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Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.8
USERS' SCORE
Good
Based on 2 Reviews
8.4
Top Medical Research Studies
8
Zinc may alleviate anxiety symptoms
We explored the connection between zinc intake and anxiety in adults through a systematic review of nine original studies. Two of these studies looked at how zinc consumption impacts anxiety, while the other seven focused on the relationship between serum zinc levels and anxiety symptoms. Our analysis included studies published in English within peer-reviewed journals, ensuring a solid foundation for understanding this potential link.
What we discovered was quite illuminating. The data indicated that individuals experiencing anxiety often had lower levels of zinc in their serum compared to those who did not suffer from anxiety. Additionally, we observed an inverse association between zinc intake and anxiety levels. This suggests that higher consumption of zinc may contribute to reduced anxiety symptoms.
In conclusion, the evidence points towards zinc playing a positive role in treating anxiety, although we acknowledge some limitations in the available studies. This means zinc supplementation could be a beneficial strategy for those looking to manage their anxiety, but more research is needed to confirm these findings and understand the underlying mechanisms better.
What we discovered was quite illuminating. The data indicated that individuals experiencing anxiety often had lower levels of zinc in their serum compared to those who did not suffer from anxiety. Additionally, we observed an inverse association between zinc intake and anxiety levels. This suggests that higher consumption of zinc may contribute to reduced anxiety symptoms.
In conclusion, the evidence points towards zinc playing a positive role in treating anxiety, although we acknowledge some limitations in the available studies. This means zinc supplementation could be a beneficial strategy for those looking to manage their anxiety, but more research is needed to confirm these findings and understand the underlying mechanisms better.
Read More
8
Vitamin C alleviates anxiety in autism
We set out to explore how vitamin C influences anxiety-like behaviors in a model of autism caused by valproic acid (VPA). In our study, we used fourteen female rats that underwent specific treatments to induce autism in their offspring. After a period of observation, we treated male pups with daily injections of vitamin C for four weeks. Then, we assessed their behavior to see if there were any changes in anxiety levels.
Our findings suggested that vitamin C significantly reduced anxiety-like behaviors in these rats. This outcome is particularly promising considering that autism often brings associated anxiety. By measuring various brain oxidative stress markers, we also noted improvements in mental functioning and motor skills after vitamin C treatment. Overall, our work underscores the potential benefits of vitamin C as a supportive treatment for anxiety-related issues in autism, indicating a pathway for future research and therapeutic strategies.
Our findings suggested that vitamin C significantly reduced anxiety-like behaviors in these rats. This outcome is particularly promising considering that autism often brings associated anxiety. By measuring various brain oxidative stress markers, we also noted improvements in mental functioning and motor skills after vitamin C treatment. Overall, our work underscores the potential benefits of vitamin C as a supportive treatment for anxiety-related issues in autism, indicating a pathway for future research and therapeutic strategies.
Read More
8
High-dose vitamin D reduces anxiety
We conducted a study to understand how high-dose vitamin D supplementation might impact anxiety levels, particularly in patients experiencing post-COVID symptoms. In our double-blind, randomized controlled trial, we enrolled 80 individuals dealing with fatigue or neuropsychiatric issues after COVID-19.
Participants were split into two groups: one received a weekly dose of 60,000 IU of vitamin D, while the other group received a placebo. Over eight weeks, we evaluated various outcomes, including anxiety levels using the Depression, Anxiety, and Stress Scale (DASS-21).
The results were encouraging for the vitamin D group. We observed significant improvements in anxiety levels, with a notable reduction reported by participants. However, other measures related to sleep quality, depression, cognitive function, and inflammatory markers did not show similar significant changes.
Importantly, we found that the vitamin D group reported no serious adverse effects, indicating that this supplementation is generally safe. These findings suggest that high-dose vitamin D may offer substantial benefits for anxiety relief in patients recovering from COVID-19, albeit with limited effects on other symptoms.
Participants were split into two groups: one received a weekly dose of 60,000 IU of vitamin D, while the other group received a placebo. Over eight weeks, we evaluated various outcomes, including anxiety levels using the Depression, Anxiety, and Stress Scale (DASS-21).
The results were encouraging for the vitamin D group. We observed significant improvements in anxiety levels, with a notable reduction reported by participants. However, other measures related to sleep quality, depression, cognitive function, and inflammatory markers did not show similar significant changes.
Importantly, we found that the vitamin D group reported no serious adverse effects, indicating that this supplementation is generally safe. These findings suggest that high-dose vitamin D may offer substantial benefits for anxiety relief in patients recovering from COVID-19, albeit with limited effects on other symptoms.
Read More
Most Useful Reviews
9
Energising vitamins
5 people found this helpful
A true game-changer. These vitamins have completely transformed my life! I jokingly mentioned having S.A.D. but realised I must have been severely D3 deficient. Before taking these, I suffered from severe anxiety that prevented me from driving on the freeway. After beginning the vitamins, within a week or so, I noticed a remarkable improvement in how I felt. My energy levels increased, and my anxiety diminished.
