Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 83 Researches
7.9
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.9
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Iron (from Ionic Plant Based Minerals)
2 mg
10%
HSO Probiotic Blend (5 Billion CFU)¹Saccharomyces boulardii, Organic Barley Grass², Organic Oat Grass², Lactobacillus plantarum, Bacillus subtilis, Bifidobacterium lactis, Bifidobacterium bifidum, Lactobacillus rhamnosus, Bifidobacterium breve, Lactobacillus casei, Lactobacillus salivarius, Lactobacillus acidophilus, Lactobacillus brevis, Bifidobacterium longum, Lactobacillus paracasei
410 mg
+
Ionic Plant Based Minerals
290 mg
+
Top Medical Research Studies
9
We explored how Bifidobacterium bifidum TMC3115 could help infants with cow's milk protein allergy (CMPA). In our controlled trial with 256 infants, half received B. bifidum while the other half received a placebo.
Over six months, we observed significant reductions in allergic scores and improvements in anti-inflammatory responses among those taking B. bifidum. We also found changes in gut microbiota, increasing beneficial bacteria and decreasing potentially harmful ones.
Though promising, these interventions indicate that managing CMPA may benefit from focusing on gut health.
Over six months, we observed significant reductions in allergic scores and improvements in anti-inflammatory responses among those taking B. bifidum. We also found changes in gut microbiota, increasing beneficial bacteria and decreasing potentially harmful ones.
Though promising, these interventions indicate that managing CMPA may benefit from focusing on gut health.
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7
Lactobacillus salivarius lowers allergy symptoms
We explored the impact of Lactobacillus salivarius on allergic rhinitis symptoms in children through a double-blind, randomized controlled trial. Over 12 weeks, children either received the probiotic or a placebo.
Results showed a decrease in rhinitis symptoms and medication usage in those treated with the probiotic. However, there were no significant changes in immunological or blood cell measures when comparing the two groups.
Overall, Lactobacillus salivarius may be beneficial for reducing symptoms of allergic rhinitis in children.
Results showed a decrease in rhinitis symptoms and medication usage in those treated with the probiotic. However, there were no significant changes in immunological or blood cell measures when comparing the two groups.
Overall, Lactobacillus salivarius may be beneficial for reducing symptoms of allergic rhinitis in children.
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9
Lactobacillus KBL409 reduces atopic dermatitis
We explored the effects of Lactobacillus acidophilus KBL409 on atopic dermatitis (AD) using a house dust mite-induced mouse model. The treatment notably lowered dermatitis symptoms and reduced immune cell infiltration in the skin. Additionally, it decreased levels of specific immune markers and increased anti-inflammatory responses.
L. acidophilus KBL409 also positively influenced gut microbiota and certain metabolites. The findings suggest that this probiotic may offer a promising approach to managing AD through immune system modulation and gut health improvement.
L. acidophilus KBL409 also positively influenced gut microbiota and certain metabolites. The findings suggest that this probiotic may offer a promising approach to managing AD through immune system modulation and gut health improvement.
Read More
Most Useful Reviews
9
Life saver
27 people found this helpful
Amazing stuff! I have suffered from constant diarrhoea for nearly 10 years. Diagnosed with IBS, the medication only worked to an extent. I began taking these capsules based on a friend's recommendation from a vitamin shop. Initially sceptical, I expected side effects, but after three weeks, my diarrhoea stopped, and I resumed normal bowel movements—something that hadn't happened for almost a decade! Increasing my intake to two capsules has been phenomenal! I no longer experience acid reflux, have more energy, and my allergies have improved significantly. This probiotic is a lifesaver! It's worth investing in rather than buying cheaper options.
Read More
6
Immune system boost
26 people found this helpful
Works wonders, but be cautious! Do not take it for more than a month to prevent overstimulation of the immune system. A month's intake is sufficient to positively influence the immune response. This product gently supports the gastrointestinal tract while working wonders on immunity. Tests indicate good immune dynamics. I consume it for one month, 2-3 times a year, and it does not exacerbate my allergies, which is crucial for me. Stay healthy and look after yourselves and your loved ones.
