Last update
3/14/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 20 Researches
8.4
USERS' SCORE
Good
Based on 2 Reviews
8.6
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Iron (from Ionic Plant Based Minerals)
2 mg
10%
HSO Probiotic Blend (5 Billion CFU)¹Saccharomyces boulardii, Organic Barley Grass², Organic Oat Grass², Lactobacillus plantarum, Bacillus subtilis, Bifidobacterium lactis, Bifidobacterium bifidum, Lactobacillus rhamnosus, Bifidobacterium breve, Lactobacillus casei, Lactobacillus salivarius, Lactobacillus acidophilus, Lactobacillus brevis, Bifidobacterium longum, Lactobacillus paracasei
410 mg
+
Ionic Plant Based Minerals
290 mg
+
Top Medical Research Studies
9
We explored how the probiotic yeast, Saccharomyces boulardii, impacts ulcerative colitis in mice. Through a careful setup, C57BL/6 mice received the treatment for three weeks and were later exposed to a harmful substance to induce the condition.
The results were promising; we observed that Saccharomyces boulardii significantly improved various symptoms. It helped prevent weight loss, diarrhea, and inflammation while strengthening the intestinal barrier. Furthermore, it demonstrated an ability to counteract oxidative damage effectively.
However, we also noted that while these findings are positive, further research is needed to fully understand the comprehensive benefits of this treatment in humans.
The results were promising; we observed that Saccharomyces boulardii significantly improved various symptoms. It helped prevent weight loss, diarrhea, and inflammation while strengthening the intestinal barrier. Furthermore, it demonstrated an ability to counteract oxidative damage effectively.
However, we also noted that while these findings are positive, further research is needed to fully understand the comprehensive benefits of this treatment in humans.
Read More
9.5
We explored the potential of a new composite hydrogel that combines probiotics and fucoidan to aid oral ulcer healing. This study focused on how this hydrogel adheres to tissue and releases probiotics effectively. Remarkably, the hydrogels showed better therapeutic results compared to standard oral ulcer patches by promoting faster cell migration and healing.
Overall, this innovative approach suggests a promising future for treating oral ulcers more effectively than traditional methods.
Overall, this innovative approach suggests a promising future for treating oral ulcers more effectively than traditional methods.
Read More
9
We explored the effects of delivering human epidermal growth factor (EGF) through a probiotic strain of E. coli to help treat intestinal ulcers. The study showed that treatment with EGF-EcN not only alleviated ulcers but also helped in restoring damaged barrier layers in the gut. We observed that this method promotes the recovery of important cell types and strengthens mucosal integrity. Importantly, the probiotic did not worsen any cancerous conditions related to ulcerative colitis. Overall, our findings suggest that using probiotics to deliver helpful proteins like EGF can be a safe and effective strategy for managing gastrointestinal ulcers.
Read More
Most Useful Reviews
9
Relieved heartburn
1 people found this helpful
Amazing! I have intended to write this review for months! This product (Primal Defense Ultra) has provided remarkable results. For years, I suffered from severe heartburn and even developed an ulcer a couple of years ago. On Halloween, I took one capsule before indulging in candy, which typically spells trouble. However, I felt almost immediate relief. Whatever my gut was lacking, this product supplied it! I highly recommend it to everyone, as I haven't experienced heartburn since taking the first capsule!
Read More
9
Stomach issue relief
7 people found this helpful
Since my wife and I began using this product, my stomach issues vanished, and we catch fewer colds. I had been treated for an ulcer in the past, always on the lookout for something to combat stomach acid after meals. The treatment involved a strong antibiotic that eliminated harmful bacteria. This probiotic replenishes beneficial gut bacteria. It works well and is key to maintaining a healthy immune system. When we stop taking it, we feel lethargic and our digestion worsens.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 20 Researches
8.4
- All Researches
9.5
We constructed acute gastric ulcer models in mice by administering hydrochloric acid and ethanol, then introduced white jade snail secretion (WJSS) through gastric infusion. Our findings revealed that WJSS significantly reduced ulcer areas and levels of harmful substances like malondialdehyde.
The highest concentration of WJSS led to the most remarkable reduction in ulcers and improved intestinal bacteria diversity. This suggests that WJSS not only offers promising anti-ulcer effects but also promotes beneficial gut probiotics, pointing towards its potential use in ulcer treatment.
The highest concentration of WJSS led to the most remarkable reduction in ulcers and improved intestinal bacteria diversity. This suggests that WJSS not only offers promising anti-ulcer effects but also promotes beneficial gut probiotics, pointing towards its potential use in ulcer treatment.
