We conducted a double-blind, placebo-controlled clinical trial to explore the effectiveness of a zinc oxide/glycine cream in treating cold sores caused by facial and circumoral herpes. By dividing 46 participants into two groups, one receiving the zinc treatment and the other a placebo, we aimed to measure how this formulation affected the duration and severity of cold sore symptoms.
Our results were quite promising! Participants who began using the zinc oxide/glycine cream within the first 24 hours of noticing symptoms experienced cold sore lesions that lasted only an average of 5 days, compared to 6.5 days for those on the placebo. Additionally, we noticed a significant reduction in the overall severity of their symptoms, including blistering, soreness, itching, and tingling.
As for side effects, subjects treated with the zinc cream experienced only minor and reversible issues typical of ionic zinc salt solutions. This indicates that the zinc oxide/glycine cream is not only effective but also safe for treating cold sores, presenting a valuable option for many people seeking relief from this common condition.
Read More
9
Zinc gel aids cold sore healing
[Clinical double-blind trial of topical zinc sulfate for herpes labialis recidivans].
We conducted a double-blind, placebo-controlled clinical trial to assess the impact of zinc sulfate gel on cold sores, specifically herpes labialis recidivans. In our study, patients treated with zinc sulfate gel, known as Virudermin Gel, experienced significantly reduced symptoms and faster healing compared to those who received just the gel without zinc.
The results were promising; the patients using the zinc gel reported less discomfort, and their sores healed more quickly. Importantly, this treatment showed no significant side effects, making it a safe option for managing cold sores. Additionally, the antiseptic properties of zinc sulfate helped prevent any superinfections, adding another layer of benefit to its use.
Overall, our exploration into zinc’s effectiveness provided valuable insights for both patients and healthcare providers seeking reliable cold sore treatment options. With simple application and proven results, zinc sulfate gel could become a go-to remedy for those frequently struggling with herpes labialis recidivans.
Read More
8
Zinc treatment helps cold sores
Recurrent herpes labialis: a pilot study of the efficacy of zinc therapy.
We aimed to understand how zinc might affect the occurrence and duration of cold sores, also known as herpes labialis. In our study, we treated 20 patients, mostly women with an average age of 26.6, who experienced more than six episodes of cold sores each year. They received zinc sulphate at a dose of 22.5 mg twice daily during specific months over a year while we monitored their symptoms for 12 months.
Our results were promising. Patients reported a decrease in the frequency of cold sore episodes, averaging fewer than four instances per year. Moreover, the duration of these episodes was also shortened to around 5.7 days, significantly less than usual for these conditions.
Thus, we can say that systemic zinc sulphate seemed to effectively reduce both the number of cold sore outbreaks and the recovery time. This suggests that zinc might be a beneficial option for individuals who struggle with recurrent cold sores.
Read More
Most Useful Reviews
9
Restores sense of smell
60 people found this helpful
Helped restore my sense of smell and aids with cold sores! I take zinc after meals without side effects. This zinc, as prescribed by doctors, is effective for regaining the sense of smell after COVID-19. I took it during my illness, and my sense of smell returned completely after six days. This combined with vitamin C and other supplements helps me manage symptoms quickly.
Read More
9
Strengthens reproductive health
2 people found this helpful
Now everyone knows how crucial zinc is for the immune system. I take it at the earliest signs of a cold or if I feel cold sores coming on. This organic zinc has no side effects, and I've felt great since using it.
Read More
9
Effective for colds
1 people found this helpful
This excellent zinc helps at the first signs of a cold and cold sores. I typically take it for 2-3 days alongside vitamin C and D3. Highly recommend it!
We explored the connection between zinc levels and recurrent herpes labialis (RHL), commonly known as cold sores. In a study involving 80 individuals, we compared the salivary zinc levels of healthy people with those experiencing RHL during both the acute and convalescent phases.
The findings revealed that patients in the acute phase had significantly lower zinc levels (160.8 ng/ml) compared to when they were recovering (205.7 ng/ml). Both those phases showed lower zinc levels than the healthy individuals' average. This suggests that zinc levels are not just lower when cold sores are present, but also improve after the lesions heal.
