Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.6
USERS' SCORE
Good
Based on 6 Reviews
8.1
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Thiamin (B1 from culture of S.cerevisiae)
5 mg
417%
Riboflavin (B2 from culture of S. cerevisiae)
10 mg
769%
Niacin (as Niacinamide from culture of S. cerevisiae)
45 mg
281%
Vitamin B6 (from culture of S. cerevisiae)
10 mg
588%
Folate (from culture of S. cerevisiae)
450 mcg DFE
113%
Vitamin B12 (as Methylcobalamin from culture of S. cerevisiae)
133 mcg
5542%
Biotin (from culture of S. cerevisiae)
325 mcg
1083%
Pantothenic Acid (from culture of S. cerevisiae)
45 mg
900%
RAW Organic Fruit & Vegetable Blend
360 mg
+
RAW Probiotic & Enzyme Blend
60 mg
+
Top Medical Research Studies
9.5
Pediatric migraine treatment with riboflavin
Our examination focused on the effectiveness of riboflavin, a form of Vitamin B2, in treating migraines in children and adolescents aged six to 18. We conducted a retrospective observational study involving 42 patients, where we measured the frequency, intensity, and duration of their headaches.
Remarkably, we found significant reductions in headache days per month, with intensity and duration also decreasing. Most importantly, riboflavin helped decrease the reliance on acute medication and fewer missed school days. We suggest this affordable treatment as a safe option for pediatric migraines.
Remarkably, we found significant reductions in headache days per month, with intensity and duration also decreasing. Most importantly, riboflavin helped decrease the reliance on acute medication and fewer missed school days. We suggest this affordable treatment as a safe option for pediatric migraines.
Read More
8
Vitamin B-complex shows migraine relief
We explored how vitamin B-complex supplementation might help reduce migraines in children by lowering serum homocysteine levels. In a randomized double-blinded trial with 90 kids under 15, one group received vitamin B-complex while the other got a placebo for six months.
After the treatment, we observed that the children taking vitamin B experienced fewer headaches, lower headache severity, and less overall headache-related disability compared to the placebo group.
While the results are promising, indicating a potential benefit of vitamin B-complex, more research is necessary to validate these findings.
After the treatment, we observed that the children taking vitamin B experienced fewer headaches, lower headache severity, and less overall headache-related disability compared to the placebo group.
While the results are promising, indicating a potential benefit of vitamin B-complex, more research is necessary to validate these findings.
Read More
9
We explored the impact of B vitamin supplementation on women suffering from episodic migraines. In this double-blind, placebo-controlled trial involving 120 participants, we found that those taking B vitamins experienced a significant decrease in headache frequency and migraine-related disability compared to the placebo group.
Over 12 weeks, the vitamin groups also needed fewer abortive medications. While results are promising, further research with larger samples is necessary to confirm these findings and better understand the long-term benefits of B vitamins for migraine sufferers.
Over 12 weeks, the vitamin groups also needed fewer abortive medications. While results are promising, further research with larger samples is necessary to confirm these findings and better understand the long-term benefits of B vitamins for migraine sufferers.
Read More
Most Useful Reviews
9
Much fewer headaches
247 people found this helpful
The jar is glass and features a protective membrane. The content consists of a rich blend of fruits and vegetables, probiotics, and enzymes, making this a completely natural preparation. The capsules are clear with sand-coloured powder inside. B vitamins are vital for health, preventing chronic fatigue and pain, and improving liver function. I often suffered from headaches and tension in my temples, but now they have significantly decreased. This is what matters most to me. I would recommend purchasing this!
Read More
9
Less headache pain
15 people found this helpful
The jar is glass, with a protective membrane. The content consists of a rich mixture of fruits and vegetables, probiotics, and enzymes. This preparation is fully natural, derived from unprocessed ingredients. The capsules are moderately large and transparent, containing sand-coloured powder. B vitamins are vital for human health, preventing chronic fatigue and pain, and improving women's overall health. Personally, I had frequent headaches and tension in my temples, but now they are much less. Recommended for enhancing brain function and blood circulation.
