Garden of Life Raw Calcium Supplement Vitamin D3

Magnesium's role in osteoporosis therapy

Based on 27 Researches

Mg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism.

Most Relevant Research

We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.

Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.

In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.

Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease.

Osteoporosis reversed

Most Useful Review

It worked for me! In August 2016, my doctor told me I had advanced osteoporosis. After researching the prescribed medicine and being frightened by the side effects, I began taking Garden of Life Raw Calcium. I stopped taking omeprazole and took two calcium tablets daily. Nine months later, my doctor did a scan and was amazed. He said my severe osteoporosis had reversed, and I was only in osteopenia! Incredible!

Back Pain

Vitamin D aids back pain recovery

An Unusual Mimic of Axial Spondyloarthritis: A Case Report.

Most Relevant Research

We observed a fascinating case involving a male in his 40s who experienced persistent inflammatory back pain for three months. Despite having a negative test for HLA-B27, a marker often associated with axial spondyloarthritis, clinical assessments suggested possible underlying issues.

The clinical investigation led to an MRI, which confirmed bilateral symmetrical sacroiliitis. Interestingly, further tests showed he had very low vitamin D levels along with elevated parathyroid hormone—indicating a possible deficiency impacting his condition.

After starting treatment with vitamin D alongside nonsteroidal anti-inflammatory drugs (NSAIDs), he experienced notable relief from his symptoms. His condition improved significantly, and follow-up tests indicated that his vitamin D levels had normalized.

This case demonstrates the potential benefits of vitamin D in managing back pain, especially when classical markers are inconclusive. It highlights how a thorough diagnosis can reveal interconnected health issues and improve treatment outcomes.

9.5

Improved back pain

Most Useful Review

I usually don’t write reviews, but I have to share. After two months of taking these vitamins, my back pain has ceased, and I wake up feeling refreshed. My cycle has normalised, and I’ve noticed significant hair growth. I highly recommend this for health!

Chronic Fatigue Syndrome

Vitamin D3 ineffective for CFS relief

Based on 3 Researches

Effect of intermittent vitamin D3 on vascular function and symptoms in chronic fatigue syndrome--a randomised controlled trial.

Most Relevant Research

We conducted a study to see if high-dose vitamin D3 could improve vascular health and reduce fatigue in individuals suffering from chronic fatigue syndrome (CFS). This was a well-structured trial involving 50 participants, all of whom met specific diagnostic criteria for CFS. Participants were divided into two groups: one received 100,000 units of vitamin D3 every two months, while the other received a placebo over a period of six months.

Despite a noticeable increase of 22 nmol/L in vitamin D levels for those who received the treatment compared to the placebo group, we found no significant benefits. There was no change in arterial stiffness, a key vascular health indicator, nor improvements in overall fatigue as measured by the Piper Fatigue scale.

In essence, our findings indicate that high-dose oral vitamin D3 does not offer the hoped-for relief in vascular function or fatigue for patients with chronic fatigue syndrome. This suggests that other therapeutic options may need to be explored for individuals suffering from this condition.

9.5

Calcium improvement

Most Useful Review

A great product! I take raw vitamins and supplements as I have chronic fatigue syndrome and need efficient absorption. The Raw Calcium is a wholefood and plant formula without tummy upset. My calcium levels have risen significantly since using this product, having previously been low. I appreciate Garden of Life products for their range of raw supplements.

Knee Pain

Vitamin D3 shows promise for knee OA

Based on 18 Researches

The influence of vitamin D supplementation on the expression of mediators of inflammation in knee osteoarthritis.

Most Relevant Research

We explored the potential benefits of vitamin D3 supplementation in alleviating knee pain associated with osteoarthritis (OA). In this open-label clinical trial, we assessed the effects of daily doses of 4000 IU vitamin D3 over three months in 80 patients suffering from knee OA.

Our findings revealed notable improvements in pain levels and overall physical function. The patients showed significant reductions in pain scores measured by the Visual Analog Scale (VAS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) subscores after the treatment period. Remarkably, 86.7% of those treated responded positively to the therapy.

Interestingly, we observed changes in systemic cytokine levels: while some pro-inflammatory markers increased, others, including TNF-α and IL-17, showed significant reductions. This suggests that vitamin D3 not only helps with pain relief but also may influence inflammatory processes in the body.

Overall, our results indicate that vitamin D3 supplementation could be a promising therapeutic option for managing symptoms of knee OA. Nonetheless, future research should further investigate the role of specific inflammatory mediators, like IL-33, in the progression of knee osteoarthritis.

9.5

No more back pain

Most Useful Review

Raw calcium has completely eliminated my low back ache during my monthly cycle, which I never expected. My calcium levels have been low before, and I've tried other supplements that upset my stomach. However, with this product, I experience no discomfort and can almost forget about my monthly cycle due to the absence of pain.

Common Cold

Vitamin D reduces cold severity

Influence of Vitamin D Supplementation by Simulated Sunlight or Oral D3 on Respiratory Infection during Military Training.

Most Relevant Research

We explored the connection between vitamin D levels and the frequency of upper respiratory tract infections (URTI) in physically active individuals throughout different seasons. In our research, we observed over 1,600 military recruits during their basic training, noting that only 21% were vitamin D sufficient during winter. Alarmingly, those who had sufficient vitamin D levels were found to be 40% less likely to experience URTIs compared to their deficient counterparts, suggesting that maintaining adequate vitamin D may be crucial for better respiratory health during demanding training periods.

Building on these findings, we conducted a follow-up study with 250 recruits, where we implemented various vitamin D supplementation strategies. Participants received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplementation. The results were promising: vitamin D helped alleviate the severity of URTI symptoms and significantly reduced the number of days experiencing a cold. Notably, both sunlight and dietary supplementation were equally effective in boosting vitamin D levels and improving outcomes.

Overall, achieving vitamin D sufficiency can markedly reduce the burden of URTIs, particularly in physically demanding scenarios such as military training.

9.5

Symptoms alleviated

Most Useful Review

My wife's hand bones are cold, yet she continues to use this product. Remarkably, after consuming it, her symptoms vanished.

Frozen Shoulder

Calcium treatment shows promise

Likely Very Effective

Treatment for frozen shoulder combined with calcific tendinitis of the supraspinatus.

