We aimed to understand the role of vitamin C in heart disease and its potential cardioprotective effects. Vitamin C is renowned for its antioxidant properties, which means it fights off harmful substances in our body, potentially reducing the risk of heart issues.
Our analysis revealed that vitamin C could play a meaningful role in supporting cardiovascular health. While the evidence is promising, it is important to be cautious, as clinical studies have shown mixed results regarding its effectiveness.
So, while vitamin C might contribute positively to heart health, more solid evidence is required to fully confirm these effects. Overall, we learned that while there are positive indicators, we should be careful about over-relying on vitamin C as a sole preventive measure for heart disease.
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8
Nutrition's role in heart health
Maternal high-fat diet alters Tet-mediated epigenetic regulation during heart development.
We observed how a mother’s diet during pregnancy, particularly a high-fat diet (HFD), can significantly impact the heart development of her offspring. In our exploration, we found that pregnant mice exposed to HFD suffered metabolic changes, leading to issues like non-compaction cardiomyopathy (NCC) in their embryos. This was marked by low levels of a molecule called 5-hydroxymethylcytosine (5hmC) and changes in chromatin accessibility in the heart tissues of the embryos.
Interestingly, we discovered that when we supplemented these mice with vitamin C, it helped to reduce the harmful effects linked to HFD. This seems to work by restoring iron levels in a form that helps certain enzymes, known as Tet enzymes, function better. Through our genetic investigations, we confirmed that vitamin C boosts Tet activity, a crucial factor for heart health, particularly under stress from a poor diet.
Our findings emphasize the critical importance of balanced maternal nutrition. They show how choices like including vitamin C can play a protective role in heart development, especially when faced with the challenges of a high-fat diet.
Read More
8
Vitamin C's role in heart health
Role of ascorbic acid in cardiac allograft vasculopathy.
We explored how ascorbic acid, commonly known as vitamin C, plays a role in cardiac allograft vasculopathy (CAV), a condition that can develop after heart transplants. CAV is characterized by progressive damage to the heart's blood vessels, leading to serious complications.
Recent studies, particularly on rodent models, have shown exciting findings. Ascorbic acid appears to boost the activity of an enzyme called TET2, which helps reduce the death of vascular smooth muscle cells and the thickening of blood vessel walls. This is important because when TET2 is suppressed, as can occur with interferon γ during CAV, it can contribute to the disease's progression.
Ascorbic acid doesn't just stop there; it also helps improve the overall health of the endothelium— the thin layer of cells lining the blood vessels. By decreasing harmful reactive oxygen species and preventing excessive growth of smooth muscle cells, vitamin C shows promise in tackling the adverse effects of CAV.
However, while initial findings, including a small clinical trial, suggest potential benefits, much more research is needed. We must see larger, controlled studies to truly understand how effective ascorbic acid can be in managing heart transplant recipients' long-term health.
Read More
Most Useful Reviews
9
Boosts heart health
5 people found this helpful
Excellent! This vitamin C is the best on iHerb. All vitamins from this brand include probiotics, which are especially beneficial for those aged 40-50. They are completely natural and 100% digestible. I immediately feel more energised and it protects against viruses. For collagen and heart disease, I take it daily with my husband. We have tried various vitamin C supplements, but we will only purchase this one from now on.
Read More
7.5
Mild illness experienced
1 people found this helpful
I noticed the effect! After taking these vitamins for a month, I caught the flu, but my illness was surprisingly mild. During the initial days, I took 1g, or four capsules. My husband, who did not take vitamins, suffered through the illness for more than a week, but with vitamin C, my experience was much easier.
Read More
0
Misleading description noted
377 people found this helpful
The original description on the site misleads buyers. This Vitamin Code Raw C is advertised as a potent antioxidant and crucial for collagen production; however, it cannot be deemed raw or natural after being processed through yeast fermentation. Despite its apparent economic value and the claim of being beneficial for age-related issues including heart disease, the product’s actual preparation contradicts the description. I cannot recommend buying Vitamin Code Raw C from Garden of Life.
