5/22/2025
Last update
5/22/2025
Reviewed By
Research Authors
Infographics 
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 34 Researches
7.9
USERS' SCORE
Good
Based on 7 Reviews
8.5
Supplement Facts
Serving Size: 4 Capsules
Serving Per Container: 30
Amount Per Serving
%DV
Vitamin C (from culture of S. cerevisiae)
50 mg
56%
Vitamin D (as D3 from culture of S. cerevisiae)
40 mcg (1,600 IU)
200%
Vitamin K (from culture of S. cerevisiae)
120 mcg
100%
Calcium (naturally occurring from Algae)
1,100 mg
85%
Magnesium (from Algae and Dead Sea minerals)
357 mg
85%
Vitamin K (as K2 MK-7)
50 mcg
+
Strontium (naturally occurring from Algae)
3.8 mg
+
Boron (from Brown Rice Chelate)
3 mg
+
Silica (naturally occurring from Algae)
2.2 mg
+
Vanadium (naturally occurring from Algae)
25 mcg
+
Raw Probiotic & Enzyme BlendLipase, Protease, Aspergillopepsin, beta-Glucanase, Cellulase, Bromelain, Phytase, Lactase, Papain, Peptidase, Pectinase, Hemicellulase, Xylanase, [Lactobacillus bulgaricus, Lactobacillus plantarum] (500 Million CFU).
64 mg
+
Top Medical Research Studies
8
We explored how vitamin D plays a role in managing rheumatoid arthritis (RA), a condition that causes joint inflammation and discomfort. It's been found that many people with RA often suffer from vitamin D deficiency, which may worsen their symptoms and overall disease severity.
Our review indicates that vitamin D could help modulate immune responses and lower inflammation levels. Supplementing with vitamin D has shown potential in improving various disease activity markers, signaling that it could be a valuable addition to treatment strategies for RA.
Besides vitamin D, we also looked at other important vitamins like B12, C, and K. While vitamin D stands out for its immune benefits, B12 supports energy and neurological health, C helps with collagen production and inflammation reduction, and K contributes to bone health.
Together, these vitamins create a comprehensive approach to managing RA, emphasizing the need for further research to determine the best ways to use them effectively.
Our review indicates that vitamin D could help modulate immune responses and lower inflammation levels. Supplementing with vitamin D has shown potential in improving various disease activity markers, signaling that it could be a valuable addition to treatment strategies for RA.
Besides vitamin D, we also looked at other important vitamins like B12, C, and K. While vitamin D stands out for its immune benefits, B12 supports energy and neurological health, C helps with collagen production and inflammation reduction, and K contributes to bone health.
Together, these vitamins create a comprehensive approach to managing RA, emphasizing the need for further research to determine the best ways to use them effectively.
8
Magnesium protects against bone erosion
We delved into the relationship between magnesium levels and gouty arthritis, a condition known for causing painful flare-ups and damaging joint function. Our research focused on measuring serum ionized magnesium levels in a group of 769 patients and assessing how these levels relate to bone erosion, a serious complication of gout.
Our findings revealed that patients experiencing bone erosion had significantly lower magnesium levels compared to those without erosion. When we categorized magnesium levels into quartiles, the data showed that those in the lowest quartile (Q1) were more likely to have bone erosion compared to patients in higher quartiles. In fact, the prevalence of erosion in the lowest magnesium group was much higher, illustrating a clear connection.
Through detailed analysis, we concluded that higher levels of serum ionized magnesium may serve as a protective factor against bone erosion in gouty arthritis. This suggests that magnesium supplementation could be a promising strategy for individuals suffering from this debilitating condition, potentially helping to slow down or prevent further joint damage.
Our findings revealed that patients experiencing bone erosion had significantly lower magnesium levels compared to those without erosion. When we categorized magnesium levels into quartiles, the data showed that those in the lowest quartile (Q1) were more likely to have bone erosion compared to patients in higher quartiles. In fact, the prevalence of erosion in the lowest magnesium group was much higher, illustrating a clear connection.