Most Relevant Research

We explored the effects of calcium deposition in the rotator cuff tendons on frozen shoulder, particularly in cases where calcific tendinitis was present. The study involved 32 patients who underwent a specialized procedure combining arthroscopic brisement of the shoulder joint with multiple punctures at the calcific site. This innovative approach aimed to alleviate the pain and restore mobility linked to frozen shoulder.

After following up with the patients for two years, we observed that 30 out of 32 patients reported satisfactory outcomes. While five individuals still showed some postoperative calcium deposits, many experienced significant improvements in their range of motion and relief from pain. This suggests that combining treatment methods can enhance recovery, although we recognize that the isolated effect of calcium treatment alone remains unclear.

Overall, this study contributes valuable insight into managing frozen shoulder, especially when associated with calcific tendinitis, even if it doesn't fully isolate the impact of calcium treatment.

Pain relief confirmed

Most Useful Review

After lifting weights at the gym, I injured my frozen shoulder. However, after taking Vitamin Code and RAW calcium for a month, the pain in my shoulder vanished, and my joint made a full recovery. I highly recommend it!

Headache

Magnesium aids migraine management

Magnesium and Migraine.

Most Relevant Research

We explored the impact of magnesium on migraine headaches, focusing on its potential benefits based on various studies. Magnesium deficiency is quite common and can arise from different factors, such as not consuming enough through diet or losing more through bodily systems.

A wealth of research, including case reports and controlled trials, suggests that magnesium supplementation can effectively alleviate migraines, both in the short term and long term. The proposed reasons for this effectiveness range from magnesium's role in preventing spreading cortical depression to its ability to manage oxidative stress and inflammation.

This evidence leads us to consider magnesium not just as a dietary supplement but as an important player in migraine management. Understanding these links helps us contemplate magnesium’s role in prevention and treatment, promising a potential path for those who suffer from this debilitating condition.

9.5

Headache relief

Most Useful Review

The headache and chest tightness vanished, leaving me feeling revitalised.

Leg Cramps

Magnesium oxide treats leg cramps

Likely Ineffective

Based on 26 Researches

A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.

Most Relevant Research

We conducted a study to evaluate how effective magnesium oxide monohydrate (MOMH) is in treating nocturnal leg cramps (NLC). This was a randomized, double-blind, placebo-controlled trial involving multiple centers in Ukraine, where participants took either MOMH or a placebo nightly for 60 days.

Our focus was on measuring the frequency and duration of cramps, the pain they caused, and how they affected sleep quality and overall life satisfaction. We used thorough statistical methods to compare the results between the two groups.

The findings indicated that MOMH is both effective and safe for individuals dealing with NLC. Participants reported improvements in their symptoms, demonstrating that this magnesium supplement can play a helpful role in managing nocturnal leg cramps.

9.5

Cramps disappeared

Most Useful Review

This product is excellent, made from green plants with antioxidants and phytonutrients. The ingredients are healthier than any other calcium product I've used. My leg cramps have vanished since I began taking it, as it relaxes muscles and provides sufficient calcium during sleep.

Migraine

Vitamin D helps reduce migraines

Based on 32 Researches

Vitamin D supplementation for the treatment of migraine: A meta-analysis of randomized controlled studies.

Most Relevant Research

We explored the potential benefits of vitamin D supplementation for treating migraines. Our analysis focused on several randomized controlled trials (RCTs) to examine how effective vitamin D could be in alleviating migraine symptoms.

Through our review, we included six RCTs involving 301 patients. The results were quite promising. Vitamin D supplementation significantly reduced the number of headache attacks per month and the number of headache days experienced by patients. Additionally, it improved the MIDAS score, which measures the impact of migraines on daily life.

However, it's important to note that vitamin D did not show a significant effect on how long migraine attacks lasted or the severity of the headaches. Overall, our findings suggest that while vitamin D might be beneficial for reducing certain migraine-related symptoms, it isn’t a miracle cure for everyone.

9.5

Calcium supplement approved

Most Useful Review

Finally, a calcium supplement that doesn't trigger migraines! Excellent product; every other brand caused migraines for me. As a female in my early 70s, I truly need this.

Reflux

Vitamin D3 reduces early reflux inflammation

Based on 3 Researches

Elevated Pro-inflammatory Cytokine Levels in Acute Reflux Esophagitis Are Reduced by 1,25 Dihydroxy Vitamin D3.

Most Relevant Research

We investigated how Vitamin D3 affects inflammation caused by reflux esophagitis—a condition where stomach acid irritates the esophagus. In our study, we used 70 male rats, dividing them into groups to examine the impact of Vitamin D3 at different doses on inflammation levels.

Our findings revealed that the levels of pro-inflammatory cytokines like IL-1β, IL-6, and IL-8 were significantly elevated in cases of acute reflux esophagitis. However, when we treated these rats with Vitamin D3, we observed that the inflammation markers decreased notably in the acute cases, while there wasn’t any significant change in the chronic cases.

Despite some improvements in cytokine levels with Vitamin D3, we noted that the overall morphological damage to the esophagus remained unchanged. Interestingly, while Vitamin D3 did raise serum calcium levels, it didn’t seem to help repair esophageal damage in the longer-term chronic setting.

These results suggest that while Vitamin D3 has the potential to mitigate inflammation in early stages of reflux esophagitis, it does not offer a complete solution regarding the physical damage caused by the condition over time.

9.5

No reflux issues

Most Useful Review

I have acid reflux and need to be cautious with certain supplements as they upset my stomach. Fortunately, I have experienced no issues with this calcium and intend to continue taking it!

Allergies

Vitamin D deficiency linked to allergies

Does vitamin D deficiency predispose to allergic proctocolitis?

Most Relevant Research

We investigated the potential connection between vitamin D deficiency and allergic proctocolitis (AP) in infants. Our study involved a careful comparison of vitamin D levels in infants diagnosed with AP against those of healthy infants. This meticulous, prospective approach allows us to draw insightful conclusions about how vitamin D might be influencing allergic conditions.

We found that vitamin D levels were noticeably lower in infants suffering from AP compared to their healthy peers. Notably, a significant percentage of AP patients—34.7%—were found to be vitamin D deficient or insufficient. Furthermore, the study revealed that infants with vitamin D levels below 40.75 mcg/L were 3.5 times more likely to develop AP.