Read More
9.5
We explored the potential of a new composite hydrogel that combines probiotics and fucoidan to aid oral ulcer healing. This study focused on how this hydrogel adheres to tissue and releases probiotics effectively. Remarkably, the hydrogels showed better therapeutic results compared to standard oral ulcer patches by promoting faster cell migration and healing.
Overall, this innovative approach suggests a promising future for treating oral ulcers more effectively than traditional methods.
Overall, this innovative approach suggests a promising future for treating oral ulcers more effectively than traditional methods.
Read More
We looked into how the probiotic Saccharomyces boulardii affects the treatment of Helicobacter pylori in Thai patients. In a double-blind study, participants received either a probiotic or placebo with a moxifloxacin-dexlansoprazole therapy.
While the treatment achieved high eradication rates of H. pylori, we found that the addition of the probiotic significantly reduced side effects like nausea and diarrhea compared to those on placebo. This suggests that Saccharomyces boulardii could enhance patient comfort during an effective antibiotic regimen.
While the treatment achieved high eradication rates of H. pylori, we found that the addition of the probiotic significantly reduced side effects like nausea and diarrhea compared to those on placebo. This suggests that Saccharomyces boulardii could enhance patient comfort during an effective antibiotic regimen.
Read More
9
We explored the effects of delivering human epidermal growth factor (EGF) through a probiotic strain of E. coli to help treat intestinal ulcers. The study showed that treatment with EGF-EcN not only alleviated ulcers but also helped in restoring damaged barrier layers in the gut. We observed that this method promotes the recovery of important cell types and strengthens mucosal integrity. Importantly, the probiotic did not worsen any cancerous conditions related to ulcerative colitis. Overall, our findings suggest that using probiotics to deliver helpful proteins like EGF can be a safe and effective strategy for managing gastrointestinal ulcers.
Read More
9
We recently explored the protective effects of a specific probiotic called Bifidobacterium breve (Bif195) on small-intestinal damage caused by acetylsalicylic acid (ASA), a common pain reliever. In a randomized, double-blind trial involving 75 healthy volunteers, participants took daily doses of either Bif195 or a placebo for eight weeks.
The results were promising! Those who took Bif195 experienced significantly lower levels of intestinal damage and fewer ulcers compared to the placebo group. Importantly, the use of Bif195 was well tolerated with minimal adverse events reported.
The results were promising! Those who took Bif195 experienced significantly lower levels of intestinal damage and fewer ulcers compared to the placebo group. Importantly, the use of Bif195 was well tolerated with minimal adverse events reported.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Relieved heartburn
1 people found this helpful
Amazing! I have intended to write this review for months! This product (Primal Defense Ultra) has provided remarkable results. For years, I suffered from severe heartburn and even developed an ulcer a couple of years ago. On Halloween, I took one capsule before indulging in candy, which typically spells trouble. However, I felt almost immediate relief. Whatever my gut was lacking, this product supplied it! I highly recommend it to everyone, as I haven't experienced heartburn since taking the first capsule!
Read More
9
Stomach issue relief
7 people found this helpful
Since my wife and I began using this product, my stomach issues vanished, and we catch fewer colds. I had been treated for an ulcer in the past, always on the lookout for something to combat stomach acid after meals. The treatment involved a strong antibiotic that eliminated harmful bacteria. This probiotic replenishes beneficial gut bacteria. It works well and is key to maintaining a healthy immune system. When we stop taking it, we feel lethargic and our digestion worsens.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Savitri IJ, Suprarahardiani SA, Ulinnuha LK, Prahasanti C, Wijaksana IKE, et al. TNF-α Expression and Plasma Cell and Macrophage Numbers in Traumatic Ulcers in a Rat Model Treated by Topical or Systemic Probiotic . Int J Med Sci. 2025;22:318. 10.7150/ijms.99156
