' 
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Vitamin B12 (as Methylcobalamin from culture of Saccharomyces cerevisiae)
1,000 mcg
41667%
Raw Probiotic & Enzyme BlendLipase, Protease, Aspergillopepsin, beta-Glucanase, Cellulase, Bromelain, Phytase, Lactase, Papain, Peptidase, Pectinase, Hemicellulase, Xylanase, [Lactobacillus plantarum, Lactobacillus bulgaricus] (500 Million CFU)
60 mg
+
Raw Organic Fruit & Vegetable BlendOrganic Apple (fruit), Organic Beet (root), Organic Broccoli (stalk & flower), Organic Carrot (root), Organic Spinach (leaf), Organic Tomato (fruit), Organic Strawberry (fruit), Organic Tart Cherry (fruit), Organic Blackberry (fruit), Organic Green Bell Pepper (fruit), Organic Brussels Sprout (leaf), Organic Blueberry (fruit), Organic Ginger (root), Organic Garlic bulb), Organic Green Onion (bulb), Organic Raspberry (fruit), Organic Parsley (leaf), Organic Cauliflower (flower & stem), Organic Red Cabbage (leaf), Organic Kale (leaf), Organic Cucumber (gourd), Organic Celery (stalk), Organic Asparagus (flower & stem)
20 mg
+
The product is found useful for the following medical conditions
Neuropathy details
SCIENTIFIC SCORE
Moderately Effective
Based on 13 Researches
8.2
USERS' SCORE
Good
Based on 2 Reviews
8.8
9
Nitrous oxide affects B12 levels
Correlation Between Nitrous Oxide and Functional Vitamin B12 Deficiency Resulting in Subacute Combined Degeneration of the Spinal Cord: A Case Report.
Most Relevant Research
We examined a remarkable case involving the effects of nitrous oxide (NO) on vitamin B12 levels and its neurological consequences. Nitrous oxide is not just a useful tool in medical and food industries; it is sometimes misused by young adults for recreational purposes. This misuse can lead to functional vitamin B12 deficiency, which in turn may result in serious neurological issues like peripheral neuropathy and subacute combined degeneration (SACD) of the spinal cord.
In this specific case, we identified a functional B12 deficiency, characterized by borderline normal serum vitamin B12 levels, but with increased levels of methylmalonic acid and homocysteine—key indicators of vitamin deficiency. Remarkably, after administering intramuscular vitamin B12, we observed significant clinical improvement in the patient’s condition. This suggests that vitamin B12 treatment can be effective in reversing the neurological damage caused by nitrous oxide-induced deficiency.
Our findings highlight the importance of recognizing the neurological risks associated with nitrous oxide misuse and the potential for vitamin B12 treatment to alleviate serious symptoms in affected individuals.
In this specific case, we identified a functional B12 deficiency, characterized by borderline normal serum vitamin B12 levels, but with increased levels of methylmalonic acid and homocysteine—key indicators of vitamin deficiency. Remarkably, after administering intramuscular vitamin B12, we observed significant clinical improvement in the patient’s condition. This suggests that vitamin B12 treatment can be effective in reversing the neurological damage caused by nitrous oxide-induced deficiency.
Our findings highlight the importance of recognizing the neurological risks associated with nitrous oxide misuse and the potential for vitamin B12 treatment to alleviate serious symptoms in affected individuals.
10
Neuropathy resolved
Most Useful Review
Cleared up what I thought was neuropathy in my legs. The tingling in my left thigh was maddening. It wasn't a spinal issue, and the sensation was quite inconvenient. My doctor suggested a daily dose of B-12, which I took. What I believed was neuropathy has completely vanished. I'm extremely pleased. If experiencing similar symptoms, consider a B-12 deficiency.
Anemia details
SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8.8
USERS' SCORE
Good
Based on 12 Reviews
8.7
9
Vitamin B12 effectively treats anemia
An Unusual Case of Hemolytic Anemia: A Case Report.
