5/15/2025
Last update
5/15/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.3
USERS' SCORE
Moderately Good
Based on 21 Reviews
7.7
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Organic Turmeric BlendOrganic Turmeric Root Extract standardized to 95% curcuminoids, Organic Fermented Turmeric Root (blend yielding 500 mg curcuminoids)
630 mg
+
Organic Fermented Ginger Root
50 mg
+
Organic Black Pepper Fruit Extract
7 mg
+
Probiotic BlendBifidobacterium lactis Bl-04Lactobacillus acidophilus La-14
4 mg
+
Top Medical Research Studies
9
We investigated how curcumin, the active compound in turmeric, impacts osteoarthritis (OA) by focusing on its role in reducing the formation of bone-destroying cells called osteoclasts. In our research, we used a mouse model designed to mimic OA by destabilizing the medial meniscus, allowing us to measure the effects of curcumin on joint health.
Our study included three groups of male mice: those who received a vehicle treatment after their surgery, those with OA but also receiving the vehicle, and those with OA that were treated with curcumin. Over the course of eight weeks, we monitored the mice's cartilage and bone structure, looking for any changes.
We found that curcumin significantly suppressed osteoclast formation and bone resorption without harming the cells, suggesting it may be a promising treatment to alleviate arthritis symptoms. Specifically, curcumin inhibited the activation of important signaling pathways that promote osteoclast formation and cartilage degradation. This suggests a new and exciting approach for treating osteoarthritis, offering hope for better management of this chronic condition.
Our study included three groups of male mice: those who received a vehicle treatment after their surgery, those with OA but also receiving the vehicle, and those with OA that were treated with curcumin. Over the course of eight weeks, we monitored the mice's cartilage and bone structure, looking for any changes.
We found that curcumin significantly suppressed osteoclast formation and bone resorption without harming the cells, suggesting it may be a promising treatment to alleviate arthritis symptoms. Specifically, curcumin inhibited the activation of important signaling pathways that promote osteoclast formation and cartilage degradation. This suggests a new and exciting approach for treating osteoarthritis, offering hope for better management of this chronic condition.
Read More
7
We conducted a study to see how curcumin, the key ingredient in turmeric, affects arthritis, particularly focusing on patients with knee osteoarthritis (OA). In this well-structured clinical trial, we recruited 30 female patients and randomly assigned them to receive either curcumin or a placebo over three months, ensuring a double-blind approach to keep the results unbiased.
Our findings were quite telling. We observed that the expression of the FOXO1 gene related to T helper 17 (Th17) cells significantly increased in the group that received curcumin. This is notable because FOXO1 plays a role in regulating inflammation. While we didn’t see a significant change in another important gene, FOXP3, the expression of HSA-MIR-873, a type of microRNA, did see a meaningful boost in the curcumin group.
Overall, our research suggests that curcumin has potential immunomodulatory effects that might help manage inflammation associated with arthritis, linking it closely to the FOXO1 and microRNA-873 genes. This addition to arthritis treatment could open new avenues for relief, especially for those suffering from this condition.
Our findings were quite telling. We observed that the expression of the FOXO1 gene related to T helper 17 (Th17) cells significantly increased in the group that received curcumin. This is notable because FOXO1 plays a role in regulating inflammation. While we didn’t see a significant change in another important gene, FOXP3, the expression of HSA-MIR-873, a type of microRNA, did see a meaningful boost in the curcumin group.
Overall, our research suggests that curcumin has potential immunomodulatory effects that might help manage inflammation associated with arthritis, linking it closely to the FOXO1 and microRNA-873 genes. This addition to arthritis treatment could open new avenues for relief, especially for those suffering from this condition.
Read More
7
Curcumin influences arthritis immune response
We explored how curcumin, a compound found in turmeric, can help manage arthritis by influencing immune responses. The study focused on understanding the effects of both free curcumin and its phytosomal form in a collagen-induced arthritis model. This involved isolating splenocytes, a type of immune cell, after inducing arthritis and then re-stimulating them with collagen in the presence of different doses of curcumin. We measured the expression of key transcription factors T-bet and Foxp3, which are important for regulating T helper cells and regulatory T cells.