Through detailed analysis, we concluded that higher levels of serum ionized magnesium may serve as a protective factor against bone erosion in gouty arthritis. This suggests that magnesium supplementation could be a promising strategy for individuals suffering from this debilitating condition, potentially helping to slow down or prevent further joint damage.
We set out to explore the potential benefits of vitamin D supplementation for people suffering from end-stage knee osteoarthritis (OA). Our research took the form of a double-blinded, randomized controlled trial involving 56 patients with vitamin D insufficiency. This careful design allowed us to compare the effects of vitamin D against a placebo, ensuring that neither the patients nor the assessors knew who received what treatment.
Over six months, participants in the vitamin D group took capsules containing 4,000 IU daily, while the others received a placebo. We measured muscle strength, pain levels, physical function, and signs of sarcopenia at several points: at the start, after three months, and again at the six-month mark.
We aimed to see whether this cost-effective and well-tolerated supplement could improve quality of life by boosting muscle strength and reducing pain for knee OA patients. Given the growing number of people waiting for knee replacements in Hong Kong, our findings could have significant implications for patient care.
Our study's findings may help clarify whether vitamin D supplementation is a viable option for alleviating some symptoms associated with knee osteoarthritis. With ongoing interest in non-surgical therapies, understanding the role of vitamin D (particularly in muscle health) is more relevant than ever.
Over six months, participants in the vitamin D group took capsules containing 4,000 IU daily, while the others received a placebo. We measured muscle strength, pain levels, physical function, and signs of sarcopenia at several points: at the start, after three months, and again at the six-month mark.
We aimed to see whether this cost-effective and well-tolerated supplement could improve quality of life by boosting muscle strength and reducing pain for knee OA patients. Given the growing number of people waiting for knee replacements in Hong Kong, our findings could have significant implications for patient care.
Our study's findings may help clarify whether vitamin D supplementation is a viable option for alleviating some symptoms associated with knee osteoarthritis. With ongoing interest in non-surgical therapies, understanding the role of vitamin D (particularly in muscle health) is more relevant than ever.
Most Useful Reviews
9
Increased mobility
10 people found this helpful
Second Purchase and I now can walk farther! This product really works. I can walk miles now, even with my osteoarthritis in my knees. I think this is a wonderful supplement and cannot recommend it highly enough.
9
Pain reduction
7 people found this helpful
Better than pain pills! I have osteoarthritis and osteoporosis. This product was recommended at my local health store. After a couple of weeks, my knees and hips, which had been killing me, felt so much better! My pain was gone, and I was dancing around the house again. Once I ran out and couldn’t afford more, the pain returned. I found it cheaper on Amazon. It works, is clean, and without bad ingredients.
7.5
Pain relief
6 people found this helpful
It helped me. I was taking this for a couple of months and felt great. After stopping, I noticed my old aches and pains returning. I reordered, it was delivered the next day, and I’ve been taking it ever since. I can tell the difference; it makes my knees and back feel so much better! I have arthritis and scoliosis, so I really need to keep on this. I feel it is a great product, and if you’re like me, it can’t hurt to give it a try.
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 34 Researches
7.9
- All Researches
9
We investigated the potential of 2D layered calcium disilicide nanoparticles (CSNs) to treat rheumatoid arthritis (RA) through their unique properties. CSNs are crafted using a straightforward method of aqueous exfoliation, and their hydrolysis generates several beneficial components including hydrogen gas, alkaline calcium hydroxide (Ca(OH)), and silica.
These components support healing by improving anti-oxidation and reducing inflammation while promoting bone regeneration. The hydrogen gas helps eliminate harmful radicals and can alter macrophage behavior, which is crucial for regulating inflammation. Meanwhile, calcium hydroxide works to balance the acidic environment in the joints, limiting the harmful activity of osteoclasts, the cells that break down bone.
Furthermore, the calcium released can bind with phosphates, aiding in the formation of calcium phosphate, which is essential for bone mineralization. We confirmed these multifaceted benefits through tests on arthritic mice and rabbits, demonstrating that CSNs can provide a promising, biocompatible treatment strategy that enhances therapy beyond just addressing inflammation.
