism and migraine experiences in children aged 7 to 18. The study involved 54 children with migraine symptoms and a control group of 115 others without neurological issues.
Focusing on four specific genetic variants linked to folate metabolism, we found that children with migraines were more likely to have a certain rare genetic variant that may increase plasma homocysteine levels, potentially indicating a hidden folate deficiency. In addition to genetic testing, we looked at vitamin B levels and the effectiveness of Cortexin, a treatment administered to the children.
After a 10-day course of Cortexin, many children reported significant improvements in their migraine symptoms, such as less headache pain, reduced fatigue, and better emotional stability. This suggests that while there’s a genetic connection to migraine, the treatment with Cortexin also plays a critical role in alleviating symptoms.
Focusing on four specific genetic variants linked to folate metabolism, we found that children with migraines were more likely to have a certain rare genetic variant that may increase plasma homocysteine levels, potentially indicating a hidden folate deficiency. In addition to genetic testing, we looked at vitamin B levels and the effectiveness of Cortexin, a treatment administered to the children.
After a 10-day course of Cortexin, many children reported significant improvements in their migraine symptoms, such as less headache pain, reduced fatigue, and better emotional stability. This suggests that while there’s a genetic connection to migraine, the treatment with Cortexin also plays a critical role in alleviating symptoms.
Read More
9
Folate intake may reduce headaches
Association between dietary folate intake and severe headache among adults in the USA: a cross-sectional survey.
Study directly examines folate effects
We examined the effects of dietary folate intake on severe headaches by analyzing data from a large national health survey. The study involved nearly 10,000 participants over the age of 20, where individuals self-reported their experiences with severe headaches.
Through sophisticated analysis methods, including multivariate logistic regression, we discovered that higher dietary folate intake appears to be associated with a lower likelihood of experiencing severe headaches. Specifically, participants who consumed more folate had significantly reduced odds of reporting severe headaches, with the most substantial impact seen in those with the highest intake levels.
Interestingly, we found that women aged 20 to 50 exhibited a non-linear association between folate and headache severity, suggesting that they might benefit from being more mindful of their folate consumption.
This research underscores the potential for dietary folate to play a protective role against severe headaches, encouraging individuals to consider increasing their folate intake for headache prevention.
Through sophisticated analysis methods, including multivariate logistic regression, we discovered that higher dietary folate intake appears to be associated with a lower likelihood of experiencing severe headaches. Specifically, participants who consumed more folate had significantly reduced odds of reporting severe headaches, with the most substantial impact seen in those with the highest intake levels.
Interestingly, we found that women aged 20 to 50 exhibited a non-linear association between folate and headache severity, suggesting that they might benefit from being more mindful of their folate consumption.
This research underscores the potential for dietary folate to play a protective role against severe headaches, encouraging individuals to consider increasing their folate intake for headache prevention.
Read More
9
Folate's unclear role in headaches
Cerebral venous thrombosis with hyperhomocysteinemia due to loss of heterozygosity at methylenetetrahydrofolate reductase (MTHFR) locus: a case report.
Moderate relevance; mixed treatment effects
We explored the case of a 14-year-old girl who faced severe headaches and nausea due to cerebral venous thrombosis (CVT) and high levels of homocysteine. After thorough examinations, including brain imaging and genetic testing, she underwent treatment that included anticoagulants and supplementation with folate, as well as vitamins B12 and B6.
The patient showed significant improvement in her condition within a month. She experienced relief from headaches, and her intracranial pressure decreased considerably. While the study indicates that folate was part of a comprehensive treatment approach, the specific contribution of folate alone to the relief of her headaches remains unclear due to the combined nature of the treatments.
This case highlights a unique instance of loss of heterozygosity at the methylenetetrahydrofolate reductase (MTHFR) gene and suggests that analyzing this genetic factor could be important in patients with CVT and hyperhomocysteinemia. However, we must interpret the efficacy of folate cautiously, as its isolated impact on headache resolution wasn't specifically tested.
The patient showed significant improvement in her condition within a month. She experienced relief from headaches, and her intracranial pressure decreased considerably. While the study indicates that folate was part of a comprehensive treatment approach, the specific contribution of folate alone to the relief of her headaches remains unclear due to the combined nature of the treatments.
This case highlights a unique instance of loss of heterozygosity at the methylenetetrahydrofolate reductase (MTHFR) gene and suggests that analyzing this genetic factor could be important in patients with CVT and hyperhomocysteinemia. However, we must interpret the efficacy of folate cautiously, as its isolated impact on headache resolution wasn't specifically tested.
