Effect of magnesium oxide or citrate supplements on metabolic risk factors in kidney stone formers with idiopathic hyperoxaluria: a randomized clinical trial.
We conducted a randomized, double-blind, placebo-controlled clinical trial to explore how magnesium treatments influence kidney stones, specifically for those with high levels of oxalate in their urine. Our study involved 90 participants with a history of calcium kidney stones, all of whom were experiencing idiopathic hyperoxaluria. They were divided into three groups receiving either magnesium oxide (MgO), magnesium citrate (MgCit), or a placebo for eight weeks, while their diets were monitored to keep nutritional intake consistent.
After the treatment period, we observed promising results. Both MgO and MgCit effectively reduced the excretion of oxalate in urine, which is a key factor in kidney stone formation. The Group taking magnesium citrate showed even more significant reductions in both oxalate levels and the calcium oxalate supersaturation index, which measures the concentration of stone-forming minerals in urine. This was notably true for participants with normal magnesium levels.
Overall, we found that magnesium supplements might play a beneficial role in decreasing critical risk factors for kidney stones, especially for those using magnesium citrate. It's encouraging to see that this may offer a practical option for those struggling with recurrent stones due to high oxalate excretion.
Read More
8
Vitamin K1 may reduce kidney stones
Vitamin K1 Inhibition of Renal Crystal Formation through Matrix Gla Protein in the Kidney.
We explored the effect of vitamin K1 (VK1) on kidney stone formation by treating rats for eight weeks. Our observations showed that VK1 significantly reduced crystal formation in the kidneys.
It boosted levels of matrix Gla protein, which plays a crucial role in preventing crystal deposition. We noticed that VK1 even countered the negative effects of warfarin on cell viability. Overall, our findings suggest that VK1 could be a promising treatment to help prevent kidney stones.
Read More
8
Dietary magnesium may reduce stones
Dietary Magnesium Intake and Kidney Stone: The National Health and Nutrition Examination Survey 2011-2018.
We wanted to understand the relationship between dietary magnesium intake and the prevalence of kidney stones. By examining data from the National Health and Nutrition Examination Survey spanning 2011 to 2018, we were able to analyze the self-reported history of kidney stones among participants.
Our findings indicated that those who consumed higher amounts of magnesium appeared to have a lower likelihood of experiencing kidney stones. Specifically, the average daily magnesium intake was lower in individuals with kidney stones, suggesting that magnesium might play a role in kidney stone formation.
In our analysis, we discovered that when grouped into different levels of magnesium intake, those in the highest intake category had significantly reduced odds of developing kidney stones compared to those in the lowest intake category. This trend suggests a protective effect of dietary magnesium against kidney stone disease.
While our results are promising, we recognize that further research is needed to determine if there is a direct causal relationship between magnesium intake and kidney stones. The evidence points towards a beneficial link, but more prospective studies will help clarify this important topic for better health outcomes.
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Most Useful Reviews
9
Osteoporosis prevention
1 people found this helpful
Garden of Life, Vitamin Code, RAW Calcium reduces the risk of osteoporosis while strengthening bones and teeth. This formula uses natural plant calcium (1,100mg) alongside 50mcg vitamin D3 to enhance calcium absorption in bones. It also includes vitamin K2 and magnesium to support long-term bone health.
Read More
7.5
Nutrient absorption support
2 people found this helpful
The best complex for addressing calcium deficiency. Alongside magnesium and vitamin D, it contains K2 and trace elements that aid proper calcium absorption in bones, rather than in kidneys and blood vessels. It’s advisable to first remove deficiencies in vitamin D and magnesium before taking calcium.
Read More
1
Recommendation against use
2 people found this helpful
Gave me kidney stones and isn't assimilatable. They claim it's whole food grown on algae, but it felt like egg shells. After using it, I experienced pain in my urinary tract and had to use herbs to alleviate it. Stopping its use ceased my discomfort. I do not recommend this product and am disappointed with this brand.
Effect of magnesium oxide or citrate supplements on metabolic risk factors in kidney stone formers with idiopathic hyperoxaluria: a randomized clinical trial.