Our results indicate that maintaining adequate zinc levels might be beneficial for people suffering from cold sores. Incorporating zinc supplements could play a role in both treating and preventing these uncomfortable outbreaks. We found that increasing serum zinc might help RHL patients, shedding light on a potential supportive treatment strategy for cold sores.
Read More
9
Zinc may relieve cold sores
Safety and effectiveness of an L-lysine, zinc, and herbal-based product on the treatment of facial and circumoral herpes.
We conducted a small pilot study to investigate how a combination of L-lysine, zinc, and herbal ingredients could help treat cold sores caused by the Herpes simplex virus. Our goal was to observe the changes in symptoms such as itching, burning, and soreness among participants over the course of treatment.
Thirty individuals, split evenly between genders, participated in our open-label study. We monitored their symptoms through various methods, including self-reported outcomes, photographs, and daily diaries. By the sixth day of treatment, most participants showed considerable improvement, with some experiencing full resolution of their symptoms.
While we didn't isolate the effect of zinc alone, its inclusion in the treatment mix seems promising. By the end of our study, we found that 87 percent of participants had improved symptomatically, which indicates that the combination treatment may effectively relieve cold sore symptoms. Importantly, no adverse effects were reported during the study, which adds to our understanding of these treatments' safety.
Read More
9
Zinc cream alleviates cold sores
A randomized clinical trial on the treatment of oral herpes with topical zinc oxide/glycine.
We conducted a double-blind, placebo-controlled clinical trial to explore the effectiveness of a zinc oxide/glycine cream in treating cold sores caused by facial and circumoral herpes. By dividing 46 participants into two groups, one receiving the zinc treatment and the other a placebo, we aimed to measure how this formulation affected the duration and severity of cold sore symptoms.
Our results were quite promising! Participants who began using the zinc oxide/glycine cream within the first 24 hours of noticing symptoms experienced cold sore lesions that lasted only an average of 5 days, compared to 6.5 days for those on the placebo. Additionally, we noticed a significant reduction in the overall severity of their symptoms, including blistering, soreness, itching, and tingling.
As for side effects, subjects treated with the zinc cream experienced only minor and reversible issues typical of ionic zinc salt solutions. This indicates that the zinc oxide/glycine cream is not only effective but also safe for treating cold sores, presenting a valuable option for many people seeking relief from this common condition.
Read More
9
Zinc gel aids cold sore healing
[Clinical double-blind trial of topical zinc sulfate for herpes labialis recidivans].
We conducted a double-blind, placebo-controlled clinical trial to assess the impact of zinc sulfate gel on cold sores, specifically herpes labialis recidivans. In our study, patients treated with zinc sulfate gel, known as Virudermin Gel, experienced significantly reduced symptoms and faster healing compared to those who received just the gel without zinc.
The results were promising; the patients using the zinc gel reported less discomfort, and their sores healed more quickly. Importantly, this treatment showed no significant side effects, making it a safe option for managing cold sores. Additionally, the antiseptic properties of zinc sulfate helped prevent any superinfections, adding another layer of benefit to its use.
Overall, our exploration into zinc’s effectiveness provided valuable insights for both patients and healthcare providers seeking reliable cold sore treatment options. With simple application and proven results, zinc sulfate gel could become a go-to remedy for those frequently struggling with herpes labialis recidivans.
Read More
8
Pomegranate extract reduces inflammation
Anti-inflammatory activity of Punica granatum L. (Pomegranate) rind extracts applied topically to ex vivo skin.
We examined how the combination of pomegranate rind extract (PRE) and zinc impacts cold sores, particularly focusing on inflammation. By applying these substances to ex vivo porcine skin, we were able to assess their ability to modulate COX-2, a key player in the inflammation process.
Our findings revealed that the topical application of PRE significantly reduced COX-2 levels in the skin after just six hours and maintained this effect for 24 hours. When we combined PRE with zinc, the results matched those of PRE alone, indicating that zinc didn't add extra benefits to inflammation control when used together.