Most Relevant Research
We observed a compelling case surrounding the impact of vitamin B12 on anemia, particularly in a 62-year-old man facing severe deficiencies due to factors like drug use, hepatitis C, smoking, and alcoholism. Initially, this patient presented with symptoms such as fatigue, fever, and confusion, raising concerns about more critical conditions like thrombotic thrombocytopenic purpura (TTP). Laboratory tests indicated severe pancytopenia and signs of hemolysis, making the situation quite alarming.
However, further investigation revealed that the root cause was a significant deficiency of vitamin B12 coupled with folate. This discovery shifted our focus toward treatment strategies that addressed the underlying deficiency rather than applying unnecessary and invasive procedures like plasmapheresis. Upon administering vitamin B12 injections, we witnessed a refreshing turnaround as the patient's blood counts began to normalize progressively, along with an alleviation of symptoms.
This case emphasizes the necessity for healthcare providers to consider vitamin B12 deficiency when diagnosing patients presenting with hemolytic anemia and thrombocytopenia. By doing so, unnecessary treatments can be avoided, paving the way for a swift recovery through proper vitamin supplementation.
However, further investigation revealed that the root cause was a significant deficiency of vitamin B12 coupled with folate. This discovery shifted our focus toward treatment strategies that addressed the underlying deficiency rather than applying unnecessary and invasive procedures like plasmapheresis. Upon administering vitamin B12 injections, we witnessed a refreshing turnaround as the patient's blood counts began to normalize progressively, along with an alleviation of symptoms.
This case emphasizes the necessity for healthcare providers to consider vitamin B12 deficiency when diagnosing patients presenting with hemolytic anemia and thrombocytopenia. By doing so, unnecessary treatments can be avoided, paving the way for a swift recovery through proper vitamin supplementation.
9.5
Improved haemoglobin
Most Useful Review
The composition is good, and the product is very beneficial. The doctor prescribed this drug for my B-12 deficiency anaemia, which caused broken nails, dizziness, and shortness of breath. After a three-month course, I experienced a significant improvement; my haemoglobin levels normalised, and I no longer have shortness of breath. I highly recommend this! ❤️
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.4
USERS' SCORE
Good
Based on 3 Reviews
8.6
0
Vitamin B12 ineffective for CFS
N of 1 trials. Managing patients with chronic fatigue syndrome: two case reports.
Most Relevant Research
We explored the effectiveness of high-dose vitamin B12 injections on chronic fatigue syndrome (CFS) through two case reports that utilized N of 1 trials. This approach allowed us to make tailored treatment decisions based on individual responses to the therapy.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
9.5
Mood improvement
Most Useful Review
This is the most effective B-12 I've tried! It's gentle on my stomach, and I've noticed a remarkable boost in my mood and energy in under a week. Previously, various other brands either caused discomfort or were ineffective. If I skip my daily pill for about a week, I start to feel fatigued and moody, but this restores me instantly.
Depression details
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7
USERS' SCORE
Good
Based on 4 Reviews
8.6
2
Vitamin B12 shows no benefit for depression
Assessment of Vitamin B12 Efficacy on Cognitive Memory Function and Depressive Symptoms: A Systematic Review and Meta-Analysis.
Most Relevant Research
We assessed the effect of vitamin B12 supplementation on depressive symptoms by reviewing several randomized controlled trials (RCTs). Our analysis focused on participants who may experience mild cognitive impairment, an area where low vitamin B12 levels could potentially raise the risk of depression.
After a thorough examination of studies, we found that the included trials did not support a significant benefit of vitamin B12 for alleviating depressive symptoms. In our evaluation of three studies focusing specifically on depression, the average difference in symptoms was negligible, indicating no real effect.
This outcome reflects that while vitamin B12 is essential for various bodily functions, its role in improving mood and reducing depression symptoms may not be as effective as some might hope. Further exploration is still warranted to better understand the contexts in which vitamin B12 could be beneficial.