Read More
7.5
Headaches diminished
52 people found this helpful
I noticed visible effects after my first use! I cannot prescribe this product, but I can recommend it based on my personal experience. It has helped alleviate my headaches, reduced flatulence, improved my sleep quality, and had no adverse effects on my stomach. I've been using it for two months and feel a noticeable difference. If my feedback is of any use, please indicate that!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.6
- All Researches
9.5
Pediatric migraine treatment with riboflavin
Our examination focused on the effectiveness of riboflavin, a form of Vitamin B2, in treating migraines in children and adolescents aged six to 18. We conducted a retrospective observational study involving 42 patients, where we measured the frequency, intensity, and duration of their headaches.
Remarkably, we found significant reductions in headache days per month, with intensity and duration also decreasing. Most importantly, riboflavin helped decrease the reliance on acute medication and fewer missed school days. We suggest this affordable treatment as a safe option for pediatric migraines.
Remarkably, we found significant reductions in headache days per month, with intensity and duration also decreasing. Most importantly, riboflavin helped decrease the reliance on acute medication and fewer missed school days. We suggest this affordable treatment as a safe option for pediatric migraines.
Read More
9
We looked at a rare case involving a 14-year-old girl experiencing persistent headaches and high intracranial pressure. Testing revealed a significant plasma homocysteine level and a mutation related to the MTHFR gene, previously unreported in cerebral venous thrombosis (CVT) cases.
After administering anticoagulation therapy and B-vitamin supplements, her symptoms improved significantly within a month, with no headaches reported and reduced thrombosis. This case highlights the importance of checking for specific genetic factors when dealing with unusual CVT cases and underscores the potential for successful treatment.
After administering anticoagulation therapy and B-vitamin supplements, her symptoms improved significantly within a month, with no headaches reported and reduced thrombosis. This case highlights the importance of checking for specific genetic factors when dealing with unusual CVT cases and underscores the potential for successful treatment.
Read More
9
We explored the impact of B vitamin supplementation on women suffering from episodic migraines. In this double-blind, placebo-controlled trial involving 120 participants, we found that those taking B vitamins experienced a significant decrease in headache frequency and migraine-related disability compared to the placebo group.
Over 12 weeks, the vitamin groups also needed fewer abortive medications. While results are promising, further research with larger samples is necessary to confirm these findings and better understand the long-term benefits of B vitamins for migraine sufferers.
Over 12 weeks, the vitamin groups also needed fewer abortive medications. While results are promising, further research with larger samples is necessary to confirm these findings and better understand the long-term benefits of B vitamins for migraine sufferers.
Read More
9
We delved into how Vitamin B2 could aid in preventing migraines, traditionally tackled with medications. This systematic review and meta-analysis involved rigorous searching across several databases, analyzing data from nine studies with over 670 participants.
We discovered that a daily dose of 400 mg of Vitamin B2 for three months notably reduced the number of migraine days, their duration, frequency, and pain intensity. These findings support the potential of Vitamin B2 as an effective supplement for those suffering from migraines.
We discovered that a daily dose of 400 mg of Vitamin B2 for three months notably reduced the number of migraine days, their duration, frequency, and pain intensity. These findings support the potential of Vitamin B2 as an effective supplement for those suffering from migraines.
Read More
8
We explored the potential of riboflavin, or vitamin B2, as a treatment for migraine prevention in adults. The findings suggest that riboflavin can be recommended for adults dealing with migraines, albeit with no proven benefit for children.
While adverse events are minimal, caution is advised when considering other nutraceuticals like coenzyme Q10 and feverfew, as their effectiveness and safety require further research.
Overall, vitamin B2 shows promise for adults struggling with headaches, but more robust studies are needed to confirm its efficacy.
While adverse events are minimal, caution is advised when considering other nutraceuticals like coenzyme Q10 and feverfew, as their effectiveness and safety require further research.
