Last update
3/10/2026
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.9
USERS' SCORE
Good
Based on 4 Reviews
8.1
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Iron (from Ionic Plant Based Minerals)
2 mg
10%
HSO Probiotic Blend (5 Billion CFU)¹Saccharomyces boulardii, Organic Barley Grass², Organic Oat Grass², Lactobacillus plantarum, Bacillus subtilis, Bifidobacterium lactis, Bifidobacterium bifidum, Lactobacillus rhamnosus, Bifidobacterium breve, Lactobacillus casei, Lactobacillus salivarius, Lactobacillus acidophilus, Lactobacillus brevis, Bifidobacterium longum, Lactobacillus paracasei
410 mg
+
Ionic Plant Based Minerals
290 mg
+
Top Medical Research Studies
We explored how extracellular vesicles (EVs) from the bacteria Odoribacter splanchnicus may help alleviate inflammatory bowel disease (IBD). Using a mouse model, we found that these Os-EVs improved symptoms like weight loss and colon damage. They also helped restore the intestinal barrier and reduced inflammation by inhibiting the NLRP3 inflammasome. Importantly, our work suggests that probiotic-derived EVs might be a promising avenue for treating IBD effectively.
Read More
9
We explored how the probiotic strain 016 (LF) impacts gut health, particularly for those experiencing ulcerative colitis (UC). In a study involving C57BL/6 mice, LF supplementation demonstrated considerable benefits.
It helped reduce weight loss, diarrhea, and colonic damage in UC models, while improving gut microbiota composition and enhancing tryptophan metabolism.
Additionally, LF appeared to bolster antioxidant activity and intestinal barrier function, suggesting it could be a valuable tool in managing inflammatory bowel diseases like UC.
It helped reduce weight loss, diarrhea, and colonic damage in UC models, while improving gut microbiota composition and enhancing tryptophan metabolism.
Additionally, LF appeared to bolster antioxidant activity and intestinal barrier function, suggesting it could be a valuable tool in managing inflammatory bowel diseases like UC.
Read More
9
We explored a new method for delivering probiotics aimed at treating inflammatory bowel disease (IBD). By modifying broken spore shells as carriers, we boosted the delivery efficiency of the probiotic SHA113.
Our approach showed significant improvements, with up to 81% loading efficiency and an extended retention time in the colon. Animal tests indicated that using our modified carriers led to enhanced therapeutic effects for IBD.
This innovative delivery method holds promise for future advancements in probiotic therapies.
Our approach showed significant improvements, with up to 81% loading efficiency and an extended retention time in the colon. Animal tests indicated that using our modified carriers led to enhanced therapeutic effects for IBD.
This innovative delivery method holds promise for future advancements in probiotic therapies.
Read More
Most Useful Reviews
3
Minimal effect
2 people found this helpful
I purchased this supplement for my Crohn's disease, primarily affecting my large intestine. It was satisfactory and didn't upset my stomach as many others do. I had been using Saccharomyces boulardii along with 24-hour yogurt and some lactobacillus GG but wanted to eliminate dairy. Although I returned to my previous regime, which I found more effective, I believe this product could be beneficial for someone not currently taking any probiotics.
Read More
9
Symptom control
1 people found this helpful
After trying various diets and supplements, I found that The Makers Diet and Primal Defense successfully controlled my Crohn's symptoms. This product truly works!
Read More
9
Long-term relief
Amazing product. My son, who has Crohn's disease, has been using it for years.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.9
- All Researches
9
We explored how the probiotic strain 016 (LF) impacts gut health, particularly for those experiencing ulcerative colitis (UC). In a study involving C57BL/6 mice, LF supplementation demonstrated considerable benefits.
It helped reduce weight loss, diarrhea, and colonic damage in UC models, while improving gut microbiota composition and enhancing tryptophan metabolism.
Additionally, LF appeared to bolster antioxidant activity and intestinal barrier function, suggesting it could be a valuable tool in managing inflammatory bowel diseases like UC.
It helped reduce weight loss, diarrhea, and colonic damage in UC models, while improving gut microbiota composition and enhancing tryptophan metabolism.
Additionally, LF appeared to bolster antioxidant activity and intestinal barrier function, suggesting it could be a valuable tool in managing inflammatory bowel diseases like UC.
Read More
We explored how extracellular vesicles (EVs) from the bacteria Odoribacter splanchnicus may help alleviate inflammatory bowel disease (IBD). Using a mouse model, we found that these Os-EVs improved symptoms like weight loss and colon damage. They also helped restore the intestinal barrier and reduced inflammation by inhibiting the NLRP3 inflammasome. Importantly, our work suggests that probiotic-derived EVs might be a promising avenue for treating IBD effectively.
Read More
9
We investigated how certain probiotic strains derived from infant feces could help protect against inflammatory bowel disease (IBD) in mice. This study used a murine model of colitis to assess the effectiveness of three specific strains and their mixture.
Encouragingly, we observed improvements in body weight and colon health in mice treated with the probiotic mixture. Additionally, we noted beneficial changes in gut microbiota composition, which suggests a potential for these probiotics to ease symptoms of IBD by enhancing gut health. However, further research in humans is necessary to confirm these effects.
Encouragingly, we observed improvements in body weight and colon health in mice treated with the probiotic mixture. Additionally, we noted beneficial changes in gut microbiota composition, which suggests a potential for these probiotics to ease symptoms of IBD by enhancing gut health. However, further research in humans is necessary to confirm these effects.