Read More
7.5
Supports family health
109 people found this helpful
Excellent, especially for black men! I purchase these for the men in my family. My brother has insomnia and anxiety; this product, along with Calm Magnesium, aids his sleep and boosts his energy during the day. He found that when he stopped taking these, his anxiety returned.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.8
- All Researches
9
We aimed to understand how zinc chloride may help reduce anxiety, particularly when combined with diazepam. In our study, we organized Wistar albino rats into five groups, with each group receiving different combinations of zinc chloride and diazepam. The dosages included two different levels of diazepam (1 and 2 mg/kg) paired with a consistent dose of zinc chloride (10 mg/kg).
To assess the anxiety levels of the rats, we employed four established models: the Elevated Plus Maze, the hole board, the light and dark box, and the mirror chamber. Our observations indicated that when combined, zinc chloride and diazepam produced more potent anxiolytic effects compared to when either treatment was used alone. This suggests a possible synergistic effect that could enhance anxiety relief.
Overall, we found that zinc chloride, especially when combined with diazepam, can significantly improve anxiety outcomes in these animal models. This research opens the door to further studies on zinc's role in anxiety management and its potential as a supplementary treatment option alongside traditional medications.
To assess the anxiety levels of the rats, we employed four established models: the Elevated Plus Maze, the hole board, the light and dark box, and the mirror chamber. Our observations indicated that when combined, zinc chloride and diazepam produced more potent anxiolytic effects compared to when either treatment was used alone. This suggests a possible synergistic effect that could enhance anxiety relief.
Overall, we found that zinc chloride, especially when combined with diazepam, can significantly improve anxiety outcomes in these animal models. This research opens the door to further studies on zinc's role in anxiety management and its potential as a supplementary treatment option alongside traditional medications.
Read More
9
Zinc reduces anxiety in treatment
In a recent study, we investigated how zinc supplementation could impact anxiety levels among patients undergoing methadone maintenance treatment for opioid use disorder. The research involved a randomized controlled trial with 68 participants. We divided them into two groups: one received zinc supplements along with their usual methadone treatment, while the other group only received methadone.
Our findings revealed some encouraging results regarding anxiety reduction. Specifically, we noted a significant decrease in anxiety levels among those who took zinc, with a marked difference when compared to the control group. This was assessed using the Depression, Anxiety, and Stress Scale 21 (DASS-21), where we observed a notable reduction in anxiety scores following the treatment period.
Overall, it appears that zinc supplementation may contribute positively to reducing anxiety in this particular patient demographic. However, since zinc was combined with methadone treatment, it's essential we approach these findings with caution and encourage further research to clarify the role of zinc supplementation alone.
Our findings revealed some encouraging results regarding anxiety reduction. Specifically, we noted a significant decrease in anxiety levels among those who took zinc, with a marked difference when compared to the control group. This was assessed using the Depression, Anxiety, and Stress Scale 21 (DASS-21), where we observed a notable reduction in anxiety scores following the treatment period.
Overall, it appears that zinc supplementation may contribute positively to reducing anxiety in this particular patient demographic. However, since zinc was combined with methadone treatment, it's essential we approach these findings with caution and encourage further research to clarify the role of zinc supplementation alone.
Read More
8
Vitamin C alleviates anxiety in autism
We set out to explore how vitamin C influences anxiety-like behaviors in a model of autism caused by valproic acid (VPA). In our study, we used fourteen female rats that underwent specific treatments to induce autism in their offspring. After a period of observation, we treated male pups with daily injections of vitamin C for four weeks. Then, we assessed their behavior to see if there were any changes in anxiety levels.
Our findings suggested that vitamin C significantly reduced anxiety-like behaviors in these rats. This outcome is particularly promising considering that autism often brings associated anxiety. By measuring various brain oxidative stress markers, we also noted improvements in mental functioning and motor skills after vitamin C treatment. Overall, our work underscores the potential benefits of vitamin C as a supportive treatment for anxiety-related issues in autism, indicating a pathway for future research and therapeutic strategies.
Our findings suggested that vitamin C significantly reduced anxiety-like behaviors in these rats. This outcome is particularly promising considering that autism often brings associated anxiety. By measuring various brain oxidative stress markers, we also noted improvements in mental functioning and motor skills after vitamin C treatment. Overall, our work underscores the potential benefits of vitamin C as a supportive treatment for anxiety-related issues in autism, indicating a pathway for future research and therapeutic strategies.
Read More
8
High-dose vitamin D reduces anxiety
We conducted a study to understand how high-dose vitamin D supplementation might impact anxiety levels, particularly in patients experiencing post-COVID symptoms. In our double-blind, randomized controlled trial, we enrolled 80 individuals dealing with fatigue or neuropsychiatric issues after COVID-19.