Our findings revealed that curcumin did have a modulatory effect on the expression of T-bet, a crucial factor for Th1 cells. However, we observed that only the free-form curcumin increased the expression of Foxp3, which is indicative of regulatory T cells. This could be attributed to the lower bioavailability of the phytosomal form, meaning that the curcumin in this complex wasn't as effective at the same dosage. Thus, while curcumin shows promise in impacting immune responses in arthritis, its effectiveness may vary depending on its delivery form.
Our findings revealed that curcumin did have a modulatory effect on the expression of T-bet, a crucial factor for Th1 cells. However, we observed that only the free-form curcumin increased the expression of Foxp3, which is indicative of regulatory T cells. This could be attributed to the lower bioavailability of the phytosomal form, meaning that the curcumin in this complex wasn't as effective at the same dosage. Thus, while curcumin shows promise in impacting immune responses in arthritis, its effectiveness may vary depending on its delivery form.
Read More
Most Useful Reviews
7.5
Joint improvement
47 people found this helpful
After beginning these capsules eight months ago, my joints, affected by fibromyalgia and osteoarthritis, have felt much improved.
Read More
9
Effective alternative
9 people found this helpful
IT WORKS. If you suffer from arthritis or general inflammation, you need this product! I used to take 800 mg of ibuprofen three times a day for joint inflammation. After just 10 days on this turmeric supplement, I no longer require ibuprofen, avoiding potential damage to my organs. Garden of Life’s MY KIND offers great quality for the price, secured in a robust dark bottle to protect the supplements from light. I’ve recommended it to numerous people, and everyone has loved it.
Read More
7
Reduced pain
6 people found this helpful
Having used various turmeric supplements, I was cautiously optimistic about this one, which contains black pepper for better absorption. I experienced no digestive issues, and after a few days of use, my joint pain from arthritis markedly decreased, although not entirely gone. I will continue using it as it appears beneficial during challenging times when my arthritis flares up.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.3
- All Researches
9
We delved into the effects of curcumin, particularly through a method called photodynamic therapy (CUR-PDT), in the context of rheumatoid arthritis. The research focused on how this treatment might trigger a specific type of cell death known as ferroptosis in fibroblast-like synoviocytes (FLSs), which are key players in arthritis inflammation.
Our study incorporated both in vivo and in vitro methods. In the animal model, we observed that CUR-PDT helped reduce joint swelling and associated inflammation. We also looked closely at how this treatment affected specific markers within FLSs, particularly focusing on the Nrf2/xCT/GPX4 signaling pathway. This pathway is crucial because it helps regulate responses to oxidative stress—something that can be detrimental in arthritis.
Through various tests, including measuring cell viability and cell responses to oxidative stress, we found that CUR-PDT effectively induced ferroptosis in the FLSs. This led to decreased cell proliferation and therefore suggests a potential avenue for treating rheumatoid arthritis more effectively. Although our findings show promising results regarding curcumin's role, it is important to emphasize that these effects stemmed more from the method of photodynamic therapy than solely from curcumin itself.
Overall, this research shines a light on the importance of understanding how curcumin, when utilized in specific therapeutic approaches, may contribute to better managing rheumatoid arthritis. However, the exact applications and benefits still require further exploration.
Our study incorporated both in vivo and in vitro methods. In the animal model, we observed that CUR-PDT helped reduce joint swelling and associated inflammation. We also looked closely at how this treatment affected specific markers within FLSs, particularly focusing on the Nrf2/xCT/GPX4 signaling pathway. This pathway is crucial because it helps regulate responses to oxidative stress—something that can be detrimental in arthritis.
Through various tests, including measuring cell viability and cell responses to oxidative stress, we found that CUR-PDT effectively induced ferroptosis in the FLSs. This led to decreased cell proliferation and therefore suggests a potential avenue for treating rheumatoid arthritis more effectively. Although our findings show promising results regarding curcumin's role, it is important to emphasize that these effects stemmed more from the method of photodynamic therapy than solely from curcumin itself.
