5/30/2025
Last update
5/30/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.6
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.6
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Vitamin C (from culture of S. cerevisiae)
25 mg
28%
Folate (from culture of S. cerevisiae)
400 mcg DFE
100%
Vitamin B12 (as Methylcobalamin from culture of S. cerevisiae)
500 mcg
20833%
Iron (from Brown Rice Chelate)
22 mg
122%
RAW Organic Fruit & Vegetable BlendOrganic Apple (fruit), Organic Beet (root), Organic Broccoli (stalk & flower), Organic Carrot (root), Organic Spinach (leaf), Organic Tomato (fruit), Organic Strawberry (fruit), Organic Tart Cherry (fruit), Organic Blackberry (fruit), Organic Green Bell Pepper (fruit), Organic Brussels Sprout (leaf), Organic Blueberry (fruit), Organic Ginger (root), Organic Garlic (bulb), Organic Green Onion (bulb), Organic Raspberry (fruit), Organic Parsley (leaf), Organic Cauliflower (flower & stem), Organic Red Cabbage (leaf), Organic Kale (leaf), Organic Cucumber (gourd), Organic Celery (stalk), Organic Asparagus Juice (flower & stem)
310 mg
+
RAW Probiotic & Enzyme BlendLipase, Protease, Aspergillopepsin, beta-Glucanase, Cellulase, Bromelain, Phytase, Lactase, Papain, Peptidase, Pectinase, Hemicellulase, Xylanase, [Lactobacillus plantarum, Lactobacillus bulgaricus] (500 Million CFU)
60 mg
+
Top Medical Research Studies
9
We investigated the role of iron treatment in managing heart disease, particularly its isolated effects. The research closely looked at how iron supplementation interacts with other therapies in patients with heart conditions.
Heart disease can often be complicated by iron deficiency, leading to questions about the potential benefits of treating this deficiency. Our findings revealed that while iron treatment showed some promise, its overall effectiveness on improving heart disease symptoms or outcomes appeared limited when considered in isolation.
Additionally, the study emphasized the importance of viewing iron treatment not as a standalone solution, but as part of a broader approach that includes other therapies. This nuanced understanding can help guide healthcare practices in treating heart disease patients more effectively.
Heart disease can often be complicated by iron deficiency, leading to questions about the potential benefits of treating this deficiency. Our findings revealed that while iron treatment showed some promise, its overall effectiveness on improving heart disease symptoms or outcomes appeared limited when considered in isolation.
Additionally, the study emphasized the importance of viewing iron treatment not as a standalone solution, but as part of a broader approach that includes other therapies. This nuanced understanding can help guide healthcare practices in treating heart disease patients more effectively.
Read More
We conducted a case-control study to look into how maternal folic acid supplementation affects the risk of congenital heart disease (CHD) in children and whether genetic factors, specifically MTRR gene polymorphisms, play a role in this relationship.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
Read More
9
We explored how vitamin B12 can act as a safeguard against heart damage caused by ischemia/reperfusion (I/R) injury. In our study, we used a mouse model subjected to I/R injury by occluding the left anterior descending coronary artery, followed by 24 hours of reperfusion.
Our aim was to see if high doses of vitamin B12 could improve heart function and reduce damage. Through various evaluations, including echocardiography and biochemical methods, we revealed that vitamin B12 supplementation does indeed help. It mitigates oxidative stress and lowers levels of harmful reactive oxygen species.
Additionally, we found that B12 supplementation reduced cell apoptosis—essentially cell death—in heart tissues. This response was linked to the action of specific signaling pathways, particularly the SIRT3/AMPK pathway. However, we noted that these protective effects diminished when a SIRT3 inhibitor was introduced, indicating the importance of this pathway.
Moreover, RNA sequencing data showed that vitamin B12 also plays a role in reducing inflammation during I/R injury. Overall, our findings suggest that high doses of vitamin B12 might serve as an effective strategy for treating myocardial damage from I/R events, potentially paving the way for new therapies in heart health.
Our aim was to see if high doses of vitamin B12 could improve heart function and reduce damage. Through various evaluations, including echocardiography and biochemical methods, we revealed that vitamin B12 supplementation does indeed help. It mitigates oxidative stress and lowers levels of harmful reactive oxygen species.
Additionally, we found that B12 supplementation reduced cell apoptosis—essentially cell death—in heart tissues. This response was linked to the action of specific signaling pathways, particularly the SIRT3/AMPK pathway. However, we noted that these protective effects diminished when a SIRT3 inhibitor was introduced, indicating the importance of this pathway.
Moreover, RNA sequencing data showed that vitamin B12 also plays a role in reducing inflammation during I/R injury. Overall, our findings suggest that high doses of vitamin B12 might serve as an effective strategy for treating myocardial damage from I/R events, potentially paving the way for new therapies in heart health.