Our findings suggest an intriguing association between vitamin D deficiency and allergic proctocolitis, hinting that the rising rates of such allergies may be influenced by environmental factors. It appears crucial that we assess vitamin D levels in infants diagnosed with AP, as this could contribute to better understanding and management of the condition.

8.8

No more exfoliation

Most Useful Review

I have been taking care of my mother for 65 years; her nails have stopped exfoliating and she does not experience allergies.

Arthritis

Vitamin D aids rheumatoid arthritis

Based on 33 Researches

The role of vitamins D, B12, C, and K in modulating inflammation and disease management in rheumatoid arthritis: a comprehensive review.

Most Relevant Research

We explored how vitamin D plays a role in managing rheumatoid arthritis (RA), a condition that causes joint inflammation and discomfort. It's been found that many people with RA often suffer from vitamin D deficiency, which may worsen their symptoms and overall disease severity.

Our review indicates that vitamin D could help modulate immune responses and lower inflammation levels. Supplementing with vitamin D has shown potential in improving various disease activity markers, signaling that it could be a valuable addition to treatment strategies for RA.

Besides vitamin D, we also looked at other important vitamins like B12, C, and K. While vitamin D stands out for its immune benefits, B12 supports energy and neurological health, C helps with collagen production and inflammation reduction, and K contributes to bone health.

Together, these vitamins create a comprehensive approach to managing RA, emphasizing the need for further research to determine the best ways to use them effectively.

8.3

Increased mobility

Most Useful Review

Second Purchase and I now can walk farther! This product really works. I can walk miles now, even with my osteoarthritis in my knees. I think this is a wonderful supplement and cannot recommend it highly enough.

Bloating

Vitamin D3 may reduce bloating

Based on 10 Researches

Calcium vitamin D3 supplementation in clinical practice: side effect and satisfaction.

Most Relevant Research

We aimed to assess how the supplement OsteoCalVitFort, which includes 500 mg of calcium and 400 I.U. of vitamin D3, affects bloating and overall satisfaction among users. In our study, 186 participants aged between 18 and 65 were invited to take two tablets daily—one after breakfast and one after dinner—over a period defined by the contents of a single pack.

After the supplement use, we discovered that symptoms like bloating and constipation showed a remarkable decline. Specifically, the reported cases of bloating decreased from 12.5% to just 0.6%. Similarly, occurrences of constipation dropped significantly, evidencing that the supplement not only supports bone health but also alleviates some common digestive concerns.

With a fantastic 94% satisfaction rate among users, it seems that OsteoCalVitFort stands out as a favorable option for those looking to enhance their calcium and vitamin D intake without experiencing the side effects often associated with similar supplements. Overall, this study gives us encouraging insights into the positive effects of vitamin D in reducing bloating.

9.5

No bloating experienced

Most Useful Review

This brand of vegan calcium has helped me after a few months; I've noticed a significant reduction in bloating. The quality is good, with ingredients being 100% clean and no unpleasant smell. I hope that by taking this calcium supplement, my bone health will improve. The calcium supplements come in a glass bottle.

Blood Clot

Vitamin D counteracts blood clotting

Based on 11 Researches

Vitamin D Inhibits IL-6 Pro-Atherothrombotic Effects in Human Endothelial Cells: A Potential Mechanism for Protection against COVID-19 Infection?

Most Relevant Research

Our research focused on understanding how Vitamin D (VitD) might influence blood clotting, especially in the context of COVID-19. We found that when human endothelial cells were exposed to IL-6—an inflammatory cytokine associated with severe COVID-19—it led to dysfunction in these cells. This dysfunction was marked by increased levels of Tissue Factor (TF) and cell adhesion molecules (CAMs), which promote blood clotting.

Remarkably, when we treated these endothelial cells with VitD, we observed a reversal of these harmful effects. VitD appeared to inhibit the expression of TF and CAMs and even modulated the levels of the ACE2 receptor, which is crucial for the entry of the virus into cells. Our findings suggest that VitD could play a protective role against the blood clotting complications associated with COVID-19 by counteracting IL-6's effects on endothelial cells.

Overall, this study paves the way for further research into VitD as a potential therapeutic option for mitigating thrombotic risks in COVID-19 patients.

9.5

Eliminated back ache

Most Useful Review

Raw Calcium has completely alleviated my low back ache during my monthly cycle, which I didn’t expect. My blood calcium levels have been low before, and unlike other calcium supplements, this one does not cause me chest pain. Initially, I was hesitant to try it, but I’m now thrilled I did, as it has made my monthly experience much more manageable by removing my back pain.

Bone Pain

Vitamin D3 correction improves pain

Based on 4 Researches

Role of Pre-operative Correction of Vitamin D3 Deficiency in Controlling Post-operative Bone Pain after Unicompartmental Knee Arthroplasty.

Most Relevant Research

We explored the impact of vitamin D3 levels on bone pain that patients experience after undergoing unicompartmental knee arthroplasty (UKA). The study involved 240 participants who were divided into three groups based on their vitamin D status—some received treatment before surgery, some after, and others had normal levels to begin with.

By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.

Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.

9.5

Reduced PMS symptoms

Most Useful Review

I liked this product after taking it for two weeks. It positively affected my PMS, with a significant decrease in emotional reactions and appetite, and I've lost 3kg. My knee pain during physical activity has almost disappeared. I advise trying it, as it seems much more effective than others I've used, with no digestive issues.

Brain Tumor

Vitamin D treatment shows promise

Molecular Determinants of Calcitriol Signaling and Sensitivity in Glioma Stem-like Cells.

Most Relevant Research

We investigated the effects of vitamin D, specifically its active form calcitriol, on glioblastoma, the most common type of primary brain cancer in adults. With very limited treatment options and a grim prognosis, glioblastoma poses a serious challenge due to its ability to develop resistance to therapies and acquire stem-like properties that fuel its growth.

In our study, we treated glioblastoma stem-like cells in the lab with calcitriol and discovered some promising results. Among the more than 40 cell cultures we examined, approximately half showed sensitivity to the treatment. Notably, for a quarter of these cell lines, the response was classified as particularly strong.

We found that the effectiveness of calcitriol in reducing tumor growth and blocking stem-like traits could be linked to specific genetic variations in the vitamin D receptor. Importantly, the high responders displayed characteristics indicating reduced potential for both stemness and migration, which are key factors in tumor aggressiveness.