This study emphasizes the importance of calcium and its interactive role in more comprehensive arthritis treatments, fostering both anti-inflammatory and pro-osteogenic effects vital for joint health.
These components support healing by improving anti-oxidation and reducing inflammation while promoting bone regeneration. The hydrogen gas helps eliminate harmful radicals and can alter macrophage behavior, which is crucial for regulating inflammation. Meanwhile, calcium hydroxide works to balance the acidic environment in the joints, limiting the harmful activity of osteoclasts, the cells that break down bone.
Furthermore, the calcium released can bind with phosphates, aiding in the formation of calcium phosphate, which is essential for bone mineralization. We confirmed these multifaceted benefits through tests on arthritic mice and rabbits, demonstrating that CSNs can provide a promising, biocompatible treatment strategy that enhances therapy beyond just addressing inflammation.
This study emphasizes the importance of calcium and its interactive role in more comprehensive arthritis treatments, fostering both anti-inflammatory and pro-osteogenic effects vital for joint health.
9
We explored how vitamin D (VD) affects osteoarthritis (OA), a condition that commonly leads to joint pain and stiffness. Our research focused on the idea that vitamin D might help reduce inflammation and tissue damage driven by the NF-κB pathway, a crucial player in OA development.
To investigate this, we examined the effects of vitamin D on chondrocytes—cells responsible for cartilage health. By observing how vitamin D influences these cells, we found that it does indeed help maintain cartilage integrity. The study highlighted that vitamin D stabilizes the NF-κB pathway, which normally promotes inflammation, and by doing so, it encourages cellular processes like autophagy that are essential for keeping the cartilage healthy.
We observed significant changes in cartilage condition when vitamin D's role was emphasized, suggesting that vitamin D could be a valuable ally in managing OA symptoms. These findings recommend vitamin D as a potential therapeutic strategy for arthritis, opening new avenues for treatment options that could improve joint health and function for people dealing with this challenging condition.
To investigate this, we examined the effects of vitamin D on chondrocytes—cells responsible for cartilage health. By observing how vitamin D influences these cells, we found that it does indeed help maintain cartilage integrity. The study highlighted that vitamin D stabilizes the NF-κB pathway, which normally promotes inflammation, and by doing so, it encourages cellular processes like autophagy that are essential for keeping the cartilage healthy.
We observed significant changes in cartilage condition when vitamin D's role was emphasized, suggesting that vitamin D could be a valuable ally in managing OA symptoms. These findings recommend vitamin D as a potential therapeutic strategy for arthritis, opening new avenues for treatment options that could improve joint health and function for people dealing with this challenging condition.
9
We explored how magnesium (Mg) supplementation impacts rheumatoid arthritis (RA) by analyzing the effects on specific tissues in mice. In our study, we observed that mice with KRN serum-induced arthritis were given either a high magnesium diet or a regular diet for 15 days. After this period, we analyzed the gene activity in their spleens and joint tissues.
Our findings revealed significant changes in the expression of genes associated with RA and biological processes like oxidative stress and senescence—key factors involved in the disease's progression. Specifically, we noted that high magnesium intake led to higher expression levels of certain genes, while others were suppressed.
This supports the idea that increased magnesium can modify the way our body responds to the stresses associated with arthritis. Overall, our research adds to the evidence that suggests that magnesium supplementation might be a promising approach to managing RA and helps pave the way for new treatment options for autoimmune and inflammatory diseases.
Our findings revealed significant changes in the expression of genes associated with RA and biological processes like oxidative stress and senescence—key factors involved in the disease's progression. Specifically, we noted that high magnesium intake led to higher expression levels of certain genes, while others were suppressed.
This supports the idea that increased magnesium can modify the way our body responds to the stresses associated with arthritis. Overall, our research adds to the evidence that suggests that magnesium supplementation might be a promising approach to managing RA and helps pave the way for new treatment options for autoimmune and inflammatory diseases.
9
We explored how magnesium affects arthritis, particularly osteoarthritis (OA), focusing on its role in both cartilage and bone health. By studying the protective effects of magnesium at the cellular and animal levels, we sought to understand how it interacts with joint tissues to potentially alleviate symptoms of OA.