Read More
8
Folate intake decreases migraine severity
Association between dietary folate intake and severe headache or migraine in adults: a cross-sectional study of the National Health and Nutrition Examination Survey.
Directly evaluates folate effects
We explored how dietary folate intake might be linked to severe headaches or migraines through a comprehensive analysis of data from the National Health and Nutrition Examination Survey (NHANES) conducted from 1999 to 2004. By examining over 4,100 adults, we observed that around 17% reported experiencing severe headaches or migraines. Importantly, our study used advanced statistical methods to ensure accurate and meaningful results.
Our findings revealed a clear relationship: higher intake of dietary folate appeared to correlate with fewer headaches. Specifically, those with higher folate intake, measured in categorized segments, had significantly lower odds of experiencing severe headaches or migraines compared to those with lower intake levels. The results suggested that as folate intake increased, the likelihood of suffering from severe headaches decreased, supporting the idea of a beneficial relationship.
In summary, our study indicated a linear negative relationship between dietary folate and headache severity, suggesting that incorporating more folate-rich foods into our diets could potentially help reduce the occurrence of migraines. This research provides valuable insights into dietary interventions for managing headache symptoms.
Our findings revealed a clear relationship: higher intake of dietary folate appeared to correlate with fewer headaches. Specifically, those with higher folate intake, measured in categorized segments, had significantly lower odds of experiencing severe headaches or migraines compared to those with lower intake levels. The results suggested that as folate intake increased, the likelihood of suffering from severe headaches decreased, supporting the idea of a beneficial relationship.
In summary, our study indicated a linear negative relationship between dietary folate and headache severity, suggesting that incorporating more folate-rich foods into our diets could potentially help reduce the occurrence of migraines. This research provides valuable insights into dietary interventions for managing headache symptoms.
Read More
8
Folate linked to migraine relief
Vitamin B and folate intake are associated with lower risk of severe headache or migraine in adults: An analysis based on NHANES 1999-2004.
Study explores nutrient effects
We examined how folate and vitamin B can affect the occurrence of migraines, drawing from data collected in a large survey of adults in the United States. Our analysis focused on the dietary intake of these nutrients and their relationship with headaches.
The study involved over 7,000 participants, with about 1,350 reporting migraines. Interestingly, we found that higher intakes of both folate and vitamin B were associated with a reduced risk of experiencing severe headaches or migraines. Specifically, those who consumed sufficient amounts—2.39 mg/day of vitamin B and 502.01 µg/day of folate—enjoyed even more significant benefits.
Moreover, we observed a synergistic effect when both nutrients were consumed in higher amounts together, indicating they may work better as a team in preventing migraines. These findings suggest that ensuring adequate folate intake, along with vitamin B, could be a simple strategy for those who suffer from severe headaches.
The study involved over 7,000 participants, with about 1,350 reporting migraines. Interestingly, we found that higher intakes of both folate and vitamin B were associated with a reduced risk of experiencing severe headaches or migraines. Specifically, those who consumed sufficient amounts—2.39 mg/day of vitamin B and 502.01 µg/day of folate—enjoyed even more significant benefits.
Moreover, we observed a synergistic effect when both nutrients were consumed in higher amounts together, indicating they may work better as a team in preventing migraines. These findings suggest that ensuring adequate folate intake, along with vitamin B, could be a simple strategy for those who suffer from severe headaches.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.3
9.5
Headaches resolved
I've been using this product repeatedly and it has completely eradicated my headaches during menstruation. Unlike other iron supplements that upset my stomach, this plant-derived one is gentle. I take it daily, particularly five days before my period begins, and it has significantly improved my physical condition.
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9.5
No pain experienced
These are the best iron pills I've used. Most cause headaches or stomach pain, but this one doesn't. I can take it either on an empty stomach or with food without issues. Just remember not to take it with dairy, as it hampers iron absorption.
8.8
Significant improvement
Good. Initially, I had worse iron deficiency anaemia. I often experienced headaches, but after starting this, I noticed my menstrual syndrome improved by over 80%. I used to struggle for a week, but now it's manageable. There are no issues with constipation, and I appreciate the convenience of taking just one capsule a day.
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8.8
Relief from headaches
This supplement is a relief for my frequent headaches caused by anaemia. It includes organic vegetables and fruits, which is rare in Japan, making it genuinely helpful.
8.8
PMS relief
I purchased this iron supplement to alleviate my fatigue and light anaemia. The capsules were larger than expected but easy to swallow, and they didn't upset my stomach. I've noticed less discomfort during PMS and I hope this helps my anaemia long-term.