9.5

Effective treatment

Most Useful Review

I use this Arnica daily to strengthen my brain following injuries. Since 2017, I’ve taken 3 pellets twice a day. I am living proof that it works—despite numerous neurological injuries, my brain hasn’t re-injured after taking it. Last year, I fell and twisted my body but thankfully my brain remained intact. I am very grateful for this product, as previously I found nothing that helped with my condition.

Cancer

Magnesium alloy inhibits cancer growth

Based on 11 Researches

Biodegradable Mg-1%Ca alloy inhibits the growth of cervical cancer.

Most Relevant Research

We explored how magnesium alloy, particularly a variant containing 1% calcium, impacts cervical cancer cells. Our investigation revealed that this alloy has promising antitumor properties which could pave the way for new treatments.

In our experiments, we tested the effects of the Mg-1%Ca alloy both in laboratory settings and in living organisms. This alloy was found to release magnesium ions and hydroxide ions more slowly than expected. We observed that it effectively inhibited the growth of cervical cancer cells, specifically SiHa and HeLa cell lines.

Additionally, the presence of the alloy induced apoptosis, or programmed cell death, in the cancer cells, disrupted their structural integrity, and hindered their ability to migrate and invade other tissues. Importantly, the Mg-1%Ca alloy was seen to influence key molecular pathways, specifically the MAPK/ERK signaling pathway, which plays a role in cancer cell proliferation.

With these results, it's evident that magnesium alloy could serve as a useful adjunct to current cervical cancer therapies, potentially helping to prevent both cancer growth and metastasis.

9.5

Enhanced anti-cancer immunity

Most Useful Review

I have been taking this for five years to enhance my anti-cancer immunity, and it exhibits the highest efficacy among calcium products.

Ear Infection

Vitamin D reduces ear infection risk

Based on 10 Researches

Vitamin D supplementation reduces the risk of acute otitis media in otitis-prone children.

Most Relevant Research

We explored the relationship between vitamin D (VD) supplementation and the risk of ear infections, specifically in children who frequently suffer from acute otitis media (AOM). The study involved 116 children with a history of recurrent ear infections, who were randomly assigned to receive either a daily dose of 1000 IU of vitamin D or a placebo for four months. Their number of AOM episodes was monitored for six months after the treatment period.

Our findings were quite revealing: the children who received vitamin D supplements had a significantly lower incidence of AOM compared to those who were given the placebo. Specifically, only 26 children in the vitamin D group experienced at least one episode of AOM, versus 38 in the placebo group—a notable difference that became even more pronounced when looking specifically at uncomplicated AOM cases.

We concluded that vitamin D deficiency is common among children who frequently experience ear infections. By restoring serum vitamin D levels to above 30 ng/mL through supplementation, we observed a significant reduction in the risk of uncomplicated AOM. This suggests that vitamin D could play a beneficial role in managing ear infections in children prone to these issues.

9.5

Effective nutritional solution

Most Useful Review

Meet at once!! I found it beneficial to use a comprehensive nutritional solution to help reduce ear infection issues since it eliminates the need to purchase multiple supplements.

Hypothyroidism

Vitamin D improves thyroid function

Based on 14 Researches

Effects of vitamin D supplementation on autoantibodies and thyroid function in patients with Hashimoto's thyroiditis: A systematic review and meta-analysis.

Most Relevant Research

We conducted a thorough exploration of how vitamin D supplementation can affect hypothyroidism, particularly in patients with Hashimoto's thyroiditis (HT). Our findings draw from a meta-analysis of twelve randomized controlled trials, involving a total of 862 participants. These studies compared the effects of vitamin D against placebo or no treatment, focusing on various thyroid function indicators and autoantibodies.

The results were promising. We found that vitamin D supplementation significantly reduced the levels of anti-thyroid antibodies, specifically thyroid peroxidase antibodies (TPO-Ab) and thyroglobulin antibodies (TG-Ab). Additionally, it appeared to enhance thyroid function by lowering thyroid-stimulating hormone (TSH) levels and increasing free triiodothyronine (FT3) and free thyroxine (FT4) levels.

Notably, we observed that active forms of vitamin D, like calcitriol, were more effective in reducing TPO-Ab compared to the more common D2 and D3 forms. We also noted that longer treatment durations, particularly those exceeding 12 weeks, led to greater improvements in thyroid hormone levels and antibody reductions.

Overall, our study suggests that vitamin D may play a beneficial role in managing Hashimoto’s thyroiditis, potentially helping to modulate immune responses and improve thyroid function.

9.5

Improved condition

Most Useful Review

The best 👍 My husband has hypothyroidism, and after starting this, his condition improved significantly. I will continue ordering it^^

Insomnia

Magnesium improves elderly insomnia

Based on 14 Researches

The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial.

Most Relevant Research

We conducted a double-blind, placebo-controlled clinical trial to investigate the effects of magnesium supplementation on insomnia in elderly individuals. Our study involved 46 participants who were assigned either to receive 500 mg of magnesium daily or a placebo for a duration of 8 weeks.

Throughout the study, we employed various questionnaires, including the Insomnia Severity Index (ISI), to evaluate the participants' sleep quality both before and after the treatment period. We also monitored the intake of other nutrients and performed blood tests to assess hormone levels related to sleep.

The results showed that magnesium supplementation led to significant improvements in areas such as sleep efficiency, sleep onset timing, and overall insomnia severity. We observed increases in serum levels of melatonin and changes in cortisol and renin levels, indicating a physiological response that could enhance sleep quality.

Overall, it seems that supplementing with magnesium has the potential to improve sleep for older adults struggling with insomnia. This finding could pave the way for new, accessible treatment options for those affected by sleep disorders.

8.8

Improved sleep quality

Most Useful Review

I really like the ingredients in this calcium. Initially, I experienced some insomnia when I began taking it, but that has since resolved. It was likely just an adjustment period.

Irritable Bowel Syndrome

Vitamin D benefits IBS patients

Based on 18 Researches

The efficacy of vitamin D supplementation for irritable bowel syndrome: a systematic review with meta-analysis.