Read More
Most Useful Reviews
9
Supports iron levels
Garden of Life, Vitamin Code, RAW Iron, 30 Vegan Capsules is excellent for naturally supporting iron levels. Made from high-quality, allergen-free ingredients, it benefits blood and heart health. I've experienced a notable improvement in my iron levels since using it, making it vital for managing heart disease.
Read More
0
Allergy caution
3 people found this helpful
I have low ferritin and Hashimoto's and am allergic to dairy, gluten, and nuts. Despite the product claiming to be allergen-free, it may cause reactions due to possible cross-contamination. I experienced diarrhoea and fatigue, making it unsuitable for those with allergies, especially concerning heart disease.
Read More
7.5
Strengthening effects
1 people found this helpful
Super! Raw iron, no side effects. It gives me strength! However, one must be cautious, as chronic diseases may worsen with iron supplements, particularly those related to heart disease. It’s better to ensure full remission first!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.6
- All Researches
9.5
We explored the effects of folate, a form of vitamin B, on heart problems associated with TANGO2-deficiency disorder (TDD). This genetic condition can lead to dangerous heart rhythms that don’t respond well to standard treatments. To dive deeper into this issue, we established patient-derived heart cells, known as iPSC-CMs, to mimic the heart abnormalities seen in TDD.
In our observations, we found that high doses of folate almost completely eliminated arrhythmias in these heart cells. Interestingly, our clinical observations revealed that TDD patients taking multivitamins, particularly those high in B vitamins, experienced a significant reduction in cardiac crises. This suggests that folate may play a critical role in protecting against these life-threatening heart issues.
Our findings not only highlight the potential of folate as an effective treatment but also emphasize the importance of considering dietary supplements in managing cardiac risks in patients with TDD. Thus, we believe that boosting folate intake could offer a valuable strategy to enhance heart health in those affected by this disorder.
In our observations, we found that high doses of folate almost completely eliminated arrhythmias in these heart cells. Interestingly, our clinical observations revealed that TDD patients taking multivitamins, particularly those high in B vitamins, experienced a significant reduction in cardiac crises. This suggests that folate may play a critical role in protecting against these life-threatening heart issues.
Our findings not only highlight the potential of folate as an effective treatment but also emphasize the importance of considering dietary supplements in managing cardiac risks in patients with TDD. Thus, we believe that boosting folate intake could offer a valuable strategy to enhance heart health in those affected by this disorder.
Read More
9
We explored how iron impacts heart disease by developing a targeted delivery system that addresses myocardial ischemia-reperfusion injury (MIRI), a condition that leads to significant heart damage. This integrated system utilized cerium oxide (CeO) nanoparticles alongside dexrazoxane (DXZ), an iron-chelating agent, to improve therapeutic outcomes. By loading these components into mesoporous polydopamine nanoparticles, we aimed to enhance their delivery to the heart and specifically to the damaged mitochondria where they are most needed.
The results of our study were promising. We found that the combination of iron chelation and antioxidant properties significantly reduced oxidative stress and inhibited ferroptosis, a form of cell death linked to heart injury. Additionally, this approach led to improved cardiac function and reduced inflammation, which are crucial for recovery after MIRI.
Overall, this hierarchical targeting system offers a new avenue not only for the clinical use of DXZ but also for advancing nanomedicine interventions in heart repair. However, it’s important to note that while iron plays a role in this therapeutic approach, isolating its specific effects on heart disease remains challenging due to the combination with other treatment methods in our study.
The results of our study were promising. We found that the combination of iron chelation and antioxidant properties significantly reduced oxidative stress and inhibited ferroptosis, a form of cell death linked to heart injury. Additionally, this approach led to improved cardiac function and reduced inflammation, which are crucial for recovery after MIRI.
Overall, this hierarchical targeting system offers a new avenue not only for the clinical use of DXZ but also for advancing nanomedicine interventions in heart repair. However, it’s important to note that while iron plays a role in this therapeutic approach, isolating its specific effects on heart disease remains challenging due to the combination with other treatment methods in our study.
Read More
9
We investigated the role of iron treatment in managing heart disease, particularly its isolated effects. The research closely looked at how iron supplementation interacts with other therapies in patients with heart conditions.
Heart disease can often be complicated by iron deficiency, leading to questions about the potential benefits of treating this deficiency. Our findings revealed that while iron treatment showed some promise, its overall effectiveness on improving heart disease symptoms or outcomes appeared limited when considered in isolation.
Additionally, the study emphasized the importance of viewing iron treatment not as a standalone solution, but as part of a broader approach that includes other therapies. This nuanced understanding can help guide healthcare practices in treating heart disease patients more effectively.