We conducted a randomized, double-blind, placebo-controlled clinical trial to explore how magnesium treatments influence kidney stones, specifically for those with high levels of oxalate in their urine. Our study involved 90 participants with a history of calcium kidney stones, all of whom were experiencing idiopathic hyperoxaluria. They were divided into three groups receiving either magnesium oxide (MgO), magnesium citrate (MgCit), or a placebo for eight weeks, while their diets were monitored to keep nutritional intake consistent.
After the treatment period, we observed promising results. Both MgO and MgCit effectively reduced the excretion of oxalate in urine, which is a key factor in kidney stone formation. The Group taking magnesium citrate showed even more significant reductions in both oxalate levels and the calcium oxalate supersaturation index, which measures the concentration of stone-forming minerals in urine. This was notably true for participants with normal magnesium levels.
Overall, we found that magnesium supplements might play a beneficial role in decreasing critical risk factors for kidney stones, especially for those using magnesium citrate. It's encouraging to see that this may offer a practical option for those struggling with recurrent stones due to high oxalate excretion.
Read More
8
Vitamin D may lower kidney stones
Multivitamins co-intake can reduce the prevalence of kidney stones: a large-scale cross-sectional study.
We explored the connection between vitamin D and kidney stones by analyzing data from a large national health survey. Our goal was to understand whether increasing vitamin D intake could help reduce the prevalence of kidney stones, a painful condition affecting many people.
From our investigation, we observed that higher levels of vitamin D intake were linked to a lower likelihood of experiencing kidney stones. Specifically, those with high vitamin D intake showed a significant protective effect compared to those with lower intake levels. This suggests that vitamin D may play a beneficial role in kidney health.
However, our study also revealed some nuances. While vitamin D seemed to provide protection, the relationship with vitamin C intake was more complicated. As vitamin C intake rose, its effects shifted—initially protective but later potentially harmful if consumed in excess.
Additionally, our findings indicated that when vitamin D is taken alongside other vitamins, the protective effects against kidney stones could be enhanced. Overall, co-exposure to multiple vitamins was seen as beneficial, making vitamin combinations an interesting area for further research.
Read More
8
Vitamin K1 may reduce kidney stones
Vitamin K1 Inhibition of Renal Crystal Formation through Matrix Gla Protein in the Kidney.
We explored the effect of vitamin K1 (VK1) on kidney stone formation by treating rats for eight weeks. Our observations showed that VK1 significantly reduced crystal formation in the kidneys.
It boosted levels of matrix Gla protein, which plays a crucial role in preventing crystal deposition. We noticed that VK1 even countered the negative effects of warfarin on cell viability. Overall, our findings suggest that VK1 could be a promising treatment to help prevent kidney stones.
Read More
8
Magnesium's complex role in kidney stones
Machine Learning Models Decoding the Association Between Urinary Stone Diseases and Metabolic Urinary Profiles.
We analyzed how magnesium levels in urine might influence the occurrence of kidney stones. The study involved a mix of 468 patients who had been diagnosed with various types of urinary stones and underwent a detailed 24-hour urine analysis.
Our investigation found that 24-hour urinary magnesium was positively associated with both kidney stones and stones in multiple locations. Specifically, higher levels of magnesium corresponded with increased risk for these conditions. This relationship was particularly interesting because magnesium was highly correlated with another mineral, urinary phosphorus.
On the flip side, we also identified that 24-hour urinary creatinine acted as a protective factor against kidney and ureter stones, suggesting that maintaining adequate creatinine levels could potentially help prevent these types of stones. Additionally, eGFR (estimated Glomerular Filtration Rate) was noted as a risk factor especially for ureter stones and those that appear in multiple locations.
Ultimately, our study underscores that while magnesium is linked to stone formation, there are other contributing factors at play as well. This knowledge could guide improvements in dietary or medicinal strategies aimed at preventing kidney stones, especially emphasizing the need for a balanced intake of minerals in our diets.
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8
Magnesium's role in kidney stones
Oral supplementation with probiotics, potassium citrate, and magnesium in reducing crystalluria in stone formers: A phase II study.
