Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.5
USERS' SCORE
Good
Based on 2 Reviews
8.4
Top Medical Research Studies
8
Vitamin D3 ethosomal gel for psoriasis
We explored the development of ethosomal gels infused with vitamin D3 to target psoriasis, a chronic skin condition driven by immune responses. Vitamin D3 has long been recognized for its vital role in skin health, particularly in promoting the growth and maturation of skin cells known as keratinocytes.
Our research focused on creating a formulation that combines vitamin D3 with soya lecithin, propylene glycol, and ethanol. Through a series of tests, we assessed the size, shape, and encapsulation efficiency of the ethosomes, finding an impressive encapsulation rate of 96.25%.
The optimized ethosomes measured between 148 and 657 nanometers, with a manageable level of aggregation. We confirmed the formulation's safety and stability over six months, making it suitable for patient use. Additionally, our study demonstrated that this delivery system enabled effective permeation of the drug through membrane barriers.
As we delved into the physical characteristics and effectiveness of these gels, we observed that they could provide a novel and practical option for psoriasis sufferers seeking topical treatments.
Our research focused on creating a formulation that combines vitamin D3 with soya lecithin, propylene glycol, and ethanol. Through a series of tests, we assessed the size, shape, and encapsulation efficiency of the ethosomes, finding an impressive encapsulation rate of 96.25%.
The optimized ethosomes measured between 148 and 657 nanometers, with a manageable level of aggregation. We confirmed the formulation's safety and stability over six months, making it suitable for patient use. Additionally, our study demonstrated that this delivery system enabled effective permeation of the drug through membrane barriers.
As we delved into the physical characteristics and effectiveness of these gels, we observed that they could provide a novel and practical option for psoriasis sufferers seeking topical treatments.
Read More
9
Vitamin D's role in psoriasis treatment
We investigated the impact of vitamin D treatment on psoriasis, emphasizing its effectiveness for this skin condition. Our focus was on vitamin D as a topical treatment option, particularly in relation to nail psoriasis, a chronic and often challenging ailment.
Through a review of existing studies, we found strong evidence supporting the use of topical vitamin D analogs alongside tazarotene for managing nail psoriasis effectively. This means that for individuals dealing with nail psoriasis, there is a credible therapeutic option that can assist in reducing symptoms and improving overall nail health.
However, when we looked at other nail disorders and broader treatments involving vitamin D, the evidence was limited. We didn’t uncover significant benefits for many conditions when relying solely on vitamins, suggesting that while vitamin D can be helpful, more robust research is needed to ascertain its full potential across various nail disorders.
In conclusion, while there’s promising news for nail psoriasis patients, the journey for solid, proven treatments for other nail conditions could use further exploration.
Through a review of existing studies, we found strong evidence supporting the use of topical vitamin D analogs alongside tazarotene for managing nail psoriasis effectively. This means that for individuals dealing with nail psoriasis, there is a credible therapeutic option that can assist in reducing symptoms and improving overall nail health.
However, when we looked at other nail disorders and broader treatments involving vitamin D, the evidence was limited. We didn’t uncover significant benefits for many conditions when relying solely on vitamins, suggesting that while vitamin D can be helpful, more robust research is needed to ascertain its full potential across various nail disorders.
In conclusion, while there’s promising news for nail psoriasis patients, the journey for solid, proven treatments for other nail conditions could use further exploration.
Read More
8
We explored the potential of DDH-1, a unique derivative of ascorbic acid, in treating psoriasis, a chronic inflammatory skin condition driven by certain cytokines. In our research, mice with psoriasis-like skin lesions induced by imiquimod were treated with DDH-1 to examine its effects on inflammatory markers.
During our study, we found that treatment with DDH-1 significantly reduced the expression of inflammatory cytokines IL-1β and TNF-α in the affected skin. This finding is crucial, as these cytokines are key players in the development and persistence of psoriasis.
Additionally, we observed noticeable improvement in the skin lesions of the mice following the application of DDH-1. These promising results indicate that DDH-1 may be beneficial for those looking to manage psoriasis and could serve as a supplement in treatment strategies.
During our study, we found that treatment with DDH-1 significantly reduced the expression of inflammatory cytokines IL-1β and TNF-α in the affected skin. This finding is crucial, as these cytokines are key players in the development and persistence of psoriasis.
Additionally, we observed noticeable improvement in the skin lesions of the mice following the application of DDH-1. These promising results indicate that DDH-1 may be beneficial for those looking to manage psoriasis and could serve as a supplement in treatment strategies.