Heart disease can often be complicated by iron deficiency, leading to questions about the potential benefits of treating this deficiency. Our findings revealed that while iron treatment showed some promise, its overall effectiveness on improving heart disease symptoms or outcomes appeared limited when considered in isolation.
Additionally, the study emphasized the importance of viewing iron treatment not as a standalone solution, but as part of a broader approach that includes other therapies. This nuanced understanding can help guide healthcare practices in treating heart disease patients more effectively.
Read More
9
We investigated how Apelin-13 can protect heart cells from injury caused by lack of oxygen and subsequent reoxygenation, a significant issue in coronary artery disease. In our analysis, using heart cell models, we discovered that Apelin-13 reduces oxidative stress and improves heart cell function.
It lowers harmful iron levels and enhances protective substances in the cells, thus preventing cell death through a process called ferroptosis. Importantly, the protective effects depend on the activation of a specific protein called Nrf2. These findings suggest that Apelin-13 holds promise for future treatments in heart disease.
It lowers harmful iron levels and enhances protective substances in the cells, thus preventing cell death through a process called ferroptosis. Importantly, the protective effects depend on the activation of a specific protein called Nrf2. These findings suggest that Apelin-13 holds promise for future treatments in heart disease.
Read More
9
We explored the effectiveness of a bioconductive patch aimed at treating atrial fibrillation (AF) using superparamagnetic iron oxide nanoparticles. This patch not only improves electrical conduction but also helps reduce AF episodes in animal models. Over a 60-day period, the patch showed better outcomes than a standard gelatin variant, enabling continuous, noninvasive monitoring of its therapeutic effects through magnetic resonance imaging. However, further research is necessary to fully understand its long-term benefits in treating AF.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Supports iron levels
Garden of Life, Vitamin Code, RAW Iron, 30 Vegan Capsules is excellent for naturally supporting iron levels. Made from high-quality, allergen-free ingredients, it benefits blood and heart health. I've experienced a notable improvement in my iron levels since using it, making it vital for managing heart disease.
Read More
0
Allergy caution
3 people found this helpful
I have low ferritin and Hashimoto's and am allergic to dairy, gluten, and nuts. Despite the product claiming to be allergen-free, it may cause reactions due to possible cross-contamination. I experienced diarrhoea and fatigue, making it unsuitable for those with allergies, especially concerning heart disease.
Read More
7.5
Strengthening effects
1 people found this helpful
Super! Raw iron, no side effects. It gives me strength! However, one must be cautious, as chronic diseases may worsen with iron supplements, particularly those related to heart disease. It’s better to ensure full remission first!
Read More
7.5
Immune support
This product significantly boosts my immune system, helps in lowering blood pressure, and keeps my heart healthy.
Read More
Frequently Asked Questions
7.5
Immune support
This product significantly boosts my immune system, helps in lowering blood pressure, and keeps my heart healthy.
7.5
Strengthening effects
1 people found this helpful
Super! Raw iron, no side effects. It gives me strength! However, one must be cautious, as chronic diseases may worsen with iron supplements, particularly those related to heart disease. It’s better to ensure full remission first!
0
Allergy caution
3 people found this helpful
I have low ferritin and Hashimoto's and am allergic to dairy, gluten, and nuts. Despite the product claiming to be allergen-free, it may cause reactions due to possible cross-contamination. I experienced diarrhoea and fatigue, making it unsuitable for those with allergies, especially concerning heart disease.
9
Supports iron levels
Garden of Life, Vitamin Code, RAW Iron, 30 Vegan Capsules is excellent for naturally supporting iron levels. Made from high-quality, allergen-free ingredients, it benefits blood and heart health. I've experienced a notable improvement in my iron levels since using it, making it vital for managing heart disease.