Overall, vitamin B2 shows promise for adults struggling with headaches, but more robust studies are needed to confirm its efficacy.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Much fewer headaches
247 people found this helpful
The jar is glass and features a protective membrane. The content consists of a rich blend of fruits and vegetables, probiotics, and enzymes, making this a completely natural preparation. The capsules are clear with sand-coloured powder inside. B vitamins are vital for health, preventing chronic fatigue and pain, and improving liver function. I often suffered from headaches and tension in my temples, but now they have significantly decreased. This is what matters most to me. I would recommend purchasing this!
Read More
9
Less headache pain
15 people found this helpful
The jar is glass, with a protective membrane. The content consists of a rich mixture of fruits and vegetables, probiotics, and enzymes. This preparation is fully natural, derived from unprocessed ingredients. The capsules are moderately large and transparent, containing sand-coloured powder. B vitamins are vital for human health, preventing chronic fatigue and pain, and improving women's overall health. Personally, I had frequent headaches and tension in my temples, but now they are much less. Recommended for enhancing brain function and blood circulation.
Read More
7.5
Headaches diminished
52 people found this helpful
I noticed visible effects after my first use! I cannot prescribe this product, but I can recommend it based on my personal experience. It has helped alleviate my headaches, reduced flatulence, improved my sleep quality, and had no adverse effects on my stomach. I've been using it for two months and feel a noticeable difference. If my feedback is of any use, please indicate that!
Read More
7.5
Significantly reduces headaches
3 people found this helpful
This excellent Brain Complex is presented in a glass jar with a protective membrane. The composition is rich, with a natural blend of fruits and vegetables, probiotics, and enzymes. The complex is known as "raw" as its components are derived from unprocessed sources. The capsules are moderately sized, transparent, filled with sand-coloured powder. The B vitamins are crucial for overall wellbeing; they help alleviate chronic fatigue, chronic pain, and enhance liver function. I experienced frequent headaches and tensions, but now they are much less frequent. This is a significant benefit for me.
Read More
6
Reduced headaches
257 people found this helpful
The complex is aptly named "raw," as it is rich in natural ingredients. The mixture includes fruits, vegetables, probiotics, and enzymes, all sourced from unprocessed organic ingredients. The capsules are moderately large and transparent, containing a sand-coloured powder. B vitamins are critical for health, helping to alleviate chronic fatigue and pain, improve liver function, and support women's health. Personally, I frequently experienced headaches and tension in my temples, but since using this product, it has greatly improved.
Read More
Frequently Asked Questions
7.5
Headaches diminished
52 people found this helpful
I noticed visible effects after my first use! I cannot prescribe this product, but I can recommend it based on my personal experience. It has helped alleviate my headaches, reduced flatulence, improved my sleep quality, and had no adverse effects on my stomach. I've been using it for two months and feel a noticeable difference. If my feedback is of any use, please indicate that!
9
Much fewer headaches
247 people found this helpful
The jar is glass and features a protective membrane. The content consists of a rich blend of fruits and vegetables, probiotics, and enzymes, making this a completely natural preparation. The capsules are clear with sand-coloured powder inside. B vitamins are vital for health, preventing chronic fatigue and pain, and improving liver function. I often suffered from headaches and tension in my temples, but now they have significantly decreased. This is what matters most to me. I would recommend purchasing this!
9
Less headache pain
15 people found this helpful
The jar is glass, with a protective membrane. The content consists of a rich mixture of fruits and vegetables, probiotics, and enzymes. This preparation is fully natural, derived from unprocessed ingredients. The capsules are moderately large and transparent, containing sand-coloured powder. B vitamins are vital for human health, preventing chronic fatigue and pain, and improving women's overall health. Personally, I had frequent headaches and tension in my temples, but now they are much less. Recommended for enhancing brain function and blood circulation.