Read More
0
Contains soy
2 people found this helpful
Contains soy. If you have allergies to soy, this product contains it. I did not understand why they included soy in probiotics.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 83 Researches
7.9
- All Researches
9.5
We sought to understand if Bifiform Kids, a probiotic, could help prevent respiratory infections in children with recurrent infections and gastrointestinal allergy symptoms. In our controlled trial with 92 children aged 4 to 5, those taking the probiotic showed a significant 3-fold reduction in respiratory infections compared to the control group.
After 21 days, there were notable immune system improvements, including an increase in protective IgA levels and a decrease in allergic IgE. These findings suggest that Bifiform Kids is effective for preventing respiratory infections in children facing allergic issues.
After 21 days, there were notable immune system improvements, including an increase in protective IgA levels and a decrease in allergic IgE. These findings suggest that Bifiform Kids is effective for preventing respiratory infections in children facing allergic issues.
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9
Lactobacillus KBL409 reduces atopic dermatitis
We explored the effects of Lactobacillus acidophilus KBL409 on atopic dermatitis (AD) using a house dust mite-induced mouse model. The treatment notably lowered dermatitis symptoms and reduced immune cell infiltration in the skin. Additionally, it decreased levels of specific immune markers and increased anti-inflammatory responses.
L. acidophilus KBL409 also positively influenced gut microbiota and certain metabolites. The findings suggest that this probiotic may offer a promising approach to managing AD through immune system modulation and gut health improvement.
L. acidophilus KBL409 also positively influenced gut microbiota and certain metabolites. The findings suggest that this probiotic may offer a promising approach to managing AD through immune system modulation and gut health improvement.
Read More
9
We investigated the effects of Lactobacillus acidophilus on allergies, particularly its peptidoglycan derived from dairy. In a mouse model of β-lactoglobulin allergy, we discovered that this peptidoglycan helped lower IgE production and promoted a healthier immune response. It also appeared to influence specific immune signaling pathways that help manage allergic reactions.
However, while the results showed promise, they were conducted in a controlled lab setting and further studies are needed to understand how these effects translate to humans.
However, while the results showed promise, they were conducted in a controlled lab setting and further studies are needed to understand how these effects translate to humans.
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9
We conducted a thorough investigation to see how Lactobacillus acidophilus L-92 affects skin symptoms in adults with atopic dermatitis. In this double-blind study involving 50 participants, we compared this probiotic against a placebo over 24 weeks.
Our findings showed that those taking L-92 experienced significant improvements in skin condition compared to the placebo group. There were reductions in symptoms and overall severity, with no adverse effects reported. This suggests that L-92 may help manage inflammation linked to allergies.
Our findings showed that those taking L-92 experienced significant improvements in skin condition compared to the placebo group. There were reductions in symptoms and overall severity, with no adverse effects reported. This suggests that L-92 may help manage inflammation linked to allergies.
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9
Lactobacillus acidophilus may reduce allergies
Our study assessed how Lactobacillus acidophilus in probiotic Dahi affects allergies, particularly cow milk allergy in mice. Mice were given two types of probiotic Dahi before being exposed to whey proteins.
The results were promising; we found that the probiotic treatment reduced allergy-related immune responses. Specifically, it lowered certain IgE levels and shifted the immune response from a Th2-type to a Th1-type, which is generally more protective against allergens.
While further research is needed, these findings suggest that probiotics could be a potential avenue for managing food allergies.
The results were promising; we found that the probiotic treatment reduced allergy-related immune responses. Specifically, it lowered certain IgE levels and shifted the immune response from a Th2-type to a Th1-type, which is generally more protective against allergens.