We analyzed a study focused on the effects of a combination of probiotics, potassium, and magnesium on kidney stone formation, specifically looking at crystalluria, which is the presence of crystals in urine that can signal the recurrence of kidney stones. The study involved 23 patients with calcium oxalate kidney stones who had crystalluria but normal metabolic profiles.
Over the course of 20 days, the patients received daily supplementation with beneficial bacteria, including Lactobacillus paracasei, Lactobacillus plantarum, and Bifidobacterium breve, along with potassium citrate and magnesium. After treatment, we observed a decrease in the presence of crystalluria at multiple follow-up points—1, 3, 6, and 12 months later.
Interestingly, while we noted that the probiotics and other agents helped reduce crystalluria, the study did not isolate the specific effects of magnesium alone. Therefore, we must be cautious in drawing firm conclusions about magnesium’s standalone effectiveness in this context.
Overall, the findings suggest that combining these supplements can be beneficial for patients with kidney stones, but the role of magnesium specifically requires further investigation.
Garden of Life, Vitamin Code, RAW Calcium reduces the risk of osteoporosis while strengthening bones and teeth. This formula uses natural plant calcium (1,100mg) alongside 50mcg vitamin D3 to enhance calcium absorption in bones. It also includes vitamin K2 and magnesium to support long-term bone health.
Read More
7.5
Nutrient absorption support
2 people found this helpful
The best complex for addressing calcium deficiency. Alongside magnesium and vitamin D, it contains K2 and trace elements that aid proper calcium absorption in bones, rather than in kidneys and blood vessels. It’s advisable to first remove deficiencies in vitamin D and magnesium before taking calcium.
Read More
1
Recommendation against use
2 people found this helpful
Gave me kidney stones and isn't assimilatable. They claim it's whole food grown on algae, but it felt like egg shells. After using it, I experienced pain in my urinary tract and had to use herbs to alleviate it. Stopping its use ceased my discomfort. I do not recommend this product and am disappointed with this brand.
Read More
9
Natural calcium source
Taking 2 capsules twice daily is an excellent way to replenish deficiencies in calcium, magnesium, and other trace elements. It contains raw, unprocessed ingredients, with calcium sourced from AlgaeCal brown seaweed for high bioavailability, ensuring easy absorption and no negative reactions.
Read More
9
Plant-based calcium
This is the only calcium I trust, being plant-based and not causing calcification that could clog arteries or lead to kidney stones.
Kidney stones are hard deposits made of minerals and salts that form inside your kidneys. While they can vary in size from tiny particles to large stones, they all begin as crystallized substances that develop when urine contains more crystal-forming substances than the fluid in your urine can dilute. When the crystals stick together, they can form stones, which may cause severe pain, especially when they pass through the urinary tract. Common types of kidney stones include calcium stones, struvite stones, uric acid stones, and cystine stones.
The symptoms of kidney stones can include sharp pain in the side and back, pain during urination, pink or red urine, and frequent urination. Various factors can increase the risk of developing kidney stones, including dehydration, certain dietary choices, and genetic predisposition. Preventing kidney stones often involves drinking plenty of water, avoiding excessive salt and animal protein, and ensuring a balanced intake of calcium. For those who suffer from kidney stones, a medical evaluation may be necessary to determine the best management and preventive strategies.
Calcium is a chemical element represented by the symbol Ca and atomic number 20. It is an essential mineral in the body, playing a critical role in various physiological processes. As one of the most abundant elements in nature, calcium is particularly vital for maintaining strong bones and teeth, where about 99% of the body's calcium is stored. Beyond its structural function, calcium is crucial in muscle contraction, blood clotting, and nerve transmission, making it a key player in overall health.
Dietary sources of calcium include dairy products such as milk, yogurt, and cheese, as well as leafy green vegetables, nuts, seeds, and fortified foods. The recommended daily intake of calcium varies by age and sex, but generally, adults should aim for approximately 1,000 mg per day. For those who may struggle to meet their needs through diet alone, calcium supplements are available but should be taken with caution. It's essential to consult with a healthcare provider before starting any supplement regimen to avoid potential side effects or interactions with medications.