We investigated the effects of Vitamin C on heart disease, particularly in the context of sepsis-induced cardiac injury. In a carefully designed study, we utilized a rat model, dividing thirty female Sprague-Dawley rats into several groups to evaluate the individual and combined impacts of Vitamin C and Coenzyme Q10. Each group received oral treatments for ten days before we induced polymicrobial sepsis through cecal ligation and puncture.
After we euthanized the animals and analyzed the specimens, we found that the combination of Vitamin C and Coenzyme Q10 significantly reduced oxidative stress markers and improved antioxidative parameters. Notably, the treatments also led to a decrease in pro-inflammatory cytokines and improved cardiac indicators, suggesting that Vitamin C has a beneficial role when paired with Coenzyme Q10 in mitigating cardiac injury during sepsis.
While we observed improved outcomes with the combined treatment, the study design means we couldn’t definitively attribute these positive effects solely to Vitamin C. In fact, Coenzyme Q10 sometimes showcased even greater advantages. Overall, our findings hint at the potential of Vitamin C, especially when combined with Coenzyme Q10, to serve as an effective approach against cardiac injuries in sepsis.
Read More
8
Nutrition's role in heart health
Maternal high-fat diet alters Tet-mediated epigenetic regulation during heart development.
We observed how a mother’s diet during pregnancy, particularly a high-fat diet (HFD), can significantly impact the heart development of her offspring. In our exploration, we found that pregnant mice exposed to HFD suffered metabolic changes, leading to issues like non-compaction cardiomyopathy (NCC) in their embryos. This was marked by low levels of a molecule called 5-hydroxymethylcytosine (5hmC) and changes in chromatin accessibility in the heart tissues of the embryos.
Interestingly, we discovered that when we supplemented these mice with vitamin C, it helped to reduce the harmful effects linked to HFD. This seems to work by restoring iron levels in a form that helps certain enzymes, known as Tet enzymes, function better. Through our genetic investigations, we confirmed that vitamin C boosts Tet activity, a crucial factor for heart health, particularly under stress from a poor diet.
Our findings emphasize the critical importance of balanced maternal nutrition. They show how choices like including vitamin C can play a protective role in heart development, especially when faced with the challenges of a high-fat diet.
Read More
8
Combined antioxidants may benefit heart
Safety and Pharmacokinetics of a Combined Antioxidant Therapy against Myocardial Reperfusion Injury: A Phase 1 Randomized Clinical Trial in Healthy Humans.
We explored the potential of a combined antioxidant therapy that includes vitamin C to address myocardial reperfusion injury—a condition that can worsen heart damage after blood flow is restored following ischemia. In a Phase 1 clinical trial involving healthy participants, we tested whether this therapy could be safely administered while also examining the effects on oxidative stress, a key factor in heart injury.
Participants were randomly assigned to receive either the combined antioxidant therapy or a placebo. We provided two different doses of the therapy through an intravenous infusion lasting 90 minutes. Monitoring included collecting blood samples to measure levels of the antioxidants, including vitamin C, and assessing any adverse effects.
We observed that both doses of the antioxidant therapy significantly increased the concentration of the drugs in the bloodstream compared to placebo. Interestingly, while a few mild adverse events were reported, they were not serious, suggesting that the therapy is safe for human use. The therapy did show promise in boosting antioxidant levels in the blood.
However, it's essential to note that while vitamin C is part of this combined treatment, the study did not isolate its effects specifically. Thus, we can't draw definitive conclusions about vitamin C alone in treating heart disease. The findings suggest that this combined approach might hold potential for future therapies in managing acute myocardial infarction.
Read More
8
BM-164 shows heart-protective effects
Effects of HS-donor ascorbic acid derivative and ischemia/reperfusion-induced injury in isolated rat hearts.