While further research is needed, these findings suggest that probiotics could be a potential avenue for managing food allergies.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
9
Life saver
27 people found this helpful
Amazing stuff! I have suffered from constant diarrhoea for nearly 10 years. Diagnosed with IBS, the medication only worked to an extent. I began taking these capsules based on a friend's recommendation from a vitamin shop. Initially sceptical, I expected side effects, but after three weeks, my diarrhoea stopped, and I resumed normal bowel movements—something that hadn't happened for almost a decade! Increasing my intake to two capsules has been phenomenal! I no longer experience acid reflux, have more energy, and my allergies have improved significantly. This probiotic is a lifesaver! It's worth investing in rather than buying cheaper options.
Read More
6
Immune system boost
26 people found this helpful
Works wonders, but be cautious! Do not take it for more than a month to prevent overstimulation of the immune system. A month's intake is sufficient to positively influence the immune response. This product gently supports the gastrointestinal tract while working wonders on immunity. Tests indicate good immune dynamics. I consume it for one month, 2-3 times a year, and it does not exacerbate my allergies, which is crucial for me. Stay healthy and look after yourselves and your loved ones.
Read More
0
Contains soy
2 people found this helpful
Contains soy. If you have allergies to soy, this product contains it. I did not understand why they included soy in probiotics.
Read More
9
Effective gut health
Excellent! A must-have! For over 10 years, I have been using Primal Defense, which has helped me eliminate food allergies and intolerances by balancing my gut flora, combined with a healthy diet. It is truly fantastic.
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7.5
Food allergy relief
A great product! I have numerous food allergies and digestive issues that I suspect stem from chemotherapy years ago. These problems began during treatment and have persisted. I have experimented with various probiotic formulations, but this one is my favourite. I take one capsule before meals with CaprZyme, and I experience no adverse reactions.
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Frequently Asked Questions
6
Immune system boost
26 people found this helpful
Works wonders, but be cautious! Do not take it for more than a month to prevent overstimulation of the immune system. A month's intake is sufficient to positively influence the immune response. This product gently supports the gastrointestinal tract while working wonders on immunity. Tests indicate good immune dynamics. I consume it for one month, 2-3 times a year, and it does not exacerbate my allergies, which is crucial for me. Stay healthy and look after yourselves and your loved ones.
9
Effective gut health
Excellent! A must-have! For over 10 years, I have been using Primal Defense, which has helped me eliminate food allergies and intolerances by balancing my gut flora, combined with a healthy diet. It is truly fantastic.
7.5
Food allergy relief
A great product! I have numerous food allergies and digestive issues that I suspect stem from chemotherapy years ago. These problems began during treatment and have persisted. I have experimented with various probiotic formulations, but this one is my favourite. I take one capsule before meals with CaprZyme, and I experience no adverse reactions.
8
We investigated the potential of Lactobacillus acidophilus KLDS 1.0738 to alleviate allergic inflammation, focusing on its ability to influence a specific inflammatory pathway in macrophages. By treating β-lactoglobulin-induced macrophages with viable L. acidophilus, we found that it effectively reduced inflammation by inhibiting the TLR4/NF-κB signaling pathway. This strain outperformed other probiotics in its effectiveness. Additionally, it was linked to increased levels of miR-146a, a molecule that regulates inflammation. These findings suggest that probiotics could play a significant role in managing milk allergies, particularly in infants.
8
Lactobacillus acidophilus reduces allergy symptoms
We explored how Lactobacillus acidophilus affects allergy responses in mice sensitized to cow’s milk protein. Over four weeks, mice were treated with this probiotic before being exposed to the allergen.
Our findings showed that L. acidophilus significantly lessened allergy symptoms, increased gut diversity, and boosted beneficial short-chain fatty acids. Additionally, the treatment enhanced receptors linked to gut health, indicating that L. acidophilus plays a protective role against allergic inflammation by improving gut microbiota and metabolic responses.
Our findings showed that L. acidophilus significantly lessened allergy symptoms, increased gut diversity, and boosted beneficial short-chain fatty acids. Additionally, the treatment enhanced receptors linked to gut health, indicating that L. acidophilus plays a protective role against allergic inflammation by improving gut microbiota and metabolic responses.