Most Relevant Research

We examined how vitamin D supplementation could help improve symptoms for those suffering from irritable bowel syndrome (IBS). This systematic review pulled together findings from four randomized, placebo-controlled trials, with a total of 335 participants, to determine the effectiveness of vitamin D on various IBS measures.

Participants with IBS often struggle with symptoms like pain and discomfort, and vitamin D deficiency has been frequently noted in these individuals. Our research indicated that taking vitamin D could lead to significant improvements in IBS severity compared to a placebo. The results showed that those receiving vitamin D reported notable changes in their IBS severity scores and quality of life scores after the supplementation.

Specifically, after taking vitamin D, participants fared much better in terms of symptom relief than those who received a placebo. While we found some variability in the overall effects on the total score of IBS, the positive outcomes in severity and quality of life were compelling. Overall, our findings suggest that vitamin D supplementation presents a promising option for managing IBS symptoms.

8.8

Regulates bowel movements

Most Useful Review

I find this calcium great; my body responds well to it. I take just two a day due to my small frame, and it also helps with my bowel regularity. Taking too much can make things overly frequent.

Nausea

Vitamin D and nausea in gastroparesis

Based on 6 Researches

Low Vitamin D Levels in Patients with Symptoms of Gastroparesis: Relationships with Nausea and Vomiting, Gastric Emptying and Gastric Myoelectrical Activity.

Most Relevant Research

We delved into an intriguing question: how do low vitamin D levels affect nausea in people experiencing gastroparesis, a condition that slows gastric emptying? By measuring the vitamin D levels of patients from the Gastroparesis Clinical Consortium Registry, we aimed to uncover the relationships between vitamin D, nausea, and gastric function.

Our findings revealed that over half of the patients had low vitamin D levels, specifically 56.1% of the 513 individuals studied. We observed a clear association between these low levels of vitamin D and increased experiences of nausea and vomiting. This was particularly notable in patients with delayed gastric emptying, where those with low vitamin D levels reported significantly more nausea.

While the study showed a correlation, it did not address whether supplementing with vitamin D could directly alleviate these symptoms. Instead, we found that lower vitamin D levels also related to a greater retention of food in the stomach after meals, which hints at a connection to gastric neuromuscular dysfunction. Overall, our study emphasized a noteworthy link between vitamin D and nausea but stopped short of confirming any direct treatment benefits.

9.5

Headaches resolved

Most Useful Review

I am very pleased with the fast delivery, high quality, and convenient packaging. Although the capsules are slightly large, I have no issues swallowing them, and they taste citrusy. I take one capsule daily with meals, alongside vitamin D3+K2, magnesium, and vitamin B6. After 10 days, I have noticed significant benefits; my energy has increased, headaches have stopped, and my mood has improved. I recommend it, especially for those interested in sports or following a diet, as omega-3 replenishes what the body lacks and helps treat nausea.

Tendonitis

Vitamin D's potential in tendonitis

Based on 9 Researches

Controlled vitamin D delivery with injectable hyaluronic acid-based hydrogel for restoration of tendinopathy.

Most Relevant Research

We explored the impact of vitamin D on tendonitis, focusing on how it affects tendon cells, specifically tenocytes. Traditional treatments often merely mask the pain without addressing the underlying issues, but we aimed to find a more effective solution. Our research introduced an innovative delivery system using vitamin D formulated in a hyaluronic acid-based hydrogel, designed to provide localized therapy directly to the affected area.

In our study, we observed that this new vitamin D delivery system, called Vit D@Gel/T80, showed promise in protecting human tenocytes from damage induced by inflammatory markers. During in vitro tests, it successfully reduced harmful effects from TNF-α, a protein involved in inflammation. Moreover, in an animal model, the injection of this system led to indicators of tendon restoration, reinforcing our hypotheses about vitamin D's potential benefits in tendon healing.

Overall, our findings suggest that this localized treatment approach could be a significant advancement in managing tendonitis, offering hope for improved recovery and regeneration of tendon tissue. We believe that by enhancing the delivery of vitamin D, we can potentially change the way tendon disorders are treated, moving beyond just pain relief to fostering true healing.

9.5

Pain relief achieved

Most Useful Review

Love using this after menopause! At 51, I struggled with tendonitis, arthritis, and menopause which worsened my pain. I had tried various supplements but switched to this one due to concerns about side effects. After a year of taking it, I feel almost free from my bodily pain, and my daily life is much better. Women's bodies are delicate, so why not invest in your health?

Cardiovascular Disease

Magnesium's impact on heart health

Based on 20 Researches

The Role of Dietary Magnesium in Cardiovascular Disease.

Most Relevant Research

We examined the connection between dietary magnesium and cardiovascular disease, focusing on how magnesium intake or serum levels relate to heart health. Over the last couple of decades, numerous studies have shown that low magnesium levels are associated with several heart-related issues, including high blood pressure, heart attacks, and even heart failure.

Our insights reveal that even mild or moderate magnesium deficiencies can trigger physiological and metabolic changes that may heighten cardiovascular risks. When magnesium levels are insufficient, we see a rise in inflammation, oxidative stress, and issues with how fats are processed in the body, which can lead to serious heart problems.

Furthermore, we noted that many individuals often consume less magnesium than what is recommended, particularly those who do not regularly eat whole grains, legumes, or green vegetables. This widespread lack of magnesium is concerning, as it could be a significant factor influencing heart disease in the general population.

8.8

Supports bone health

Most Useful Review

Excellent! I’ve been taking “Garden of Life Vitamin Code Raw Calcium”, as recommended by my doctor, for two years now. I take two pills each evening with 200mg of magnesium. This combination significantly improves my sleep quality and alleviates heavy muscle pain, making me feel lighter in the morning. I found it particularly beneficial for bone health and cardiovascular disease.

Heart Attack

Magnesium implantation improves heart recovery

Based on 26 Researches

Magnesium implantation as a continuous hydrogen production generator for the treatment of myocardial infarction in rats.

Most Relevant Research

We explored the potential of magnesium implantation as a new approach to combat heart attacks, specifically myocardial infarction (MI). Our research centered on using magnesium slices implanted under the skin of rats to generate hydrogen gas continuously. This method could ensure a greater and longer-lasting concentration of hydrogen directly reaching the heart, which is crucial for its therapeutic effects.