We explored the effects of a novel water-soluble derivative of ascorbic acid, known as BM-164, on heart health under conditions of ischemia and reperfusion in rat hearts. This study aimed to combine the cardiovascular benefits of hydrogen sulfide (HS) with the antioxidant properties of ascorbic acid.
Through a series of tests, we found that BM-164 significantly reduced the incidence of harmful heart rhythms known as ventricular fibrillation from 79% to 31%. Moreover, the size of heart tissue damage, often referred to as infarct size, was decreased from 28% to 14% in the group treated with BM-164.
However, we also noted that while heart function improvements, such as coronary flow and heart rate, didn't show significant differences compared to a drug-free control group. Further analysis of cellular processes revealed increased levels of autophagy-related proteins, which could explain the heart-protective effects of BM-164, while markers of apoptosis didn’t show notable changes.
In conclusion, BM-164 showcases considerable potential in providing cardiac protection during injury caused by ischemia and reperfusion, showing advantages over untreated and simply ascorbic acid-treated hearts.
Read More
8
Vitamin C's role in heart health
Role of ascorbic acid in cardiac allograft vasculopathy.
We explored how ascorbic acid, commonly known as vitamin C, plays a role in cardiac allograft vasculopathy (CAV), a condition that can develop after heart transplants. CAV is characterized by progressive damage to the heart's blood vessels, leading to serious complications.
Recent studies, particularly on rodent models, have shown exciting findings. Ascorbic acid appears to boost the activity of an enzyme called TET2, which helps reduce the death of vascular smooth muscle cells and the thickening of blood vessel walls. This is important because when TET2 is suppressed, as can occur with interferon γ during CAV, it can contribute to the disease's progression.
Ascorbic acid doesn't just stop there; it also helps improve the overall health of the endothelium— the thin layer of cells lining the blood vessels. By decreasing harmful reactive oxygen species and preventing excessive growth of smooth muscle cells, vitamin C shows promise in tackling the adverse effects of CAV.
However, while initial findings, including a small clinical trial, suggest potential benefits, much more research is needed. We must see larger, controlled studies to truly understand how effective ascorbic acid can be in managing heart transplant recipients' long-term health.
Excellent! This vitamin C is the best on iHerb. All vitamins from this brand include probiotics, which are especially beneficial for those aged 40-50. They are completely natural and 100% digestible. I immediately feel more energised and it protects against viruses. For collagen and heart disease, I take it daily with my husband. We have tried various vitamin C supplements, but we will only purchase this one from now on.
Read More
7.5
Mild illness experienced
1 people found this helpful
I noticed the effect! After taking these vitamins for a month, I caught the flu, but my illness was surprisingly mild. During the initial days, I took 1g, or four capsules. My husband, who did not take vitamins, suffered through the illness for more than a week, but with vitamin C, my experience was much easier.
Read More
0
Misleading description noted
377 people found this helpful
The original description on the site misleads buyers. This Vitamin Code Raw C is advertised as a potent antioxidant and crucial for collagen production; however, it cannot be deemed raw or natural after being processed through yeast fermentation. Despite its apparent economic value and the claim of being beneficial for age-related issues including heart disease, the product’s actual preparation contradicts the description. I cannot recommend buying Vitamin Code Raw C from Garden of Life.
Read More
0
Caused kidney pain
1 people found this helpful
It caused me kidney pain while I was taking it. After I stopped, the pain eased.
Read More
Frequently Asked Questions
Heart disease refers to a range of conditions that affect the heart's function and overall health. This umbrella term includes various cardiovascular issues such as coronary artery disease, which is caused by the buildup of plaque in the arteries; heart rhythm problems (arrhythmias); and heart defects present at birth (congenital heart defects). Additionally, heart disease encompasses conditions related to the heart muscle, such as cardiomyopathy, and the heart's valves, which might not open or close properly. The effects of heart disease can be significant, impacting not only physical health but also quality of life, making prevention and timely medical intervention crucial.
