Last update
4/4/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6
USERS' SCORE
Good
Based on 2 Reviews
8.2
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Iron (from Ionic Plant Based Minerals)
2 mg
10%
HSO Probiotic Blend (5 Billion CFU)¹Saccharomyces boulardii, Organic Barley Grass², Organic Oat Grass², Lactobacillus plantarum, Bacillus subtilis, Bifidobacterium lactis, Bifidobacterium bifidum, Lactobacillus rhamnosus, Bifidobacterium breve, Lactobacillus casei, Lactobacillus salivarius, Lactobacillus acidophilus, Lactobacillus brevis, Bifidobacterium longum, Lactobacillus paracasei
410 mg
+
Ionic Plant Based Minerals
290 mg
+
Top Medical Research Studies
8
We explored the effects of Lactobacillus acidophilus, both free and in floating beads, as a possible treatment for chronic fatigue syndrome in a rat model. The study involved inducing fatigue through a forced swim test and then administering the probiotics over the last week of the experiment.
Remarkably, we found that both forms of Lactobacillus led to significant reductions in fatigue-like behaviors and improved biomarkers associated with stress. This indicates that lactobacilli may serve as a beneficial option for alleviating symptoms of chronic fatigue syndrome.
Remarkably, we found that both forms of Lactobacillus led to significant reductions in fatigue-like behaviors and improved biomarkers associated with stress. This indicates that lactobacilli may serve as a beneficial option for alleviating symptoms of chronic fatigue syndrome.
Read More
4
We aimed to understand if Lactobacillus acidophilus and other probiotics could help alleviate fatigue in chronic fatigue syndrome (CFS) patients. In our study with 15 participants, we first looked at their baseline fatigue prior to a four-week probiotic treatment.
While we observed some neurocognitive improvements, fatigue and physical activity levels showed no significant changes overall. Interestingly, six patients reported feeling better by the end. Our findings invite further exploration of probiotics as potential support for individuals dealing with CFS.
While we observed some neurocognitive improvements, fatigue and physical activity levels showed no significant changes overall. Interestingly, six patients reported feeling better by the end. Our findings invite further exploration of probiotics as potential support for individuals dealing with CFS.
Read More
Most Useful Reviews
6
Better digestion
8 people found this helpful
I'm satisfied with this product, much better than ordinary lactic acid bacteria. It's effective for chronic fatigue syndrome, although results may vary. Give it a couple of weeks before switching to alternatives.
Read More
9
Pain relief
I’ve had severe abdominal discomfort associated with chronic fatigue syndrome and tried many probiotics with little relief. After three days of using Primal Defense, I noticed reduced pain and more regular bowel movements. Now, I feel healthier overall.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6
- All Researches
8
We explored the effects of Lactobacillus acidophilus, both free and in floating beads, as a possible treatment for chronic fatigue syndrome in a rat model. The study involved inducing fatigue through a forced swim test and then administering the probiotics over the last week of the experiment.
Remarkably, we found that both forms of Lactobacillus led to significant reductions in fatigue-like behaviors and improved biomarkers associated with stress. This indicates that lactobacilli may serve as a beneficial option for alleviating symptoms of chronic fatigue syndrome.
Remarkably, we found that both forms of Lactobacillus led to significant reductions in fatigue-like behaviors and improved biomarkers associated with stress. This indicates that lactobacilli may serve as a beneficial option for alleviating symptoms of chronic fatigue syndrome.
Read More
4
We aimed to understand if Lactobacillus acidophilus and other probiotics could help alleviate fatigue in chronic fatigue syndrome (CFS) patients. In our study with 15 participants, we first looked at their baseline fatigue prior to a four-week probiotic treatment.
While we observed some neurocognitive improvements, fatigue and physical activity levels showed no significant changes overall. Interestingly, six patients reported feeling better by the end. Our findings invite further exploration of probiotics as potential support for individuals dealing with CFS.
While we observed some neurocognitive improvements, fatigue and physical activity levels showed no significant changes overall. Interestingly, six patients reported feeling better by the end. Our findings invite further exploration of probiotics as potential support for individuals dealing with CFS.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
6
Better digestion
8 people found this helpful
I'm satisfied with this product, much better than ordinary lactic acid bacteria. It's effective for chronic fatigue syndrome, although results may vary. Give it a couple of weeks before switching to alternatives.
Read More
9
Pain relief
I’ve had severe abdominal discomfort associated with chronic fatigue syndrome and tried many probiotics with little relief. After three days of using Primal Defense, I noticed reduced pain and more regular bowel movements. Now, I feel healthier overall.
Read More
Frequently Asked Questions
9
Pain relief
I’ve had severe abdominal discomfort associated with chronic fatigue syndrome and tried many probiotics with little relief. After three days of using Primal Defense, I noticed reduced pain and more regular bowel movements. Now, I feel healthier overall.
6
Better digestion
8 people found this helpful
I'm satisfied with this product, much better than ordinary lactic acid bacteria. It's effective for chronic fatigue syndrome, although results may vary. Give it a couple of weeks before switching to alternatives.
8
We explored the effects of Lactobacillus acidophilus, both free and in floating beads, as a possible treatment for chronic fatigue syndrome in a rat model. The study involved inducing fatigue through a forced swim test and then administering the probiotics over the last week of the experiment.
Remarkably, we found that both forms of Lactobacillus led to significant reductions in fatigue-like behaviors and improved biomarkers associated with stress. This indicates that lactobacilli may serve as a beneficial option for alleviating symptoms of chronic fatigue syndrome.
Remarkably, we found that both forms of Lactobacillus led to significant reductions in fatigue-like behaviors and improved biomarkers associated with stress. This indicates that lactobacilli may serve as a beneficial option for alleviating symptoms of chronic fatigue syndrome.
4
We aimed to understand if Lactobacillus acidophilus and other probiotics could help alleviate fatigue in chronic fatigue syndrome (CFS) patients. In our study with 15 participants, we first looked at their baseline fatigue prior to a four-week probiotic treatment.
While we observed some neurocognitive improvements, fatigue and physical activity levels showed no significant changes overall. Interestingly, six patients reported feeling better by the end. Our findings invite further exploration of probiotics as potential support for individuals dealing with CFS.
While we observed some neurocognitive improvements, fatigue and physical activity levels showed no significant changes overall. Interestingly, six patients reported feeling better by the end. Our findings invite further exploration of probiotics as potential support for individuals dealing with CFS.
References
- Singh PK, Chopra K, Kuhad A, Kaur IP. Role of Lactobacillus acidophilus loaded floating beads in chronic fatigue syndrome: behavioral and biochemical evidences. Neurogastroenterol Motil. 2012;24:366. 10.1111/j.1365-2982.2011.01861.x
- Sullivan A, Nord CE, Evengård B. Effect of supplement with lactic-acid producing bacteria on fatigue and physical activity in patients with chronic fatigue syndrome. Nutr J. 2009;8:4. 10.1186/1475-2891-8-4