After a thorough examination of studies, we found that the included trials did not support a significant benefit of vitamin B12 for alleviating depressive symptoms. In our evaluation of three studies focusing specifically on depression, the average difference in symptoms was negligible, indicating no real effect.
This outcome reflects that while vitamin B12 is essential for various bodily functions, its role in improving mood and reducing depression symptoms may not be as effective as some might hope. Further exploration is still warranted to better understand the contexts in which vitamin B12 could be beneficial.
9.5
Improved mood
Most Useful Review
Amazing B12! This supplement has made a massive difference to my energy levels and mood swings. After taking it alongside a B-complex for just three days, I felt fantastic. I've struggled with severe depression for years, but these two supplements truly work for me. I take them with a fruit smoothie in the morning, and I can’t recommend them enough; simply awesome!
Bone Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.5
9.5
Relieved muscle pain
Most Useful Review
I purchased it to alleviate muscle pain. Now, on the fourth day of use, I find that after an unfamiliar squat, I no longer feel the bone pain I previously experienced, even when turning over. I recommend it.
Insomnia details
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.9
USERS' SCORE
Good
Based on 3 Reviews
8.5
8
Vitamin B12 promotes sleep in rats
Effects of intravenously administered vitamin B12 on sleep in the rat.
Most Relevant Research
We sought to determine the impact of vitamin B12 (VB12) on sleep patterns in rats, particularly considering its potential benefits for those struggling with insomnia. By giving rats a daily intravenous dose of VB12, we monitored their sleep using polysomnographic recordings over a four-day period.
During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.
Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.
During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.
Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.
8.3
Significant improvement
Most Useful Review
After suffering from insomnia despite taking melatonin, I switched to this B12 upon a friend's suggestion. It has significantly helped reduce stress and improved my sleep quality. Although there are only 30 capsules, each contains 1000 micrograms of B12, and the product is raw and healthy with no fillers. After three months, I take two capsules daily, and I've experienced a 30% improvement in migraines and a notable enhancement in brain concentration.
Tinnitus details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.5
7.5
Significant improvement
Most Useful Review
Following online advice about managing tinnitus, I began taking B vitamins, B12, and zinc. After a while, I've noticed a significant improvement in my tinnitus.
Heart Attack details
SCIENTIFIC SCORE
Likely Ineffective
Based on 2 Researches
3
USERS' SCORE
Good
Based on 2 Reviews
8.3
4
Vitamin B12 shows no heart attack benefit
Urinary excretion of homocysteine thiolactone and the risk of acute myocardial infarction in coronary artery disease patients: the WENBIT trial.
Most Relevant Research
In a recent study, we delved into the role of homocysteine thiolactone, a metabolite linked to heart disease, in predicting the risk of acute myocardial infarction (AMI). Conducted with a sizable group of 2049 patients suspected of having coronary artery disease (CAD), the trial was meticulously designed as a double-blind clinical intervention.
Participants were divided randomly into four distinct groups, receiving a combination of folic acid and other B vitamins or a placebo. Notably, we measured urinary levels of homocysteine thiolactone at different points throughout the study to draw correlations with heart attack incidents.
Our analysis revealed that while the homocysteine thiolactone/creatinine ratio was a significant predictor of AMI risk, there was no observable effect from the vitamin B treatments received by participants. This suggests that vitamin B12, when part of a group of B vitamins, did not independently influence the likelihood of having a heart attack.
Ultimately, we found that higher levels of homocysteine thiolactone correlated with a greater risk of AMI, but the combination of vitamin B treatments did not alter this outcome. This points to the potential of homocysteine thiolactone as an important marker in understanding cardiovascular health.
Participants were divided randomly into four distinct groups, receiving a combination of folic acid and other B vitamins or a placebo. Notably, we measured urinary levels of homocysteine thiolactone at different points throughout the study to draw correlations with heart attack incidents.
Our analysis revealed that while the homocysteine thiolactone/creatinine ratio was a significant predictor of AMI risk, there was no observable effect from the vitamin B treatments received by participants. This suggests that vitamin B12, when part of a group of B vitamins, did not independently influence the likelihood of having a heart attack.