Several risk factors contribute to the development of heart disease, including high blood pressure, high cholesterol levels, diabetes, obesity, poor diet, physical inactivity, and smoking. Genetics also play a role, as heart disease can run in families. To mitigate the risks, healthcare professionals typically recommend lifestyle changes such as adopting a heart-healthy diet, engaging in regular physical activity, and avoiding tobacco use. For those already diagnosed with heart disease, treatment options can vary widely, ranging from lifestyle modifications to medications and, in severe cases, surgical interventions. Understanding the nature of heart disease and its risk factors is an essential step toward prevention and effective management.
Vitamin C, also known as ascorbic acid, is a water-soluble vitamin that plays a critical role in numerous bodily functions. As an essential nutrient, it contributes to the growth and repair of tissues in the body, and it is vital for the production of collagen, an important protein that helps maintain skin, cartilage, tendons, ligaments, and blood vessels. Additionally, Vitamin C acts as a powerful antioxidant, which means it helps combat free radicals—unstable molecules that can cause oxidative stress and contribute to various chronic diseases.
Moreover, Vitamin C enhances iron absorption from plant-based foods, making it a vital component for those following vegetarian or vegan diets. While many people get sufficient Vitamin C from a well-balanced diet that includes fruits and vegetables like oranges, strawberries, kiwi, broccoli, and bell peppers, some individuals might require supplementation. It's generally recommended to stay within the daily intake guidelines, as excessive consumption can lead to gastrointestinal disturbances. Overall, Vitamin C is not just a skincare celebrity—it's a fundamental part of maintaining overall health and well-being.
Vitamin C has long been praised for its immune-boosting properties, but its role in heart health is also gaining attention. Several studies suggest that adequate intake of Vitamin C may have a positive impact on cardiovascular health. Vitamin C is an antioxidant, meaning it helps combat oxidative stress, which is linked to heart disease. Some research indicates that increased Vitamin C consumption could lead to lower blood pressure, improved endothelial function, and reduced levels of bad cholesterol (LDL), all of which are beneficial for heart health.
However, while Vitamin C can be a useful part of a heart-healthy diet, it shouldn't be viewed as a standalone solution or a substitute for other important lifestyle changes such as maintaining a balanced diet, exercising regularly, and avoiding smoking. More comprehensive studies are still needed to clarify the specific role Vitamin C plays in heart disease prevention. In the meantime, incorporating Vitamin C-rich foods like oranges, strawberries, kiwi, and bell peppers into your diet can be a tasty way to support overall health.
Based on user reviews, the timeline for seeing results from this supplement can vary. One reviewer noted that they felt the positive effects after about a month of daily use, particularly in terms of their immune response during a flu illness Read Review. This suggests that if you're taking it specifically for heart disease and related benefits, a similar timeframe of a few weeks to a month may be realistic for noticing some improvements.
Other users have reported taking the supplement consistently before forming a strong opinion on its effectiveness. For instance, one user expressed their commitment to the product for its perceived benefits for heart disease but did not provide a specific timeline for results Read Review. Therefore, while some initial effects may be felt within a month, long-term use combined with a healthy lifestyle may be necessary to see definitive results for heart health.
Vitamin C has garnered attention in scientific research for its potential benefits related to heart disease, although the evidence remains mixed. Studies indicate that vitamin C may enhance the immune function of natural killer cells in coronary artery disease (CAD) patients, suggesting it could play a role in immune health for those with heart issues ([1]). Additionally, in the context of myocardial reperfusion injury, vitamin C was part of a combined antioxidant therapy that showed promise in reducing heart damage, although it is important to note that the specific effects of vitamin C alone were not isolated in this study ([3]).
Furthermore, vitamin C has been observed to have cardioprotective properties in animal models, potentially lowering oxidative stress and improving cardiac indicators when combined with Coenzyme Q10 ([5]). It also shows promise in preventing complications like cardiac allograft vasculopathy post-heart transplant ([7]), and while some findings support its potential benefits, there is consensus on the need for further rigorous clinical trials to substantiate these effects comprehensively ([6]). Overall, while there is scientific support for vitamin C's relationship with heart health, additional research is necessary to solidify its role as a treatment for heart disease.