Participants were split into two groups: one received a weekly dose of 60,000 IU of vitamin D, while the other group received a placebo. Over eight weeks, we evaluated various outcomes, including anxiety levels using the Depression, Anxiety, and Stress Scale (DASS-21).
The results were encouraging for the vitamin D group. We observed significant improvements in anxiety levels, with a notable reduction reported by participants. However, other measures related to sleep quality, depression, cognitive function, and inflammatory markers did not show similar significant changes.
Importantly, we found that the vitamin D group reported no serious adverse effects, indicating that this supplementation is generally safe. These findings suggest that high-dose vitamin D may offer substantial benefits for anxiety relief in patients recovering from COVID-19, albeit with limited effects on other symptoms.
Participants were split into two groups: one received a weekly dose of 60,000 IU of vitamin D, while the other group received a placebo. Over eight weeks, we evaluated various outcomes, including anxiety levels using the Depression, Anxiety, and Stress Scale (DASS-21).
The results were encouraging for the vitamin D group. We observed significant improvements in anxiety levels, with a notable reduction reported by participants. However, other measures related to sleep quality, depression, cognitive function, and inflammatory markers did not show similar significant changes.
Importantly, we found that the vitamin D group reported no serious adverse effects, indicating that this supplementation is generally safe. These findings suggest that high-dose vitamin D may offer substantial benefits for anxiety relief in patients recovering from COVID-19, albeit with limited effects on other symptoms.
Read More
8
Vitamin D mitigates anxiety symptoms
We explored the impact of changing levels of a specific enzyme, CYP11A1, in the placenta and how it might influence anxiety and social behavior in offspring. Using a unique mouse model, we found that higher levels of this enzyme are associated with behaviors similar to those seen in autism spectrum disorders (ASD), such as reduced social interaction and increased anxiety.
Interestingly, we observed that these anxiety-related behaviors improved significantly after administering vitamin D3. Behavioral tests, including open field and elevated plus maze assessments, showed that the mice exhibited less anxiety when given this supplement.
Additionally, our study highlighted that vitamin D3 could help correct some of the hormonal imbalances linked to CYP11A1 overexpression. Higher progesterone levels and increased inflammation were noted in the affected mice, and these issues seemed to reverse with vitamin D3 treatment.
This research underscores not only the potential role of vitamin D in managing anxiety but also suggests that examining CYP11A1 levels could be important for understanding and perhaps preventing some neurodevelopmental disorders. Overall, it appears vitamin D3 may serve as a useful tool in mitigating anxiety linked to hormonal changes during development.
Interestingly, we observed that these anxiety-related behaviors improved significantly after administering vitamin D3. Behavioral tests, including open field and elevated plus maze assessments, showed that the mice exhibited less anxiety when given this supplement.
Additionally, our study highlighted that vitamin D3 could help correct some of the hormonal imbalances linked to CYP11A1 overexpression. Higher progesterone levels and increased inflammation were noted in the affected mice, and these issues seemed to reverse with vitamin D3 treatment.
This research underscores not only the potential role of vitamin D in managing anxiety but also suggests that examining CYP11A1 levels could be important for understanding and perhaps preventing some neurodevelopmental disorders. Overall, it appears vitamin D3 may serve as a useful tool in mitigating anxiety linked to hormonal changes during development.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Energising vitamins
5 people found this helpful
A true game-changer. These vitamins have completely transformed my life! I jokingly mentioned having S.A.D. but realised I must have been severely D3 deficient. Before taking these, I suffered from severe anxiety that prevented me from driving on the freeway. After beginning the vitamins, within a week or so, I noticed a remarkable improvement in how I felt. My energy levels increased, and my anxiety diminished.