- Cheng Q, Wang K, Lu R, Xiong Y, Luo X, et al. Effect of white jade snail secretion on antioxidant capacity and intestinal microbial diversity in mouse model of acute gastric ulcer. J Sci Food Agric. 2024;104:1723. 10.1002/jsfa.13059
- Dou X, Li G, Wang S, Shao D, Wang D, et al. Probiotic-loaded calcium alginate/fucoidan hydrogels for promoting oral ulcer healing. Int J Biol Macromol. 2023;244:125273. 10.1016/j.ijbiomac.2023.125273
- Isik M, Ozbayer C, Donmez DB, Colak E, Ustuner MC, et al. Effects of the probiotic, , on ulcer pathogenesis, HSP70 stress protein and nitric oxide levels in stress induced ulcer. Biotech Histochem. 2022;97:449. 10.1080/10520295.2022.2028308
- Vijayasarathy S, Gayathri P, Suneetha V. Fermented Foods and Their Abating Role in Gastric Ulcers. J Am Nutr Assoc. 2022;41:826. 10.1080/07315724.2021.1962768
- Yu M, Kim J, Ahn JH, Moon Y. Nononcogenic restoration of the intestinal barrier by E. coli-delivered human EGF. JCI Insight. 2019;4. 10.1172/jci.insight.125166
- Mortensen B, Murphy C, O'Grady J, Lucey M, Elsafi G, et al. Bifidobacteriumbreve Bif195 Protects Against Small-Intestinal Damage Caused by Acetylsalicylic Acid in Healthy Volunteers. Gastroenterology. 2019;157:637. 10.1053/j.gastro.2019.05.008
- Yang L, Li W, Zhao Q, Mo Q, Liu T, et al. Alleviates Colitis by Regulating FXR-NLRP3 Mediated Macrophage Pyroptosis. J Inflamm Res. 2025;18:3161. 10.2147/JIR.S504957
- Zhang Y, Lu B, Dong Y, Zhang Y, Du Q, et al. Saccharomyces boulardii combined with triple therapy alter the microbiota in the eradication of Helicobacter pylori infection. Sci Rep. 2024;14:13152. 10.1038/s41598-024-63894-z
- Heavey MK, Hazelton A, Wang Y, Garner M, Anselmo AC, et al. Targeted delivery of the probiotic Saccharomyces boulardii to the extracellular matrix enhances gut residence time and recovery in murine colitis. Nat Commun. 2024;15:3784. 10.1038/s41467-024-48128-0
- Simon O'Brien E, Robert A, Gauthier D, Le Cavorzin A, Planchais J, et al. Protective effects of Saccharomyces boulardii CNCM I-745 in an experimental model of NSAID-induced enteropathy. Benef Microbes. 2023;14:239. 10.3920/BM2023.0003
- Gao H, Li Y, Sun J, Xu H, Wang M, et al. Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice by Regulating NF-B and Nrf2 Signaling Pathways. Oxid Med Cell Longev. 2021;2021:1622375. 10.1155/2021/1622375
- Wang C, Li W, Wang H, Ma Y, Zhao X, et al. Saccharomyces boulardii alleviates ulcerative colitis carcinogenesis in mice by reducing TNF-α and IL-6 levels and functions and by rebalancing intestinal microbiota. BMC Microbiol. 2019;19:246. 10.1186/s12866-019-1610-8
- Lam S, Zuo T, Ho M, Chan FKL, Chan PKS, et al. Review article: fungal alterations in inflammatory bowel diseases. Aliment Pharmacol Ther. 2019;50:1159. 10.1111/apt.15523
- Chotivitayatarakorn P, Mahachai V, Vilaichone RK. Effectiveness of 7-Day and 14-Day Moxifloxacin-Dexlansoprazole Based Triple Therapy and Probiotic Supplement for Helicobacter Pylori Eradication in Thai Patients with Non-Ulcer Dyspepsia: A Double-Blind Randomized Placebo-Controlled Study. Asian Pac J Cancer Prev. 2017;18:2839. PubMed
- Ganji-Arjenaki M, Rafieian-Kopaei M. Probiotics are a good choice in remission of inflammatory bowel diseases: A meta analysis and systematic review. J Cell Physiol. 2018;233:2091. 10.1002/jcp.25911
- Thomas S, Metzke D, Schmitz J, Dörffel Y, Baumgart DC. Anti-inflammatory effects of Saccharomyces boulardii mediated by myeloid dendritic cells from patients with Crohn's disease and ulcerative colitis. Am J Physiol Gastrointest Liver Physiol. 2011;301:G1083. 10.1152/ajpgi.00217.2011
- Girard P, Coppé MC, Pansart Y, Gillardin JM. Gastroprotective effect of Saccharomyces boulardii in a rat model of ibuprofen-induced gastric ulcer. Pharmacology. 2010;85:188. 10.1159/000275146
- Duman DG, Bor S, Ozütemiz O, Sahin T, Oğuz D, et al. Efficacy and safety of Saccharomyces boulardii in prevention of antibiotic-associated diarrhoea due to Helicobacterpylori eradication. Eur J Gastroenterol Hepatol. 2005;17:1357. PubMed
- Guslandi M, Giollo P, Testoni PA. A pilot trial of Saccharomyces boulardii in ulcerative colitis. Eur J Gastroenterol Hepatol. 2003;15:697. PubMed
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