' 
SCIENTIFIC SCORE
Possibly Effective
Based on 33 Researches
7.1
USERS' SCORE
Moderately Good
Based on 1 Review
7.7
Supplement Facts
Serving Size: 4 Capsules
Serving Per Container: 30
Amount Per Serving
%DV
Vitamin C (from culture of S. cerevisiae)
50 mg
56%
Vitamin D (as D3 from culture of S. cerevisiae)
40 mcg (1,600 IU)
200%
Vitamin K (from culture of S. cerevisiae)
120 mcg
100%
Calcium (naturally occurring from Algae)
1,100 mg
85%
Magnesium (from Algae and Dead Sea minerals)
357 mg
85%
Vitamin K (as K2 MK-7)
50 mcg
+
Strontium (naturally occurring from Algae)
3.8 mg
+
Boron (from Brown Rice Chelate)
3 mg
+
Silica (naturally occurring from Algae)
2.2 mg
+
Vanadium (naturally occurring from Algae)
25 mcg
+
Raw Probiotic & Enzyme BlendLipase, Protease, Aspergillopepsin, beta-Glucanase, Cellulase, Bromelain, Phytase, Lactase, Papain, Peptidase, Pectinase, Hemicellulase, Xylanase, [Lactobacillus bulgaricus, Lactobacillus plantarum] (500 Million CFU).
64 mg
+
Top Medical Research Studies
9
Vitamin K1 reduces coronary calcifications
Effect of vitamin K1 supplementation on coronary calcifications in hemodialysis patients: a randomized controlled trial.
High relevance for heart disease
We aimed to determine how vitamin K1 affects coronary artery calcifications in patients undergoing hemodialysis. In our study with 60 participants, we compared the effects of intravenous vitamin K1 against a placebo over 12 months.
The results showed that vitamin K1 significantly slowed the progression of coronary artery calcifications by 55%, compared to the placebo group. This finding suggests vitamin K1 may offer an important benefit in managing heart health for those with chronic kidney disease.
The results showed that vitamin K1 significantly slowed the progression of coronary artery calcifications by 55%, compared to the placebo group. This finding suggests vitamin K1 may offer an important benefit in managing heart health for those with chronic kidney disease.
Read More
7
Vitamin D's role in heart health
The Impact of Vitamin D Deficiency on Coronary Artery Disease Severity Based on Myocardial Perfusion Imaging: A Cross-Sectional Study.
Direct focus on heart disease
We examined how low levels of vitamin D (Vit D) could impact the severity of heart disease, specifically looking at myocardial ischemia. Our study involved two hundred patients who underwent myocardial perfusion imaging at Namazi Hospital in Shiraz, Iran, in 2019. We assessed both the severity of ischemia in patients and their vitamin D levels.
The results revealed a clear pattern: when vitamin D levels dropped below 10 ng/mL, patients showed a significant increase in severe myocardial ischemia. Conversely, in patients with higher levels of vitamin D, we did not find any substantial association with abnormalities in heart imaging. This indicates that maintaining adequate vitamin D levels may play a role in reducing heart disease severity.
Overall, our findings suggest that vitamin D deficiency, especially levels below 10 ng/mL, could contribute to more severe heart conditions. This could prompt health care providers to consider monitoring and addressing vitamin D levels in patients at risk for heart disease.
The results revealed a clear pattern: when vitamin D levels dropped below 10 ng/mL, patients showed a significant increase in severe myocardial ischemia. Conversely, in patients with higher levels of vitamin D, we did not find any substantial association with abnormalities in heart imaging. This indicates that maintaining adequate vitamin D levels may play a role in reducing heart disease severity.
Overall, our findings suggest that vitamin D deficiency, especially levels below 10 ng/mL, could contribute to more severe heart conditions. This could prompt health care providers to consider monitoring and addressing vitamin D levels in patients at risk for heart disease.
