Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.5
USERS' SCORE
Good
Based on 2 Reviews
8.6
Supplement Facts
Serving Size: 2 Softgels
Amount Per Serving
%DV
Total Omega-3 Fatty Acids
500 mg
+
DHA (Docosahexaenoic Acid)
500 mg
Astaxanthin
1.5 mg
+
Top Medical Research Studies
8
We explored the impact of omega-3 fatty acid supplementation, particularly docosahexaenoic acid (DHA), on cardiovascular health through the Vitamin D and Omega-3 Trial (VITAL). This comprehensive study included nearly 26,000 older adults from the U.S., who received a daily dose of 840 mg of omega-3 fatty acids.
Although we anticipated significant benefits, the results showed no overall reductions in major cardiovascular events, such as heart attacks and strokes, among the participants. However, our Bayesian analyses, which considered earlier research, suggested that omega-3 FA may still lower the risk of coronary events specifically.
While the evidence pointed towards limited effectiveness for stroke prevention, there seems to be a stronger case for incorporating omega-3 supplementation for reducing coronary-related issues. Overall, these findings enhance our understanding of how consistent omega-3 intake can be a valuable tool in primary prevention strategies for heart health.
Although we anticipated significant benefits, the results showed no overall reductions in major cardiovascular events, such as heart attacks and strokes, among the participants. However, our Bayesian analyses, which considered earlier research, suggested that omega-3 FA may still lower the risk of coronary events specifically.
While the evidence pointed towards limited effectiveness for stroke prevention, there seems to be a stronger case for incorporating omega-3 supplementation for reducing coronary-related issues. Overall, these findings enhance our understanding of how consistent omega-3 intake can be a valuable tool in primary prevention strategies for heart health.
Read More
7
Marine n-3 PUFAs and cardiovascular risk
We set out to explore how levels of marine n-3 polyunsaturated fatty acids (PUFAs), particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), relate to cardiovascular (CV) events and overall mortality, specifically in patients receiving hemodialysis. This prospective study tracked 336 patients over five years, monitoring their CV health and vital statistics.
Our findings revealed a significant connection: patients with lower levels of these essential fatty acids had a heightened risk of experiencing CV events and higher all-cause mortality. We found that those in the lower tertile of n-3 PUFA levels (below 5.06 weight percent) faced notably worse outcomes. Interestingly, those with moderate to high n-3 PUFA levels enjoyed a reduced risk of CV complications and even all-cause mortality, which indicates that increasing levels of EPA and DHA might be beneficial.
These insights suggest that maintaining healthy levels of marine n-3 PUFAs could be crucial for patients undergoing hemodialysis. We observed a potential threshold effect, indicating that risks of CV issues climb for those with n-3 PUFA levels below a certain point. This reinforces the importance of dietary omega-3 fatty acids for heart health, especially in vulnerable populations.
Our findings revealed a significant connection: patients with lower levels of these essential fatty acids had a heightened risk of experiencing CV events and higher all-cause mortality. We found that those in the lower tertile of n-3 PUFA levels (below 5.06 weight percent) faced notably worse outcomes. Interestingly, those with moderate to high n-3 PUFA levels enjoyed a reduced risk of CV complications and even all-cause mortality, which indicates that increasing levels of EPA and DHA might be beneficial.
These insights suggest that maintaining healthy levels of marine n-3 PUFAs could be crucial for patients undergoing hemodialysis. We observed a potential threshold effect, indicating that risks of CV issues climb for those with n-3 PUFA levels below a certain point. This reinforces the importance of dietary omega-3 fatty acids for heart health, especially in vulnerable populations.
Read More
7
We examined the effects of omega-3 fatty acids, particularly docosahexaenoic acid (DHA), on the risk of atrial fibrillation (AF), a common heart rhythm disorder.
Through a thorough review of various studies—including randomized clinical trials and cohort studies—we focused on how DHA influences cardiovascular health. Interestingly, our findings revealed a complex relationship between omega-3 intake and AF risk.
While higher dietary consumption of omega-3 was linked to a decreased risk of AF, we found that pharmaceutical doses of omega-3 fats could actually increase this risk in a dose-dependent manner. The trials indicated a significant increase in AF risk associated with higher doses of DHA and eicosapentaenoic acid (EPA), suggesting that moderation is key.
This dual effect may be related to changes in vagal tone, where moderate levels promote heart health, while excessive amounts may trigger issues. Ultimately, we observed that maintaining a balanced intake of omega-3s is crucial for cardiovascular wellbeing.
Through a thorough review of various studies—including randomized clinical trials and cohort studies—we focused on how DHA influences cardiovascular health. Interestingly, our findings revealed a complex relationship between omega-3 intake and AF risk.
