We evaluated how switching to ferric citrate hydrate (FCH) impacts nausea in women with iron deficiency anemia (IDA) who struggled with oral iron. In a multicenter study of 30 patients, those on FCH experienced significant improvements. Nausea scores dropped from 5.7 to 1.7, and the overall incidence of nausea decreased notably. Also, 80% reported better experiences compared to previous treatments.
Overall, our findings suggest that FCH not only enhances medication adherence but also effectively reduces nausea and improves quality of life in these patients.
Read More
9
Iron treatment eases nausea in pregnancy
Efficacy and Safety of Microsomal Ferric Pyrophosphate Supplement for Iron Deficiency Anemia in Pregnancy.
We conducted a study to examine the effectiveness of a specific iron supplement, emulsified microsomal ferric pyrophosphate (EMFP), in treating iron deficiency anemia among pregnant women. Our focus was not only on improving hemoglobin levels but also on alleviating related symptoms, including nausea.
Within 30 days of starting treatment with EMFP, we observed significant increases in hemoglobin levels, alongside marked improvements in serum ferritin and iron levels. As nausea is a common complaint among pregnant women, we noted a decrease in various symptoms, including nausea, breathlessness, and dizziness, which contributed to a better quality of life for the participants.
Notably, treatment compliance was remarkably high at 99.5%, indicating that the participants were committed to managing their anemia effectively. Importantly, we did not encounter any severe side effects related to the treatment, suggesting a favorable safety profile.
Overall, our findings support the idea that iron treatment can help alleviate nausea and other discomforts related to iron deficiency anemia in pregnancy, positively impacting both mother and baby.
Read More
7
Daily vs. TIW iron supplementation
Daily versus three times weekly dosing for treatment of iron deficiency nonanemia in NCAA Division 1 female athletes.
We explored the effects of daily versus three times weekly (TIW) oral iron supplementation on nausea in NCAA Division 1 female athletes. The study involved 33 athletes who were either in track and field or soccer. Participants were given either daily doses or TIW doses of ferrous bisglycinate over eight weeks.
Both groups showed an increase in serum ferritin levels, which is a marker of iron stores. However, the TIW regimen resulted in a smaller increase of about 5.17 μg/L, compared to an increase of 12.88 μg/L with the daily regimen. Notably, those taking daily supplements experienced significantly more nausea and constipation than those on the TIW schedule.
While the daily regimen may boost iron levels more effectively, it can come at the cost of increased gastrointestinal discomfort. Meanwhile, the TIW regimen offers a gentler option with fewer side effects, positioning it as a viable alternative for athletes concerned about nausea.
Read More
Most Useful Reviews
9
Nausea-free experience
23 people found this helpful
They work well! UPDATE: My teen and I have been using this for low iron, and it works perfectly! It does not constipate us, and we feel better within 20-30 minutes. My iron levels have improved, and neither of us experiences nausea, despite having sensitive stomachs. I'll keep purchasing this!
Read More
10
Improved comfort
7 people found this helpful
Iron is essential! After a blood test revealed anaemia, I was prescribed iron but discontinued due to nausea and stomach pain. I switched to this supplement which includes vitamins C and B12 for better absorption. After about ten days, I feel more energised and less short of breath, and my complexion has improved. Initially, I experienced diarrhoea, but my stomach is now fine, and I feel I’m gradually getting better.
Read More
10
No nausea issues
3 people found this helpful
This iron supplement is gentle; I experienced no nausea or discomfort. After 1.5 months, my Ferritin levels increased from a deficit to just below the normal range. I’m very pleased.
We conducted a study to examine the effectiveness of a specific iron supplement, emulsified microsomal ferric pyrophosphate (EMFP), in treating iron deficiency anemia among pregnant women. Our focus was not only on improving hemoglobin levels but also on alleviating related symptoms, including nausea.
Within 30 days of starting treatment with EMFP, we observed significant increases in hemoglobin levels, alongside marked improvements in serum ferritin and iron levels. As nausea is a common complaint among pregnant women, we noted a decrease in various symptoms, including nausea, breathlessness, and dizziness, which contributed to a better quality of life for the participants.
Notably, treatment compliance was remarkably high at 99.5%, indicating that the participants were committed to managing their anemia effectively. Importantly, we did not encounter any severe side effects related to the treatment, suggesting a favorable safety profile.
Overall, our findings support the idea that iron treatment can help alleviate nausea and other discomforts related to iron deficiency anemia in pregnancy, positively impacting both mother and baby.