References
- Margineanu C, Antohi L, Ambrosy A, Bartos D, Collins S, et al. Impact of iron deficiency on congestion and postdischarge survival in patients recently hospitalised for decompensated heart failure: a multicentre, prospective, observational analysis of the FERIC-RO study. Open Heart. 2025;12. 10.1136/openhrt-2024-002851
- Zhu K, Wang K, Zhang R, Zhu Z, Wang W, et al. Iron chelators loaded on myocardiocyte mitochondria-targeted nanozyme system for treating myocardial ischemia-reperfusion injury in mouse models. J Nanobiotechnology. 2025;23:112. 10.1186/s12951-025-03197-1
- Meloni A, Saba L, Positano V, Taccori M, Pistoia L, et al. Left ventricular diastolic and systolic functions by cardiac magnetic resonance in beta-thalassemia major: correlation with clinical findings and cardiac complications. Int J Cardiovasc Imaging. 2025. 10.1007/s10554-025-03352-7
- Ezekowitz JA, Mulder H, Mentz RJ, Butler J, DE Pasquale CG, et al. Prediction and Longer-Term Outcomes of All-cause and Cardiovascular Mortality in the HEART-FID Trial. J Card Fail. 2025. 10.1016/j.cardfail.2025.01.009
- Anker SD, Friede T, Butler J, Talha KM, Diek M, et al. Rationale and design of the FAIR-HF2-DZHK05 trial: Ferric carboxymaltose assessment of morbidity and mortality in patients with iron deficiency and chronic heart failure. Eur J Heart Fail. 2025. 10.1002/ejhf.3574
- Gan S, Azzo JD, Zhao L, Pourmussa B, Dib MJ, et al. Transferrin Saturation, Serum Iron, and Ferritin in Heart Failure: Prognostic Significance and Proteomic Associations. Circ Heart Fail. 2025;18:e011728. 10.1161/CIRCHEARTFAILURE.124.011728
- Maeder MT, Verbrugge FH. Ironing Out the Controversies Surrounding the Iron Deficiency Definition in Heart Failure. Circ Heart Fail. 2025;18:e012675. 10.1161/CIRCHEARTFAILURE.124.012675
- Liang F, Li C, Liu Y, Sui Y. Apelin-13 Protects Against Myocardial Hypoxia/Reoxygenation (H/R) Injury by Inhibiting Ferroptosis Via Nrf2 Activation. J Biochem Mol Toxicol. 2025;39:e70223. 10.1002/jbt.70223
- Dychiao AT, Lu TH, Peng SY, Fan C, Song S, et al. Noninvasive assessment of a bioconductive patch for treating atrial fibrillation with magnetic resonance imaging. J Control Release. 2025;380:317. 10.1016/j.jconrel.2025.01.092
- Li Q, Pan Z, Zeng Y, Wang X, Li D, et al. Associations Between Hemoglobin and Serum Iron Levels and the Risk of Mortality Among Patients with Coronary Artery Disease. Nutrients. 2024;17. 10.3390/nu17010139
- Ruan X, Shang W, Lu J, Li Z, Yang J, et al. Maternal multivitamin supplementation mitigates the risk of fetal congenital heart disease associated with high indoor total volatile organic compounds exposure in east china: a case-control study. Environ Health. 2024;23:110. 10.1186/s12940-024-01150-7
- Li L, Ou J, Chen Y, Chen Q, Luo M, et al. Association of maternal folic acid supplementation and offspring MTRR gene polymorphism with congenital heart disease: a hospital-based case-control study in Han population. J Health Popul Nutr. 2024;43:220. 10.1186/s41043-024-00699-w
- Qu Y, Liu X, Lin S, Bloom MS, Wang X, et al. Maternal Serum Folate During Pregnancy and Congenital Heart Disease in Offspring. JAMA Netw Open. 2024;7:e2438747. 10.1001/jamanetworkopen.2024.38747
- Ma L, Zeng L, Wang X. MTHFR C677T gene polymorphism in patients with coronary heart disease and hypertension treated with enalapril and folic acid: implications for prognosis. Cell Mol Biol (Noisy-le-grand). 2024;70:142. 10.14715/cmb/2024.70.9.20
- Xu W, Cao Y, Stephens SB, Arredondo MJ, Chen Y, et al. Folate as a potential treatment for lethal ventricular arrhythmias in TANGO2-deficiency disorder. JCI Insight. 2024;9. 10.1172/jci.insight.171005
- Hjalmarsson C, Backelin C, Thoren A, Bergh N, Sloan JL, et al. Severe heart failure in a unique case of cobalamin-C-deficiency resolved with LVAD implantation and subsequent heart transplantation. Mol Genet Metab Rep. 2024;39:101089. 10.1016/j.ymgmr.2024.101089
- Domínguez-López I, Kovatcheva M, Casas R, Toledo E, Fitó M, et al. Higher circulating vitamin B12 is associated with lower levels of inflammatory markers in individuals at high cardiovascular risk and in naturally aged mice. J Sci Food Agric. 2024;104:875. 10.1002/jsfa.12976
- Qin Y, Shi Y, Yu Q, Yang S, Wang Y, et al. Vitamin B12 alleviates myocardial ischemia/reperfusion injury via the SIRT3/AMPK signaling pathway. Biomed Pharmacother. 2023;163:114761. 10.1016/j.biopha.2023.114761
- Mohan A, Kumar R, Kumar V, Yadav M. Homocysteine, Vitamin B12 and Folate Level: Possible Risk Factors in the Progression of Chronic Heart and Kidney Disorders. Curr Cardiol Rev. 2023;19:e090223213539. 10.2174/1573403X19666230209111854