Overall, this research shines a light on the importance of understanding how curcumin, when utilized in specific therapeutic approaches, may contribute to better managing rheumatoid arthritis. However, the exact applications and benefits still require further exploration.
Read More
9
We delved into the effects of turmeric, specifically curcumin, on rheumatoid arthritis (RA) through a systematic network meta-analysis. By gathering data from several major databases, we aimed to determine how this plant-derived substance might alleviate symptoms associated with RA.
Our analysis revealed that curcumin stands out for its ability to reduce swollen and tender joint counts significantly compared to placebo treatments. Additionally, it helped decrease inflammatory markers, which are crucial in managing RA effectively.
We also found that other substances like quercetin and resveratrol showed notable benefits, with quercetin being effective in lowering pain levels and resveratrol improving overall disease activity scores.
While these findings are promising and suggest that patients could benefit from turmeric as part of their treatment plan, we highlight that further research is necessary to confirm these results and ensure safety in long-term use.
Our analysis revealed that curcumin stands out for its ability to reduce swollen and tender joint counts significantly compared to placebo treatments. Additionally, it helped decrease inflammatory markers, which are crucial in managing RA effectively.
We also found that other substances like quercetin and resveratrol showed notable benefits, with quercetin being effective in lowering pain levels and resveratrol improving overall disease activity scores.
While these findings are promising and suggest that patients could benefit from turmeric as part of their treatment plan, we highlight that further research is necessary to confirm these results and ensure safety in long-term use.
Read More
9
We investigated the effects of curcumin, a natural compound found in turmeric, along with vitamin D, on knee osteoarthritis (OA) using a rat model. The study divided male Wistar rats into five groups: a control group, a group receiving curcumin, another getting vitamin D, one that received a combination of both, and a sham-operated group. Each supplement was given daily for 12 weeks to assess their impacts on pain and inflammation associated with OA.
Our findings reveal that curcumin and vitamin D worked well to reduce pain levels individually. Interestingly, when combined, they provided even better relief from pain. We also observed notable changes in inflammation markers; while pro-inflammatory cytokines were reduced, the anti-inflammatory cytokine interleukin-10 (IL-10) increased in the groups receiving the supplements. Additionally, curcumin and vitamin D demonstrated a beneficial effect on oxidative stress markers, leading to improved joint structure and cartilage health.
Histological analysis showed that the treated groups maintained better joint architecture, less inflammation of the synovium, and preserved cartilage integrity compared to the control group. Therefore, we recognize the potential of curcumin and vitamin D as natural agents that could play a role in managing knee osteoarthritis and associated pain. This research suggests they may offer valuable strategies for delaying OA progression and enhancing patient care in clinical settings.
Our findings reveal that curcumin and vitamin D worked well to reduce pain levels individually. Interestingly, when combined, they provided even better relief from pain. We also observed notable changes in inflammation markers; while pro-inflammatory cytokines were reduced, the anti-inflammatory cytokine interleukin-10 (IL-10) increased in the groups receiving the supplements. Additionally, curcumin and vitamin D demonstrated a beneficial effect on oxidative stress markers, leading to improved joint structure and cartilage health.
Histological analysis showed that the treated groups maintained better joint architecture, less inflammation of the synovium, and preserved cartilage integrity compared to the control group. Therefore, we recognize the potential of curcumin and vitamin D as natural agents that could play a role in managing knee osteoarthritis and associated pain. This research suggests they may offer valuable strategies for delaying OA progression and enhancing patient care in clinical settings.
Read More
9
We explored how curcumin, a key compound in turmeric, might help alleviate symptoms of knee osteoarthritis. In our study, we focused on the inflammatory response in cartilage cells, known as chondrocytes, which can be triggered by interleukin IL-1β. To better understand curcumin’s role, we created chondrocytes that overexpress a protein called TRPM2, allowing us to investigate the underlying mechanisms more closely.