However, we also noted that zinc alone showed no significant anti-inflammatory effect, highlighting that the benefits we observed were primarily due to the pomegranate extract rather than zinc. This suggests that while zinc is commonly thought beneficial for treating cold sores, its impact on inflammation might be limited unless paired with more potent anti-inflammatory agents like PRE.
In conclusion, pomegranates present a promising approach to managing inflammation and pain associated with cold sores, but zinc’s standalone effectiveness requires reconsideration.
Helped restore my sense of smell and aids with cold sores! I take zinc after meals without side effects. This zinc, as prescribed by doctors, is effective for regaining the sense of smell after COVID-19. I took it during my illness, and my sense of smell returned completely after six days. This combined with vitamin C and other supplements helps me manage symptoms quickly.
Read More
9
Strengthens reproductive health
2 people found this helpful
Now everyone knows how crucial zinc is for the immune system. I take it at the earliest signs of a cold or if I feel cold sores coming on. This organic zinc has no side effects, and I've felt great since using it.
Read More
9
Effective for colds
1 people found this helpful
This excellent zinc helps at the first signs of a cold and cold sores. I typically take it for 2-3 days alongside vitamin C and D3. Highly recommend it!
Read More
9
No side effects
1 people found this helpful
Wonderful zinc! What matters to me is that this zinc doesn’t cause nausea like others do! It helps my cold symptoms disappear quickly.
Read More
9
Immune foundation
1 people found this helpful
Working zinc at the ideal daily dosage. Zinc is crucial during colds and viruses; it supports immunity and has helped me recover taste and smell after Covid.
Cold sores, also known as fever blisters, are small, fluid-filled blisters that typically appear on or around the lips, although they can also occur in other areas of the face. They are caused by the herpes simplex virus (HSV), primarily HSV-1, and are highly contagious. The initial outbreak may be accompanied by symptoms such as fever, swollen lymph nodes, and a general feeling of malaise. Once infected, the virus remains dormant in the body and can reactivate, leading to recurring outbreaks, often triggered by stress, illness, or exposure to sunlight.
Treatment options for cold sores often focus on alleviating symptoms and speeding up healing. Over-the-counter creams containing antiviral medication like docosanol can help reduce the duration of an outbreak when applied early on. Prescription medications may be recommended for more severe cases. Home remedies, such as applying ice, using aloe vera, or taking lysine supplements, may also offer some relief. Prevention strategies include avoiding known triggers and practicing good hygiene, like not sharing utensils or personal items with infected individuals.
Zinc is a versatile metal known for its various applications in industry and health. It is a bluish-white metallic element represented by the symbol Zn and atomic number 30 on the periodic table. Zinc is primarily used for galvanizing steel to prevent rusting, in the manufacturing of alloys, and as a component in batteries. Additionally, zinc plays a crucial role in biological processes, making it an essential trace element in the human diet. It is involved in immune function, protein synthesis, wound healing, and DNA synthesis, highlighting its importance in maintaining overall health and well-being.
Zinc is often touted as a potential remedy for cold sores, primarily due to its immune-boosting properties and its role in skin health. Research suggests that zinc may help reduce the severity and duration of cold sore outbreaks, as it can inhibit the replication of the herpes simplex virus, the virus responsible for cold sores. It is available in various forms, including topical ointments and oral supplements. When applied directly to the affected area, zinc oxide or zinc sulfate creams may help soothe the skin and promote healing.
However, it's important to note that while zinc may aid in managing cold sores, it is not a cure. Results can vary from person to person, and some may find topical treatments to be more effective than others. Always consult a healthcare professional before starting any new treatment regimen, as they can provide guidance tailored to your specific situation. Additionally, maintaining a healthy lifestyle, including proper nutrition and stress management, can further support your immune system in preventing and managing outbreaks effectively.
Based on user reviews, results from taking zinc for cold sores can typically be seen quite quickly, often within a few days. Several users report that they notice improvements after just 2-3 days of consistent usage, particularly when taken at the first signs of a cold or cold sore outbreak Read Review. One reviewer mentioned seeing benefits after a week, including improved skin condition and quicker recovery from symptoms Read Review.