Through our study, we measured how effectively the magnesium produced hydrogen and evaluated its safety. The results were promising; we observed that magnesium implantation not only improved cardiac function in rats suffering from MI, but also played a role in eliminating harmful free radicals from mitochondrial dysfunction. Furthermore, it helped reduce cell death in heart muscle cells, which is a common consequence of heart attacks.

Compared to traditional hydrogen inhalation, which has limitations in delivering sufficient doses over time, magnesium implantation proved to be a superior method. Overall, our findings pave the way for innovative treatments that could enhance recovery after heart attacks by harnessing the unique properties of magnesium for hydrogen production.

8.8

Potential heart issues

Most Useful Review

The only calcium I take. I believe the raw calcium with K2 included is less likely to cause heart attack issues.

Menopause

Vitamin D supports bone health

Based on 16 Researches

Correlation between serum vitamin D levels and bone mass density evaluated by radiofrequency echographic multi-spectrometry technology (REMS) in menopausal women.

Most Relevant Research

We aimed to uncover the relationship between vitamin D levels and bone mineral density (BMD) in menopausal women, a group particularly vulnerable to osteoporosis due to hormonal changes. To achieve this, we conducted a thorough study involving 32 participants, all of whom were menopausal women without a history of hormone replacement therapy or vitamin D supplementation.

Throughout our research, we measured the participants' serum vitamin D levels and evaluated their bone density using a technique called radiofrequency echographic multi-spectrometry (REMS). Our findings revealed a significant positive correlation between vitamin D levels and BMD—indicating that higher vitamin D levels were associated with better bone density.

This suggests that maintaining adequate vitamin D levels might be crucial for preserving bone health during menopause. Given the particular vulnerability of this demographic to osteoporosis, our study underscores the importance of monitoring and potentially supplementing vitamin D to support bone health in menopausal women.

Overall, we believe our findings contribute to the conversation around menopause management by highlighting the role of vitamin D in promoting healthier bones, and we suggest that REMS could serve as a valuable tool in assessing these changes in postmenopausal women.

8.8

Pain relief achieved

Most Useful Review

I love drinking this supplement after menopause. I dealt with pain issues related to menopause at age 51 and tried various supplements. I switched to this low multivitamin after a year, and it has significantly improved my whole-body pain. My daily life has settled down. If you're apprehensive about supplements, I encourage you to try it. The side effects of medication are daunting, and I believe it's vital to invest in your health.

Eighteen-month clinical and radiographic evaluation of two root canal-filling materials in primary teeth with pulp necrosis secondary to trauma.

Most Relevant Research

We compared two root canal-filling materials used in treating primary teeth with pulp necrosis caused by trauma. Our main focus was on the effectiveness of a calcium hydroxide-based paste versus traditional zinc oxide and eugenol cement, specifically looking at clinical and radiographic outcomes after 18 months.

In our study involving 26 children, we found that both materials demonstrated similar success rates. Clinical success included factors like the absence of pain and tooth mobility, while radiographic success was determined by the healing of tooth roots. Our results indicated that both calcium treatment and zinc oxide function well for the root canal filling in children suffering from pulp necrosis, making them suitable options.

Overall, our findings suggest that whether we use calcium hydroxide or zinc oxide, parents and dentists can expect effective outcomes when treating dental trauma in young children. Thus, both materials are viable choices for addressing toothache related to pulp issues in primary teeth.

9.5

Toothache relief

Most Useful Review

Excellent product! I follow a specific scheme for taking it. My bone pain has decreased, and the toothache has stopped since I started. I can't imagine discontinuing the supplement. It has no noticeable smell, and I am very satisfied.

Sleep Apnea

Vitamin D's role in sleep apnea

Based on 8 Researches

Sleepiness and Vitamin D Levels in Patients with Obstructive Sleep Apnea.

Most Relevant Research

We aimed to explore the connection between Vitamin D levels and excessive daytime sleepiness in patients diagnosed with obstructive sleep apnea (OSA). In this study, we analyzed serum Vitamin D levels in a group of newly diagnosed OSA patients, dividing them into two categories: those who experienced excessive daytime sleepiness (EDS) and those who did not.

Our findings indicated that patients with EDS had significantly lower levels of Vitamin D compared to their non-somnolent counterparts. The study showed that lower Vitamin D levels correlated with higher apnea-hypopnea indices (AHI) and lower oxyhemoglobin saturation during sleep. This suggests that sleep-related hypoxia may impact Vitamin D status and contribute to sleepiness.

Moreover, our analysis indicated that lower Vitamin D levels were independent predictors of EDS. This further emphasizes the potential role of Vitamin D in managing sleep quality for these patients. In summary, our study highlights an important association between Vitamin D levels and daytime sleepiness in people with sleep apnea, suggesting that improving Vitamin D status could be beneficial for managing EDS in these individuals.

7.5

Improved sleep quality

Most Useful Review

I took this upon recommendation due to the belief that calcium deficiency can affect the quality of sleep. I've repurchased it and am taking it again as I believe calcium enhances my sleep more than other nutrients.

Urinary Tract Infection

Calcium fosfomycin effective for UTIs

Based on 16 Researches

Pharmacokinetic/Pharmacodynamic Analysis of Oral Calcium Fosfomycin: Are Urine Levels Sufficient to Ensure Efficacy for Urinary Tract Infections?

Most Relevant Research

We explored the potential of calcium fosfomycin, a well-known antibiotic, in treating urinary tract infections (UTIs). Our focus was on how effectively it works when taken orally by healthy women. We dove into the drug’s urine concentration levels after administration, noting that about 18% of the drug is excreted through urine. This low level of excretion relates back to its poor oral absorption and reliance on the kidneys to filter it out.

By conducting a pharmacokinetic/pharmacodynamic analysis, we established thresholds for its effectiveness based on various dosage regimens. For a single dose of 500 mg, 1000 mg, and a schedule of 1000 mg every 8 hours for 3 days, we identified breakpoints of 8, 16, and 32 mg/L, respectively. Notably, our findings indicated that the chances of success for treating UTIs with the 1000 mg every 8 hours regimen are quite high—over 95%—given the susceptibility profile of the bacteria causing these infections.

Overall, our analysis confirms that using calcium fosfomycin in this manner can provide sufficient urine concentrations to effectively combat UTIs in women, supporting its continued use in this area.