Read More
9
We explored a new method for delivering probiotics aimed at treating inflammatory bowel disease (IBD). By modifying broken spore shells as carriers, we boosted the delivery efficiency of the probiotic SHA113.
Our approach showed significant improvements, with up to 81% loading efficiency and an extended retention time in the colon. Animal tests indicated that using our modified carriers led to enhanced therapeutic effects for IBD.
This innovative delivery method holds promise for future advancements in probiotic therapies.
Our approach showed significant improvements, with up to 81% loading efficiency and an extended retention time in the colon. Animal tests indicated that using our modified carriers led to enhanced therapeutic effects for IBD.
This innovative delivery method holds promise for future advancements in probiotic therapies.
Read More
8
Probiotics may aid IBD treatment
We explored a new probiotic treatment designed to fight inflammatory bowel disease (IBD) by focusing on gut health. This special probiotic, called NE-EcN-pA, helps adjust tryptophan metabolism and boosts gut bacteria diversity.
Our findings in mice indicated that this treatment reduced intestinal inflammation effectively and helped restore the gut barrier. It also showed benefits in balancing gut flora and increasing beneficial short-chain fatty acids.
Overall, NE-EcN-pA appears promising for improving the management of bowel disorders, but further research is essential to confirm its efficacy in humans.
Our findings in mice indicated that this treatment reduced intestinal inflammation effectively and helped restore the gut barrier. It also showed benefits in balancing gut flora and increasing beneficial short-chain fatty acids.
Overall, NE-EcN-pA appears promising for improving the management of bowel disorders, but further research is essential to confirm its efficacy in humans.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
3
Minimal effect
2 people found this helpful
I purchased this supplement for my Crohn's disease, primarily affecting my large intestine. It was satisfactory and didn't upset my stomach as many others do. I had been using Saccharomyces boulardii along with 24-hour yogurt and some lactobacillus GG but wanted to eliminate dairy. Although I returned to my previous regime, which I found more effective, I believe this product could be beneficial for someone not currently taking any probiotics.
Read More
9
Symptom control
1 people found this helpful
After trying various diets and supplements, I found that The Makers Diet and Primal Defense successfully controlled my Crohn's symptoms. This product truly works!
Read More
9
Long-term relief
Amazing product. My son, who has Crohn's disease, has been using it for years.
Read More
8
Bacterial balance
I have Crohn's disease, which necessitates maintaining a higher level of good bacteria in my gut than bad, and this product genuinely aids in doing that.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Liu A, Ma J, Liu Z, Qiu T, Zhao Q, et al. "Shield" Armed Programmable Probiotics Harboring α-Aminoadipate Aminotransferase Gene Regulate Tryptophan Metabolism and Gut Microbiota to Alleviate the Inflammatory Bowel Disease. J Agric Food Chem. 2025;73:7920. 10.1021/acs.jafc.4c13017
- Wu Y, Huang X, Li Q, Yang C, Huang X, et al. Reducing severity of inflammatory bowel disease through colonization of Lactiplantibacillus plantarum and its extracellular vesicles release. J Nanobiotechnology. 2025;23:227. 10.1186/s12951-025-03280-7
- Schanne G, Vincent A, Chain F, Ruffié P, Carbonne C, et al. SOD mimics delivered to the gut using lactic acid bacteria mitigate the colitis symptoms in a mouse model of inflammatory bowel diseases. Free Radic Res. 2025;59:262. 10.1080/10715762.2025.2478121
- Zuo X, Zhang T, Dong X, Liu J, Liu Y. Identification of the key tryptophan metabolic characteristics of Lactiplantibacillus plantarum for aryl hydrocarbon receptor activation and ulcerative colitis alleviation. Food Res Int. 2025;203:115766. 10.1016/j.foodres.2025.115766
- Hoteit M, Hellani M, Karaja M, Zayour N, Sadek Z, et al. Evaluating the Efficacy of Probiotics on Disease Progression, Quality of Life, and Nutritional Status Among Patients with Crohn's Disease: A Multicenter, Randomized, Single-Blinded Controlled Trial. Nutrients. 2025;17. 10.3390/nu17040708
- Pan H, Yang S, Kulyar MF, Ma H, Li K, et al. 016 Alleviates Mice Colitis by Modulating Oxidative Stress, Gut Microbiota, and Microbial Metabolism. Nutrients. 2025;17. 10.3390/nu17030452
- Zhuang J, Zhuang Z, Chen B, Yang Y, Chen H, et al. Odoribacter splanchnicus-derived extracellular vesicles alleviate inflammatory bowel disease by modulating gastrointestinal inflammation and intestinal barrier function via the NLRP3 inflammasome suppression. Mol Med. 2025;31:56. 10.1186/s10020-025-01063-2
- Joung JY, Choi K, Lee JH, Oh NS. Protective Potential of Strains and Their Mixture on Inflammatory Bowel Disease via Regulating Gut Microbiota in Mice. J Microbiol Biotechnol. 2024;35:e2410009. 10.4014/jmb.2410.10009
- Liao N, Wang J, Liu G, Li Y, Xu F, et al. Modification of spore shells into probiotic carriers: selective loading and colonic delivery of and effective therapy of inflammatory bowel disease. Food Funct. 2025;16:908. 10.1039/d4fo04523h
Data last updated:
