Last update
8/31/2025
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.6
USERS' SCORE
Moderately Good
Based on 1 Review
7.9
Supplement Facts
Serving Size: 1 softgel
Amount Per Serving
%DV
Calories
9
Calories from Fat
7
Total Fat
1 g
1%¹
Saturated Fat
0 g
0%¹
Unsaturated Fat
0.5 g
Trans Fat
0 g
Total Omega-3 Fatty Acids
640 mg
+
DHA (Docosahexanoic Acid)
480 mg
EPA (Eicosapentaenoic Acid)
104 mg
Other Omega-3s
56 mg
Top Medical Research Studies
9.5
We conducted a 12-week study to explore how eicosapentaenoic acid (EPA) affects individuals suffering from episodic migraines. In our trial, 70 participants were randomly split into two groups—one received 2 grams of fish oil with 1.8 grams of pure EPA daily, while the other group got a placebo made of soybean oil.
The results were quite promising. Those taking EPA reported a significant reduction in the number of migraine days per month, averaging about 4.4 fewer days compared to just 0.6 fewer days in the placebo group. We also noticed a decline in the usage of medication to treat headache symptoms among those taking EPA.
Additionally, participants experienced less severe headaches and improved psychological wellbeing, as indicated by better scores in anxiety, depression, and overall quality of life measures. Notably, women seemed to benefit even more from EPA.
Overall, it appears that high-dose EPA can be an effective preventive treatment for episodic migraines, helping to ease frequency, severity, and even the emotional toll associated with chronic headaches. Importantly, the treatment was well tolerated, with no significant adverse effects reported.
The results were quite promising. Those taking EPA reported a significant reduction in the number of migraine days per month, averaging about 4.4 fewer days compared to just 0.6 fewer days in the placebo group. We also noticed a decline in the usage of medication to treat headache symptoms among those taking EPA.
Additionally, participants experienced less severe headaches and improved psychological wellbeing, as indicated by better scores in anxiety, depression, and overall quality of life measures. Notably, women seemed to benefit even more from EPA.
Overall, it appears that high-dose EPA can be an effective preventive treatment for episodic migraines, helping to ease frequency, severity, and even the emotional toll associated with chronic headaches. Importantly, the treatment was well tolerated, with no significant adverse effects reported.
Read More
8
A recent study examined the impact of eicosapentaenoic acid (EPA) on chronic migraine sufferers. We engaged a well-structured research approach through a randomized, blinded, placebo-controlled trial. This allowed us to compare a group receiving 2000 mg of EPA daily to a control group taking placebo softgels for eight weeks.
Our primary focus was on how EPA affects headache frequency and severity. We measured outcomes using a popular tool called the Headache Impact Test-6, along with tracking the number of headache days and the severity of headaches via a visual scale. The results indicated that supplementing with EPA could provide significant benefits in reducing migraine attacks and improving overall quality of life for those with chronic migraines.
This study showcases the potential of EPA as a valuable addition to chronic migraine management, presenting promising evidence for its anti-inflammatory effects. Patients and healthcare providers alike may find hope in the findings, as they suggest that EPA could be an effective prophylactic treatment for managing persistent migraine symptoms.
Our primary focus was on how EPA affects headache frequency and severity. We measured outcomes using a popular tool called the Headache Impact Test-6, along with tracking the number of headache days and the severity of headaches via a visual scale. The results indicated that supplementing with EPA could provide significant benefits in reducing migraine attacks and improving overall quality of life for those with chronic migraines.
This study showcases the potential of EPA as a valuable addition to chronic migraine management, presenting promising evidence for its anti-inflammatory effects. Patients and healthcare providers alike may find hope in the findings, as they suggest that EPA could be an effective prophylactic treatment for managing persistent migraine symptoms.
Read More
8
We aimed to explore the link between dietary intake of long-chain omega-3 fatty acids, specifically docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), and their potential impact on headache prevalence in the U.S. Using data from the National Health and Nutrition Examination Surveys conducted between 1999 and 2004, we looked at a diverse group of over 12,000 adults aged 20 and older.
Through interviews, participants reported experiences of severe headaches or migraines in the past three months. We also measured dietary EPA and DHA from their food intake and assessed levels of C-reactive protein, which is an indicator of inflammation. Our analysis suggested that increased intake of omega-3 fatty acids correlated with a lower prevalence of severe headaches or migraines. Specifically, each log unit increase in EPA was linked to a 6% reduction in the prevalence—while DHA showed a similar reduction.
