Randomized, multicenter, active-controlled open-label study of NPC-25, zinc histidine hydrate, (non-inferiority to NOBELZIN™, zinc acetate dihydrate) for patients with hypozincemia.
We conducted a study to evaluate how effective NPC-25, a new form of zinc, is compared to a well-known treatment, NOBELZIN™, for patients with low zinc levels. Participants in this trial had their zinc levels checked and were grouped to receive either NPC-25 or NOBELZIN™.
For a period of up to 24 weeks, we aimed to maintain their zinc levels within a specific target range while closely monitoring for side effects. One of our main goals was to see if NPC-25 could maintain these target zinc levels similarly to NOBELZIN™.
Our findings revealed that NPC-25 was indeed non-inferior to NOBELZIN™, meaning it worked just as well. Importantly, we also observed that those taking NPC-25 reported fewer digestive issues, like nausea and vomiting. This suggests that while both treatments were effective, NPC-25 might be the gentler option.
Read More
7
Zinc treatment in hypozincemia study
Post-marketing surveillance of zinc acetate dihydrate for hypozincemia in Japan.
We explored the impact of zinc acetate dihydrate on several symptoms, including nausea, through a comprehensive study that assessed its safety and effectiveness for treating hypozincemia over a 52-week period. From the data collected, we observed an overall adverse reaction rate of 9.4%, with nausea reported in 1.4% of patients.
Despite nausea being a concern, the benefit of zinc acetate dihydrate for other indications was notable, with an efficacy rate of 83%. For patients experiencing symptoms such as pressure ulcers or stomatitis, the effectiveness was strikingly high. However, the specific effect of zinc on nausea is not definitively isolated within the study results, making it hard to gauge its direct and unique benefits.
In essence, while zinc acetate dihydrate shows promise for a variety of symptoms, including nausea, the evidence does not conclusively highlight its effectiveness for this particular issue on its own. Overall, it appears that zinc treatment can contribute positively to addressing several related health problems.
Read More
4
Zinc affects post-op nausea minimally
Comparing the Effect of Zinc-impregnated Pharyngeal Packs with Conventional Methods on the Level of Sore Throat Among Patients Undergoing Septorhinoplasty.
We explored the effectiveness of zinc-impregnated pharyngeal packs in reducing post-operative nausea and sore throat among patients undergoing septorhinoplasty. In this study, we divided 220 patients into four groups, each receiving different types of pharyngeal packs: normal saline-impregnated vibril, normal saline-impregnated gauze, zinc solution-impregnated vibril, and zinc solution-impregnated gauze.
Our findings revealed that there was no significant difference between the groups regarding the occurrence of sore throat shortly after surgery and at various intervals thereafter. However, we did observe that those using zinc solution-impregnated gauze experienced significantly less severity of nausea two hours post-surgery compared to those using normal saline-impregnated gauze. Ultimately, while zinc did not help with sore throat, it showed promise in alleviating nausea.
Read More
Most Useful Reviews
9
No nausea noted
26 people found this helpful
I consume vitamin and mineral complexes with zinc seasonally, twice a year to bolster my immune system and maintain healthy skin. The capsules are stored in a dark glass jar, protected by mica and a paper membrane upon first opening. I experienced no side effects, and there was no sensation of nausea after taking it, which is often an issue with zinc supplements.
Read More
9
No nausea felt
13 people found this helpful
The manufacturer "Garden of Life" uses plant-based and raw materials for their vitamins and minerals. This preparation focuses on zinc, especially from brown rice in a chelated form, optimising absorption without causing discomfort like nausea. The dosage provides therapeutic benefits, and the combination with vitamin C and organic enzymes makes it effective. I have experienced improved health during colder months.
Read More
9
No nausea observed
12 people found this helpful
I regularly purchase zinc to boost my health during virus and cold seasons. I've had no discomfort, such as nausea, during these two months of use. I highly recommend it.
Randomized, multicenter, active-controlled open-label study of NPC-25, zinc histidine hydrate, (non-inferiority to NOBELZIN™, zinc acetate dihydrate) for patients with hypozincemia.
We conducted a study to evaluate how effective NPC-25, a new form of zinc, is compared to a well-known treatment, NOBELZIN™, for patients with low zinc levels. Participants in this trial had their zinc levels checked and were grouped to receive either NPC-25 or NOBELZIN™.