We conducted a series of experiments to assess how curcumin affects cell viability, reactive oxygen species (ROS) levels, and the release of inflammatory factors like TNF-α and IL-6. Our findings showed that curcumin effectively improved the inflammatory response in chondrocytes, protecting them against damage induced by IL-1β. Moreover, in tests conducted on a rat model of knee osteoarthritis, we observed that curcumin helped maintain cartilage integrity and reduced inflammation, confirming its potential as a therapeutic option.
Overall, our study highlights the ability of curcumin to target the TRPM2/NLRP3 signaling pathway, leading to reduced cell death and inflammation in osteoarthritis. This suggests that incorporating curcumin could offer a natural approach to managing arthritis symptoms.
We conducted a series of experiments to assess how curcumin affects cell viability, reactive oxygen species (ROS) levels, and the release of inflammatory factors like TNF-α and IL-6. Our findings showed that curcumin effectively improved the inflammatory response in chondrocytes, protecting them against damage induced by IL-1β. Moreover, in tests conducted on a rat model of knee osteoarthritis, we observed that curcumin helped maintain cartilage integrity and reduced inflammation, confirming its potential as a therapeutic option.
Overall, our study highlights the ability of curcumin to target the TRPM2/NLRP3 signaling pathway, leading to reduced cell death and inflammation in osteoarthritis. This suggests that incorporating curcumin could offer a natural approach to managing arthritis symptoms.
Read More
9
We explored the potential of using curcumin, a compound commonly found in turmeric, alongside methylprednisolone to improve treatments for rheumatoid arthritis. By employing a model that induced arthritis in rats, we aimed to see how this combination could minimize the amount of steroids needed, potentially reducing side effects while maintaining effectiveness.
In our research, we used polyvinyl alcohol-coated copper oxide nanoparticles as a method of delivering these drugs in a controlled manner. The nanoparticles, created through ultrasound synthesis, showed a promising size and demonstrated good biocompatibility. This means they are safe for cell life, which is crucial in medical applications.
What stood out in our findings were the benefits of the nanoparticle delivery system. Both curcumin and methylprednisolone were released into the body more gradually, which can be advantageous. Moreover, the combined treatment significantly reduced swelling and clinical symptoms in the rats, along with lower levels of certain pro-inflammatory cytokines associated with pain and inflammation.
Overall, our findings suggest that curcumin, especially when paired with methylprednisolone and delivered through these nanoparticles, could provide a more effective therapy for those suffering from arthritis, bridging natural and pharmaceutical solutions for better health.
In our research, we used polyvinyl alcohol-coated copper oxide nanoparticles as a method of delivering these drugs in a controlled manner. The nanoparticles, created through ultrasound synthesis, showed a promising size and demonstrated good biocompatibility. This means they are safe for cell life, which is crucial in medical applications.
What stood out in our findings were the benefits of the nanoparticle delivery system. Both curcumin and methylprednisolone were released into the body more gradually, which can be advantageous. Moreover, the combined treatment significantly reduced swelling and clinical symptoms in the rats, along with lower levels of certain pro-inflammatory cytokines associated with pain and inflammation.
Overall, our findings suggest that curcumin, especially when paired with methylprednisolone and delivered through these nanoparticles, could provide a more effective therapy for those suffering from arthritis, bridging natural and pharmaceutical solutions for better health.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 21 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Joint improvement
47 people found this helpful
After beginning these capsules eight months ago, my joints, affected by fibromyalgia and osteoarthritis, have felt much improved.
Read More
9
Effective alternative
9 people found this helpful
IT WORKS. If you suffer from arthritis or general inflammation, you need this product! I used to take 800 mg of ibuprofen three times a day for joint inflammation. After just 10 days on this turmeric supplement, I no longer require ibuprofen, avoiding potential damage to my organs. Garden of Life’s MY KIND offers great quality for the price, secured in a robust dark bottle to protect the supplements from light. I’ve recommended it to numerous people, and everyone has loved it.