Many users also emphasize the importance of pairing zinc with other supplements, such as Vitamin C, to enhance its effectiveness in managing cold symptoms and cold sores Read Review. Overall, while individual experiences may vary, a number of reviews suggest that consistent use of zinc can lead to noticeable improvements in cold sore symptoms relatively quickly.
Scientific research indicates that zinc may have a supportive role in managing cold sores, particularly in terms of recovery time and frequency of outbreaks. One study involving patients who suffer from recurrent herpes labialis found a link between lower zinc levels and longer recovery times [1]. Another piece of research indicated that systemic zinc sulfate supplementation significantly reduced both the occurrences of cold sore outbreaks and the recovery duration for patients over a year-long period [5]. These findings suggest that maintaining adequate zinc levels could be beneficial for those prone to cold sores.
However, it's essential to note that while zinc's potential is promising, the effects can be modest compared to other treatments. For example, a study on zinc oxide/glycine cream showed a reduction in cold sore duration, but the benefits were notably better when combined with antiviral therapies [7]. Additionally, while topical application of zinc was beneficial in some instances, such as with zinc sulfate gel, the full effectiveness often relies on combining zinc with other active ingredients like pomegranate extract to address inflammation [2]. Overall, while zinc supplementation might contribute positively to cold sore management, it should be part of a broader treatment strategy.
Based on user reviews, zinc supplements have been reported to yield a variety of positive outcomes for individuals dealing with symptoms related to colds and cold sores. Many users experience faster recovery times when they take zinc at the earliest signs of illness, with one individual noting that their cold symptoms seemed to disappear after just a few days of use Read Review. Others specifically mention the efficacy of zinc in helping restore their sense of smell and taste following COVID-19, with some users indicating complete recovery after six days Read Review.
Additionally, several reviews highlight the improvement in skin conditions, particularly hormonal acne, with one user observing fewer outbreaks of cold sores as well Read Review. Users have also lauded the absence of side effects commonly associated with other zinc formulations, making the experience more pleasant Read Review. Overall, while experiences can vary, a substantial number of users report significant benefits from incorporating zinc into their supplement routine, particularly when combined with other vitamins like C for enhanced effects Read Review.
Users have enthusiastically reported the effectiveness of combining zinc supplements with other vitamins, particularly vitamin C and D3, to manage cold sore symptoms. Several reviews underscore that this synergistic approach not only aids in alleviating the symptoms of colds but also helps in expediting recovery from cold sores. One user mentions taking zinc alongside vitamin C, stating that it assists in managing symptoms quickly during illness Read Review. Another user echoes this sentiment, recommending a regimen of zinc with vitamin C and D3 for a couple of days at the onset of cold symptoms, highlighting the enhanced benefits Read Review.
Moreover, the reviews affirm that users have experienced improved skin conditions, including a reduction in acne and fewer cold sore outbreaks during certain seasons. One review states that after taking zinc, the individual noticed a significant decrease in cold sore occurrences while also observing improvements in their skin health Read Review. The absence of side effects often associated with other zinc formulations seems to further enhance the overall user experience when paired with these additional supplements Read Review. Overall, users appear to find that the combination of zinc with complementary vitamins forms a robust defense against cold sores and cold symptoms.
The research surrounding zinc for treating cold sores suggests that it may have a beneficial role, although the optimal dosing and efficacy can vary. A study indicated that taking zinc sulfate at a dose of 22.5 mg twice daily led to a reduction in both the frequency and duration of cold sore episodes among patients, averaging fewer than four outbreaks per year and shortening episodes to about 5.7 days in length [5]. Additionally, topical treatments like zinc oxide creams have shown promise in significantly reducing symptom severity and healing time when applied early in an outbreak [7].
While some studies did not find a direct significant benefit from zinc alone, lower serum zinc levels were correlated with longer recovery times for cold sores, suggesting that maintaining adequate zinc levels may help speed recovery [1]. Importantly, combining zinc with other treatments, such as pomegranate extract, did not further enhance its anti-inflammatory effects, indicating that zinc's benefits may be limited when used alone without other supportive therapies [2]. For a comprehensive treatment approach, individuals may consider using zinc supplements or topical treatments alongside antiviral medications for optimal results in managing cold sores.