Read More
9
FCH reduces nausea in IDA treatment
A Multicenter Single-Arm Study of Switching to Ferric Citrate Hydrate for Iron Deficiency Anemia in Patients Intolerant to Oral Iron: RIO-SWITCH.
We evaluated how switching to ferric citrate hydrate (FCH) impacts nausea in women with iron deficiency anemia (IDA) who struggled with oral iron. In a multicenter study of 30 patients, those on FCH experienced significant improvements. Nausea scores dropped from 5.7 to 1.7, and the overall incidence of nausea decreased notably. Also, 80% reported better experiences compared to previous treatments.
Overall, our findings suggest that FCH not only enhances medication adherence but also effectively reduces nausea and improves quality of life in these patients.
Read More
8
Vitamin B12's role in nausea unclear
May headache be the first sign of mutation in the MTHFR gene?
We explored the role of vitamin B12 in treating nausea related to cerebral venous thrombosis (CVT). In a case study involving a 28-year-old man, we noted that after undergoing treatment with heparin, warfarin, and vitamin B12, his nausea improved along with his persistent headache symptoms.
Although we observed positive outcomes associated with this vitamin, it was part of a broader treatment approach rather than a standalone intervention. The study indicated that the combination of these treatments effectively alleviated nausea, but we cannot draw firm conclusions on vitamin B12's isolated impact due to the lack of control or blinding in the study design.
Overall, while vitamin B12 may have contributed to symptom relief, we must recognize that its specific role remains uncertain within the context of CVT treatment. Further studies would be needed to better define its effectiveness solely for nausea.
Read More
7
Daily vs. TIW iron supplementation
Daily versus three times weekly dosing for treatment of iron deficiency nonanemia in NCAA Division 1 female athletes.
We explored the effects of daily versus three times weekly (TIW) oral iron supplementation on nausea in NCAA Division 1 female athletes. The study involved 33 athletes who were either in track and field or soccer. Participants were given either daily doses or TIW doses of ferrous bisglycinate over eight weeks.
Both groups showed an increase in serum ferritin levels, which is a marker of iron stores. However, the TIW regimen resulted in a smaller increase of about 5.17 μg/L, compared to an increase of 12.88 μg/L with the daily regimen. Notably, those taking daily supplements experienced significantly more nausea and constipation than those on the TIW schedule.
While the daily regimen may boost iron levels more effectively, it can come at the cost of increased gastrointestinal discomfort. Meanwhile, the TIW regimen offers a gentler option with fewer side effects, positioning it as a viable alternative for athletes concerned about nausea.
Read More
7
Ferric carboxymaltose reduces nausea
Low-dose ferric carboxymaltose vs. oral iron for improving hemoglobin levels in postpartum East Asian women: A randomized controlled trial.
This randomized controlled trial explored how low-dose ferric carboxymaltose (FCM) affects hemoglobin levels and nausea in postpartum East Asian women. Participants received either an intravenous FCM infusion or oral iron for four weeks.
We found that while FCM significantly increased hemoglobin levels after two weeks, both treatments showed no significant difference in final hemoglobin results after four weeks.
Notably, the FCM group experienced fewer gastrointestinal side effects, including nausea, suggesting it may be a more comfortable option for new mothers.
They work well! UPDATE: My teen and I have been using this for low iron, and it works perfectly! It does not constipate us, and we feel better within 20-30 minutes. My iron levels have improved, and neither of us experiences nausea, despite having sensitive stomachs. I'll keep purchasing this!
Read More
10
Improved comfort
7 people found this helpful
Iron is essential! After a blood test revealed anaemia, I was prescribed iron but discontinued due to nausea and stomach pain. I switched to this supplement which includes vitamins C and B12 for better absorption. After about ten days, I feel more energised and less short of breath, and my complexion has improved. Initially, I experienced diarrhoea, but my stomach is now fine, and I feel I’m gradually getting better.
Read More
10
No nausea issues
3 people found this helpful
This iron supplement is gentle; I experienced no nausea or discomfort. After 1.5 months, my Ferritin levels increased from a deficit to just below the normal range. I’m very pleased.
Read More
10
No nausea
1 people found this helpful
A friend recommended this product, and it has worked wonders for my low iron. It’s very gentle on my stomach—no nausea or discomfort like with other iron supplements. Plus, it's made from whole foods, ensuring it’s both natural and high quality.