8
We investigated the use of a symbiotic food supplement, combining probiotics and prebiotics, in combatting birch pollen allergies. Conducted in a controlled allergen exposure chamber, our research monitored patients' symptoms over four months.
The results showed noticeable improvements in allergy symptoms and overall well-being after regular use of the supplement. This suggests such supplements can be a helpful addition to managing allergic rhinitis, with a strong safety record.
The results showed noticeable improvements in allergy symptoms and overall well-being after regular use of the supplement. This suggests such supplements can be a helpful addition to managing allergic rhinitis, with a strong safety record.
8
Probiotics beneficial for eczema treatment
We examined the use of probiotics in alleviating symptoms of atopic dermatitis in children. Through a thorough review of multiple studies, we found that certain probiotic strains, particularly Mix1 and Mix6, significantly improved allergic symptoms compared to a placebo.
Although evidence was strongest for Mix1 among the strains assessed, Mix6 showed promising potential as well. Conversely, while Lactobacillus casei DN-114001 indicated some benefit, the certainty of this effect was lower.
Overall, specific probiotic preparations do seem to help in managing allergies associated with pediatric atopic dermatitis.
Although evidence was strongest for Mix1 among the strains assessed, Mix6 showed promising potential as well. Conversely, while Lactobacillus casei DN-114001 indicated some benefit, the certainty of this effect was lower.
Overall, specific probiotic preparations do seem to help in managing allergies associated with pediatric atopic dermatitis.
8
We aimed to assess how probiotic supplementation, particularly using Lactobacillus acidophilus, can help treat adult atopic dermatitis (AD). After analyzing nine studies, we found that specific probiotics, including L. acidophilus, provided some benefits, especially for those with moderate to severe AD.
However, changes in skin severity did not significantly improve patients’ quality of life. Importantly, the effectiveness of probiotics varied by strain, and there are still many unknowns about the best dosage and treatment duration.
However, changes in skin severity did not significantly improve patients’ quality of life. Importantly, the effectiveness of probiotics varied by strain, and there are still many unknowns about the best dosage and treatment duration.
8
We explored whether the probiotic strain ssp. SA-03 could counteract asthma caused by phthalate exposure in mice. In our study, female BALB/c mice were exposed to a harmful chemical and then given different doses of the probiotic, alongside a substance to induce asthma.
We noticed significant improvements in asthma symptoms, including reduced IgE levels and inflammation markers in the high-dose group. This suggests that higher doses of the probiotic may help modulate the inflammatory response related to asthma. Our findings support the idea that probiotics might be a promising approach for managing asthma triggered by environmental toxins.
We noticed significant improvements in asthma symptoms, including reduced IgE levels and inflammation markers in the high-dose group. This suggests that higher doses of the probiotic may help modulate the inflammatory response related to asthma. Our findings support the idea that probiotics might be a promising approach for managing asthma triggered by environmental toxins.