Calcium plays a complex role in the formation and prevention of kidney stones. While it's often thought that reducing calcium intake can help prevent stones, recent research indicates that maintaining adequate dietary calcium may actually lower the risk of developing certain types of stones, particularly calcium oxalate stones, which are the most common. This might seem counterintuitive, but the evidence suggests that dietary calcium can bind with oxalate in the gut, reducing its absorption and subsequent excretion in urine, ultimately lowering the risk of stones.
If you're predisposed to kidney stones, incorporating moderate amounts of calcium-rich foods, such as dairy products, leafy greens, and fortified foods, is generally advisable. However, it's essential to balance this with adequate hydration and to limit high-oxalate foods, such as spinach and nuts. Individuals with a history of stones should consult a healthcare provider for personalized advice, as kidney stone composition can vary widely among individuals, making it crucial to tailor prevention strategies accordingly.
Based on user reviews, the timeline for seeing results when taking this supplement for kidney stones can vary. Some users report an immediate sense of safety due to the plant-based formulation, stating they have not experienced negative effects while using it. For instance, one user mentioned having taken the product post-bone scan related to kidney stone issues and found no problems since starting it Read Review. However, another user indicated that while they have not noticed an immediate effect, they’ve experienced no recurrences of kidney stones since starting the supplement Read Review.
In general, while some users may find reassurance and a sense of improvement fairly quickly, others may not see a direct impact on their kidney stones but still report a positive outcome in terms of recurrence. Therefore, it seems that while immediate results may vary, many users highlight a long-term benefit that comes with consistent use. If you are considering this supplement, it may take some time before determining its full effect on your kidney stone concerns.
Current research on the relationship between dietary supplements and kidney stones offers mixed insights, especially concerning vitamin D, magnesium, and calcium supplementation. Studies have suggested that while high calcium levels can be linked to an increased risk of kidney stones, particularly through genetic analysis, no strong association was found in observational data [1]. Vitamin D's role in kidney stone formation appears nuanced; although a UK Biobank study indicated higher vitamin D levels may protect older women from kidney stones, the overall benefit remains limited, especially when serum calcium is normal [2].
Magnesium, on the other hand, appears to have a more consistent connection with stone prevention. Research shows higher magnesium intake can lower the risk of kidney stones, particularly among adults over 50 [11]. However, it's important to note that while magnesium supplements may effectively help those with high oxalate levels excrete less oxalate, the role of magnesium alone in preventing stones still requires more targeted investigations [13]. In general, combining supplements might provide the most substantial benefits for kidney stone prevention, but each individual's situation can vary significantly. Overall, it's crucial for those at risk of kidney stones to consult healthcare professionals before beginning any supplementation regimen.
Based on user reviews, many individuals have reported a range of improvements in their symptoms while using this calcium supplement. Users often highlight that the plant-based source of calcium and the inclusion of vitamin D3 and K2 make it a preferable option for promoting bone health without the risk of negative side effects such as kidney stone formation. One reviewer specifically noted that the product has not caused any problems related to kidney stones after a bone scan Read Review. Additionally, another user mentioned that although their husband didn't notice any immediate changes, there have been no recurrences of kidney stones since he started taking the supplement Read Review.
While individual experiences can vary significantly, these testimonials suggest that users feel more secure in their choice of supplement, benefiting from both calcium replenishment and a reduction in potential adverse health effects. Many have appreciated the formulation’s focus on long-term bone health, encompassing not only calcium but also magnesium and trace elements that support proper absorption in the body. A user also commended the product for its natural ingredients, which are sourced for high bioavailability Read Review. This aligns with a general sentiment that consistent use of the product may lead to significant health benefits over time.
Based on user reviews, individuals have reported varying experiences when combining this calcium supplement with other vitamins and minerals for managing kidney stones. Many users appreciate the formulation’s emphasis on including vitamin D and magnesium, suggesting that addressing deficiencies in these nutrients before starting calcium supplementation may enhance its effectiveness. One user recommended correcting deficiencies in vitamin D and magnesium first to optimize calcium's benefits, thereby reducing any risk of calcification that can lead to kidney stones Read Review.