For a period of up to 24 weeks, we aimed to maintain their zinc levels within a specific target range while closely monitoring for side effects. One of our main goals was to see if NPC-25 could maintain these target zinc levels similarly to NOBELZIN™.
Our findings revealed that NPC-25 was indeed non-inferior to NOBELZIN™, meaning it worked just as well. Importantly, we also observed that those taking NPC-25 reported fewer digestive issues, like nausea and vomiting. This suggests that while both treatments were effective, NPC-25 might be the gentler option.
Read More
7
Zinc treatment in hypozincemia study
Post-marketing surveillance of zinc acetate dihydrate for hypozincemia in Japan.
We explored the impact of zinc acetate dihydrate on several symptoms, including nausea, through a comprehensive study that assessed its safety and effectiveness for treating hypozincemia over a 52-week period. From the data collected, we observed an overall adverse reaction rate of 9.4%, with nausea reported in 1.4% of patients.
Despite nausea being a concern, the benefit of zinc acetate dihydrate for other indications was notable, with an efficacy rate of 83%. For patients experiencing symptoms such as pressure ulcers or stomatitis, the effectiveness was strikingly high. However, the specific effect of zinc on nausea is not definitively isolated within the study results, making it hard to gauge its direct and unique benefits.
In essence, while zinc acetate dihydrate shows promise for a variety of symptoms, including nausea, the evidence does not conclusively highlight its effectiveness for this particular issue on its own. Overall, it appears that zinc treatment can contribute positively to addressing several related health problems.
Read More
4
Zinc affects post-op nausea minimally
Comparing the Effect of Zinc-impregnated Pharyngeal Packs with Conventional Methods on the Level of Sore Throat Among Patients Undergoing Septorhinoplasty.
We explored the effectiveness of zinc-impregnated pharyngeal packs in reducing post-operative nausea and sore throat among patients undergoing septorhinoplasty. In this study, we divided 220 patients into four groups, each receiving different types of pharyngeal packs: normal saline-impregnated vibril, normal saline-impregnated gauze, zinc solution-impregnated vibril, and zinc solution-impregnated gauze.
Our findings revealed that there was no significant difference between the groups regarding the occurrence of sore throat shortly after surgery and at various intervals thereafter. However, we did observe that those using zinc solution-impregnated gauze experienced significantly less severity of nausea two hours post-surgery compared to those using normal saline-impregnated gauze. Ultimately, while zinc did not help with sore throat, it showed promise in alleviating nausea.
Read More
4
Zinc's tolerability in diarrhoea treatment
New formulation zinc sulphate acceptability and adherence in children with acute diarrhoea: A prospective, open-label, interventional study in Bangladesh.
We aimed to understand how zinc tablets, often recommended for treating diarrhoea in young children, affect nausea and overall treatment adherence. In this open-label study, we involved children aged 3 to 59 months who visited the outpatient department at Dhaka Hospital.
Our findings revealed that a significant number of children, about 92.7%, tolerated the modified zinc tablets well. However, we also noted that 32.8% of the children experienced vomiting, and 19.5% had regurgitation, while a smaller number, 7.4%, reported nausea. Interestingly, despite these side effects, a remarkable 99.3% of caregivers expressed their willingness to continue using this zinc formulation in the future.
Overall, while our study demonstrated that the modified zinc formulation was generally well-tolerated, we cannot overlook the considerable instances of nausea and vomiting experienced by the children. Balancing these side effects with the willingness of caregivers offers a complex view of zinc's role in diarrhoea management.
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User Reviews
USERS' SCORE
Good
Based on 54 Reviews
8.1
All Reviews
Positive Reviews
Negative Reviews
9
No nausea noted
26 people found this helpful
I consume vitamin and mineral complexes with zinc seasonally, twice a year to bolster my immune system and maintain healthy skin. The capsules are stored in a dark glass jar, protected by mica and a paper membrane upon first opening. I experienced no side effects, and there was no sensation of nausea after taking it, which is often an issue with zinc supplements.