Interestingly, we found that this effect was more pronounced among non-Mexican Hispanic participants compared to others. Importantly, our results remained robust even after considering inflammation levels. Thus, this study supports the idea that omega-3 fatty acids may be beneficial in helping to prevent or alleviate headaches.
Through interviews, participants reported experiences of severe headaches or migraines in the past three months. We also measured dietary EPA and DHA from their food intake and assessed levels of C-reactive protein, which is an indicator of inflammation. Our analysis suggested that increased intake of omega-3 fatty acids correlated with a lower prevalence of severe headaches or migraines. Specifically, each log unit increase in EPA was linked to a 6% reduction in the prevalence—while DHA showed a similar reduction.
Interestingly, we found that this effect was more pronounced among non-Mexican Hispanic participants compared to others. Importantly, our results remained robust even after considering inflammation levels. Thus, this study supports the idea that omega-3 fatty acids may be beneficial in helping to prevent or alleviate headaches.
Read More
Most Useful Reviews
2
Headaches reported
1 people found this helpful
One star. Unfortunately, these didn't work for my wife. She experienced severe headaches and drowsiness.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.6
- All Researches
9.5
We conducted a clinical trial to see how dietary changes targeting omega-3 and omega-6 fatty acids could help people dealing with chronic headaches. Over 12 weeks, we divided participants into two groups: one that increased their omega-3 intake while reducing omega-6 and another that just focused on lowering omega-6.
Our findings were quite promising! Those in the group increasing their omega-3 levels experienced a greater reduction in headache severity and frequency compared to those simply lowering omega-6. Specifically, the high omega-3 group had a significant drop in both daily headache hours and pain impact, while altering levels of important headache-relief mediators in the body.
This suggests that increasing omega-3, particularly docosahexaenoic acid, can be an effective strategy for reducing headache symptoms and improving overall quality of life among chronic headache sufferers. These dietary adjustments could provide a new avenue for managing headaches more effectively.
Our findings were quite promising! Those in the group increasing their omega-3 levels experienced a greater reduction in headache severity and frequency compared to those simply lowering omega-6. Specifically, the high omega-3 group had a significant drop in both daily headache hours and pain impact, while altering levels of important headache-relief mediators in the body.
This suggests that increasing omega-3, particularly docosahexaenoic acid, can be an effective strategy for reducing headache symptoms and improving overall quality of life among chronic headache sufferers. These dietary adjustments could provide a new avenue for managing headaches more effectively.
Read More
9.5
We conducted a 12-week study to explore how eicosapentaenoic acid (EPA) affects individuals suffering from episodic migraines. In our trial, 70 participants were randomly split into two groups—one received 2 grams of fish oil with 1.8 grams of pure EPA daily, while the other group got a placebo made of soybean oil.
The results were quite promising. Those taking EPA reported a significant reduction in the number of migraine days per month, averaging about 4.4 fewer days compared to just 0.6 fewer days in the placebo group. We also noticed a decline in the usage of medication to treat headache symptoms among those taking EPA.
Additionally, participants experienced less severe headaches and improved psychological wellbeing, as indicated by better scores in anxiety, depression, and overall quality of life measures. Notably, women seemed to benefit even more from EPA.
Overall, it appears that high-dose EPA can be an effective preventive treatment for episodic migraines, helping to ease frequency, severity, and even the emotional toll associated with chronic headaches. Importantly, the treatment was well tolerated, with no significant adverse effects reported.
The results were quite promising. Those taking EPA reported a significant reduction in the number of migraine days per month, averaging about 4.4 fewer days compared to just 0.6 fewer days in the placebo group. We also noticed a decline in the usage of medication to treat headache symptoms among those taking EPA.
Additionally, participants experienced less severe headaches and improved psychological wellbeing, as indicated by better scores in anxiety, depression, and overall quality of life measures. Notably, women seemed to benefit even more from EPA.
Overall, it appears that high-dose EPA can be an effective preventive treatment for episodic migraines, helping to ease frequency, severity, and even the emotional toll associated with chronic headaches. Importantly, the treatment was well tolerated, with no significant adverse effects reported.