Our investigation indicated that magnesium has significant benefits, especially when it comes to the interaction between cartilage and bone. We found that these positive effects are primarily influenced by the PI3K/AKT signaling pathway, a crucial mechanism in cell communication and response.
To make this treatment practical, we developed tiny microspheres made from poly(lactic-co-glycolic acid) (PLGA) that are loaded with nano-magnesium oxide, modified to enhance their effectiveness. These innovative microspheres, which can be injected directly into the joints, showed encouraging results in reducing OA symptoms in rat models.
Our findings highlight the potential of magnesium-based therapies, especially with this new delivery system, paving the way for exciting clinical applications in the future.
Our investigation indicated that magnesium has significant benefits, especially when it comes to the interaction between cartilage and bone. We found that these positive effects are primarily influenced by the PI3K/AKT signaling pathway, a crucial mechanism in cell communication and response.
To make this treatment practical, we developed tiny microspheres made from poly(lactic-co-glycolic acid) (PLGA) that are loaded with nano-magnesium oxide, modified to enhance their effectiveness. These innovative microspheres, which can be injected directly into the joints, showed encouraging results in reducing OA symptoms in rat models.
Our findings highlight the potential of magnesium-based therapies, especially with this new delivery system, paving the way for exciting clinical applications in the future.
9
We delved into the potential of magnesium chloride (MgCl) as a treatment for arthritis, particularly looking at its anti-inflammatory effects. In our study, we used a model of acute arthritis where mice were injected with zymosan to induce inflammation in their knees. To evaluate the impact of magnesium, we administered it both orally and directly into the joint, comparing its effects to a control group that received a saline solution.
The results were promising! We observed that magnesium chloride treatment lowered inflammation, reduced pain levels, and decreased the presence of certain inflammatory cells and cytokines, specifically interleukin-1. Both systemic and local administrations of MgCl significantly improved the conditions in the mice compared to the saline group.
Importantly, one of the mechanisms behind these benefits seems to involve the suppression of a key inflammatory pathway known as NFκB. This study marks a significant step forward, as it is the first to show how magnesium chloride can effectively reduce signs of arthritis in a live model, leading to decreased inflammation and relief from pain.
The results were promising! We observed that magnesium chloride treatment lowered inflammation, reduced pain levels, and decreased the presence of certain inflammatory cells and cytokines, specifically interleukin-1. Both systemic and local administrations of MgCl significantly improved the conditions in the mice compared to the saline group.
Importantly, one of the mechanisms behind these benefits seems to involve the suppression of a key inflammatory pathway known as NFκB. This study marks a significant step forward, as it is the first to show how magnesium chloride can effectively reduce signs of arthritis in a live model, leading to decreased inflammation and relief from pain.
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Increased mobility
10 people found this helpful
Second Purchase and I now can walk farther! This product really works. I can walk miles now, even with my osteoarthritis in my knees. I think this is a wonderful supplement and cannot recommend it highly enough.
9
Pain reduction
7 people found this helpful
Better than pain pills! I have osteoarthritis and osteoporosis. This product was recommended at my local health store. After a couple of weeks, my knees and hips, which had been killing me, felt so much better! My pain was gone, and I was dancing around the house again. Once I ran out and couldn’t afford more, the pain returned. I found it cheaper on Amazon. It works, is clean, and without bad ingredients.
7.5
Pain relief
6 people found this helpful
It helped me. I was taking this for a couple of months and felt great. After stopping, I noticed my old aches and pains returning. I reordered, it was delivered the next day, and I’ve been taking it ever since. I can tell the difference; it makes my knees and back feel so much better! I have arthritis and scoliosis, so I really need to keep on this. I feel it is a great product, and if you’re like me, it can’t hurt to give it a try.
9
Recommended for bones
I have taken this supplement for several years due to my knee arthritis. It doesn’t cause any discomfort or constipation, and my digestion is great. I highly recommend it for bone health.
9
Calcium effectiveness
This is a superb calcium supplement containing natural cofactors like magnesium and boron, which ensure calcium reaches the bones instead of causing issues like arthritis. It also aids in blood sugar regulation.