Read More
7.5
Supports family health
109 people found this helpful
Excellent, especially for black men! I purchase these for the men in my family. My brother has insomnia and anxiety; this product, along with Calm Magnesium, aids his sleep and boosts his energy during the day. He found that when he stopped taking these, his anxiety returned.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Tarahomi P, Arab M, Seyedinia SA, Rahmani M, Rashidy-Pour A, et al. Vitamin C and Gallic Acid Ameliorate Motor Dysfunction, Cognitive Deficits, and Brain Oxidative Stress in a Valproic Acid-Induced Model of Autism. Brain Behav. 2025;15:e70262. 10.1002/brb3.70262
- Charoenporn V, Tungsukruthai P, Teacharushatakit P, Hanvivattanakul S, Sriyakul K, et al. Effects of an 8-week high-dose vitamin D supplementation on fatigue and neuropsychiatric manifestations in post-COVID syndrome: A randomized controlled trial. Psychiatry Clin Neurosci. 2024;78:595. 10.1111/pcn.13716
- Yin H, Zhang J, Chen Y, Guo J, Li Q, et al. Placenta-specific CYP11A1 overexpression lead to autism-like symptom in offspring with altered steroid hormone biosynthesis in the placenta-brain axis and rescued by vitamin D intervention. Brain Behav Immun. 2024;121:13. 10.1016/j.bbi.2024.07.012
- Domacassé D, de Rooij SR, Vrijkotte T, de Jonge A, Henrichs J. Associations Between Early-Pregnancy Vitamin D Status and Postpartum Depressive and Anxiety Symptoms. Psychosom Med. 2024;86:648. 10.1097/PSY.0000000000001328
- Wen Z, Bai L, Wu S, Chen J, Jama HA, et al. Association of serum vitamin D with anxiety in US adults: a cross-sectional study. Front Nutr. 2024;11:1371170. 10.3389/fnut.2024.1371170
- Zhao W, Zhu DM, Shen Y, Zhang Y, Chen T, et al. The protective effect of vitamin D supplementation as adjunctive therapy to antidepressants on brain structural and functional connectivity of patients with major depressive disorder: a randomized controlled trial. Psychol Med. 2024;54:2403. 10.1017/S0033291724000539
- Jouët P, Altman C, Bruley DES Varannes S, Juhel C, Henri F. Probiotics plus vitamin D in irritable bowel syndrome: a prospective multicentric non-interventional study. Minerva Gastroenterol (Torino). 2024;70:332. 10.23736/S2724-5985.24.03581-2
- Renteria KM, Constantine E, Teoh CM, Cooper A, Lozano N, et al. Combination of vitamin D and fructooligosaccharides upregulates colonic vitamin D receptor in C57BL/6J mice and affects anxiety-related behavior in a sex-specific manner. Nutr Res. 2024;125:16. 10.1016/j.nutres.2024.02.003
- Gammoh O, Ibrahim A, Yehya A, Alqudah A, Qnais E, et al. Exploring the Roles of Vitamins C and D and Etifoxine in Combination with Citalopram in Depression/Anxiety Model: A Focus on ICAM-1, SIRT1 and Nitric Oxide. Int J Mol Sci. 2024;25. 10.3390/ijms25041960
- Ajibare AJ, Akintoye OO, Oriowo OA, Asuku AO, Oriyomi IA, et al. Zinc Ameliorates Acrylamide-Induced Cognitive Impairment in Male Wistar Rats: Modulation of Oxidative Stress, Neuro-inflammation, and Neurotrophic Pathways. Biol Trace Elem Res. 2024. 10.1007/s12011-024-04490-0
- Apryatin S, Lopachev A, Zhukov I, Efimova E, Apryatina V. BEHAVIORAL AND NEUROCHEMICAL CHANGES DURING INTRANASAL ADMINISTRATION OF ALPHA-GLUTAMYL-TRYPTOPHAN AND CHELATE COMPLEX OF ZINC ARGINYL-GLYCINATE ON MONOAMINE SYSTEMS DYSFUNCTIONS KNOCK-OUT MODELS. Georgian Med News. 2024.
- Naik VV, Desai VH, Noronha S. Synergistic anxiolytic efficacy exploring the combined effects of diazepam and zinc chloride in wistar albino rats. Drug Res (Stuttg). 2024;74:220. 10.1055/a-2308-9192
- Tomas-Sanchez C, Blanco-Alvarez VM, Gonzalez-Barrios JA, Martinez-Fong D, Soto-Rodriguez G, et al. Prophylactic zinc and therapeutic selenium administration in adult rats prevents long-term cognitive and behavioral sequelae by a transient ischemic attack. Heliyon. 2024;10:e30017. 10.1016/j.heliyon.2024.e30017
- Sameei P, Fatehfar S, Abdollahzadeh N, Chodari L, Saboory E, et al. The effects of forced exercise and zinc supplementation during pregnancy on prenatally stress-induced behavioral and neurobiological consequences in adolescent female rat offspring. Dev Psychobiol. 2023;65:e22411. 10.1002/dev.22411
- Azargoonjahromi A. A systematic review of the association between zinc and anxiety. Nutr Rev. 2024;82:612. 10.1093/nutrit/nuad076
- Hamdi E, Muñiz-Gonzalez AB, Hidouri S, Bermejo AM, Sakly M, et al. Prevention of neurotoxicity and cognitive impairment induced by zinc nanoparticles by oral administration of saffron extract. J Anim Physiol Anim Nutr (Berl). 2023;107:1473. 10.1111/jpn.13848
- Amini Z, HeidariFarsani E. Investigating the effect of zinc supplementation on probability of relapse and mental health in patients with opioid use disorder undergoing methadone maintenance treatment. Subst Abuse Treat Prev Policy. 2023;18:1. 10.1186/s13011-023-00514-5