Read More
7
Reduced pain
6 people found this helpful
Having used various turmeric supplements, I was cautiously optimistic about this one, which contains black pepper for better absorption. I experienced no digestive issues, and after a few days of use, my joint pain from arthritis markedly decreased, although not entirely gone. I will continue using it as it appears beneficial during challenging times when my arthritis flares up.
Read More
7.5
Reduces inflammation
3 people found this helpful
Perfectly, I have been taking this for over two years before bed. It genuinely helps with my arthritis pain and other joint discomfort, allowing me to sleep soundly. This formula is also antioxidant-rich and contains fantastic ingredients. I recommend it for reducing inflammation in your body and improving your well-being. The package is designed for a month’s supply.
Read More
9
Almost eliminated pain
2 people found this helpful
Excellent! I have been taking it for six months, and my osteoarthritis knee pain has nearly disappeared. I keep purchasing it and no longer require anti-inflammatories. I wholeheartedly recommend it!
Read More
Frequently Asked Questions
9
Almost eliminated pain
2 people found this helpful
Excellent! I have been taking it for six months, and my osteoarthritis knee pain has nearly disappeared. I keep purchasing it and no longer require anti-inflammatories. I wholeheartedly recommend it!
9
Pain almost gone
Awesome product! This is one of the best I've ever tried. I have osteoarthritis in my knees, and my pain is almost non-existent after taking it for around one to two years. I take two tablets daily, and it works brilliantly; inflammation and joint pain have vanished. I only feel a bit sore when the room temperature is very cold. Excellent quality!
10
Game changer for pain
As someone with osteoarthritis, I found the GOL Turmeric for joints and mobility to be a game changer. This product has dramatically reduced my pain, making daily use essential.
7.5
Reduces inflammation
3 people found this helpful
Perfectly, I have been taking this for over two years before bed. It genuinely helps with my arthritis pain and other joint discomfort, allowing me to sleep soundly. This formula is also antioxidant-rich and contains fantastic ingredients. I recommend it for reducing inflammation in your body and improving your well-being. The package is designed for a month’s supply.
7.5
Inflammation relief
Best turmeric available! My husband suffers from osteoarthritis, and this product has significantly helped control the inflammation. It’s expensive, but it works.
9
We delved into the effects of turmeric, specifically curcumin, on rheumatoid arthritis (RA) through a systematic network meta-analysis. By gathering data from several major databases, we aimed to determine how this plant-derived substance might alleviate symptoms associated with RA.
Our analysis revealed that curcumin stands out for its ability to reduce swollen and tender joint counts significantly compared to placebo treatments. Additionally, it helped decrease inflammatory markers, which are crucial in managing RA effectively.
We also found that other substances like quercetin and resveratrol showed notable benefits, with quercetin being effective in lowering pain levels and resveratrol improving overall disease activity scores.
While these findings are promising and suggest that patients could benefit from turmeric as part of their treatment plan, we highlight that further research is necessary to confirm these results and ensure safety in long-term use.
Our analysis revealed that curcumin stands out for its ability to reduce swollen and tender joint counts significantly compared to placebo treatments. Additionally, it helped decrease inflammatory markers, which are crucial in managing RA effectively.
We also found that other substances like quercetin and resveratrol showed notable benefits, with quercetin being effective in lowering pain levels and resveratrol improving overall disease activity scores.
While these findings are promising and suggest that patients could benefit from turmeric as part of their treatment plan, we highlight that further research is necessary to confirm these results and ensure safety in long-term use.
9
We investigated the effects of curcumin, a natural compound found in turmeric, along with vitamin D, on knee osteoarthritis (OA) using a rat model. The study divided male Wistar rats into five groups: a control group, a group receiving curcumin, another getting vitamin D, one that received a combination of both, and a sham-operated group. Each supplement was given daily for 12 weeks to assess their impacts on pain and inflammation associated with OA.