Frequently Asked Questions
7.5
Pain relief achieved
7 people found this helpful
I love using this supplement after menopause. Despite dealing with arthritis and other menopausal issues, I found this product a year ago, and it significantly alleviated my body pain. I opted for a low multivitamin to avoid overdose, as I believe in investing in my health. If you're hesitant about supplements, I encourage you to try it; the side effects of drugs seem worse!
9
Recommended for bones
I have taken this supplement for several years due to my knee arthritis. It doesn’t cause any discomfort or constipation, and my digestion is great. I highly recommend it for bone health.
9
Calcium effectiveness
This is a superb calcium supplement containing natural cofactors like magnesium and boron, which ensure calcium reaches the bones instead of causing issues like arthritis. It also aids in blood sugar regulation.
8
We explored the effects of vitamin D supplementation on adults with rheumatoid arthritis (RA), an inflammatory condition affecting millions worldwide. By examining clinical studies that compared vitamin D to either a placebo or standard care, we focused on how these supplements might influence various health outcomes for those suffering from RA.
Our analysis included 11 studies, highlighting several noteworthy findings. We observed a significant improvement in key measures: the Disease Activity Score 28 (DAS-28) showed a meaningful reduction, while levels of C-reactive protein (CRP) and the erythrocyte sedimentation rate (ESR) also decreased. Furthermore, vitamin D supplementation led to an increase in serum vitamin D levels.
Despite these positive results, vitamin D supplementation did not appear to significantly impact the health assessment questionnaire (HAQ) and visual analog scale for pain (VAS-pain) scores. Consequently, while vitamin D can help reduce inflammation and improve specific health parameters in RA patients, the optimal dosage and duration of treatment remain unclear.
Overall, our findings suggest that boosting vitamin D levels might offer benefits for managing RA, and further research may help refine treatment strategies for optimal outcomes.
Our analysis included 11 studies, highlighting several noteworthy findings. We observed a significant improvement in key measures: the Disease Activity Score 28 (DAS-28) showed a meaningful reduction, while levels of C-reactive protein (CRP) and the erythrocyte sedimentation rate (ESR) also decreased. Furthermore, vitamin D supplementation led to an increase in serum vitamin D levels.
Despite these positive results, vitamin D supplementation did not appear to significantly impact the health assessment questionnaire (HAQ) and visual analog scale for pain (VAS-pain) scores. Consequently, while vitamin D can help reduce inflammation and improve specific health parameters in RA patients, the optimal dosage and duration of treatment remain unclear.
Overall, our findings suggest that boosting vitamin D levels might offer benefits for managing RA, and further research may help refine treatment strategies for optimal outcomes.
8
We explored how vitamin D plays a role in managing rheumatoid arthritis (RA), a condition that causes joint inflammation and discomfort. It's been found that many people with RA often suffer from vitamin D deficiency, which may worsen their symptoms and overall disease severity.
Our review indicates that vitamin D could help modulate immune responses and lower inflammation levels. Supplementing with vitamin D has shown potential in improving various disease activity markers, signaling that it could be a valuable addition to treatment strategies for RA.
Besides vitamin D, we also looked at other important vitamins like B12, C, and K. While vitamin D stands out for its immune benefits, B12 supports energy and neurological health, C helps with collagen production and inflammation reduction, and K contributes to bone health.
Together, these vitamins create a comprehensive approach to managing RA, emphasizing the need for further research to determine the best ways to use them effectively.
Our review indicates that vitamin D could help modulate immune responses and lower inflammation levels. Supplementing with vitamin D has shown potential in improving various disease activity markers, signaling that it could be a valuable addition to treatment strategies for RA.
Besides vitamin D, we also looked at other important vitamins like B12, C, and K. While vitamin D stands out for its immune benefits, B12 supports energy and neurological health, C helps with collagen production and inflammation reduction, and K contributes to bone health.
Together, these vitamins create a comprehensive approach to managing RA, emphasizing the need for further research to determine the best ways to use them effectively.