Read More
9
No nausea felt
13 people found this helpful
The manufacturer "Garden of Life" uses plant-based and raw materials for their vitamins and minerals. This preparation focuses on zinc, especially from brown rice in a chelated form, optimising absorption without causing discomfort like nausea. The dosage provides therapeutic benefits, and the combination with vitamin C and organic enzymes makes it effective. I have experienced improved health during colder months.
Read More
9
No nausea observed
12 people found this helpful
I regularly purchase zinc to boost my health during virus and cold seasons. I've had no discomfort, such as nausea, during these two months of use. I highly recommend it.
Read More
9
Nausea-free experience
7 people found this helpful
A fantastic zinc supplement, I experienced no nausea after taking it.
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9
No discomfort reported
7 people found this helpful
This product was well-tolerated, with no discomfort or nausea experienced. I noticed a slight improvement in my skin condition, but I don't expect dramatic results.
Nausea is a sensation that often precedes vomiting and is characterized by an uneasy feeling in the stomach. It can be caused by a variety of factors, including motion sickness, certain medications, food poisoning, or underlying health conditions. The experience of nausea can range from mildly uncomfortable to intensely distressing and is often accompanied by other symptoms such as sweating, increased salivation, or a feeling of lightheadedness.
Many people experience nausea at some point in their lives, making it a common issue. Fortunately, there are several remedies and treatments available that can help alleviate this unpleasant sensation. Over-the-counter medications, home remedies like ginger tea, and lifestyle changes, such as eating smaller meals or avoiding certain triggers, can be effective in reducing nausea. However, if nausea is persistent or accompanied by severe symptoms like severe abdominal pain or fever, it’s essential to consult with a healthcare professional for an accurate diagnosis and appropriate treatment.
Zinc is a versatile metal known for its various applications in industry and health. It is a bluish-white metallic element represented by the symbol Zn and atomic number 30 on the periodic table. Zinc is primarily used for galvanizing steel to prevent rusting, in the manufacturing of alloys, and as a component in batteries. Additionally, zinc plays a crucial role in biological processes, making it an essential trace element in the human diet. It is involved in immune function, protein synthesis, wound healing, and DNA synthesis, highlighting its importance in maintaining overall health and well-being.
Zinc may play a role in alleviating certain types of nausea, especially when it is associated with specific conditions, such as pregnancy or certain gastrointestinal issues. Some studies have indicated that zinc supplements might help in reducing nausea symptoms due to their potential to support overall gut health and maintain immune function. However, the evidence is not conclusive, and results can vary from person to person.
It's important to note that while zinc supplementation might benefit some individuals, it is not universally effective for all types of nausea. If you're considering using zinc to address nausea, consult with a healthcare professional to ensure it's appropriate for your situation and to discuss the ideal dosage. Additionally, it's crucial to address the underlying cause of nausea rather than just treating the symptom itself.
Based on user reviews, many individuals report experiencing relief from nausea soon after starting this zinc supplement. In particular, one user noted a significant improvement in health within just a few days of switching to this brand, having previously suffered from nausea with other zinc products Read Review. Another reviewer mentioned noticing marked benefits in just two weeks, highlighting the effectiveness of this supplement in alleviating nausea and other symptoms Read Review.
Overall, users seem to appreciate that this zinc supplement does not typically induce nausea, which is a common side effect of many other zinc products. For those concerned about nausea when taking zinc, this particular formulation is often recommended as it’s well-tolerated and produces results within a relatively short timeframe. Thus, if you’re looking for a supplement to address nausea, you might start noticing improvements within a few days to weeks, as indicated by the positive experiences shared by users.
Zinc supplements have shown some promise in studies related to nausea, though the evidence varies in strength and clarity. A notable study indicated that a new form of zinc, NPC-25, resulted in fewer reports of digestive issues, including nausea and vomiting, compared to an established treatment over a 24-week period [1]. This finding suggests that certain zinc formulations may be gentler on the stomach, potentially benefiting those prone to nausea.
However, other studies provide a more nuanced view. For instance, while zinc acetate dihydrate was explored for its effectiveness in treating nausea among other symptoms, the specific effects on nausea were not definitively isolated, complicating the assessment of its direct efficacy [2]. Additionally, another research highlighted that zinc solution-impregnated gauze reduced the severity of post-operative nausea compared to saline alternatives, indicating a potential role for zinc in specific contexts [3]. Therefore, while there's some evidence supporting the use of zinc supplements in relation to nausea, it's important to approach its effectiveness as part of a broader treatment strategy rather than a standalone solution.