Read More
7
Magnesium supplements lower heart failure risk
Nonprescription Magnesium Supplement Use and Risk of Heart Failure in Patients With Diabetes: A Target Trial Emulation.
Findings support further investigation
We examined how magnesium supplements might influence heart failure and serious heart-related issues in diabetic patients.
In a study involving over 94,000 veterans, we found that those taking magnesium supplements experienced a lower risk of heart failure compared to nonusers. Specifically, 8.0% of supplement users developed heart failure, versus 9.7% of nonusers.
Furthermore, magnesium intake was linked to a reduced chance of major adverse cardiac events. However, it’s important to note that these findings need further investigation through randomized controlled trials.
In a study involving over 94,000 veterans, we found that those taking magnesium supplements experienced a lower risk of heart failure compared to nonusers. Specifically, 8.0% of supplement users developed heart failure, versus 9.7% of nonusers.
Furthermore, magnesium intake was linked to a reduced chance of major adverse cardiac events. However, it’s important to note that these findings need further investigation through randomized controlled trials.
Read More
Most Useful Reviews
0
Gastritis impact
I suffer from gastritis which causes pain in my heart. Despite this, it is essential to treat heart disease effectively to ensure my overall health improves.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 33 Researches
7.1
- All Researches
9
Mitochondrial calcium uptake and heart
Enhancement of mitochondrial calcium uptake is cardioprotective against maladaptive hypertrophy by retrograde signaling uptuning Akt.
MCU's role in heart health
We explored how enhancing mitochondrial calcium uptake can influence heart disease, particularly in the context of heart hypertrophy, a condition that can lead to heart failure. The study focused on the mitochondrial calcium uniporter (MCU), a protein responsible for transporting calcium into mitochondria.
By examining heart samples from humans and mice at different stages of hypertrophy, we found that MCU levels increased during the initial adaptive phase but decreased when heart failure occurred. This tells us that the body tries to cope with added stress before ultimately struggling.
Our experiments involved manipulating MCU levels in mice through viral techniques, allowing us to observe the effects during pressure overload, simulating conditions of heart disease. We noticed that reducing MCU led to faster deterioration of heart function and increased fibrosis, indicating a poorer health status. Conversely, boosting MCU seemed to help preserve heart function and maintain tissue health even under stress.
Importantly, we found that improved mitochondrial calcium uptake triggered protective signals involving reactive oxygen species and Akt activation within the heart cells. These findings suggest that enhancing calcium uptake could offer a potential therapeutic strategy against maladaptive heart hypertrophy and contribute to a healthier heart response under stress.
By examining heart samples from humans and mice at different stages of hypertrophy, we found that MCU levels increased during the initial adaptive phase but decreased when heart failure occurred. This tells us that the body tries to cope with added stress before ultimately struggling.
Our experiments involved manipulating MCU levels in mice through viral techniques, allowing us to observe the effects during pressure overload, simulating conditions of heart disease. We noticed that reducing MCU led to faster deterioration of heart function and increased fibrosis, indicating a poorer health status. Conversely, boosting MCU seemed to help preserve heart function and maintain tissue health even under stress.
Importantly, we found that improved mitochondrial calcium uptake triggered protective signals involving reactive oxygen species and Akt activation within the heart cells. These findings suggest that enhancing calcium uptake could offer a potential therapeutic strategy against maladaptive heart hypertrophy and contribute to a healthier heart response under stress.
Read More
9
Vitamin K1 reduces coronary calcifications
Effect of vitamin K1 supplementation on coronary calcifications in hemodialysis patients: a randomized controlled trial.
High relevance for heart disease
We aimed to determine how vitamin K1 affects coronary artery calcifications in patients undergoing hemodialysis. In our study with 60 participants, we compared the effects of intravenous vitamin K1 against a placebo over 12 months.
The results showed that vitamin K1 significantly slowed the progression of coronary artery calcifications by 55%, compared to the placebo group. This finding suggests vitamin K1 may offer an important benefit in managing heart health for those with chronic kidney disease.