References
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- Husein-ElAhmed H, Steinhoff M. Effects of probiotic supplementation in adult with atopic dermatitis: a systematic review with meta-analysis. Clin Exp Dermatol. 2023;49:46. doi:10.1093/ced/llad318
- Li A, Yang J, Zhang C, Chi H, Zhang C, et al. Lactobacillus acidophilus KLDS 1.0738 inhibits TLR4/NF-κB inflammatory pathway in β-lactoglobulin-induced macrophages via modulating miR-146a. J Food Biochem. 2021;45:e13662. doi:10.1111/jfbc.13662
- Bergmann KC, Krause L, Hiller J, Becker S, Kugler S, et al. First evaluation of a symbiotic food supplement in an allergen exposure chamber in birch pollen allergic patients. World Allergy Organ J. 2021;14:100494. doi:10.1016/j.waojou.2020.100494
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- Wang JJ, Zhang QM, Ni WW, Zhang X, Li Y, et al. Modulatory effect of Lactobacillus acidophilus KLDS 1.0738 on intestinal short-chain fatty acids metabolism and GPR41/43 expression in β-lactoglobulin-sensitized mice. Microbiol Immunol. 2019;63:303. doi:10.1111/1348-0421.12723
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- Yamamoto K, Yokoyama K, Matsukawa T, Kato S, Kato S, et al. Efficacy of prolonged ingestion of Lactobacillus acidophilus L-92 in adult patients with atopic dermatitis. J Dairy Sci. 2016;99:5039. doi:10.3168/jds.2015-10605
- Shandilya UK, Sharma A, Kapila R, Kansal VK. Probiotic Dahi containing Lactobacillus acidophilus and Bifidobacterium bifidum modulates immunoglobulin levels and cytokines expression in whey proteins sensitised mice. J Sci Food Agric. 2016;96:3180. doi:10.1002/jsfa.7497
- Simpson MR, Dotterud CK, Storrø O, Johnsen R, Øien T. Perinatal probiotic supplementation in the prevention of allergy related disease: 6 year follow up of a randomised controlled trial. BMC Dermatol. 2015;15:13. doi:10.1186/s12895-015-0030-1
- Xu H, Duan X, Wang Y, Geng W. Amelioration Effect of ZW3 on Ovalbumin-Induced Allergic Symptoms in BALB/c Mice. Foods. 2024;14. doi:10.3390/foods14010016
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- Song S, Zhang H, Liu L, Li M, Wang X, et al. Probiotic DNA regulates intestinal Th2 polarization by inducing epithelial cells to produce PD-L1. Apoptosis. 2025;30:239. doi:10.1007/s10495-024-02043-3
- Mennini M, Piccirillo M, Furio S, Valitutti F, Ferretti A, et al. Probiotics and other adjuvants in allergen-specific immunotherapy for food allergy: a comprehensive review. Front Allergy. 2024;5:1473352. doi:10.3389/falgy.2024.1473352
- Malekiantaghi A, Ghanaati F, Shabani-Mirzaee H, Shariat M, Mojtahedi SY, et al. Helps to Reduce the Duration of Bleeding in Breastfed Infants with Allergic Proctocolitis. Breastfeed Med. 2025;20:59. doi:10.1089/bfm.2024.0185
- Xue J, Liu Z, Xie B, Dong R, Wu J, et al. Probiotic nucleotides increase IL-10 expression in airway macrophages to mitigate airway allergy. Inflamm Res. 2024;73:1919. doi:10.1007/s00011-024-01940-2
- Puisto R, Gómez-Gallego C, Collado MC, Turta O, Isolauri E, et al. The Role of Infant Gut Microbiota Modulation by Perinatal Maternal Probiotic Intervention in Atopic Eczema Risk Reduction. Neonatology. 2025;122:84. doi:10.1159/000540075
- Uberos J, Garcia-Cuesta A, Carrasco-Solis M, Ruiz-López A, Fernandez-Marı N E, et al. Lacticaseibacillus rhamnosus and breastmilk are associated with a decreased risk of atopic dermatitis in very low birth weight premature infants. Benef Microbes. 2023;14:433. doi:10.1163/18762891-20220144