Read More
Most Useful Reviews
7.5
Skin clearing up
13 people found this helpful
Amazing on my psoriasis! I have battled chronic psoriasis for 33 years, trying various medications, creams, and treatments. I eventually decided to take matters into my own hands by juicing extensively, which noticeably improved my skin. My husband started experiencing psoriasis as well, and upon discovering his low Vitamin D levels, I decided to seek a natural D3 supplement without synthetic additives. Within just two weeks of taking one pill daily, my skin has begun clearing! I grew so encouraged that today I took two pills (although I don't recommend this for others). I’m still juicing greens and hope for continued improvement!
Read More
9
Controls breakouts
1 people found this helpful
Absolutely necessary for psoriasis; this phenomenal product helps control my husband’s breakouts.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.5
- All Researches
9
We examined a case involving a 45-year-old woman with a history of psoriasis who developed serious respiratory distress attributed to a pustular flare of her skin condition. Admitted to the intensive care unit, she presented with acute symptoms, including a diffuse rash and difficulty breathing, alongside findings consistent with non-cardiogenic pulmonary edema.
In evaluating her treatment, we noted that vitamin C was part of a comprehensive regimen that also included low-dose corticosteroids and cyclosporine. While we observed remarkable improvement in her condition—she transitioned to nasal cannulae just 24 hours after starting treatment—it's essential to remember that vitamin C was not the sole intervention applied. This dual approach complicates our ability to isolate the specific benefits of vitamin C on psoriasis.
Ultimately, while the inclusion of vitamin C shows promise, we must acknowledge the lack of definitive evidence connecting it directly to improvements in psoriasis on its own. The dramatic recovery of the patient suggests a multifaceted treatment effect rather than a singular benefit from vitamin C.
In evaluating her treatment, we noted that vitamin C was part of a comprehensive regimen that also included low-dose corticosteroids and cyclosporine. While we observed remarkable improvement in her condition—she transitioned to nasal cannulae just 24 hours after starting treatment—it's essential to remember that vitamin C was not the sole intervention applied. This dual approach complicates our ability to isolate the specific benefits of vitamin C on psoriasis.
Ultimately, while the inclusion of vitamin C shows promise, we must acknowledge the lack of definitive evidence connecting it directly to improvements in psoriasis on its own. The dramatic recovery of the patient suggests a multifaceted treatment effect rather than a singular benefit from vitamin C.
Read More
9
Vitamin D's role in psoriasis treatment
We investigated the impact of vitamin D treatment on psoriasis, emphasizing its effectiveness for this skin condition. Our focus was on vitamin D as a topical treatment option, particularly in relation to nail psoriasis, a chronic and often challenging ailment.
Through a review of existing studies, we found strong evidence supporting the use of topical vitamin D analogs alongside tazarotene for managing nail psoriasis effectively. This means that for individuals dealing with nail psoriasis, there is a credible therapeutic option that can assist in reducing symptoms and improving overall nail health.
However, when we looked at other nail disorders and broader treatments involving vitamin D, the evidence was limited. We didn’t uncover significant benefits for many conditions when relying solely on vitamins, suggesting that while vitamin D can be helpful, more robust research is needed to ascertain its full potential across various nail disorders.
In conclusion, while there’s promising news for nail psoriasis patients, the journey for solid, proven treatments for other nail conditions could use further exploration.
Through a review of existing studies, we found strong evidence supporting the use of topical vitamin D analogs alongside tazarotene for managing nail psoriasis effectively. This means that for individuals dealing with nail psoriasis, there is a credible therapeutic option that can assist in reducing symptoms and improving overall nail health.
However, when we looked at other nail disorders and broader treatments involving vitamin D, the evidence was limited. We didn’t uncover significant benefits for many conditions when relying solely on vitamins, suggesting that while vitamin D can be helpful, more robust research is needed to ascertain its full potential across various nail disorders.
In conclusion, while there’s promising news for nail psoriasis patients, the journey for solid, proven treatments for other nail conditions could use further exploration.
Read More
9
We evaluated the role of zinc treatment in addressing skin lesions that resemble psoriasis. Our focus was on a teenage boy who displayed characteristic symptoms of acrodermatitis enteropathica (AE) along with low serum zinc levels. Over time, his condition progressed into more widespread pustular psoriasis-like symptoms.
Notably, after initiating zinc supplementation, we observed a rapid improvement in his skin conditions. This led us to ponder whether zinc malabsorption might be a common factor triggering both AE and psoriasis-like skin issues. By restoring zinc levels, we believe we may have found a straightforward yet effective approach to manage these overlapping skin manifestations.