While higher dietary consumption of omega-3 was linked to a decreased risk of AF, we found that pharmaceutical doses of omega-3 fats could actually increase this risk in a dose-dependent manner. The trials indicated a significant increase in AF risk associated with higher doses of DHA and eicosapentaenoic acid (EPA), suggesting that moderation is key.
This dual effect may be related to changes in vagal tone, where moderate levels promote heart health, while excessive amounts may trigger issues. Ultimately, we observed that maintaining a balanced intake of omega-3s is crucial for cardiovascular wellbeing.
Read More
Most Useful Reviews
9.5
Improved cardiovascular health
Minami Nutrition provides high-quality products, such as the Algae Omega-3. This algae-based source of omega-3 is a superb replacement for fish oil. I saw improvements in my cardiovascular health and cholesterol levels. I highly recommend it to anyone pursuing a healthy lifestyle, particularly vegetarians and vegans.
Read More
8.8
Reduces inflammation
Groovy! This high-quality product contains natural omega-3 acids from algae, which help to keep the body clear of inflammation, thus reducing the risk of cardiovascular disease and high cholesterol. It is a fantastic alternative to fish oil for both vegans and vegetarians. The flavour is pleasant, and as always with Garden of Life, the packaging is delightful!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.5
- All Researches
9
We conducted a network meta-analysis to investigate the effects of docosahexaenoic acid, an omega-3 fatty acid, on heart failure management. By examining various randomized controlled trials, we aimed to understand how different dosages and durations of supplementation impact heart function.
Our findings revealed that high-dose supplementation—ranging from 2000 to 4000 mg per day—over more than one year significantly improved heart function, particularly left ventricular ejection fraction and peak oxygen consumption. This indicates a promising role for docosahexaenoic acid in enhancing cardiovascular health in patients dealing with heart failure.
However, we also noted that lower doses and shorter treatment periods did not yield the same benefits. Importantly, the analysis showed no significant increase in dropout rates or all-cause mortality associated with omega-3 supplementation when compared to control groups.
Overall, the evidence suggests that long-term, high-dose docosahexaenoic acid supplementation can positively influence heart function without heightened risk. Future research should focus on more rigorous trials to further validate these findings and address any biases.
Our findings revealed that high-dose supplementation—ranging from 2000 to 4000 mg per day—over more than one year significantly improved heart function, particularly left ventricular ejection fraction and peak oxygen consumption. This indicates a promising role for docosahexaenoic acid in enhancing cardiovascular health in patients dealing with heart failure.
However, we also noted that lower doses and shorter treatment periods did not yield the same benefits. Importantly, the analysis showed no significant increase in dropout rates or all-cause mortality associated with omega-3 supplementation when compared to control groups.
Overall, the evidence suggests that long-term, high-dose docosahexaenoic acid supplementation can positively influence heart function without heightened risk. Future research should focus on more rigorous trials to further validate these findings and address any biases.
Read More
8
We explored the impact of omega-3 fatty acid supplementation, particularly docosahexaenoic acid (DHA), on cardiovascular health through the Vitamin D and Omega-3 Trial (VITAL). This comprehensive study included nearly 26,000 older adults from the U.S., who received a daily dose of 840 mg of omega-3 fatty acids.
Although we anticipated significant benefits, the results showed no overall reductions in major cardiovascular events, such as heart attacks and strokes, among the participants. However, our Bayesian analyses, which considered earlier research, suggested that omega-3 FA may still lower the risk of coronary events specifically.
While the evidence pointed towards limited effectiveness for stroke prevention, there seems to be a stronger case for incorporating omega-3 supplementation for reducing coronary-related issues. Overall, these findings enhance our understanding of how consistent omega-3 intake can be a valuable tool in primary prevention strategies for heart health.
Although we anticipated significant benefits, the results showed no overall reductions in major cardiovascular events, such as heart attacks and strokes, among the participants. However, our Bayesian analyses, which considered earlier research, suggested that omega-3 FA may still lower the risk of coronary events specifically.
While the evidence pointed towards limited effectiveness for stroke prevention, there seems to be a stronger case for incorporating omega-3 supplementation for reducing coronary-related issues. Overall, these findings enhance our understanding of how consistent omega-3 intake can be a valuable tool in primary prevention strategies for heart health.
Read More
8
We assessed the relationship between various serum metabolites and the occurrence of major adverse cardiovascular events (MACE) in middle-aged and elderly adults. One of the key metabolites we looked at was docosahexaenoic acid (DHA), which has been noted for its potential cardiovascular benefits.
Throughout our study involving over 54,000 UK Biobank participants, we found that DHA and some other metabolic markers were linked to MACE risk, particularly among middle-aged individuals. Interestingly, in the elderly, DHA showcased a protective role, revealing how certain metabolic factors may play a different part in heart health as we age.