- Shi J, Dong P, Liu C, Xu Y, Zheng M, et al. Probio-M9 alleviates OVA-sensitized food allergy through modulating gut microbiota and its metabolism. Food Funct. 2023;14:10784. doi:10.1039/d3fo03321j
- Li L, Wen X, Gong Y, Chen Y, Xu J, et al. HMGN2 and Histone H1.2: potential targets of a novel probiotic mixture for seasonal allergic rhinitis. Front Microbiol. 2023;14:1202858. doi:10.3389/fmicb.2023.1202858
- Vasconcelos JA, Mota AS, Olímpio F, Rosa PC, Damaceno-Rodrigues N, et al. Lactobacillus rhamnosus Modulates Lung Inflammation and Mitigates Gut Dysbiosis in a Murine Model of Asthma-COPD Overlap Syndrome. Probiotics Antimicrob Proteins. 2025;17:588. doi:10.1007/s12602-023-10167-2
- Tan Lim CSC, Sajo MEJV, Orteza KEMP, Fernandez PBA, Vila MJC. Next-Gen biotherapeutics: A systematic review and network meta-analysis on postbiotics as treatment for pediatric atopic dermatitis. Pediatr Allergy Immunol. 2023;34:e14022. doi:10.1111/pai.14022
- Komulainen M, Saros L, Vahlberg T, Nermes M, Jartti T, et al. Maternal fish oil and/or probiotics intervention: Allergic diseases in children up to two years old. Pediatr Allergy Immunol. 2023;34:e14004. doi:10.1111/pai.14004
- Hou Y, Zheng S, Zou F, Wang D, Da H, et al. Lactobacillus rhamnosus 76 alleviates airway inflammation in ovalbumin-allergic mice and improves mucus secretion by down-regulating STAT6/SPDEF pathway. Immunobiology. 2023;228:152712. doi:10.1016/j.imbio.2023.152712
- Vorobieva OA, Shih EV, Drozdov VN, Shikh NV. [The results of the use of a combined probiotic ( and spp. ВB-12) in children with gastrointestinal and skin manifestations of food allergy]. Vopr Pitan. 2023;92:79. doi:10.33029/0042-8833-2023-92-3-79-86
- Lee JY, Park JY, Jeong Y, Kang CH. Anti-Inflammatory Response in TNFα/IFNγ-Induced HaCaT Keratinocytes and Probiotic Properties of MG4644, MG4693, and MG5474. J Microbiol Biotechnol. 2023;33:1039. doi:10.4014/jmb.2301.01028
- Lin TJ, Huang CC, Lee MC, Lee YP, Huang WC, et al. Effects of ssp. SA-03 Supplementation on Reversing Phthalate-Induced Asthma in Mice. Nutrients. 2024;16. doi:10.3390/nu16081160
- Yang S, Peng Z, Hardie WJ, Huang T, Tang H, et al. Screening of probiotic Lactobacillus to reduce peanut allergy and with potential anti-allergic activity. J Sci Food Agric. 2024;104:2006. doi:10.1002/jsfa.13089
- Uwaezuoke SN, Ayuk AC, Eze JN, Odimegwu CL, Ndiokwelu CO, et al. Postnatal probiotic supplementation can prevent and optimize treatment of childhood asthma and atopic disorders: A systematic review of randomized controlled trials. Front Pediatr. 2022;10:956141. doi:10.3389/fped.2022.956141
- Holowacz S, Blondeau C, Guinobert I, Guilbot A, Hidalgo S, et al. Lactobacillus salivarius LA307 and Lactobacillus rhamnosus LA305 attenuate skin inflammation in mice. Benef Microbes. 2018;9:299. doi:10.3920/BM2017.0084
- Nettis E, Di Leo E, Pastore A, Distaso M, Zaza I, et al. Probiotics and refractory chronic spontaneous urticaria. Eur Ann Allergy Clin Immunol. 2016;48:182.
- Neau E, Delannoy J, Marion C, Cottart CH, Labellie C, et al. Three Novel Candidate Probiotic Strains with Prophylactic Properties in a Murine Model of Cow's Milk Allergy. Appl Environ Microbiol. 2016;82:1722. doi:10.1128/AEM.03440-15
- Yun X, Shang Y, Li M. Effect of Lactobacillus salivarius on Th1/Th2 cytokines and the number of spleen CD4⁺ CD25⁺ Foxp3⁺ Treg in asthma Balb/c mouse. Int J Clin Exp Pathol. 2015;8:7661.