Overall, our findings suggest that maintaining a balanced zinc homeostasis could help alleviate symptoms for those affected by both AE and psoriasiform lesions.
Notably, after initiating zinc supplementation, we observed a rapid improvement in his skin conditions. This led us to ponder whether zinc malabsorption might be a common factor triggering both AE and psoriasis-like skin issues. By restoring zinc levels, we believe we may have found a straightforward yet effective approach to manage these overlapping skin manifestations.
Overall, our findings suggest that maintaining a balanced zinc homeostasis could help alleviate symptoms for those affected by both AE and psoriasiform lesions.
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9
We aimed to explore the effectiveness of zinc phthalocyanine, especially its sugar-conjugated forms, in treating psoriasis. This skin condition affects millions and is characterized by rapid skin cell growth and inflammation. Through our research, we synthesized both protected and unprotected versions of these conjugates to see how well they worked against psoriasis-related symptoms.
In tests with cells designed to mimic psoriasis, we found that the protected glucose-zinc phthalocyanine (Glu-4-ZnPc-P) showed the strongest phototoxic effects. It was significantly more effective than other variations, demonstrating its potential as a targeted therapy. When we stimulated cells with IL-17A, a key player in psoriasis, we observed that this enhanced the uptake of the unprotected variant, suggesting an interesting interaction that could enhance treatment efficacy.
Additionally, our tests in a psoriasis-like model demonstrated that using Glu-4-ZnPc-P led to marked improvements in skin condition and reduced inflammation, indicating its promising role in photodynamic therapy. Overall, our findings underscore the potential of sugar-conjugated zinc phthalocyanine as a novel treatment avenue for psoriasis, paving the way for future clinical studies.
In tests with cells designed to mimic psoriasis, we found that the protected glucose-zinc phthalocyanine (Glu-4-ZnPc-P) showed the strongest phototoxic effects. It was significantly more effective than other variations, demonstrating its potential as a targeted therapy. When we stimulated cells with IL-17A, a key player in psoriasis, we observed that this enhanced the uptake of the unprotected variant, suggesting an interesting interaction that could enhance treatment efficacy.
Additionally, our tests in a psoriasis-like model demonstrated that using Glu-4-ZnPc-P led to marked improvements in skin condition and reduced inflammation, indicating its promising role in photodynamic therapy. Overall, our findings underscore the potential of sugar-conjugated zinc phthalocyanine as a novel treatment avenue for psoriasis, paving the way for future clinical studies.
Read More
8
We explored the potential of DDH-1, a unique derivative of ascorbic acid, in treating psoriasis, a chronic inflammatory skin condition driven by certain cytokines. In our research, mice with psoriasis-like skin lesions induced by imiquimod were treated with DDH-1 to examine its effects on inflammatory markers.
During our study, we found that treatment with DDH-1 significantly reduced the expression of inflammatory cytokines IL-1β and TNF-α in the affected skin. This finding is crucial, as these cytokines are key players in the development and persistence of psoriasis.
Additionally, we observed noticeable improvement in the skin lesions of the mice following the application of DDH-1. These promising results indicate that DDH-1 may be beneficial for those looking to manage psoriasis and could serve as a supplement in treatment strategies.
During our study, we found that treatment with DDH-1 significantly reduced the expression of inflammatory cytokines IL-1β and TNF-α in the affected skin. This finding is crucial, as these cytokines are key players in the development and persistence of psoriasis.
Additionally, we observed noticeable improvement in the skin lesions of the mice following the application of DDH-1. These promising results indicate that DDH-1 may be beneficial for those looking to manage psoriasis and could serve as a supplement in treatment strategies.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Skin clearing up
13 people found this helpful
Amazing on my psoriasis! I have battled chronic psoriasis for 33 years, trying various medications, creams, and treatments. I eventually decided to take matters into my own hands by juicing extensively, which noticeably improved my skin. My husband started experiencing psoriasis as well, and upon discovering his low Vitamin D levels, I decided to seek a natural D3 supplement without synthetic additives. Within just two weeks of taking one pill daily, my skin has begun clearing! I grew so encouraged that today I took two pills (although I don't recommend this for others). I’m still juicing greens and hope for continued improvement!