Furthermore, testimonials indicate that users feel assured about this supplement's plant-based calcium source, noting that it does not contribute to harmful calcification in the kidneys. One individual specifically mentioned starting the supplement after experiencing kidney stone issues and has had no related problems since Read Review. Additionally, a report from another user highlights that their husband has not had any recurrences of kidney stones after beginning the supplement, even without experiencing immediate effects Read Review. Overall, users seem to find a positive synergy when combining this calcium supplement with other key nutrients to support kidney health.
Based on user reviews, there is a consensus that a thoughtful approach to calcium intake is essential for those concerned about kidney stones. Some users recommend taking specific dosages such as two capsules twice daily, which allows them to replenish deficiencies in calcium, magnesium, and other trace elements without adverse effects (Read Review). Additionally, users have noted that combining calcium with adequate vitamin D and magnesium is advisable, as these nutrients can aid in proper calcium absorption in bones rather than allowing it to accumulate in the kidneys which could lead to stones (Read Review).
Moreover, some users specifically highlight the importance of using plant-based calcium sources, believing they help mitigate the risk of calcification that could potentially lead to kidney stones (Read Review). Overall, while personal experiences with calcium supplementation vary, many users report positive outcomes and no recurrence of kidney stones when cautious about the source and dosage of calcium taken (Read Review). This reinforces the importance of tailoring calcium intake while considering overall dietary health.
7.5
Kidney stones support
I started this product after a bone scan due to kidney stones issues. It’s designed to support my system while taking calcium, and so far, I have not experienced any problems.
7.5
Kidney stones prevention
Recommended for men in their 40s, I bought this for my husband who has kidney stones. Although there hasn't been a noticeable effect, there have been no recurrences of kidney stones since he started taking it.
9
Natural calcium source
Taking 2 capsules twice daily is an excellent way to replenish deficiencies in calcium, magnesium, and other trace elements. It contains raw, unprocessed ingredients, with calcium sourced from AlgaeCal brown seaweed for high bioavailability, ensuring easy absorption and no negative reactions.
7.5
Nutrient absorption support
2 people found this helpful
The best complex for addressing calcium deficiency. Alongside magnesium and vitamin D, it contains K2 and trace elements that aid proper calcium absorption in bones, rather than in kidneys and blood vessels. It’s advisable to first remove deficiencies in vitamin D and magnesium before taking calcium.
9
Plant-based calcium
This is the only calcium I trust, being plant-based and not causing calcification that could clog arteries or lead to kidney stones.
5
Calcium's role in kidney stones
Associations between 25-hydroxyvitamin D/calcium/alkaline phosphatase levels and the risk of developing kidney stones: Results from NHANES (2013-2018)-based and Mendelian randomization studies.
We explored the connections between calcium levels and kidney stones using data from the National Health and Nutrition Examination Survey (NHANES) spanning 2013 to 2018, along with more advanced genetic analyses. Our aim was to understand how the levels of 25-hydroxyvitamin D, calcium, and alkaline phosphatase (ALP) might influence the risk of developing kidney stones.
While observational analyses suggested a relationship between ALP levels and kidney stones, we found that calcium levels did not display a significant association with kidney stones when looking at the data directly. However, utilizing Mendelian randomization analysis, we observed a potential causal link, indicating that elevated calcium levels could indeed raise the risk of developing kidney stones.
The key takeaway from our research is that while observational studies show no strong link between calcium and kidney stones, our genetic analysis implies that higher calcium may contribute to stone formation. Our work provides valuable insights and directions for future studies focused on preventing and treating this painful condition.
5
Vitamin D's impact on kidney stones
Association between serum 25-hydroxyvitamin D concentrations and kidney stone: a cohort study in the UK Biobank.