Ultimately, we found that higher levels of homocysteine thiolactone correlated with a greater risk of AMI, but the combination of vitamin B treatments did not alter this outcome. This points to the potential of homocysteine thiolactone as an important marker in understanding cardiovascular health.
8
Energy boost
Most Useful Review
This is a high-quality product. It boosts concentration and energy while supporting metabolism and heart health. Folic acid and niacin enhance overall well-being. The natural composition and high dosage of active ingredients replenish deficiencies in the body. The pills are easy to swallow, have a neutral taste, and come in a convenient package.
Migraine details
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.7
USERS' SCORE
Good
Based on 2 Reviews
8.3
7
Vitamin B12 deficiency and migraines
The correlation between vitamin B12 serum levels and migraine: a case-control study.
Most Relevant Research
We examined the connection between vitamin B12 serum levels and migraine, both chronic and episodic. In our study, we compared two groups: 90 individuals suffering from migraines and 90 healthy participants. We measured the serum vitamin B12 levels of all subjects using a method known as enzyme-linked immunosorbent assay (ELISA).
Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.
This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.
Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.
This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.
8.8
Migraine relief
Most Useful Review
I've noticed an improvement in my migraine headaches; I plan to continue using it.
Back Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.3
USERS' SCORE
Good
Based on 6 Reviews
8
9
Vitamin B12 aids low back pain
Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study.
Most Relevant Research
We conducted a thorough investigation to understand whether intramuscular vitamin B12 treatment could effectively relieve low back pain. This study was designed as a double-blind, placebo-controlled trial involving 60 patients aged 18 to 65 who suffered from mechanical low back pain or sciatic neuritis. Each participant had a history of back pain lasting from six months to five years and reported significant pain intensity according to a standard scale.
By comparing two groups—the one receiving vitamin B12 injections and the other receiving a placebo—we focused on measuring changes in pain and disability levels, as well as any changes in paracetamol consumption. What we found was quite impressive. Both groups reported decreases in pain and disability. However, those who received vitamin B12 showed significantly better results compared to the placebo group. The difference was not only notable in terms of pain relief but also in lower dependency on paracetamol for pain management.
Our findings confirm that vitamin B12 can be a safe and effective option for patients with low back pain, particularly for those who don't have any signs of nutritional deficiency. The data suggest that patients experiencing this common ailment could consider discussing vitamin B12 treatment with their healthcare provider as part of their pain management strategy.
By comparing two groups—the one receiving vitamin B12 injections and the other receiving a placebo—we focused on measuring changes in pain and disability levels, as well as any changes in paracetamol consumption. What we found was quite impressive. Both groups reported decreases in pain and disability. However, those who received vitamin B12 showed significantly better results compared to the placebo group. The difference was not only notable in terms of pain relief but also in lower dependency on paracetamol for pain management.
Our findings confirm that vitamin B12 can be a safe and effective option for patients with low back pain, particularly for those who don't have any signs of nutritional deficiency. The data suggest that patients experiencing this common ailment could consider discussing vitamin B12 treatment with their healthcare provider as part of their pain management strategy.
9.5
Muscle relief
Most Useful Review
Muscle pain relief was my goal. After my fourth session with unfamiliar squats, I no longer experienced the painful muscle discomfort I felt previously, even when turning over. I highly recommend this.
Dizziness details
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.1
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.8
9
Vitamin B12 improves dizziness symptoms
Acute presentation of dizziness in vitamin B12 deficient old patient of cardiac disease: a case report.
Most Relevant Research
We observed a fascinating case involving an elderly patient who experienced acute dizziness, ataxia, and imbalance shortly after receiving a pacemaker. Upon investigation, we discovered that her symptoms were linked to a significant deficiency in vitamin B12.
The patient's vitamin B12 levels were notably low, accompanied by increased plasma homocysteine and methylmalonic acid levels. Despite her neurological symptoms suggesting peripheral neuropathy, her brain scan returned normal results. What stood out to us was the absence of the typical hematological signs often associated with vitamin B12 deficiency.