Read More
10
Easily digestible
This iron supplement is fantastic! It’s easily digestible and doesn’t cause constipation or nausea. I’m thrilled with it!
Nausea is a sensation that often precedes vomiting and is characterized by an uneasy feeling in the stomach. It can be caused by a variety of factors, including motion sickness, certain medications, food poisoning, or underlying health conditions. The experience of nausea can range from mildly uncomfortable to intensely distressing and is often accompanied by other symptoms such as sweating, increased salivation, or a feeling of lightheadedness.
Many people experience nausea at some point in their lives, making it a common issue. Fortunately, there are several remedies and treatments available that can help alleviate this unpleasant sensation. Over-the-counter medications, home remedies like ginger tea, and lifestyle changes, such as eating smaller meals or avoiding certain triggers, can be effective in reducing nausea. However, if nausea is persistent or accompanied by severe symptoms like severe abdominal pain or fever, it’s essential to consult with a healthcare professional for an accurate diagnosis and appropriate treatment.
Iron is a chemical element with the symbol Fe, derived from the Latin word "ferrum." It is a metal that is known for its strength and versatility, making it one of the most widely used materials in construction, manufacturing, and various industrial applications. Iron is the fourth most abundant element in the universe by mass and is primarily obtained through the mining of iron ores, such as hematite and magnetite. Once mined, it undergoes processes like smelting and refining to produce usable forms like cast iron, wrought iron, and steel.
In addition to its industrial uses, iron is also crucial for human health, as it plays a significant role in the production of hemoglobin, the protein in red blood cells responsible for transporting oxygen throughout the body. A deficiency in iron can lead to anemia, characterized by fatigue and weakened immunity. Overall, iron is a fundamental element that supports modern infrastructure and is vital for maintaining good health.
Based on user reviews, the timeline for experiencing results from this supplement can vary significantly. Some users report feeling improvements in energy and symptoms after about ten days of use. One user noted that after transitioning to this supplement, they felt more energised within a week and a half, associating this with the time it took for their condition to feel better and reduce nausea experiences Read Review. However, others have mentioned needing longer periods to assess the effects, with one review indicating that it took about 1.5 months to see a notable increase in Ferritin levels Read Review.
It's important to note that experiences can vary, as some users have had adverse reactions like nausea or fatigue, causing them to stop the supplementation altogether Read Review. For others, adjustments in timing and meal pairing have alleviated nausea Read Review. Therefore, while several users report positive results within a few weeks, individual experiences will differ, so it's advisable to monitor your response closely.
Scientific research supports the idea that certain iron supplements can alleviate nausea, particularly in specific populations. For instance, a study focusing on pregnant women with iron deficiency anemia found that treatment with emulsified microsomal ferric pyrophosphate (EMFP) led not only to significant increases in hemoglobin levels but also contributed to a notable decrease in nausea and other related symptoms within just 30 days of starting treatment [1]. Furthermore, a study examining ferric citrate hydrate (FCH) showed a similar trend, revealing that patients experienced a significant drop in nausea scores from 5.7 to 1.7, suggesting that switching to FCH could enhance medication adherence and improve the overall quality of life for women with iron deficiency anemia [4].
In the realm of athletic performance, a study comparing daily iron supplementation with a three-times-weekly regimen observed that while both approaches improved serum ferritin levels, those on the daily regimen faced more gastrointestinal complaints, including nausea. The three-times-a-week schedule resulted in fewer side effects, making it a preferable option for athletes concerned about nausea [2]. Overall, these findings indicate that while various iron supplements can help combat nausea, the effectiveness may vary depending on the individual's circumstances and the specific type of supplement used.
Users report a variety of improvements when taking this iron supplement, particularly in terms of energy levels and overall wellness. Several reviewers noted enhanced vitality after making the switch, with one user feeling more energised and experiencing less shortness of breath within ten days Read Review. Others have observed a significant increase in their Ferritin levels over a month and a half Read Review. Many highlighted the gentle formulation of the supplement, which allowed for a smoother gastrointestinal experience, free from common side effects like nausea or constipation Read ReviewRead Review.
However, it is crucial to emphasize that experiences can vary widely. While some users relished the lack of gastrointestinal discomfort, others encountered severe side effects, such as nausea and fatigue, prompting them to stop taking the supplement altogether Read Review. A few individuals had to adjust their intake timing to mitigate adverse reactions, indicating the importance of personalizing one's approach to supplementation Read Review. Thus, while many users report positive results, individual responses will vary, and it is advisable to monitor your body's reaction closely.