We set out to investigate whether there’s a connection between vitamin D levels and kidney stone disease (KSD) using data from the UK Biobank, which included a large group of participants. By analyzing this data through survival models, we aimed to find out if higher levels of serum 25-hydroxyvitamin D (25(OH)D) could influence the likelihood of developing kidney stones.
Our analysis covered over 444,000 people, and we tracked the incidence of kidney stones over an average of 12.6 years. Interestingly, while higher 25(OH)D levels didn’t show a clear connection to kidney stones across the general population, we noted a significant finding in women over 60 years old. For this group, higher serum vitamin D concentrations were actually linked to a lower risk of KSD, suggesting a potential protective effect.
Despite these observations, it's noteworthy that an increase in vitamin D didn't correlate with a higher incidence of kidney stones, especially when serum calcium levels remained normal. This news could ease concerns around vitamin D supplementation solely aimed at boosting 25(OH)D levels. Overall, we could conclude that while there are nuances depending on age and sex, vitamin D’s role in kidney stone prevention appears limited.
7
Magnesium reduces kidney stone risk
Association Between Magnesium Intake and Chronic Kidney Diseases and Kidney Stones in Adults Aged 50 years and Older: Dose-Response Analysis of a Nationally Representative Population-Based Study.
We examined the relationship between magnesium intake and the risk of kidney stones in adults aged 50 and older. By analyzing data collected from the National Health and Nutrition Examination Survey spanning over a decade, we aimed to understand whether increasing magnesium levels could help reduce the chances of developing kidney stones.
Our findings revealed that there is indeed a noteworthy link between magnesium consumption and kidney stones. Specifically, we observed that individuals who consumed higher amounts of magnesium had lower odds of experiencing kidney stones. This trend was especially significant for women, who showed a clearer inverse relationship with magnesium intake.
Interestingly, our results indicated that the protective benefits of magnesium plateau around a daily intake of 350 mg. This means that while increasing magnesium consumption can lower the risk of kidney stones, beyond this threshold, additional magnesium may not yield further benefits.
Overall, our study sheds light on the potential role of magnesium in preventing kidney stones and emphasizes the importance of maintaining a balanced diet rich in this essential mineral for individuals over 50.
9
Magnesium reduces kidney stone risk
Effect of magnesium oxide or citrate supplements on metabolic risk factors in kidney stone formers with idiopathic hyperoxaluria: a randomized clinical trial.
We conducted a randomized, double-blind, placebo-controlled clinical trial to explore how magnesium treatments influence kidney stones, specifically for those with high levels of oxalate in their urine. Our study involved 90 participants with a history of calcium kidney stones, all of whom were experiencing idiopathic hyperoxaluria. They were divided into three groups receiving either magnesium oxide (MgO), magnesium citrate (MgCit), or a placebo for eight weeks, while their diets were monitored to keep nutritional intake consistent.
After the treatment period, we observed promising results. Both MgO and MgCit effectively reduced the excretion of oxalate in urine, which is a key factor in kidney stone formation. The Group taking magnesium citrate showed even more significant reductions in both oxalate levels and the calcium oxalate supersaturation index, which measures the concentration of stone-forming minerals in urine. This was notably true for participants with normal magnesium levels.
Overall, we found that magnesium supplements might play a beneficial role in decreasing critical risk factors for kidney stones, especially for those using magnesium citrate. It's encouraging to see that this may offer a practical option for those struggling with recurrent stones due to high oxalate excretion.