- Drago L, De Vecchi E, Gabrieli A, De Grandi R, Toscano M. Immunomodulatory Effects of Lactobacillus salivarius LS01 and Bifidobacterium breve BR03, Alone and in Combination, on Peripheral Blood Mononuclear Cells of Allergic Asthmatics. Allergy Asthma Immunol Res. 2015;7:409. doi:10.4168/aair.2015.7.4.409
- Drago L, De Vecchi E, Toscano M, Vassena C, Altomare G, et al. Treatment of atopic dermatitis eczema with a high concentration of Lactobacillus salivarius LS01 associated with an innovative gelling complex: a pilot study on adults. J Clin Gastroenterol. 2014;48 Suppl 1:S47. doi:10.1097/MCG.0000000000000249
- Niccoli AA, Artesi AL, Candio F, Ceccarelli S, Cozzali R, et al. Preliminary results on clinical effects of probiotic Lactobacillus salivarius LS01 in children affected by atopic dermatitis. J Clin Gastroenterol. 2014;48 Suppl 1:S34. doi:10.1097/MCG.0000000000000233
- Allen SJ, Jordan S, Storey M, Thornton CA, Gravenor MB, et al. Probiotics in the prevention of eczema: a randomised controlled trial. Arch Dis Child. 2014;99:1014. doi:10.1136/archdischild-2013-305799
- Drago L, Toscano M, De Vecchi E, Piconi S, Iemoli E. Changing of fecal flora and clinical effect of L. salivarius LS01 in adults with atopic dermatitis. J Clin Gastroenterol. 2012;46 Suppl:S56. doi:10.1097/MCG.0b013e318265ef38
- Iemoli E, Trabattoni D, Parisotto S, Borgonovo L, Toscano M, et al. Probiotics reduce gut microbial translocation and improve adult atopic dermatitis. J Clin Gastroenterol. 2012;46 Suppl:S33. doi:10.1097/MCG.0b013e31826a8468
- Lin TY, Chen CJ, Chen LK, Wen SH, Jan RH. Effect of probiotics on allergic rhinitis in Df, Dp or dust-sensitive children: a randomized double blind controlled trial. Indian Pediatr. 2013;50:209.
- Anania C, Matys V, Marra S, De Canditiis D, Olivero F, et al. Effect of Supplementation with a Specific Probiotic ( PRL2010) in Pregnancy for the Prevention of Atopic Dermatitis in Children: Preliminary Results of a Randomized Trial. Nutrients. 2025;17. doi:10.3390/nu17040673
- Chan OM, Xu W, Cheng NS, Leung ASY, Ching JYL, et al. A novel infant microbiome formula (SIM03) improved eczema severity and quality of life in preschool children. Sci Rep. 2024;14:3168. doi:10.1038/s41598-024-53848-w
- Jing W, Liu Q, Wang W. Bifidobacterium bifidum TMC3115 ameliorates milk protein allergy in by affecting gut microbiota: A randomized double-blind control trial. J Food Biochem. 2020;44:e13489. doi:10.1111/jfbc.13489
- Cheng R, Guo J, Pu F, Wan C, Shi L, et al. Loading ceftriaxone, vancomycin, and Bifidobacteria bifidum TMC3115 to neonatal mice could differently and consequently affect intestinal microbiota and immunity in adulthood. Sci Rep. 2019;9:3254. doi:10.1038/s41598-018-35737-1
- Suzuki S, Campos-Alberto E, Morita Y, Yamaguchi M, Toshimitsu T, et al. Low Interleukin 10 Production at Birth Is a Risk Factor for Atopic Dermatitis in Neonates with Bifidobacterium Colonization. Int Arch Allergy Immunol. 2018;177:342. doi:10.1159/000492130
- Cheng RY, Yao JR, Wan Q, Guo JW, Pu FF, et al. Oral administration of Bifidobacterium bifidum TMC3115 to neonatal mice may alleviate IgE-mediated allergic risk in adulthood. Benef Microbes. 2018;9:815. doi:10.3920/BM2018.0005
- Dennis-Wall JC, Culpepper T, Nieves C, Rowe CC, Burns AM, et al. Probiotics ( KS-13, G9-1, and MM-2) improve rhinoconjunctivitis-specific quality of life in individuals with seasonal allergies: a double-blind, placebo-controlled, randomized trial. Am J Clin Nutr. 2017;105:758. doi:10.3945/ajcn.116.140012
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