9
Effective for colds
1 people found this helpful
This excellent zinc helps at the first signs of a cold and cold sores. I typically take it for 2-3 days alongside vitamin C and D3. Highly recommend it!
6
Improves immune function
2 people found this helpful
These zinc capsules are beneficial, though they're a bit large to swallow. I take them with meals to avoid stomach upset. They bolster my immune system while improving hormonal acne and cold sores. After a week of use, I began seeing the benefits, especially for my skin. Particularly useful during colder months.
9
Restores sense of smell
60 people found this helpful
Helped restore my sense of smell and aids with cold sores! I take zinc after meals without side effects. This zinc, as prescribed by doctors, is effective for regaining the sense of smell after COVID-19. I took it during my illness, and my sense of smell returned completely after six days. This combined with vitamin C and other supplements helps me manage symptoms quickly.
9
No side effects
1 people found this helpful
Wonderful zinc! What matters to me is that this zinc doesn’t cause nausea like others do! It helps my cold symptoms disappear quickly.
7.5
Reduces acne outbreaks
4 people found this helpful
Zinc is the right supplement for me. After taking it, my acne cleared up, and I noticed fewer cold sores in the autumn-winter period. I appreciate that this brand avoids harmful additives.
7.5
Gentle on stomach
1 people found this helpful
Zinc helps! It's of very high quality, with no side effects for anyone in my family. We take it at the first signs of a cold, and it truly has an effect.
9
Repeated effectiveness
1 people found this helpful
Must-have! This product saved my family from cold symptoms multiple times. I appreciate the balance of zinc and vitamin C and the quality. Highly recommended!
9
Strengthens reproductive health
2 people found this helpful
Now everyone knows how crucial zinc is for the immune system. I take it at the earliest signs of a cold or if I feel cold sores coming on. This organic zinc has no side effects, and I've felt great since using it.
7
Zinc and cold sore recovery
Comparative study of serum zinc concentration in recurrent herpes labialis patients and healthy individuals.
We explored the relationship between zinc levels and recurrent herpes labialis (cold sores) through a study involving 43 patients with a history of this condition and 42 healthy individuals. By measuring serum zinc levels using a colorimetric method, we aimed to find out whether these levels differ significantly between both groups and how they relate to the severity and duration of cold sore episodes.
Although we found that serum zinc levels did not significantly differ between the patients and healthy subjects, we observed an interesting correlation regarding recovery times. Specifically, lower serum zinc levels appeared to be linked to longer recovery periods from cold sores. This suggests that zinc might play a role in speeding up recovery, though it was not a significant factor influencing relapse frequency or patient demographics such as age and sex.
Overall, while the study didn’t establish a direct benefit of zinc supplementation, the findings indicate that zinc deficiency might contribute to longer-lasting cold sores. Therefore, we suggest that evaluating zinc levels in patients experiencing recurrent cold sores could be beneficial and that zinc supplementation may be worth considering in treatment protocols.
8
Zinc treatment helps cold sores
Recurrent herpes labialis: a pilot study of the efficacy of zinc therapy.
We aimed to understand how zinc might affect the occurrence and duration of cold sores, also known as herpes labialis. In our study, we treated 20 patients, mostly women with an average age of 26.6, who experienced more than six episodes of cold sores each year. They received zinc sulphate at a dose of 22.5 mg twice daily during specific months over a year while we monitored their symptoms for 12 months.
Our results were promising. Patients reported a decrease in the frequency of cold sore episodes, averaging fewer than four instances per year. Moreover, the duration of these episodes was also shortened to around 5.7 days, significantly less than usual for these conditions.
Thus, we can say that systemic zinc sulphate seemed to effectively reduce both the number of cold sore outbreaks and the recovery time. This suggests that zinc might be a beneficial option for individuals who struggle with recurrent cold sores.