The results showed that vitamin K1 significantly slowed the progression of coronary artery calcifications by 55%, compared to the placebo group. This finding suggests vitamin K1 may offer an important benefit in managing heart health for those with chronic kidney disease.
Read More
9
DOACs outperform VKAs post-LAAC
Left atrial appendage closure in patients with failure of anticoagulation therapy: A multicenter comparative study on the hybrid strategy using DOACs and VKAs.
Significant comparative study results
We analyzed a study comparing two anticoagulation options—direct oral anticoagulants (DOACs) and vitamin K antagonists (VKAs)—in patients with non-valvular atrial fibrillation who faced blood clots despite previous treatment.
Our findings reveal that those on DOACs had significantly fewer cardioembolic events and complications following left atrial appendage closure.
In contrast, patients on VKAs did not show the same benefit, which suggests that DOACs may be a more effective option for ongoing treatment in these cases.
Our findings reveal that those on DOACs had significantly fewer cardioembolic events and complications following left atrial appendage closure.
In contrast, patients on VKAs did not show the same benefit, which suggests that DOACs may be a more effective option for ongoing treatment in these cases.
Read More
9
Magnesium reduces mortality in HFpEF
Propensity score matched cohort study on magnesium supplementation and mortality in critically ill patients with HFpEF.
High relevance to heart health
We explored how magnesium supplementation might influence mortality rates in patients with heart failure and preserved ejection fraction (HFpEF). The study involved nearly 2,000 patients, with careful matching to ensure a fair comparison between those receiving magnesium and those who weren’t.
Interestingly, we found that magnesium intake was linked to a significant reduction in 28-day mortality rates. This effect was most notable in older adults, women, and patients with high blood pressure. Despite these positive findings, magnesium treatment did lead to longer hospital and ICU stays.
Overall, magnesium shows promise as a supportive treatment for HFpEF, but further investigation is necessary to better understand its benefits and implications.
Interestingly, we found that magnesium intake was linked to a significant reduction in 28-day mortality rates. This effect was most notable in older adults, women, and patients with high blood pressure. Despite these positive findings, magnesium treatment did lead to longer hospital and ICU stays.
Overall, magnesium shows promise as a supportive treatment for HFpEF, but further investigation is necessary to better understand its benefits and implications.
Read More
8
Calcium scoring aids heart disease prevention
Effects of Combining Coronary Calcium Score With Treatment on Plaque Progression in Familial Coronary Artery Disease: A Randomized Clinical Trial.
Moderate relevance to calcium treatment
We conducted a randomized trial to see how combining coronary artery calcium (CAC) scoring with a prevention strategy could limit plaque progression in patients who have a family history of heart disease. The study involved participants aged 40 to 70 who were asymptomatic but had relatives with early-onset coronary artery disease (CAD).
For those who had a CAC score between 1 and 399, we randomized them into two groups: one followed a prevention plan informed by their CAC score, while the other received usual care. After three years, we measured the plaque volume through follow-up assessments to observe how each group fared in terms of plaque progression.
Remarkably, our findings indicated that using the CAC score alongside a primary prevention approach helped reduce harmful lipids in the blood and slowed the development of plaque compared to standard care. This suggests that the CAC score can play a vital role in informing and enhancing preventive measures for those at intermediate risk of heart disease.
For those who had a CAC score between 1 and 399, we randomized them into two groups: one followed a prevention plan informed by their CAC score, while the other received usual care. After three years, we measured the plaque volume through follow-up assessments to observe how each group fared in terms of plaque progression.
Remarkably, our findings indicated that using the CAC score alongside a primary prevention approach helped reduce harmful lipids in the blood and slowed the development of plaque compared to standard care. This suggests that the CAC score can play a vital role in informing and enhancing preventive measures for those at intermediate risk of heart disease.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 1 Review
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
0
Gastritis impact
I suffer from gastritis which causes pain in my heart. Despite this, it is essential to treat heart disease effectively to ensure my overall health improves.