Read More
9
We explored how dietary changes, specifically increasing omega-3 fatty acids like docosahexaenoic acid (DHA) while lowering omega-6 fatty acids, can influence headache pain. In a trial involving 55 chronic headache patients, we observed significant benefits from this targeted dietary intervention.
Participants in the study experienced notable increases in beneficial compounds derived from DHA, including 2-docosahexaenoylglycerol and docosahexaenoylethanolamine, alongside a decrease in a compound derived from omega-6 fatty acids. Our findings indicate that these changes in endocannabinoids are linked to reductions in both physical pain and psychological distress related to headaches.
The results suggest that adopting a diet rich in omega-3 fatty acids could be a promising way to manage headaches and related psychological issues effectively. This highlights the potential relevance of diet in addressing chronic pain, opening the door for further exploration into personalized nutrition as a valuable strategy for headache relief.
Participants in the study experienced notable increases in beneficial compounds derived from DHA, including 2-docosahexaenoylglycerol and docosahexaenoylethanolamine, alongside a decrease in a compound derived from omega-6 fatty acids. Our findings indicate that these changes in endocannabinoids are linked to reductions in both physical pain and psychological distress related to headaches.
The results suggest that adopting a diet rich in omega-3 fatty acids could be a promising way to manage headaches and related psychological issues effectively. This highlights the potential relevance of diet in addressing chronic pain, opening the door for further exploration into personalized nutrition as a valuable strategy for headache relief.
Read More
8
We investigated the potential of docosahexaenoic acid (DHA) and its oxidized derivatives in predicting chronic posttraumatic headache (PTH) after traumatic brain injury (TBI). In a study involving patients within three days of a TBI, we focused on measuring circulating oxylipins—molecules derived from fatty acids like DHA and arachidonic acid. Our goal was to see if these could help indicate which patients might develop chronic headaches later on.
We found that some DHA-related oxylipins, specifically 4-hydroxy-DHA and 19,20-epoxy-docosapentaenoate, seemed to correlate with lower headache severity. Conversely, a linoleic acid derivative known as 11-hydroxy-9-epoxy-octadecenoate was positively linked to more severe headaches. This suggests that not all fatty acid derivatives act similarly concerning headache severity.
Our findings support the idea that DHA-derived oxylipins have the potential to serve as biomarkers for predicting the onset of chronic headaches after a brain injury, highlighting an exciting area for further research into treatment options.
We found that some DHA-related oxylipins, specifically 4-hydroxy-DHA and 19,20-epoxy-docosapentaenoate, seemed to correlate with lower headache severity. Conversely, a linoleic acid derivative known as 11-hydroxy-9-epoxy-octadecenoate was positively linked to more severe headaches. This suggests that not all fatty acid derivatives act similarly concerning headache severity.
Our findings support the idea that DHA-derived oxylipins have the potential to serve as biomarkers for predicting the onset of chronic headaches after a brain injury, highlighting an exciting area for further research into treatment options.
Read More
8
We aimed to explore the link between dietary intake of long-chain omega-3 fatty acids, specifically docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), and their potential impact on headache prevalence in the U.S. Using data from the National Health and Nutrition Examination Surveys conducted between 1999 and 2004, we looked at a diverse group of over 12,000 adults aged 20 and older.
Through interviews, participants reported experiences of severe headaches or migraines in the past three months. We also measured dietary EPA and DHA from their food intake and assessed levels of C-reactive protein, which is an indicator of inflammation. Our analysis suggested that increased intake of omega-3 fatty acids correlated with a lower prevalence of severe headaches or migraines. Specifically, each log unit increase in EPA was linked to a 6% reduction in the prevalence—while DHA showed a similar reduction.
Interestingly, we found that this effect was more pronounced among non-Mexican Hispanic participants compared to others. Importantly, our results remained robust even after considering inflammation levels. Thus, this study supports the idea that omega-3 fatty acids may be beneficial in helping to prevent or alleviate headaches.
Through interviews, participants reported experiences of severe headaches or migraines in the past three months. We also measured dietary EPA and DHA from their food intake and assessed levels of C-reactive protein, which is an indicator of inflammation. Our analysis suggested that increased intake of omega-3 fatty acids correlated with a lower prevalence of severe headaches or migraines. Specifically, each log unit increase in EPA was linked to a 6% reduction in the prevalence—while DHA showed a similar reduction.