Our research highlighted that while middle-aged adults exhibited various metabolic indicators associated with increased risk of cardiovascular issues, the elderly had fewer markers that correlated with heightened risk. DHA, in particular, seemed to stand out among the compounds that may help protect against MACE in older adults, as indicated by our findings.
Overall, this research sheds light on the complexity of how dietary components like DHA interact with age-related cardiovascular risks, suggesting a need for further studies into personalized approaches for preventing cardiovascular events tailored to different age groups.
Throughout our study involving over 54,000 UK Biobank participants, we found that DHA and some other metabolic markers were linked to MACE risk, particularly among middle-aged individuals. Interestingly, in the elderly, DHA showcased a protective role, revealing how certain metabolic factors may play a different part in heart health as we age.
Our research highlighted that while middle-aged adults exhibited various metabolic indicators associated with increased risk of cardiovascular issues, the elderly had fewer markers that correlated with heightened risk. DHA, in particular, seemed to stand out among the compounds that may help protect against MACE in older adults, as indicated by our findings.
Overall, this research sheds light on the complexity of how dietary components like DHA interact with age-related cardiovascular risks, suggesting a need for further studies into personalized approaches for preventing cardiovascular events tailored to different age groups.
Read More
8
We aimed to explore the relationship between docosahexaenoic acid (DHA), a type of omega-3 fatty acid, and cardiovascular health outcomes. Our study involved an in-depth review of ten prospective cohort studies, encompassing a total of 310,955 participants over an average follow-up of nearly nine years.
We found a noteworthy connection indicating that higher levels of omega-3 fatty acids in the blood, especially DHA, may contribute to a lower risk of sudden cardiac death (SCD) and cardiovascular disease (CVD) mortality. Our results highlighted an inverse association, revealing that individuals with elevated DHA levels seemed to benefit from reduced incidence of serious cardiac events.
Notably, the summary hazard ratios we calculated showed significant decreases in risk for those with high DHA levels compared to those with lower levels. This suggests a promising cardio-protective effect of DHA, reinforcing its potential as a valuable nutrient for heart health. In conclusion, we observed that increasing DHA intake may be a critical factor in promoting better cardiovascular outcomes.
We found a noteworthy connection indicating that higher levels of omega-3 fatty acids in the blood, especially DHA, may contribute to a lower risk of sudden cardiac death (SCD) and cardiovascular disease (CVD) mortality. Our results highlighted an inverse association, revealing that individuals with elevated DHA levels seemed to benefit from reduced incidence of serious cardiac events.
Notably, the summary hazard ratios we calculated showed significant decreases in risk for those with high DHA levels compared to those with lower levels. This suggests a promising cardio-protective effect of DHA, reinforcing its potential as a valuable nutrient for heart health. In conclusion, we observed that increasing DHA intake may be a critical factor in promoting better cardiovascular outcomes.
Read More
8
We explored the effects of docosahexaenoic acid (DHA) on cardiovascular disease (CVD) and how it may influence blood pressure (BP). DHA, an omega-3 fatty acid primarily found in fish oil, has piqued interest due to its potential benefits in managing heart health.
Recent findings indicate that DHA plays a significant role in reducing inflammation and improving vascular function. These properties are crucial since high blood pressure is a key risk factor for cardiovascular issues. Studies suggest that incorporating DHA into our diet could lead to lower BP levels, ultimately contributing to a lower risk of CVD.
However, while the evidence is promising, the precise effects of DHA can vary, and dietary sources should be approached thoughtfully to maximize benefits. By adjusting our intake of fatty acids like DHA, we can take proactive steps towards protecting our heart health and managing blood pressure effectively.
In summary, DHA shows great promise in supporting cardiovascular health, particularly concerning blood pressure management, highlighting the importance of dietary recommendations in preventing heart disease.
Recent findings indicate that DHA plays a significant role in reducing inflammation and improving vascular function. These properties are crucial since high blood pressure is a key risk factor for cardiovascular issues. Studies suggest that incorporating DHA into our diet could lead to lower BP levels, ultimately contributing to a lower risk of CVD.
However, while the evidence is promising, the precise effects of DHA can vary, and dietary sources should be approached thoughtfully to maximize benefits. By adjusting our intake of fatty acids like DHA, we can take proactive steps towards protecting our heart health and managing blood pressure effectively.
In summary, DHA shows great promise in supporting cardiovascular health, particularly concerning blood pressure management, highlighting the importance of dietary recommendations in preventing heart disease.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Improved cardiovascular health
Minami Nutrition provides high-quality products, such as the Algae Omega-3. This algae-based source of omega-3 is a superb replacement for fish oil. I saw improvements in my cardiovascular health and cholesterol levels. I highly recommend it to anyone pursuing a healthy lifestyle, particularly vegetarians and vegans.