9
Zinc cream alleviates cold sores
A randomized clinical trial on the treatment of oral herpes with topical zinc oxide/glycine.
We conducted a double-blind, placebo-controlled clinical trial to explore the effectiveness of a zinc oxide/glycine cream in treating cold sores caused by facial and circumoral herpes. By dividing 46 participants into two groups, one receiving the zinc treatment and the other a placebo, we aimed to measure how this formulation affected the duration and severity of cold sore symptoms.
Our results were quite promising! Participants who began using the zinc oxide/glycine cream within the first 24 hours of noticing symptoms experienced cold sore lesions that lasted only an average of 5 days, compared to 6.5 days for those on the placebo. Additionally, we noticed a significant reduction in the overall severity of their symptoms, including blistering, soreness, itching, and tingling.
As for side effects, subjects treated with the zinc cream experienced only minor and reversible issues typical of ionic zinc salt solutions. This indicates that the zinc oxide/glycine cream is not only effective but also safe for treating cold sores, presenting a valuable option for many people seeking relief from this common condition.
8
Pomegranate extract reduces inflammation
Anti-inflammatory activity of Punica granatum L. (Pomegranate) rind extracts applied topically to ex vivo skin.
We examined how the combination of pomegranate rind extract (PRE) and zinc impacts cold sores, particularly focusing on inflammation. By applying these substances to ex vivo porcine skin, we were able to assess their ability to modulate COX-2, a key player in the inflammation process.
Our findings revealed that the topical application of PRE significantly reduced COX-2 levels in the skin after just six hours and maintained this effect for 24 hours. When we combined PRE with zinc, the results matched those of PRE alone, indicating that zinc didn't add extra benefits to inflammation control when used together.
However, we also noted that zinc alone showed no significant anti-inflammatory effect, highlighting that the benefits we observed were primarily due to the pomegranate extract rather than zinc. This suggests that while zinc is commonly thought beneficial for treating cold sores, its impact on inflammation might be limited unless paired with more potent anti-inflammatory agents like PRE.
In conclusion, pomegranates present a promising approach to managing inflammation and pain associated with cold sores, but zinc’s standalone effectiveness requires reconsideration.
References
Ranjbar Z, Zahed M, Ranjbar MA, Shirmardan Z. Comparative study of serum zinc concentration in recurrent herpes labialis patients and healthy individuals. BMC Oral Health. 2020;20:296. 10.1186/s12903-020-01277-2
Houston DM, Bugert J, Denyer SP, Heard CM. Anti-inflammatory activity of Punica granatum L. (Pomegranate) rind extracts applied topically to ex vivo skin. Eur J Pharm Biopharm. 2017;112:30. 10.1016/j.ejpb.2016.11.014
Khozeimeh F, Jafari N, Attar AM, Jafari S, Ataie M. Comparative analysis of salivary zinc level in recurrent herpes labialis. Dent Res J (Isfahan). 2012;9:19. 10.4103/1735-3327.92922
Opstelten W, Neven AK, Eekhof J. Treatment and prevention of herpes labialis. Can Fam Physician. 2008;54:1683.
Femiano F, Gombos F, Scully C. Recurrent herpes labialis: a pilot study of the efficacy of zinc therapy. J Oral Pathol Med. 2005;34:423.
Singh BB, Udani J, Vinjamury SP, Der-Martirosian C, Gandhi S, et al. Safety and effectiveness of an L-lysine, zinc, and herbal-based product on the treatment of facial and circumoral herpes. Altern Med Rev. 2005;10:123.
Godfrey HR, Godfrey NJ, Godfrey JC, Riley D. A randomized clinical trial on the treatment of oral herpes with topical zinc oxide/glycine. Altern Ther Health Med. 2001;7:49.
Kneist W, Hempel B, Borelli S. [Clinical double-blind trial of topical zinc sulfate for herpes labialis recidivans]. Arzneimittelforschung. 1995;45:624.
Brody I. Topical treatment of recurrent herpes simplex and post-herpetic erythema multiforme with low concentrations of zinc sulphate solution. Br J Dermatol. 1981;104:191.