No recurrence noted

Most Useful Review

I recommend this for men in their 40s. I bought it for my husband who has had urinary stones. I've been taking it regularly but haven’t noticed a significant effect. However, since starting it, I haven't experienced any recurrence of urinary stones.

Chest Pain

Vitamin D deficiency affects symptoms

The Association Between Vitamin D Level and Chest Pain, Anxiety, and Fatigue in Patients With Coronary Artery Disease.

Most Relevant Research

We aimed to understand how vitamin D deficiency (VDD) might influence symptoms like chest pain, anxiety, and fatigue in people living with coronary artery disease (CAD). In our investigation, we collected data from 90 CAD patients, focusing on their vitamin D levels and experiences with these symptoms.

The findings were quite revealing. A significant 80% of the participants were found to have low vitamin D levels. Interestingly, we discovered that lower vitamin D levels were linked to increased chest pain and heightened anxiety and fatigue. Specifically, there were strong negative relationships noted: as vitamin D levels dropped, chest pain, anxiety, and fatigue scores rose.

This suggests that addressing vitamin D deficiency might be an important step for managing cardiac-related symptoms in patients with CAD. As this connection unfolds, it seems valuable for healthcare providers to monitor vitamin D levels in CAD patients and consider interventions to correct deficiencies.

9.5

Eliminated back pain

Most Useful Review

Raw Calcium has completely alleviated my low back ache during my monthly cycle, something I did not expect. My calcium levels have been low in the past, and other supplements, including calcium citrate, often lead to chest pain. Thankfully, I do not experience this with GOL's raw calcium. Initially hesitant, I’m now grateful I tried it; the absence of back pain makes me nearly forget about my cycle.

Kidney Stones

Magnesium reduces kidney stone risk

Effect of magnesium oxide or citrate supplements on metabolic risk factors in kidney stone formers with idiopathic hyperoxaluria: a randomized clinical trial.

Most Relevant Research

We conducted a randomized, double-blind, placebo-controlled clinical trial to explore how magnesium treatments influence kidney stones, specifically for those with high levels of oxalate in their urine. Our study involved 90 participants with a history of calcium kidney stones, all of whom were experiencing idiopathic hyperoxaluria. They were divided into three groups receiving either magnesium oxide (MgO), magnesium citrate (MgCit), or a placebo for eight weeks, while their diets were monitored to keep nutritional intake consistent.

After the treatment period, we observed promising results. Both MgO and MgCit effectively reduced the excretion of oxalate in urine, which is a key factor in kidney stone formation. The Group taking magnesium citrate showed even more significant reductions in both oxalate levels and the calcium oxalate supersaturation index, which measures the concentration of stone-forming minerals in urine. This was notably true for participants with normal magnesium levels.

Overall, we found that magnesium supplements might play a beneficial role in decreasing critical risk factors for kidney stones, especially for those using magnesium citrate. It's encouraging to see that this may offer a practical option for those struggling with recurrent stones due to high oxalate excretion.

9.5

Osteoporosis prevention

Most Useful Review

Garden of Life, Vitamin Code, RAW Calcium reduces the risk of osteoporosis while strengthening bones and teeth. This formula uses natural plant calcium (1,100mg) alongside 50mcg vitamin D3 to enhance calcium absorption in bones. It also includes vitamin K2 and magnesium to support long-term bone health.

Cold Sores

Genetic factors in cold sores

Based on 2 Researches

Associations between host genetic variants and Herpes Simplex Labialis in the TwinsUK cohort.

Most Relevant Research

We explored how a specific genetic variant associated with vitamin D might influence the occurrence of cold sores, also known as Herpes Simplex Labialis (HSL). Our research involved nearly 1,800 participants from the TwinsUK registry, with a focus on a group of 595 that completed both blood tests and questionnaires regarding their cold sore experiences.

From the participants surveyed, 235 reported having experienced cold sores at least once, and out of these, 160 indicated that they had recurrent episodes. While we investigated several genetic variants, including three commonly discussed in relation to cold sores, we found no significant links between these particular SNPs and the occurrence or recurrence of cold sores.

However, our analysis did reveal a noteworthy association with a genetic variation in the Vitamin D Receptor (VDR) gene. This variant was significantly correlated with both the history of cold sore outbreaks and their frequency. While this suggests a potential relationship between vitamin D-related genetics and cold sore experiences, it does not mean that vitamin D treatment has a proven direct effect on reducing these occurrences.

Overall, our findings provide an intriguing glimpse into the genetic factors that may play a role in cold sore reactivation, especially as it pertains to the VDR gene. Yet, since we didn't explore the direct effects of vitamin D supplementation, more research would be needed to conclusively determine how vitamin D treatment might influence cold sore frequency.

2.5

Not suitable treatment

Most Useful Review

I purchased this for my uncle, who is 65. Unfortunately, he developed a cold sore after taking these capsules. It seems they are not suitable for him.

Yeast Infection

Vitamin D exhibits antifungal activity

Antifungal activity of vitamin D against Candida albicans in vitro and in vivo.

Most Relevant Research

We examined the potential of vitamin D as a treatment for yeast infections, specifically targeting the troublesome Candida species. The study employed both in vitro and in vivo methods to assess the antifungal capabilities of vitamin D, revealing promising results in inhibiting the growth of these fungi.

Through various tests, including broth microdilution and solid plate assays, we observed that vitamin D could effectively suppress the growth of Candida albicans and other related species in a dose-dependent manner. Notably, it also played a significant role in hindering the formation of biofilms, which are protective structures that Candida can build, making infections harder to treat.

Our exploration into how vitamin D works revealed it impacts several biological processes, affecting the growth and metabolism of Candida. In an animal model simulating intra-abdominal candidiasis, vitamin D appeared to reduce fungal levels in key organs like the liver and kidneys. This treatment not only lowered the fungal burden but also seemed to calm the inflammation associated with the infection.

These findings suggest that vitamin D could be a valuable addition to existing treatments for yeast infections, offering a novel approach against this stubborn pathogen.

2.5

Avoid synthetic vitamins

Most Useful Review

Don't take these vitamins; they're not natural. Many derive their vitamins from feeding the yeast Saccharomyces cerevisiae synthetic vitamins. This poses two issues: those allergic to yeast may react negatively, and the vitamins may not be the best forms of synthetics. It's better to opt for vitamins from the same manufacturer’s MyKind Organics series, which provides genuinely natural options. They could effectively support the treatment of yeast infection.