7.5
Significantly reduces headaches
3 people found this helpful
This excellent Brain Complex is presented in a glass jar with a protective membrane. The composition is rich, with a natural blend of fruits and vegetables, probiotics, and enzymes. The complex is known as "raw" as its components are derived from unprocessed sources. The capsules are moderately sized, transparent, filled with sand-coloured powder. The B vitamins are crucial for overall wellbeing; they help alleviate chronic fatigue, chronic pain, and enhance liver function. I experienced frequent headaches and tensions, but now they are much less frequent. This is a significant benefit for me.
6
Reduced headaches
257 people found this helpful
The complex is aptly named "raw," as it is rich in natural ingredients. The mixture includes fruits, vegetables, probiotics, and enzymes, all sourced from unprocessed organic ingredients. The capsules are moderately large and transparent, containing a sand-coloured powder. B vitamins are critical for health, helping to alleviate chronic fatigue and pain, improve liver function, and support women's health. Personally, I frequently experienced headaches and tension in my temples, but since using this product, it has greatly improved.
7.5
No more headaches
Excellent! Previously, I experienced stomach discomfort and headaches with other brands of vitamin B, but this product suits me perfectly, without any side effects. I've been taking it regularly, and I've noticed I feel less fatigued after meals.
9
We delved into how Vitamin B2 could aid in preventing migraines, traditionally tackled with medications. This systematic review and meta-analysis involved rigorous searching across several databases, analyzing data from nine studies with over 670 participants.
We discovered that a daily dose of 400 mg of Vitamin B2 for three months notably reduced the number of migraine days, their duration, frequency, and pain intensity. These findings support the potential of Vitamin B2 as an effective supplement for those suffering from migraines.
We discovered that a daily dose of 400 mg of Vitamin B2 for three months notably reduced the number of migraine days, their duration, frequency, and pain intensity. These findings support the potential of Vitamin B2 as an effective supplement for those suffering from migraines.
9
We explored the impact of B vitamin supplementation on women suffering from episodic migraines. In this double-blind, placebo-controlled trial involving 120 participants, we found that those taking B vitamins experienced a significant decrease in headache frequency and migraine-related disability compared to the placebo group.
Over 12 weeks, the vitamin groups also needed fewer abortive medications. While results are promising, further research with larger samples is necessary to confirm these findings and better understand the long-term benefits of B vitamins for migraine sufferers.
Over 12 weeks, the vitamin groups also needed fewer abortive medications. While results are promising, further research with larger samples is necessary to confirm these findings and better understand the long-term benefits of B vitamins for migraine sufferers.
8
We investigated how dietary intake of folate, or vitamin B, relates to severe headaches among adults in the U.S. By analyzing data from the National Health and Nutrition Examination Survey involving nearly 10,000 participants, we found that higher folate intake was significantly linked to lower instances of severe headaches.
Specifically, those with higher folate levels reported fewer severe headache episodes, particularly women aged 20-50, who could benefit from increased folate awareness. These findings suggest that diet could play a role in headache management.
Specifically, those with higher folate levels reported fewer severe headache episodes, particularly women aged 20-50, who could benefit from increased folate awareness. These findings suggest that diet could play a role in headache management.
8
Vitamin B-complex shows migraine relief
We explored how vitamin B-complex supplementation might help reduce migraines in children by lowering serum homocysteine levels. In a randomized double-blinded trial with 90 kids under 15, one group received vitamin B-complex while the other got a placebo for six months.
After the treatment, we observed that the children taking vitamin B experienced fewer headaches, lower headache severity, and less overall headache-related disability compared to the placebo group.
While the results are promising, indicating a potential benefit of vitamin B-complex, more research is necessary to validate these findings.
After the treatment, we observed that the children taking vitamin B experienced fewer headaches, lower headache severity, and less overall headache-related disability compared to the placebo group.
While the results are promising, indicating a potential benefit of vitamin B-complex, more research is necessary to validate these findings.