Our findings reveal that curcumin and vitamin D worked well to reduce pain levels individually. Interestingly, when combined, they provided even better relief from pain. We also observed notable changes in inflammation markers; while pro-inflammatory cytokines were reduced, the anti-inflammatory cytokine interleukin-10 (IL-10) increased in the groups receiving the supplements. Additionally, curcumin and vitamin D demonstrated a beneficial effect on oxidative stress markers, leading to improved joint structure and cartilage health.
Histological analysis showed that the treated groups maintained better joint architecture, less inflammation of the synovium, and preserved cartilage integrity compared to the control group. Therefore, we recognize the potential of curcumin and vitamin D as natural agents that could play a role in managing knee osteoarthritis and associated pain. This research suggests they may offer valuable strategies for delaying OA progression and enhancing patient care in clinical settings.
Our findings reveal that curcumin and vitamin D worked well to reduce pain levels individually. Interestingly, when combined, they provided even better relief from pain. We also observed notable changes in inflammation markers; while pro-inflammatory cytokines were reduced, the anti-inflammatory cytokine interleukin-10 (IL-10) increased in the groups receiving the supplements. Additionally, curcumin and vitamin D demonstrated a beneficial effect on oxidative stress markers, leading to improved joint structure and cartilage health.
Histological analysis showed that the treated groups maintained better joint architecture, less inflammation of the synovium, and preserved cartilage integrity compared to the control group. Therefore, we recognize the potential of curcumin and vitamin D as natural agents that could play a role in managing knee osteoarthritis and associated pain. This research suggests they may offer valuable strategies for delaying OA progression and enhancing patient care in clinical settings.
9
We explored how curcumin, a key compound in turmeric, might help alleviate symptoms of knee osteoarthritis. In our study, we focused on the inflammatory response in cartilage cells, known as chondrocytes, which can be triggered by interleukin IL-1β. To better understand curcumin’s role, we created chondrocytes that overexpress a protein called TRPM2, allowing us to investigate the underlying mechanisms more closely.
We conducted a series of experiments to assess how curcumin affects cell viability, reactive oxygen species (ROS) levels, and the release of inflammatory factors like TNF-α and IL-6. Our findings showed that curcumin effectively improved the inflammatory response in chondrocytes, protecting them against damage induced by IL-1β. Moreover, in tests conducted on a rat model of knee osteoarthritis, we observed that curcumin helped maintain cartilage integrity and reduced inflammation, confirming its potential as a therapeutic option.
Overall, our study highlights the ability of curcumin to target the TRPM2/NLRP3 signaling pathway, leading to reduced cell death and inflammation in osteoarthritis. This suggests that incorporating curcumin could offer a natural approach to managing arthritis symptoms.
We conducted a series of experiments to assess how curcumin affects cell viability, reactive oxygen species (ROS) levels, and the release of inflammatory factors like TNF-α and IL-6. Our findings showed that curcumin effectively improved the inflammatory response in chondrocytes, protecting them against damage induced by IL-1β. Moreover, in tests conducted on a rat model of knee osteoarthritis, we observed that curcumin helped maintain cartilage integrity and reduced inflammation, confirming its potential as a therapeutic option.
Overall, our study highlights the ability of curcumin to target the TRPM2/NLRP3 signaling pathway, leading to reduced cell death and inflammation in osteoarthritis. This suggests that incorporating curcumin could offer a natural approach to managing arthritis symptoms.
9
We explored the potential of using curcumin, a compound commonly found in turmeric, alongside methylprednisolone to improve treatments for rheumatoid arthritis. By employing a model that induced arthritis in rats, we aimed to see how this combination could minimize the amount of steroids needed, potentially reducing side effects while maintaining effectiveness.
In our research, we used polyvinyl alcohol-coated copper oxide nanoparticles as a method of delivering these drugs in a controlled manner. The nanoparticles, created through ultrasound synthesis, showed a promising size and demonstrated good biocompatibility. This means they are safe for cell life, which is crucial in medical applications.