Importantly, the patient responded remarkably well to treatment with parenteral vitamin B12, leading to a resolution of her dizziness. This case underscores the importance of considering vitamin B12 deficiency, especially in elderly patients who present with neuropsychiatric symptoms. As we reflected on this, it became clear that proper recognition and treatment of vitamin B12 deficiency can significantly influence patient outcomes.
The patient's vitamin B12 levels were notably low, accompanied by increased plasma homocysteine and methylmalonic acid levels. Despite her neurological symptoms suggesting peripheral neuropathy, her brain scan returned normal results. What stood out to us was the absence of the typical hematological signs often associated with vitamin B12 deficiency.
Importantly, the patient responded remarkably well to treatment with parenteral vitamin B12, leading to a resolution of her dizziness. This case underscores the importance of considering vitamin B12 deficiency, especially in elderly patients who present with neuropsychiatric symptoms. As we reflected on this, it became clear that proper recognition and treatment of vitamin B12 deficiency can significantly influence patient outcomes.
9.5
Improved symptoms
Most Useful Review
The composition is good, and the product is very useful. The doctor prescribed this specific medication for my B-12 deficiency anaemia, which caused my nails to break and dizziness, along with shortness of breath. After a three-month course, I noticed significant improvement; my haemoglobin levels are now normal, and the shortness of breath has disappeared. I highly recommend it ❤️
Chest Pain details
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.7
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.7
8
Vitamin B12 improves chest pain
Pseudo-Thrombotic Microangiopathy Secondary to Vitamin B12 Deficiency.
Most Relevant Research
We observed an intriguing case involving a patient suffering from chest pain alongside severe anemia and vitamin B12 deficiency. The patient, a 44-year-old Hispanic woman, presented with escalating non-radiating chest pain, fatigue, and shortness of breath over three weeks. Her lab results showed critical pancytopenia and macrocytosis, raising concerns about a rare condition known as pseudo-thrombotic microangiopathy (TMA), which can occur due to vitamin B12 deficiency.
Initially diagnosed with pseudo-TMA, the patient was undergoing plasmapheresis and steroid treatment. However, once she received daily injections of 1000 micrograms of parenteral vitamin B, her condition began to improve significantly, leading to a resolution of her symptoms, including the chest pain.
This case highlights the importance of considering vitamin B12 deficiency in patients presenting with hemolytic anemia and chest pain. Often misdiagnosed as other conditions, patients may receive unnecessary treatments that delay the correct intervention. It’s vital to recognize the role of sufficient vitamin B12 in addressing specific symptoms like chest pain in such contexts.
Initially diagnosed with pseudo-TMA, the patient was undergoing plasmapheresis and steroid treatment. However, once she received daily injections of 1000 micrograms of parenteral vitamin B, her condition began to improve significantly, leading to a resolution of her symptoms, including the chest pain.
This case highlights the importance of considering vitamin B12 deficiency in patients presenting with hemolytic anemia and chest pain. Often misdiagnosed as other conditions, patients may receive unnecessary treatments that delay the correct intervention. It’s vital to recognize the role of sufficient vitamin B12 in addressing specific symptoms like chest pain in such contexts.
7.5
Reduced pain
Most Useful Review
It’s effective; I have a shoulder problem, and my friend advised me to try taking B12. After about two weeks, I feel better and my chest pain has decreased significantly.
Headache details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.5
8
Vitamin B12 deficiency linked to migraines
The correlation between vitamin B12 serum levels and migraine: a case-control study.
Most Relevant Research
We conducted a case-control study to investigate the link between vitamin B12 serum levels and migraine, which affects so many people but lacks a fully understood cause. Our research included 90 individuals experiencing migraines—split into those with chronic migraines and those with episodic migraines—matched against 90 healthy participants.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
8.8
Migraine improvement
Most Useful Review
Seems that my migraines are improving; I will continue using it.