9
We investigated the potential of 2D layered calcium disilicide nanoparticles (CSNs) to treat rheumatoid arthritis (RA) through their unique properties. CSNs are crafted using a straightforward method of aqueous exfoliation, and their hydrolysis generates several beneficial components including hydrogen gas, alkaline calcium hydroxide (Ca(OH)), and silica.
These components support healing by improving anti-oxidation and reducing inflammation while promoting bone regeneration. The hydrogen gas helps eliminate harmful radicals and can alter macrophage behavior, which is crucial for regulating inflammation. Meanwhile, calcium hydroxide works to balance the acidic environment in the joints, limiting the harmful activity of osteoclasts, the cells that break down bone.
Furthermore, the calcium released can bind with phosphates, aiding in the formation of calcium phosphate, which is essential for bone mineralization. We confirmed these multifaceted benefits through tests on arthritic mice and rabbits, demonstrating that CSNs can provide a promising, biocompatible treatment strategy that enhances therapy beyond just addressing inflammation.
This study emphasizes the importance of calcium and its interactive role in more comprehensive arthritis treatments, fostering both anti-inflammatory and pro-osteogenic effects vital for joint health.
These components support healing by improving anti-oxidation and reducing inflammation while promoting bone regeneration. The hydrogen gas helps eliminate harmful radicals and can alter macrophage behavior, which is crucial for regulating inflammation. Meanwhile, calcium hydroxide works to balance the acidic environment in the joints, limiting the harmful activity of osteoclasts, the cells that break down bone.
Furthermore, the calcium released can bind with phosphates, aiding in the formation of calcium phosphate, which is essential for bone mineralization. We confirmed these multifaceted benefits through tests on arthritic mice and rabbits, demonstrating that CSNs can provide a promising, biocompatible treatment strategy that enhances therapy beyond just addressing inflammation.
This study emphasizes the importance of calcium and its interactive role in more comprehensive arthritis treatments, fostering both anti-inflammatory and pro-osteogenic effects vital for joint health.
7
We investigated how vitamin D, when combined with ketogenic diets, affects arthritis, particularly osteoarthritis (OA). The ketogenic diet has shown promise in reducing inflammation associated with OA, but we aimed to understand its long-term safety and the role of vitamin D in this context.
Our findings revealed that traditional ketogenic diets could help alleviate OA symptoms but often led to liver complications, specifically severe hepatic steatosis. To tackle this, we experimented with two variations: a ketogenic diet supplemented with vitamin D and an intermittent ketogenic diet. Remarkably, both alternatives significantly reduced inflammatory cytokines, cartilage loss, and nerve sprouting, all without causing liver issues.
Additionally, we pinpointed β-hydroxybutyrate (β-HB), a beneficial energy molecule produced by fat cells, which also seemed to improve OA symptoms without harming the liver. On a cellular level, we observed that β-HB enhances chondrocyte autophagy and decreases apoptosis through activating a specific signaling pathway known as ERBB3. This pathway was notably down-regulated in OA patients and animal models, highlighting its potential as a therapeutic target.
Overall, our exploration emphasizes the promising role of vitamin D and ketogenic dietary approaches in managing arthritis, although the full extent of vitamin D's individual effects remains uncertain due to its combination with other treatments.
Our findings revealed that traditional ketogenic diets could help alleviate OA symptoms but often led to liver complications, specifically severe hepatic steatosis. To tackle this, we experimented with two variations: a ketogenic diet supplemented with vitamin D and an intermittent ketogenic diet. Remarkably, both alternatives significantly reduced inflammatory cytokines, cartilage loss, and nerve sprouting, all without causing liver issues.
Additionally, we pinpointed β-hydroxybutyrate (β-HB), a beneficial energy molecule produced by fat cells, which also seemed to improve OA symptoms without harming the liver. On a cellular level, we observed that β-HB enhances chondrocyte autophagy and decreases apoptosis through activating a specific signaling pathway known as ERBB3. This pathway was notably down-regulated in OA patients and animal models, highlighting its potential as a therapeutic target.