Based on user reviews, experiences with combining this iron supplement with other vitamins for handling nausea vary significantly. Many users report positive outcomes, noting that the addition of vitamins C and B12 has led to better absorption and a gentler experience overall. For instance, several users mentioned no nausea or discomfort while taking the supplement, highlighting how its natural formulation seems to minimize gastrointestinal issues Read Review. Furthermore, one user found that taking the supplement in the evening alleviated their morning nausea, suggesting a degree of personalization can enhance results Read Review.
Conversely, some users did encounter severe side effects despite the formulation's reputation for being gentle. One reviewer found that no dietary adjustments could reduce their nausea, necessitating a stop to the supplement Read ReviewRead Review. This highlights that while many individuals experience relief and improved wellness, individual tolerance levels can vary greatly. As such, it may be beneficial to start with smaller doses or combine it with other remedies to assess personal reactions effectively.
When it comes to treating nausea associated with iron deficiency, recent research has indicated that specific dosing regimens can significantly influence patient comfort and treatment outcomes. For instance, a study examining the effects of different iron supplementation schedules in female athletes found that a daily regimen of ferrous bisglycinate resulted in increased nausea compared to a thrice-weekly (TIW) approach. While both regimens effectively raised serum ferritin levels, the TIW group experienced fewer gastrointestinal issues, making it a kinder alternative for those prone to nausea [2].
Moreover, an exploration of ferric carboxymaltose revealed that this intravenous treatment yielded fewer gastrointestinal side effects, including nausea, for postpartum women compared to traditional oral iron supplements [3]. Switching to ferric citrate hydrate also led to a significant drop in nausea scores in women unable to tolerate oral iron, showcasing its potential for improving adherence and overall quality of life [4]. These findings suggest that, while the optimal dose for iron treatment may vary, lower frequency regimens and alternative formulations can enhance patient comfort and minimize nausea, making them worthy considerations in treatment plans.
10
Improved comfort
7 people found this helpful
Iron is essential! After a blood test revealed anaemia, I was prescribed iron but discontinued due to nausea and stomach pain. I switched to this supplement which includes vitamins C and B12 for better absorption. After about ten days, I feel more energised and less short of breath, and my complexion has improved. Initially, I experienced diarrhoea, but my stomach is now fine, and I feel I’m gradually getting better.
10
No nausea issues
3 people found this helpful
This iron supplement is gentle; I experienced no nausea or discomfort. After 1.5 months, my Ferritin levels increased from a deficit to just below the normal range. I’m very pleased.
0
Severe nausea
2 people found this helpful
Unfortunately, this supplement caused me severe nausea and fatigue. No matter how I adjusted my diet, it didn’t suit me, and I had to stop taking it.
6
Caused nausea
1 people found this helpful
After my tests showed low iron, I began using this brand which contains natural vitamins and reasonable doses. I’ve been taking it for three weeks, and my gastrointestinal issues are fine, with regularity improved thanks to the probiotics. However, I did experience nausea when taking it in the morning, but it subsided after eating. I found that taking it in the evening worked better for me. Overall, I liked these vitamins and intend to take them periodically.
10
Easily digestible
This iron supplement is fantastic! It’s easily digestible and doesn’t cause constipation or nausea. I’m thrilled with it!
10
Highly recommended
I can't do without iron; this brand is the best! There’s no nausea or constipation involved. I highly recommend it.
0
Severe sickness
1 people found this helpful
I really wanted to like this iron supplement due to its positive reviews, but it made me severely sick with body chills and fatigue. I had to discontinue using it. I wish it had worked for me.
9
Iron treatment eases nausea in pregnancy
Efficacy and Safety of Microsomal Ferric Pyrophosphate Supplement for Iron Deficiency Anemia in Pregnancy.
We conducted a study to examine the effectiveness of a specific iron supplement, emulsified microsomal ferric pyrophosphate (EMFP), in treating iron deficiency anemia among pregnant women. Our focus was not only on improving hemoglobin levels but also on alleviating related symptoms, including nausea.
Within 30 days of starting treatment with EMFP, we observed significant increases in hemoglobin levels, alongside marked improvements in serum ferritin and iron levels. As nausea is a common complaint among pregnant women, we noted a decrease in various symptoms, including nausea, breathlessness, and dizziness, which contributed to a better quality of life for the participants.