Read More
9
Controls breakouts
1 people found this helpful
Absolutely necessary for psoriasis; this phenomenal product helps control my husband’s breakouts.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Díaz-de-la-Cruz EN, Hurtado-Nuñez GE, Sánchez-Ceja SG, Torner L, Bartolomé-Camacho MC, et al. Role of Vitamin C on methotrexate-induced nephrotoxicity in psoriasis context: A preclinical assessment. Toxicol Rep. 2024;13:101782. 10.1016/j.toxrep.2024.101782
- Kitahata K, Matsuo K, Hara Y, Naganuma T, Oiso N, et al. Ascorbic acid derivative DDH-1 ameliorates psoriasis-like skin lesions in mice by suppressing inflammatory cytokine expression. J Pharmacol Sci. 2018;138:284. 10.1016/j.jphs.2018.11.002
- Marik PE, Long A. ARDS complicating pustular psoriasis: treatment with low-dose corticosteroids, vitamin C and thiamine. BMJ Case Rep. 2018;2018. 10.1136/bcr-2017-223475
- Lee JH, Jeon YJ, Choi JH, Kim HY, Kim TY. Effects of VitabridC on Skin Inflammation. Ann Dermatol. 2017;29:548. 10.5021/ad.2017.29.5.548
- Soodgupta D, Kaul D, Kanwar AJ, Parsad D. Modulation of LXR-α and the effector genes by Ascorbic acid and Statins in psoriatic keratinocytes. Mol Cell Biochem. 2014;397:1. 10.1007/s11010-014-2063-x
- Wang ZY, Zhao ZQ, Sheng YJ, Chen KJ, Chen BZ, et al. Dual-Action Psoriasis Therapy: Antiproliferative and Immunomodulatory Effects via Self-Locking Microneedles. Adv Sci (Weinh). 2024;11:e2409359. 10.1002/advs.202409359
- Zanghaneh AJ, Elmelid A, Gillstedt M, Ahmic O, Andersson B, et al. The Expression of Vitamin D Receptor on Peripheral Blood Mononuclear Cells in Patients with Psoriasis. Int J Mol Sci. 2024;25. 10.3390/ijms251910677
- Mehmood Y, Shahid H, Ahmed S, Khursheed A, Jamshaid T, et al. Synthesis of vitamin D3 loaded ethosomes gel to cure chronic immune-mediated inflammatory skin disease: physical characterization, in vitro and ex vivo studies. Sci Rep. 2024;14:23866. 10.1038/s41598-024-72951-6
- Elmelid A, Vandikas MS, Gillstedt M, Alsterholm M, Osmancevic A. The Effect of Phototherapy on Systemic Inflammation Measured with Serum Vitamin D-Binding Protein and hsCRP in Patients with Inflammatory Skin Disease. Int J Mol Sci. 2024;25. 10.3390/ijms25168632
- Das K, Ranjan R, Kumar P, Chandra S. A Comparative Study of the Effectiveness and Safety of Topical Calcipotriol and Topical Methotrexate in Chronic Plaque Psoriasis. Cureus. 2024;16:e59878. 10.7759/cureus.59878
- Formisano E, Proietti E, Borgarelli C, Pisciotta L. Comment to "Vitamin D in psoriatic arthritis - A systematic review and meta-analysis". Semin Arthritis Rheum. 2024;67:152457. 10.1016/j.semarthrit.2024.152457
- Curtis KL, Lipner SR. Vitamins for the Management of Nail Disease: A Literature Review. Skin Appendage Disord. 2024;10:104. 10.1159/000534972
- Gong X, Gu W, Fu S, Zou G, Jiang Z. Zinc homeostasis regulates caspase activity and inflammasome activation. PLoS Pathog. 2024;20:e1012805. 10.1371/journal.ppat.1012805
- Wang L, Zou S, Zhu Y. Zinc Supplementation for Acrodermatitis Enteropathica Overlapped with Psoriasiform Lesions. Psoriasis (Auckl). 2024;14:175. 10.2147/PTT.S494519
- Makuch S, Kupczyk P, Woźniak M, Makarec A, Lipińska M, et al. In Vitro and In Vivo Antipsoriatic Efficacy of Protected and Unprotected Sugar-Zinc Phthalocyanine Conjugates. Pharmaceutics. 2024;16. 10.3390/pharmaceutics16060838
- Huang T, Chen S, Ding K, Zheng B, Lv W, et al. SLC35E1 promotes keratinocyte proliferation in psoriasis by regulating zinc homeostasis. Cell Death Dis. 2023;14:354. 10.1038/s41419-023-05874-1
- Yu C, Yu N, Jiang X, Gao X, Lv S, et al. Efficacy and safety of supramolecular active zinc in the treatment of scalp psoriasis: a multicentre, randomized, observed-blind, parallel-group, placebo- and active-controlled noninferiority trial. Clin Exp Dermatol. 2023;48:1138. 10.1093/ced/llad168