Overall, our exploration emphasizes the promising role of vitamin D and ketogenic dietary approaches in managing arthritis, although the full extent of vitamin D's individual effects remains uncertain due to its combination with other treatments.
References
- Ji P, Qiu S, Huang J, Wang L, Wang Y, et al. Hydrolysis of 2D Nanosheets Reverses Rheumatoid Arthritis Through Anti-Inflammation and Osteogenesis. Adv Mater. 2025;37:e2415543. 10.1002/adma.202415543
- Ranjbar M, Rahimlou M, Fallah M, Djafarian K, Mohammadi H. Effects of vitamin D supplementation in patients with rheumatoid arthritis: A systematic review and meta-analysis. Heliyon. 2025;11:e42463. 10.1016/j.heliyon.2025.e42463
- Montemor CN, Fernandes MTP, Marquez AS, Bignardi PR, Poli RC, et al. Impact of Reduced Vitamin D Levels on Pain, Function, and Severity in Knee or Hip Osteoarthritis. Nutrients. 2025;17. 10.3390/nu17030447
- Mende LK, Kuthati Y, Wong CS. Curcumin and Vitamin D Supplement Attenuates Knee Osteoarthritis Progression in ACLT + MMx Rat Model: Effect on Cartilage Protection and Pain Reduction. Nutrients. 2025;17. 10.3390/nu17020349
- Arellano Pérez Vertti RD, Arellano Ramírez DO, González Galarza FF, Prieto Hinojosa AI, Méndez Hernández A, et al. "Association of vitamin D blood deficiency and the rs731236 polymorphism vitamin D receptor with primary knee osteoarthritis in subjects from Mexico". Clin Rheumatol. 2025;44:1329. 10.1007/s10067-025-07332-z
- Rafati A, Ramezani R, Esmaeili Gouvarchin Ghaleh H, Bahrami S, Alvanegh AG, et al. Calcitriol Treated Mesenchymal Stem Cells Modulated Immune Response in Collagen-Induced Rheumatoid Arthritis in BALB/c Mice. Transplant Proc. 2025;57:355. 10.1016/j.transproceed.2024.12.020
- Liu P, Zhou J, Cui H, Xu J, Ruan G, et al. 1,25(OH)D induces chondrocyte autophagy and reduces the loss of proteoglycans in osteoarthritis through inhibiting the NF-κB pathway. Clin Rheumatol. 2025;44:811. 10.1007/s10067-024-07281-z
- Hijjawi N, Tout FS, Azaizeh B, Aljaafreh B. The role of vitamins D, B12, C, and K in modulating inflammation and disease management in rheumatoid arthritis: a comprehensive review. Clin Rheumatol. 2025;44:591. 10.1007/s10067-024-07285-9
- Gottreich JR, Katz JN, Jones MH. Nonsurgical Knee Osteoarthritis Treatments for Reducing Inflammation as Measured on MRI Scans: A Systematic Review of Randomized Controlled Trials. Orthop J Sports Med. 2024;12:23259671241272667. 10.1177/23259671241272667
- Zuo A, Jia Q, Zhang M, Zhou X, Li T, et al. The association of vitamin D with knee osteoarthritis pain: an analysis from the Osteoarthritis Initiative database. Sci Rep. 2024;14:30176. 10.1038/s41598-024-81845-6
- Wielińska J, Górna K, Świerkot J, Bugaj B, Kolossa K, et al. Polymorphic Variants in the Vitamin D Receptor and Clinical Parameters of Rheumatoid Arthritis Patients Undergoing Anti-TNF Treatment. Arch Immunol Ther Exp (Warsz). 2024;72. 10.2478/aite-2024-0023
- Cai Z, Zhang Z, Leng J, Xie M, Zhang K, et al. β-Hydroxybutyrate ameliorates osteoarthritis through activation of the ERBB3 signaling pathway in mice. J Bone Miner Res. 2024;40:140. 10.1093/jbmr/zjae176
- Luo H, Zhang Y, Meng C, Li C, Jia D, et al. The effect of copper and vitamin D on osteoarthritis outcomes: A Mendelian randomization study. Medicine (Baltimore). 2024;103:e39828. 10.1097/MD.0000000000039828