References
- Tepper SJ, Tepper K. Nutraceuticals and Headache 2024: Riboflavin, Coenzyme Q10, Feverfew, Magnesium, Melatonin, and Butterbur. Curr Pain Headache Rep. 2025;29:33. doi:10.1007/s11916-025-01358-3
- Tian S, Yu X, Wu L, Zheng H, Zhong X, et al. Vitamin B and folate intake are associated with lower risk of severe headache or migraine in adults: An analysis based on NHANES 1999-2004. Nutr Res. 2024;121:51. doi:10.1016/j.nutres.2023.11.008
- Sadeghvand S, Barzegar M, Shiva S, Tarmahi V, Hamed H, et al. The Effects of Vitamin B-Complex Supplementation on Serum Homocysteine Levels and Migraine Severity in Children A Randomized Controlled Trial. Iran J Child Neurol. 2023;17:143. doi:10.22037/ijcn.v17i3.40053
- Tian S, Wu L, Zheng H, Zhong X, Liu M, et al. Association between dietary folate intake and severe headache among adults in the USA: a cross-sectional survey. Br J Nutr. 2024;131:438. doi:10.1017/S000711452300137X
- Zhang M, Shi B, Zhao M. Cerebral venous thrombosis with hyperhomocysteinemia due to loss of heterozygosity at methylenetetrahydrofolate reductase (MTHFR) locus: a case report. BMC Neurol. 2023;23:154. doi:10.1186/s12883-023-03200-y
- Li D, Guo Y, Xia M, Zhang J, Zang W. Dietary intake of thiamine and riboflavin in relation to severe headache or migraine: A cross-sectional survey. Headache. 2022;62:1133. doi:10.1111/head.14384
- Nematgorgani S, Razeghi-Jahromi S, Jafari E, Togha M, Rafiee P, et al. B vitamins and their combination could reduce migraine headaches: A randomized double-blind controlled trial. Curr J Neurol. 2022;21:105. doi:10.18502/cjn.v21i2.10494
- Chen YS, Lee HF, Tsai CH, Hsu YY, Fang CJ, et al. Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis. Nutr Neurosci. 2022;25:1801. doi:10.1080/1028415X.2021.1904542
- Das R, Qubty W. Retrospective Observational Study on Riboflavin Prophylaxis in Child and Adolescent Migraine. Pediatr Neurol. 2021;114:5. doi:10.1016/j.pediatrneurol.2020.09.009
- Yamanaka G, Suzuki S, Takeshita M, Go S, Morishita N, et al. Effectiveness of low-dose riboflavin as a prophylactic agent in pediatric migraine. Brain Dev. 2020;42:523. doi:10.1016/j.braindev.2020.04.002
- Liampas IN, Siokas V, Aloizou AM, Tsouris Z, Dastamani M, et al. Pyridoxine, folate and cobalamin for migraine: A systematic review. Acta Neurol Scand. 2020;142:108. doi:10.1111/ane.13251
- Chutko LS, Surushkina SY, Yakovenko EA, Rozhkova AV, Volov MB, et al. [Possibilities of using Cytoflavin in the treatment of cognitive and emotional disorders in patients with tension headaches]. Zh Nevrol Psikhiatr Im S S Korsakova. 2019;119:32. doi:10.17116/jnevro201911911132
- Bravaccio C, Terrone G, Rizzo R, Gulisano M, Tosi M, et al. Use of nutritional supplements based on melatonin, tryptophan and vitamin B6 (Melamil Tripto®) in children with primary chronic headache, with or without sleep disorders: a pilot study. Minerva Pediatr. 2020;72:30. doi:10.23736/S0026-4946.19.05533-6
- Togha M, Razeghi Jahromi S, Ghorbani Z, Martami F, Seifishahpar M. Serum Vitamin B12 and Methylmalonic Acid Status in Migraineurs: A Case-Control Study. Headache. 2019;59:1492. doi:10.1111/head.13618
- Moscano F, Guiducci M, Maltoni L, Striano P, Ledda MG, et al. An observational study of fixed-dose Tanacetum parthenium nutraceutical preparation for prophylaxis of pediatric headache. Ital J Pediatr. 2019;45:36. doi:10.1186/s13052-019-0624-z