What stood out in our findings were the benefits of the nanoparticle delivery system. Both curcumin and methylprednisolone were released into the body more gradually, which can be advantageous. Moreover, the combined treatment significantly reduced swelling and clinical symptoms in the rats, along with lower levels of certain pro-inflammatory cytokines associated with pain and inflammation.
Overall, our findings suggest that curcumin, especially when paired with methylprednisolone and delivered through these nanoparticles, could provide a more effective therapy for those suffering from arthritis, bridging natural and pharmaceutical solutions for better health.
In our research, we used polyvinyl alcohol-coated copper oxide nanoparticles as a method of delivering these drugs in a controlled manner. The nanoparticles, created through ultrasound synthesis, showed a promising size and demonstrated good biocompatibility. This means they are safe for cell life, which is crucial in medical applications.
What stood out in our findings were the benefits of the nanoparticle delivery system. Both curcumin and methylprednisolone were released into the body more gradually, which can be advantageous. Moreover, the combined treatment significantly reduced swelling and clinical symptoms in the rats, along with lower levels of certain pro-inflammatory cytokines associated with pain and inflammation.
Overall, our findings suggest that curcumin, especially when paired with methylprednisolone and delivered through these nanoparticles, could provide a more effective therapy for those suffering from arthritis, bridging natural and pharmaceutical solutions for better health.
9
We investigated how curcumin, particularly when combined with zinc oxide nanoparticles, can help in managing rheumatoid arthritis (RA). To explore this, we induced RA in experimental rabbits using a specific method and then treated them with either curcumin, zinc oxide nanoparticles, or a combination of both. This allowed us to closely observe the potential benefits each treatment might have on the animals' recovery and overall health.
Throughout the study, we monitored the levels of various biological markers associated with RA as well as measures of antioxidant status in their serum. Our findings revealed that the combination treatment with zinc oxide nanoparticles-doped curcumin showed the most promise. The treated rabbits exhibited reduced levels of certain inflammatory markers and an improvement in their antioxidant capacity.
Overall, our observations suggest that curcumin could play a significant role in managing the symptoms of arthritis when used in this innovative form. It's worth noting that while other treatments did improve conditions to some extent, curcumin combined with zinc oxide nanoparticles yielded the most notable results. This study highlights the potential of curcumin-based treatments in supporting joint health and fighting inflammation.
Throughout the study, we monitored the levels of various biological markers associated with RA as well as measures of antioxidant status in their serum. Our findings revealed that the combination treatment with zinc oxide nanoparticles-doped curcumin showed the most promise. The treated rabbits exhibited reduced levels of certain inflammatory markers and an improvement in their antioxidant capacity.
Overall, our observations suggest that curcumin could play a significant role in managing the symptoms of arthritis when used in this innovative form. It's worth noting that while other treatments did improve conditions to some extent, curcumin combined with zinc oxide nanoparticles yielded the most notable results. This study highlights the potential of curcumin-based treatments in supporting joint health and fighting inflammation.