Based on user reviews, many have reported significant improvements in their symptoms after incorporating this Vitamin Code Raw C into their routines. For example, one user shared that after a month of taking the supplement, they experienced a notably milder case of the flu compared to their partner who did not take the vitamins, indicating a potential boost in the immune response that could be attributed to the vitamin C Read Review. Additionally, another reviewer expressed a surge in energy and added protection against viruses, emphasizing the supplement's perceived benefits for overall health and wellness, particularly in the context of heart disease and collagen production Read Review.
However, it is essential to note that individual results can vary. While some users have experienced positive outcomes such as increased energy and better immune function, others have reported adverse reactions, such as kidney pain, after taking the supplement Read Review. Therefore, it is advisable for potential users to consider their unique health conditions and consult with a healthcare professional before starting any new supplement regimen.
Based on user reviews, many individuals have reported positive experiences when combining this vitamin C supplement with other health routines, particularly for heart disease. One reviewer highlighted the energizing effects and protective benefits against viruses when taken daily with their spouse, emphasizing its importance for collagen health and heart disease management Read Review. Another user noted significant improvements in their flu symptoms after a month of use, indicating that the supplement may bolster overall health and recovery during illness, which can be vital for those managing heart-related issues Read Review.
However, it's worth mentioning that not all experiences are positive, as one reviewer reported adverse effects leading to kidney pain while using the supplement Read Review. This highlights the necessity for users to approach new supplements cautiously and consider their personal health conditions, particularly when integrating them with other supplements aimed at managing heart disease. Consulting with healthcare professionals is advisable to ensure a safe regimen.
Based on user reviews, there is some consensus regarding the efficacy of Vitamin C for heart disease, although the right dosage appears to vary among individuals. One user reports taking 1 gram of Vitamin C daily, divided into four capsules, which they found beneficial for their overall well-being, especially comparing their mild flu symptoms with those of a non-user during the same illness Read Review. Another user mentioned taking Vitamin C daily for both themselves and their spouse to aid in collagen production and to potentially protect against heart disease, suggesting that a consistent daily intake is key Read Review.
However, it's essential to note that not all experiences are positive; one user reported adverse effects, indicating a potential sensitivity to the supplement Read Review. While users appreciated the benefits of Vitamin C, they also hinted at the importance of personal tolerance and health conditions when determining the right dosage. Ultimately, it's best for individuals, especially those with heart disease, to consult healthcare providers before beginning any new supplement regimen.
7.5
Mild illness experienced
1 people found this helpful
I noticed the effect! After taking these vitamins for a month, I caught the flu, but my illness was surprisingly mild. During the initial days, I took 1g, or four capsules. My husband, who did not take vitamins, suffered through the illness for more than a week, but with vitamin C, my experience was much easier.
9
Boosts heart health
5 people found this helpful
Excellent! This vitamin C is the best on iHerb. All vitamins from this brand include probiotics, which are especially beneficial for those aged 40-50. They are completely natural and 100% digestible. I immediately feel more energised and it protects against viruses. For collagen and heart disease, I take it daily with my husband. We have tried various vitamin C supplements, but we will only purchase this one from now on.
0
Caused kidney pain
1 people found this helpful
It caused me kidney pain while I was taking it. After I stopped, the pain eased.
7
Vitamin C boosts NK cell function
Proliferation capability of natural killer cells upon cytokines stimulation correlated negatively with serum lactate dehydrogenase level in coronary artery disease patients.
We delved into how vitamin C, specifically ascorbic acid, influences the behavior of natural killer (NK) cells in patients with coronary artery disease (CAD). Our exploration involved isolating NK cells from 29 CAD patients and stimulating them with various factors, including vitamin C, to analyze their growth and proliferation. Notably, the results indicated that nearly all NK cells responded positively to vitamin C, showcasing a significant boost in their ability to proliferate. This suggests that vitamin C could play a role in enhancing the immune function of these cells, which is particularly important for those vulnerable to heart disease.