Read More
8.8
Reduces inflammation
Groovy! This high-quality product contains natural omega-3 acids from algae, which help to keep the body clear of inflammation, thus reducing the risk of cardiovascular disease and high cholesterol. It is a fantastic alternative to fish oil for both vegans and vegetarians. The flavour is pleasant, and as always with Garden of Life, the packaging is delightful!
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Hamaya R, Cook NR, Sesso HD, Buring JE, Manson JE. A Bayesian Analysis of the VITAL Trial: Effects of Omega-3 Fatty Acid Supplementation on Cardiovascular Events. Am J Clin Nutr. 2025. doi:10.1016/j.ajcnut.2025.02.028
- Liboriussen C, Nygaard L, Jensen JD, Schmidt EB, Glerup RI, et al. Low Plasma Marine N-3 Polyunsaturated Fatty Acids are Associated with Increased Risk of Cardiovascular Events in Patients Treated with Maintenance Hemodialysis. J Ren Nutr. 2025. doi:10.1053/j.jrn.2025.02.001
- Yunoki K, Matsumi H, Miyoshi T, Kubo M, Hata Y, et al. Clinical Significance of Serum Omega-3 Fatty Acids on Endothelial Function in Patients with Coronary Artery Disease Under Statin Therapy. J Cardiovasc Dev Dis. 2025;12. doi:10.3390/jcdd12020060
- Ren Y, Chen B, Zhang H, Xu S. A cohort study reveals shared and distinct serum metabolic biomarkers for major adverse cardiovascular events in middle-aged and older adults. Geroscience. 2025. doi:10.1007/s11357-025-01544-6
- Tseng PT, Zeng BY, Hsu CW, Liang CS, Stubbs B, et al. The Optimal Dosage and Duration of ω-3 PUFA Supplementation in Heart Failure Management: Evidence from a Network Meta-Analysis. Adv Nutr. 2025;16:100366. doi:10.1016/j.advnut.2025.100366
- Kim JY, Kong SYJ, Jung E, Cho YS. Omega-3 Fatty Acids as Potential Predictors of Sudden Cardiac Death and Cardiovascular Mortality: A Systematic Review and Meta-Analysis. J Clin Med. 2024;14. doi:10.3390/jcm14010026
- Arghavani H, Bilodeau JF, Rudkowska I. Association Between Circulating Fatty Acids and Blood Pressure: A Review. Curr Nutr Rep. 2025;14:15. doi:10.1007/s13668-024-00602-3
- Li J, Guo J, Yuen M, Yuen H, Peng Q. The comparative effects of ω-7 fatty acid-rich sea buckthorn oil and ω-3 fatty acid-rich DHA algal oil on improving high-fat diet-induced hyperlipidemia. Food Funct. 2025;16:1241. doi:10.1039/d4fo04961f
- Lamon-Fava S. Associations between omega-3 fatty acid-derived lipid mediators and markers of inflammation in older subjects with low-grade chronic inflammation. Prostaglandins Other Lipid Mediat. 2025;176:106948. doi:10.1016/j.prostaglandins.2025.106948
- Berkowitz L, Echeverría G, Salazar C, Faúndez C, Coe CL, et al. Lipidomic Signature of Healthy Diet Adherence and Its Association with Cardiometabolic Risk in American Adults. Nutrients. 2024;16. doi:10.3390/nu16233995
- O'Keefe EL, O'Keefe JH, Abuissa H, Metzinger M, Murray E, et al. Omega-3 and Risk of atrial fibrillation: Vagally-mediated double-edged sword. Prog Cardiovasc Dis. 2024. doi:10.1016/j.pcad.2024.11.003
- So J, Yao JH, Magadmi R, Matthan NR, Lamon-Fava S. Sex differences in lipid mediators derived from omega-3 fatty acids in older individuals with low-grade chronic inflammation. Prostaglandins Leukot Essent Fatty Acids. 2024;203:102655. doi:10.1016/j.plefa.2024.102655
- Choi GY, Calder PC. The differential effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovascular risk factors: an updated systematic review of randomized controlled trials. Front Nutr. 2024;11:1423228. doi:10.3389/fnut.2024.1423228
- Shi F, Chowdhury R, Sofianopoulou E, Koulman A, Sun L, et al. Association of circulating fatty acids with cardiovascular disease risk: analysis of individual-level data in three large prospective cohorts and updated meta-analysis. Eur J Prev Cardiol. 2025;32:233. doi:10.1093/eurjpc/zwae315
- Koutsaliaris IK, Pantazi D, Tsouka AN, Argyropoulou O, Tellis CC, et al. Differential Effect of Omega-3 Fatty Acids on Platelet Inhibition by Antiplatelet Drugs In Vitro. Int J Mol Sci. 2024;25. doi:10.3390/ijms251810136