Interestingly, we found that this effect was more pronounced among non-Mexican Hispanic participants compared to others. Importantly, our results remained robust even after considering inflammation levels. Thus, this study supports the idea that omega-3 fatty acids may be beneficial in helping to prevent or alleviate headaches.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 1 Review
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
2
Headaches reported
1 people found this helpful
One star. Unfortunately, these didn't work for my wife. She experienced severe headaches and drowsiness.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Sanders AE, Weatherspoon ED, Ehrmann BM, Soma PS, Shaikh SR, et al. Circulating Polyunsaturated Fatty Acids and Pain Intensity in Five Chronic Pain Conditions. J Pain. 2023;24:478. 10.1016/j.jpain.2022.10.008
- Faurot KR, Cole WR, MacIntosh BA, Dunlap M, Moore CB, et al. Targeted dietary interventions to reduce pain in persistent post-traumatic headache among service members: Protocol for a randomized, controlled parallel-group trial. Contemp Clin Trials. 2022;119:106851. 10.1016/j.cct.2022.106851
- Ramsden CE, Zamora D, Faurot KR, MacIntosh B, Horowitz M, et al. Dietary alteration of n-3 and n-6 fatty acids for headache reduction in adults with migraine: randomized controlled trial. BMJ. 2021;374:n1448. 10.1136/bmj.n1448
- Domenichiello AF, Jensen JR, Zamora D, Horowitz M, Yuan ZX, et al. Identifying oxidized lipid mediators as prognostic biomarkers of chronic posttraumatic headache. Pain. 2020;161:2775. 10.1097/j.pain.0000000000001983
- Sanders AE, Shaikh SR, Slade GD. Long-chain omega-3 fatty acids and headache in the U.S. population. Prostaglandins Leukot Essent Fatty Acids. 2018;135:47. 10.1016/j.plefa.2018.06.008
- Mann JD, Faurot KR, MacIntosh B, Palsson OS, Suchindran CM, et al. A sixteen-week three-armed, randomized, controlled trial investigating clinical and biochemical effects of targeted alterations in dietary linoleic acid and n-3 EPA+DHA in adults with episodic migraine: Study protocol. Prostaglandins Leukot Essent Fatty Acids. 2018;128:41. 10.1016/j.plefa.2017.11.002
- Sadeghi O, Maghsoudi Z, Khorvash F, Ghiasvand R, Askari G. The relationship between different fatty acids intake and frequency of migraine attacks. Iran J Nurs Midwifery Res. 2015;20:334.
- Ramsden CE, Zamora D, Makriyannis A, Wood JT, Mann JD, et al. Diet-induced changes in n-3- and n-6-derived endocannabinoids and reductions in headache pain and psychological distress. J Pain. 2015;16:707. 10.1016/j.jpain.2015.04.007
- Ramsden CE, Faurot KR, Zamora D, Suchindran CM, MacIntosh BA, et al. Targeted alteration of dietary n-3 and n-6 fatty acids for the treatment of chronic headaches: a randomized trial. Pain. 2013;154:2441. 10.1016/j.pain.2013.07.028
- Mohammadnezhad G, Assarzadegan F, Koosha M, Esmaily H. Eicosapentaenoic acid versus placebo as adjunctive therapy in chronic migraine: A randomized controlled trial. Headache. 2025;65:153. 10.1111/head.14808
- Wang HF, Liu WC, Zailani H, Yang CC, Chen TB, et al. A 12-week randomized double-blind clinical trial of eicosapentaenoic acid intervention in episodic migraine. Brain Behav Immun. 2024;118:459. 10.1016/j.bbi.2024.03.019
- Soares AA, Louçana PMC, Nasi EP, Sousa KMH, Sá OMS, et al. A double- blind, randomized, and placebo-controlled clinical trial with omega-3 polyunsaturated fatty acids (OPFA ɷ-3) for the prevention of migraine in chronic migraine patients using amitriptyline. Nutr Neurosci. 2018;21:219. 10.1080/1028415X.2016.1266133
- Taha AY, Cheon Y, Faurot KF, Macintosh B, Majchrzak-Hong SF, et al. Dietary omega-6 fatty acid lowering increases bioavailability of omega-3 polyunsaturated fatty acids in human plasma lipid pools. Prostaglandins Leukot Essent Fatty Acids. 2014;90:151. 10.1016/j.plefa.2014.02.003