- Zang K, Bhatia R, Xue E, Bennett KJ, Luo KH, et al. Vitamin D as a Modifiable Risk Factor for Juvenile Idiopathic Arthritis: A Systematic Review and Meta-analysis of Observational Studies Comparing Baseline Vitamin D in Children with JIA to Individuals Without. Nutr Rev. 2024. 10.1093/nutrit/nuae148
- Kirikovich SS, Levites EV, Proskurina AS, Ritter GS, Dolgova EV, et al. Production of GcMAF with Anti-Inflammatory Properties and Its Effect on Models of Induced Arthritis in Mice and Cystitis in Rats. Curr Issues Mol Biol. 2024;46:10934. 10.3390/cimb46100650
- Feng Y, Zhu P, Yan D, Wang X, Chen C, et al. Implications of vitamin D levels or status for mortality in rheumatoid arthritis: analysis of 2001-2018 data from the National Health and Nutrition Examination Survey. Front Immunol. 2024;15:1425119. 10.3389/fimmu.2024.1425119
- Wang QW, Ong MT, Man GC, Yeung YM, He X, et al. The effectiveness of vitamin D supplementation in patients with end-stage knee osteoarthritis: Study protocol for a double-blinded, randomized controlled trial. PLoS One. 2024;19:e0309610. 10.1371/journal.pone.0309610
- He J, Wu J, Zheng J, Xu Y, Li K, et al. Injectable Chondroitin Sulfate Microspheres with Gallic Acid-Magnesium MOF for Anti-Inflammatory and Cartilage Degeneration Alleviation in Osteoarthritis Treatment. ACS Appl Mater Interfaces. 2025;17:11898. 10.1021/acsami.4c22415
- Chathoth BM, Helmholz H, Angrisani N, Wiese B, Reifenrath J, et al. Investigating the Potential of Magnesium Microparticles on Cartilage and Bone Regeneration Utilizing an In Vitro Osteoarthritis Model. J Biomed Mater Res A. 2025;113:e37862. 10.1002/jbm.a.37862
- Laragione T, Harris C, Gulko PS. Magnesium Supplementation Modifies Arthritis Synovial and Splenic Transcriptomic Signatures Including Ferroptosis and Cell Senescence Biological Pathways. Nutrients. 2024;16. 10.3390/nu16234247
- Li Y, Wang Y, Xu L, Liu C, Cui J, et al. Serum ionized magnesium acts as an independent protective factor against bone erosion in patients with gouty arthritis: a cross-sectional study. Front Endocrinol (Lausanne). 2024;15:1375871. 10.3389/fendo.2024.1375871
- Mei S, Jiang F, Liu N, Feng Z, Zheng Y, et al. Sol-gel synthesis of magnesium oxide nanoparticles and their evaluation as a therapeutic agent for the treatment of osteoarthritis. Nanomedicine (Lond). 2024;19:1867. 10.1080/17435889.2024.2382421
- Liu H, Zhang K, Xiong L. Dietary magnesium intake and rheumatoid arthritis patients' all-cause mortality: evidence from the NHANES database. J Health Popul Nutr. 2024;43:112. 10.1186/s41043-024-00597-1
- Zheng L, Zhao S, Li Y, Xu J, Yan W, et al. Engineered MgO nanoparticles for cartilage-bone synergistic therapy. Sci Adv. 2024;10:eadk6084. 10.1126/sciadv.adk6084
- Pinto ACMD, de Melo Nunes R, de Freitas Carvalho WV, Girão VCC, Rocha FAC. Systemic and local antiinflammatory effect of magnesium chloride in experimental arthritis. Adv Rheumatol. 2024;64:6. 10.1186/s42358-023-00346-8
- Fu H, Guo Y, Fang W, Wang J, Hu P, et al. Anti-Acidification and Immune Regulation by Nano-Ceria-Loaded Mg-Al Layered Double Hydroxide for Rheumatoid Arthritis Therapy. Adv Sci (Weinh). 2024;11:e2307094. 10.1002/advs.202307094
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