References
- Sun L, Niu Y, Liao B, Liu L, Peng Y, et al. CUR-PDT induces ferroptosis of RA-FLS via the Nrf2/xCT/GPX4 pathway to inhibit proliferation in rheumatoid arthritis. Inflamm Res. 2025;74:53. 10.1007/s00011-025-02019-2
- Peng Q, Wang J, Li K, Xia C, Yao C, et al. Effects of plant active substances in rheumatoid arthritis-a systematic review and network meta-analysis. Front Pharmacol. 2025;16:1536023. 10.3389/fphar.2025.1536023
- Mende LK, Kuthati Y, Wong CS. Curcumin and Vitamin D Supplement Attenuates Knee Osteoarthritis Progression in ACLT + MMx Rat Model: Effect on Cartilage Protection and Pain Reduction. Nutrients. 2025;17. 10.3390/nu17020349
- Khamar F, Atabaki M, Samadi M, Reisi M, Sandoughi M. Immunomodulatory effects of novel nano micelle based curcumin in rheumatoid arthritis patients: A double blind randomized clinical trial. Rheumatol Immunol Res. 2024;5:227. 10.1515/rir-2024-0031
- Hidayat R, Parlindungan F, Nisa JI, Mahendra AI, Indika MI, et al. Efficacy of in relieving pain symptoms of knee osteoarthritis patients: a systematic review and meta-analysis of clinical trials. J Rheum Dis. 2025;32:17. 10.4078/jrd.2024.0062
- Zhu K, Bi J, Zhang Q, Yang Y, Li J, et al. Mechanism of action of curcumin targeting TRPM2/NLRP3 signaling axis to mediate cell death in the treatment of knee osteoarthritis. Hum Exp Toxicol. 2024;43:9603271241308798. 10.1177/09603271241308798
- Zarei K, Jahanbakhshi M, Nahavandi R, Emadi R. Optimized co-delivery of curcumin and methylprednisolone using polyvinyl alcohol-coated CuO nanoparticles for synergistic rheumatoid arthritis treatment. Heliyon. 2024;10:e40429. 10.1016/j.heliyon.2024.e40429
- Noori E, Atabaki M, Dehnavi S, Tavakol Afshari J, Mohammadi M. The Immunomodulatory Effects of Curcumin on Forkhead Box O1 and MicroRNA-873 in Patients with Osteoarthritis. Iran J Allergy Asthma Immunol. 2024;23:526. 10.18502/ijaai.v23i5.16748
- Nosratabadi R, Ranjkesh M, Safari M, Ramezani M, Zainodini N, et al. Effects of Curcumin in Free and Phytosomal Forms on the Expression of T Helper1 and Regulatory T Cells' Transcription Factors in Collagen-Induced Arthritis. Adv Biomed Res. 2024;13:69. 10.4103/abr.abr_291_23
- El-Haddad ME, El-Refaie WM, Hammad GO, El-Massik MA. Targeted non-invasive Metformin-Curcumin co-loaded nanohyaluosomes halt osteoarthritis progression and improve articular cartilage structure: A preclinical study. Int J Pharm. 2024;666:124845. 10.1016/j.ijpharm.2024.124845
- Liu C, Du W, Zhang L, Wang J. Natural synergy: Oleanolic acid-curcumin co-assembled nanoparticles combat osteoarthritis. Colloids Surf B Biointerfaces. 2025;245:114286. 10.1016/j.colsurfb.2024.114286
- Ding D, Liu G, Yan J, Zhang Q, Meng F, et al. Curcumin alleviates osteoarthritis in mice by suppressing osteoclastogenesis in subchondral bone via inhibiting NF-κB/JNK signaling pathway. PLoS One. 2024;19:e0309807. 10.1371/journal.pone.0309807
- Zhang C, Weng Y, Wang H, Zhan S, Li C, et al. A synergistic effect of triptolide and curcumin on rheumatoid arthritis by improving cell proliferation and inducing cell apoptosis via inhibition of the IL-17/NF-κB signaling pathway. Int Immunopharmacol. 2024;142:112953. 10.1016/j.intimp.2024.112953
- Sarkar A, Saquib M, Chakraborty D, Mann S, Malik S, et al. Clo-miR-14: a medicinally valued spice-derived miRNA with therapeutic implications in rheumatoid arthritis. Biosci Rep. 2024;44. 10.1042/BSR20240311
- Chen W, Xiao J, Zhou Y, Liu W, Jian J, et al. Curcumenol regulates Histone H3K27me3 demethylases KDM6B affecting Succinic acid metabolism to alleviate cartilage degeneration in knee osteoarthritis. Phytomedicine. 2024;133:155922. 10.1016/j.phymed.2024.155922
- Azeez S, Fatima M, Gul O, Rehman H, Shad MA, et al. Zinc oxide nanoparticles-doped curcumin-assisted recovery of rheumatoid arthritis and antioxidant status in experimental rabbits. Biomedicine (Taipei). 2024;14:49. 10.37796/2211-8039.1446
