We explored whether high-dose vitamin C could help reduce pancreatic necrosis in cases of severe acute pancreatitis (SAP). Our observations reveal that platelet activation early in pancreatitis is a critical factor leading to pancreatic tissue death.
In our study, we examined the effects of high-dose vitamin C on pancreatic microcirculation in rats. We analyzed platelet activity in both SAP rats treated with vitamin C and those untreated. Additionally, we evaluated how vitamin C affects platelets from SAP patients.
To understand the mechanism at play, we used substances that could counteract vitamin C's effects, helping us pinpoint its role in platelet activation. The results indicated that vitamin C significantly improves blood flow and reduces pancreatic damage by inhibiting platelet activation, specifically through the CXCL12/CXCR4 pathway.
This research suggests that high-dose vitamin C could serve as a beneficial treatment for pancreatitis, potentially improving patient outcomes by tackling a major cause of pancreatic necrosis.
Read More
Most Useful Reviews
7.5
Good immune support
1 people found this helpful
Miracle Vitamin This vitamin C is the only one that does not irritate my gastrointestinal tract. With my gastritis and pancreatitis, it's been challenging to find a suitable vitamin. This one is well-tolerated and absorbed easily. I take it twice daily, and it provides excellent support for my immune system.
Read More
0
Caused stomach issues
39 people found this helpful
My digestive tract did not respond well to these vitamins. After a week of use, I experienced unpleasant stomach sensations and nausea, which worsened my pancreatitis. I cannot evaluate these vitamins positively, as I did not notice any benefits.
We explored whether high-dose vitamin C could help reduce pancreatic necrosis in cases of severe acute pancreatitis (SAP). Our observations reveal that platelet activation early in pancreatitis is a critical factor leading to pancreatic tissue death.
In our study, we examined the effects of high-dose vitamin C on pancreatic microcirculation in rats. We analyzed platelet activity in both SAP rats treated with vitamin C and those untreated. Additionally, we evaluated how vitamin C affects platelets from SAP patients.
To understand the mechanism at play, we used substances that could counteract vitamin C's effects, helping us pinpoint its role in platelet activation. The results indicated that vitamin C significantly improves blood flow and reduces pancreatic damage by inhibiting platelet activation, specifically through the CXCL12/CXCR4 pathway.
This research suggests that high-dose vitamin C could serve as a beneficial treatment for pancreatitis, potentially improving patient outcomes by tackling a major cause of pancreatic necrosis.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.2
All Reviews
Positive Reviews
Negative Reviews
7.5
Good immune support
1 people found this helpful
Miracle Vitamin This vitamin C is the only one that does not irritate my gastrointestinal tract. With my gastritis and pancreatitis, it's been challenging to find a suitable vitamin. This one is well-tolerated and absorbed easily. I take it twice daily, and it provides excellent support for my immune system.
Read More
0
Caused stomach issues
39 people found this helpful
My digestive tract did not respond well to these vitamins. After a week of use, I experienced unpleasant stomach sensations and nausea, which worsened my pancreatitis. I cannot evaluate these vitamins positively, as I did not notice any benefits.
Read More
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References
Gui M, Huang J, Sheng H, Chen Y, Yang Z, et al. High-Dose Vitamin C Alleviates Pancreatic Necrosis by Inhibiting Platelet Activation Through the CXCL12/CXCR4 Pathway in Severe Acute Pancreatitis. J Inflamm Res. 2023;16:2865. 10.2147/JIR.S415974