References
Ran Y, Liu Z, Ma H, Li C, Zhou J, et al. Associations between 25-hydroxyvitamin D/calcium/alkaline phosphatase levels and the risk of developing kidney stones: Results from NHANES (2013-2018)-based and Mendelian randomization studies. Medicine (Baltimore). 2025;104:e41323. 10.1097/MD.0000000000041323
Gao C, Gao M, Huang Y. Association between serum 25-hydroxyvitamin D concentrations and kidney stone: a cohort study in the UK Biobank. Int Urol Nephrol. 2024;56:3585. 10.1007/s11255-024-04111-8
Dhayat NA, Mattmann C, Seeger H, Ritter A, Ernandez T, et al. The Vitamin D Metabolite Diagnostic Ratio Associates With Phenotypic Traits of Idiopathic Hypercalciuria. Kidney Int Rep. 2024;9:1072. 10.1016/j.ekir.2024.01.004
Akinci A, Karaburun MC, Kubilay E, Solak VT, Sanci A, et al. Urinary stone in infants; should vitamin D prophylaxis be stopped?. J Pediatr Urol. 2024;20:604.e1. 10.1016/j.jpurol.2024.04.006
Zeng H, Liu Z, He Y, Chen H, He J, et al. Multivitamins co-intake can reduce the prevalence of kidney stones: a large-scale cross-sectional study. Int Urol Nephrol. 2024;56:2991. 10.1007/s11255-024-04021-9
Sardari Masihi L, Borumandnia N, Taheri M, Basiri A, Imani H, et al. Effect of two vitamin D repletion protocols on 24-h urine calcium in patients with recurrent calcium kidney stones and vitamin D deficiency: a randomized clinical trial. Eur J Med Res. 2023;28:246. 10.1186/s40001-023-01226-z
Isik G, Bozdag PG. Why is childhood urolithiasis increasing? Etiology, diagnosis and management: a single-center experience. J Nephrol. 2023;36:1599. 10.1007/s40620-023-01638-4
Li Y, Lu X, Yang B, Mao J, Jiang S, et al. Vitamin K1 Inhibition of Renal Crystal Formation through Matrix Gla Protein in the Kidney. Kidney Blood Press Res. 2019;44:1392. 10.1159/000503300
Zhang J, Luo H, Wu H, Qian Y, Tang Z, et al. The association between domestic water hardness and kidney stone disease: a prospective cohort study from the UK Biobank. Int J Surg. 2025;111:1957. 10.1097/JS9.0000000000002198
Ma L, Qiao Y, Wang R, Chen H, Liu G, et al. Machine Learning Models Decoding the Association Between Urinary Stone Diseases and Metabolic Urinary Profiles. Metabolites. 2024;14. 10.3390/metabo14120674
Zhao H, Wang Y, Guan L, Sun Y. Association Between Magnesium Intake and Chronic Kidney Diseases and Kidney Stones in Adults Aged 50 years and Older: Dose-Response Analysis of a Nationally Representative Population-Based Study. J Ren Nutr. 2024. 10.1053/j.jrn.2024.11.004
Vittori M, Bove P, Signoretti M, Cipriani C, Gasparoli C, et al. Oral supplementation with probiotics, potassium citrate, and magnesium in reducing crystalluria in stone formers: A phase II study. Urologia. 2024;91:681. 10.1177/03915603241272146
Taheri M, Jalali S, Borumandnia N, Tavasoli S, Basiri A, et al. Effect of magnesium oxide or citrate supplements on metabolic risk factors in kidney stone formers with idiopathic hyperoxaluria: a randomized clinical trial. Magnes Res. 2024;37:12. 10.1684/mrh.2024.0524
Penniston KL, Coughlin MM, Jhagroo RA. Magnesium Supplementation Increases Urine Magnesium and Citrate in Stone Formers With Hypomagnesuria. J Ren Nutr. 2024. 10.1053/j.jrn.2024.06.002
Li Q, Krieger NS, Yang L, Asplin J, Bushinsky DA. Magnesium Decreases Urine Supersaturation but Not Calcium Oxalate Stone Formation in Genetic Hypercalciuric Stone-Forming Rats. Nephron. 2024;148:480. 10.1159/000534495
Shringi S, Raker CA, Tang J. Dietary Magnesium Intake and Kidney Stone: The National Health and Nutrition Examination Survey 2011-2018. R I Med J (2013). 2023;106:20.
Rodriguez-Hesles CA, Alkhatatbeh H, Alonso Bartolomé MB, Valladares Ferreiro CA, Ayllón Blanco HR, et al. Urine alkalinization for dissolution of uric acid stones and treatment of other urological diseases with a treatment combining potassium magnesium citrate and theobromine. Arch Ital Urol Androl. 2025;97:13824. 10.4081/aiua.2025.13824