Heartburn

Calcium aids heartburn relief

Based on 6 Researches

Calcium supplementation during pregnancy and lactation: effects on the mother and the fetus.

Most Relevant Research

We explored the effectiveness of calcium in alleviating heartburn, especially in pregnant women. Our findings highlighted that many expectant mothers experience heartburn due to hormonal changes and the physical pressure of a growing fetus on the stomach.

Calcium-based antacids emerged as an excellent choice for providing relief. Not only do they help manage heartburn symptoms, but they also offer a source of calcium, which is vital for bone health in both mothers and their developing babies.

By ensuring adequate calcium intake through these antacids, we can support maternal health while addressing the discomforts of pregnancy. This dual benefit makes calcium supplementation a practical option for maintaining well-being during this critical time.

9.5

Heartburn relief

Most Useful Review

I chose this product due to its natural composition. Following numerous recommendations, I've found that it alleviates my heartburn while eating, and I'm planning to reorder.

Anxiety

High-dose vitamin D reduces anxiety

Based on 21 Researches

Effects of an 8-week high-dose vitamin D supplementation on fatigue and neuropsychiatric manifestations in post-COVID syndrome: A randomized controlled trial.

Most Relevant Research

We conducted a study to understand how high-dose vitamin D supplementation might impact anxiety levels, particularly in patients experiencing post-COVID symptoms. In our double-blind, randomized controlled trial, we enrolled 80 individuals dealing with fatigue or neuropsychiatric issues after COVID-19.

Participants were split into two groups: one received a weekly dose of 60,000 IU of vitamin D, while the other group received a placebo. Over eight weeks, we evaluated various outcomes, including anxiety levels using the Depression, Anxiety, and Stress Scale (DASS-21).

The results were encouraging for the vitamin D group. We observed significant improvements in anxiety levels, with a notable reduction reported by participants. However, other measures related to sleep quality, depression, cognitive function, and inflammatory markers did not show similar significant changes.

Importantly, we found that the vitamin D group reported no serious adverse effects, indicating that this supplementation is generally safe. These findings suggest that high-dose vitamin D may offer substantial benefits for anxiety relief in patients recovering from COVID-19, albeit with limited effects on other symptoms.

1.3

Triggered anxiety

Most Useful Review

Unfortunately, this supplement, while a good source of calcium, brought on anxiety and insomnia after just a couple of pills. I track my supplements closely to identify any changes, and in this case, anxiety returned, likely due to one of the ingredients.

Food Poisoning

Vitamin D aids gut health restoration

Based on 5 Researches

Vitamin D Reverses Disruption of Gut Epithelial Barrier Function Caused by .

Most Relevant Research

We explored the effects of vitamin D (VD) on gut health during infections caused by a common foodborne bacterium. By using intestinal cells and mouse models, we looked at how this vitamin interacts with the body’s defenses and could potentially restore the gut’s protective barrier during these infections.

Our findings reveal that infections can disrupt gut barrier function and activate the immune system. In patients suffering from campylobacteriosis, we noted that the vitamin D receptor's (VDR) activity was reduced, indicating a weakening of immune responses.

When we supplemented with VD in lab settings, we noticed impressive barrier-preserving effects. In fact, VD reversed the impairment caused by the infection, supporting better functioning of tight junctions within the gut lining. This ultimately led to decreased bacteria moving across the gut barrier.

Overall, our research suggests that vitamin D could be a promising treatment in addressing gut turmoil caused by foodborne infections. It appears that VD supplementation could restore gut barrier functionality, providing a new avenue for both human and animal health.

Stomach pain experienced

Most Useful Review

Disappointment! This product did not meet my expectations. After taking even one capsule with food, I experienced stomach pain, something I hadn't encountered before. I even tried opening the capsules and dissolving them in water, as recommended by the manufacturer, but still faced stomach issues. The dosage suggests taking two capsules twice daily. I'm regretting the money spent.

Heart Disease

Vitamin D's role in heart health

Based on 11 Researches

The Impact of Vitamin D Deficiency on Coronary Artery Disease Severity Based on Myocardial Perfusion Imaging: A Cross-Sectional Study.

Most Relevant Research

We examined how low levels of vitamin D (Vit D) could impact the severity of heart disease, specifically looking at myocardial ischemia. Our study involved two hundred patients who underwent myocardial perfusion imaging at Namazi Hospital in Shiraz, Iran, in 2019. We assessed both the severity of ischemia in patients and their vitamin D levels.

The results revealed a clear pattern: when vitamin D levels dropped below 10 ng/mL, patients showed a significant increase in severe myocardial ischemia. Conversely, in patients with higher levels of vitamin D, we did not find any substantial association with abnormalities in heart imaging. This indicates that maintaining adequate vitamin D levels may play a role in reducing heart disease severity.

Overall, our findings suggest that vitamin D deficiency, especially levels below 10 ng/mL, could contribute to more severe heart conditions. This could prompt health care providers to consider monitoring and addressing vitamin D levels in patients at risk for heart disease.

Gastritis impact

Most Useful Review

I suffer from gastritis which causes pain in my heart. Despite this, it is essential to treat heart disease effectively to ensure my overall health improves.

Diarrhea

Magnesium shows potential for diarrhea

Based on 9 Researches

Mg2+ supplementation treats secretory diarrhea in mice by activating calcium-sensing receptor in intestinal epithelial cells.

Most Relevant Research

We explored the impact of magnesium on secretory diarrhea, particularly in the context of cholera, a significant global health issue. The focus was on understanding how magnesium, often overlooked, could serve as an effective treatment option. In our study, we found that increasing levels of magnesium can significantly inhibit chloride secretion in intestinal cells, which is crucial during episodes of diarrhea.

We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.

Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.

No diarrhoea effects

Most Useful Review

No aftertaste and gentle on the gut. I recently ordered Garden of Life Raw Calcium and began taking it two days ago. It's of high quality, easy on my digestion, and seems to improve my sleep. Previous calcium supplements caused diarrhoea, but so far, this one hasn't. I prefer taking two capsules daily, as the recommended four seems excessive. I'm grateful to iHerb for their timely delivery.

Autoimmune Disorder