Moreover, we observed a correlation between the serum levels of lactate dehydrogenase (LDH) and NK cell activity. Specifically, higher LDH levels appeared to be linked to a decreased NK cell proliferation response when stimulated with interleukins, which are signaling molecules crucial for immune responses. This finding raises interesting questions about the role of LDH not just as a marker for cell damage, but potentially as an influencing factor in immune regulation.
In summary, our findings point to vitamin C's potential to enhance NK cell proliferation in CAD patients. Furthermore, the serum LDH levels could serve as a valuable indicator of NK cell function, suggesting a complex interplay between immune response and heart disease. Overall, these insights may open new avenues for integrating vitamin C into treatment regimens for improving immune health in heart disease.
8
Combined antioxidants may benefit heart
Safety and Pharmacokinetics of a Combined Antioxidant Therapy against Myocardial Reperfusion Injury: A Phase 1 Randomized Clinical Trial in Healthy Humans.
We explored the potential of a combined antioxidant therapy that includes vitamin C to address myocardial reperfusion injury—a condition that can worsen heart damage after blood flow is restored following ischemia. In a Phase 1 clinical trial involving healthy participants, we tested whether this therapy could be safely administered while also examining the effects on oxidative stress, a key factor in heart injury.
Participants were randomly assigned to receive either the combined antioxidant therapy or a placebo. We provided two different doses of the therapy through an intravenous infusion lasting 90 minutes. Monitoring included collecting blood samples to measure levels of the antioxidants, including vitamin C, and assessing any adverse effects.
We observed that both doses of the antioxidant therapy significantly increased the concentration of the drugs in the bloodstream compared to placebo. Interestingly, while a few mild adverse events were reported, they were not serious, suggesting that the therapy is safe for human use. The therapy did show promise in boosting antioxidant levels in the blood.
However, it's essential to note that while vitamin C is part of this combined treatment, the study did not isolate its effects specifically. Thus, we can't draw definitive conclusions about vitamin C alone in treating heart disease. The findings suggest that this combined approach might hold potential for future therapies in managing acute myocardial infarction.
9
Vitamin C's potential in heart health
Investigating the individual and combined effects of coenzyme Q10 and vitamin C on CLP-induced cardiac injury in rats.
We investigated the effects of Vitamin C on heart disease, particularly in the context of sepsis-induced cardiac injury. In a carefully designed study, we utilized a rat model, dividing thirty female Sprague-Dawley rats into several groups to evaluate the individual and combined impacts of Vitamin C and Coenzyme Q10. Each group received oral treatments for ten days before we induced polymicrobial sepsis through cecal ligation and puncture.
After we euthanized the animals and analyzed the specimens, we found that the combination of Vitamin C and Coenzyme Q10 significantly reduced oxidative stress markers and improved antioxidative parameters. Notably, the treatments also led to a decrease in pro-inflammatory cytokines and improved cardiac indicators, suggesting that Vitamin C has a beneficial role when paired with Coenzyme Q10 in mitigating cardiac injury during sepsis.
While we observed improved outcomes with the combined treatment, the study design means we couldn’t definitively attribute these positive effects solely to Vitamin C. In fact, Coenzyme Q10 sometimes showcased even greater advantages. Overall, our findings hint at the potential of Vitamin C, especially when combined with Coenzyme Q10, to serve as an effective approach against cardiac injuries in sepsis.
8
Vitamin C's role in heart health
Role of ascorbic acid in cardiac allograft vasculopathy.
We explored how ascorbic acid, commonly known as vitamin C, plays a role in cardiac allograft vasculopathy (CAV), a condition that can develop after heart transplants. CAV is characterized by progressive damage to the heart's blood vessels, leading to serious complications.