Notably, treatment compliance was remarkably high at 99.5%, indicating that the participants were committed to managing their anemia effectively. Importantly, we did not encounter any severe side effects related to the treatment, suggesting a favorable safety profile.
Overall, our findings support the idea that iron treatment can help alleviate nausea and other discomforts related to iron deficiency anemia in pregnancy, positively impacting both mother and baby.
9
FCH reduces nausea in IDA treatment
A Multicenter Single-Arm Study of Switching to Ferric Citrate Hydrate for Iron Deficiency Anemia in Patients Intolerant to Oral Iron: RIO-SWITCH.
We evaluated how switching to ferric citrate hydrate (FCH) impacts nausea in women with iron deficiency anemia (IDA) who struggled with oral iron. In a multicenter study of 30 patients, those on FCH experienced significant improvements. Nausea scores dropped from 5.7 to 1.7, and the overall incidence of nausea decreased notably. Also, 80% reported better experiences compared to previous treatments.
Overall, our findings suggest that FCH not only enhances medication adherence but also effectively reduces nausea and improves quality of life in these patients.
7
Daily vs. TIW iron supplementation
Daily versus three times weekly dosing for treatment of iron deficiency nonanemia in NCAA Division 1 female athletes.
We explored the effects of daily versus three times weekly (TIW) oral iron supplementation on nausea in NCAA Division 1 female athletes. The study involved 33 athletes who were either in track and field or soccer. Participants were given either daily doses or TIW doses of ferrous bisglycinate over eight weeks.
Both groups showed an increase in serum ferritin levels, which is a marker of iron stores. However, the TIW regimen resulted in a smaller increase of about 5.17 μg/L, compared to an increase of 12.88 μg/L with the daily regimen. Notably, those taking daily supplements experienced significantly more nausea and constipation than those on the TIW schedule.
While the daily regimen may boost iron levels more effectively, it can come at the cost of increased gastrointestinal discomfort. Meanwhile, the TIW regimen offers a gentler option with fewer side effects, positioning it as a viable alternative for athletes concerned about nausea.
7
Ferric carboxymaltose reduces nausea
Low-dose ferric carboxymaltose vs. oral iron for improving hemoglobin levels in postpartum East Asian women: A randomized controlled trial.
This randomized controlled trial explored how low-dose ferric carboxymaltose (FCM) affects hemoglobin levels and nausea in postpartum East Asian women. Participants received either an intravenous FCM infusion or oral iron for four weeks.
We found that while FCM significantly increased hemoglobin levels after two weeks, both treatments showed no significant difference in final hemoglobin results after four weeks.
Notably, the FCM group experienced fewer gastrointestinal side effects, including nausea, suggesting it may be a more comfortable option for new mothers.
References
Srivastav A, Kshirsagar S, Adhav T, Ganu G, Shah A. Efficacy and Safety of Microsomal Ferric Pyrophosphate Supplement for Iron Deficiency Anemia in Pregnancy. Cureus. 2024;16:e57108. 10.7759/cureus.57108
Schulte J, Peterson K, Thomsen T, Lentz S, Hall M, et al. Daily versus three times weekly dosing for treatment of iron deficiency nonanemia in NCAA Division 1 female athletes. PM R. 2024;16:316. 10.1002/pmrj.13172
Nagao T, Takahashi K, Takahashi S, Yokomizo R, Samura O, et al. Low-dose ferric carboxymaltose vs. oral iron for improving hemoglobin levels in postpartum East Asian women: A randomized controlled trial. PLoS One. 2025;20:e0319795. 10.1371/journal.pone.0319795
Wada-Hiraike O, Maruyama A, Mitobe Y, Iriyama T, Mori-Uchino M, et al. A Multicenter Single-Arm Study of Switching to Ferric Citrate Hydrate for Iron Deficiency Anemia in Patients Intolerant to Oral Iron: RIO-SWITCH. Adv Ther. 2025. 10.1007/s12325-025-03123-9
Adu-Afarwuah S, Arnold CD, Lartey A, Okronipa H, Maleta K, et al. Prevalence of morbidity symptoms among pregnant and postpartum women receiving different nutrient supplements in Ghana and Malawi: A secondary outcome analysis of two randomised controlled trials. Matern Child Nutr. 2023;19:e13501. 10.1111/mcn.13501
Dikici S, Saritas A, Besir FH, Celbek G, Arslan G. May headache be the first sign of mutation in the MTHFR gene?. World J Emerg Med. 2013;4:69.