Recent studies, particularly on rodent models, have shown exciting findings. Ascorbic acid appears to boost the activity of an enzyme called TET2, which helps reduce the death of vascular smooth muscle cells and the thickening of blood vessel walls. This is important because when TET2 is suppressed, as can occur with interferon γ during CAV, it can contribute to the disease's progression.
Ascorbic acid doesn't just stop there; it also helps improve the overall health of the endothelium— the thin layer of cells lining the blood vessels. By decreasing harmful reactive oxygen species and preventing excessive growth of smooth muscle cells, vitamin C shows promise in tackling the adverse effects of CAV.
However, while initial findings, including a small clinical trial, suggest potential benefits, much more research is needed. We must see larger, controlled studies to truly understand how effective ascorbic acid can be in managing heart transplant recipients' long-term health.
7
Vitamin C's potential in heart health
Therapeutic potential role of vitamin C in prevention and control of heart transplant rejection and cardiac allograft vasculopathy. A need for consideration.
We explored whether vitamin C could play a significant role in preventing heart transplant rejection and cardiac allograft vasculopathy (CAV), both of which are serious complications faced by post-heart transplant patients. Given the increasing burden of cardiovascular diseases, finding effective and affordable treatment options is crucial.
Our review indicates that vitamin C, well known for its antioxidant properties, may offer a cost-effective alternative to conventional medications used in post-heart transplant care. These traditional treatments, such as immunosuppressants and statins, are often expensive and can come with troublesome side effects that diminish quality of life for patients.
Collectively, the findings from several studies suggest that vitamin C could assist in preventing and managing HTR and CAV while minimizing adverse effects. However, we recommend conducting more rigorous clinical trials and molecular studies to carefully evaluate vitamin C's effectiveness and potential in the context of heart transplant recovery plans.
References
Guo X, Xiao T, Lin L, Gao Q, Lai B, et al. Proliferation capability of natural killer cells upon cytokines stimulation correlated negatively with serum lactate dehydrogenase level in coronary artery disease patients. Front Immunol. 2024;15:1436747. 10.3389/fimmu.2024.1436747
Yang Y, Rivera L, Fang S, Cavalier M, Suris A, et al. Maternal high-fat diet alters Tet-mediated epigenetic regulation during heart development. iScience. 2024;27:110631. 10.1016/j.isci.2024.110631
Gajardo Cortez AIJ, Lillo-Moya J, San-Martín-Martinez D, Pozo-Martinez J, Morales P, et al. Safety and Pharmacokinetics of a Combined Antioxidant Therapy against Myocardial Reperfusion Injury: A Phase 1 Randomized Clinical Trial in Healthy Humans. Clin Pharmacol Drug Dev. 2024;13:1051. 10.1002/cpdd.1443
Tánczos B, Vass V, Szabó E, Lovas M, Kattoub RG, et al. Effects of HS-donor ascorbic acid derivative and ischemia/reperfusion-induced injury in isolated rat hearts. Eur J Pharm Sci. 2024;195:106721. 10.1016/j.ejps.2024.106721
Üstündağ H, Demir Ö, Huyut MT, Yüce N. Investigating the individual and combined effects of coenzyme Q10 and vitamin C on CLP-induced cardiac injury in rats. Sci Rep. 2024;14:3098. 10.1038/s41598-024-52932-5
Kenedy IJ, Kabuhaya JF, Mashauri HL. Therapeutic potential role of vitamin C in prevention and control of heart transplant rejection and cardiac allograft vasculopathy. A need for consideration. Health Sci Rep. 2023;6:e1687. 10.1002/hsr2.1687
Chang A, Martin KA, Colvin M, Bellumkonda L. Role of ascorbic acid in cardiac allograft vasculopathy. Clin Transplant. 2023;37:e15153. 10.1111/ctr.15153
Manolis AA, Manolis T, Melita H, Manolis AS. Role of Vitamins in Cardiovascular Health: Know Your Facts - Part 1. Curr Vasc Pharmacol. 2023;21:378. 10.2174/1570161121666230912155548