Users have reported a variety of improvements in their symptoms after taking this zinc supplement. Many individuals specifically highlighted the absence of nausea, which is often a common complaint with zinc products. One user mentioned significant benefits to their immune health during colder months, while another attributed improved skin conditions to the supplement Read Review. Other reviewers echoed similar sentiments, noting enhancements in skin and hair quality, and a reduction in cravings and overall well-being Read Review.
Additionally, several users observed that the supplement facilitated a reduction in cold symptoms and overall respiratory health. For instance, one reviewer stated they stopped catching colds frequently after two weeks of use, while another suggested a noticeable decline in acne within weeks of starting the supplement Read Review. Overall, these anecdotal experiences suggest that while individual results can vary, many users have found this zinc supplement to be beneficial for both their immune system and skin health, all without the typical side effects associated with zinc intake.
Users have shared positive experiences regarding the combination of this zinc supplement with other vitamins and minerals to mitigate nausea. Many reviewers have reported taking it alongside vitamin C and other organic enzymes, which they found to enhance its effectiveness without causing discomfort. For instance, one user mentioned that the blend of ingredients facilitated better absorption and eliminated the nausea often associated with traditional zinc supplements Read Review. Additionally, several individuals highlighted their satisfaction with combining this product in their seasonal regimen, noting that it stayed gentle on the digestive system even when taken with food Read Review.
Overall, users consistently emphasized the absence of nausea with this particular zinc supplement, especially compared to previous experiences with synthetic options. Reviewers noted that the natural formula made it a standout choice, stressing that they could easily incorporate it into their daily routines without fear of adverse side effects Read Review. Many expressed their willingness to continue using this zinc product not only for its immune-boosting properties but also for its compatibility with other supplements, thereby enhancing their overall supplement stack Read Review.
User reviews suggest that the right dosage of zinc for treating nausea often allows users to avoid unpleasant side effects entirely. Many users specifically highlighted their experiences with zinc supplements that did not induce nausea, indicating effective formulations like those made from natural sources or chelated forms. For example, one reviewer noted a 15mg dose that provided good absorption and no nausea Read Review. Another user mentioned that taking zinc with food helps minimize discomfort, which aligns with advice from others in the reviews Read Review.
Overall, the majority of positive reports are tied to products that are well-tolerated and derived from plant-based ingredients, with multiple users recommending specific brands for their lack of gastrointestinal discomfort Read Review. However, caution was advised by one reviewer who mentioned being careful with dosage to avoid potential nausea and headaches Read Review. This suggests that while many users can take zinc without nausea, individual responses vary, making proper dosing key.
9
Effective without nausea
3 people found this helpful
After suffering nausea from synthetic zinc, I was pleased to find this natural zinc doesn't cause any discomfort. The results were noticeable within days, greatly improving my health. I highly recommend this high-quality product.
9
No nausea experienced
4 people found this helpful
The doctor recommended zinc to boost my immune system, but prior to this, every zinc caused me nausea. This zinc doesn't induce any unpleasant feelings. After two weeks, I noticed a significant improvement, having stopped catching colds frequently. The quality is excellent, though not the cheapest.
9
No nausea felt
13 people found this helpful
The manufacturer "Garden of Life" uses plant-based and raw materials for their vitamins and minerals. This preparation focuses on zinc, especially from brown rice in a chelated form, optimising absorption without causing discomfort like nausea. The dosage provides therapeutic benefits, and the combination with vitamin C and organic enzymes makes it effective. I have experienced improved health during colder months.
9
No nausea
2 people found this helpful
Zinc in brown rice chelate form is well-absorbed and did not upset my stomach, which is essential as I take zinc for my skin and thyroid. There were no nausea issues, and I noticed a reduction in sweet cravings after two weeks. The condition of my skin and hair has improved. I will continue purchasing this affordable supplement.
9
No nausea noted
1 people found this helpful
I've struggled with acne for years. After trying zinc again from this brand, I found there was no nausea like before. It helped clear my skin within weeks, despite my ongoing gastrointestinal issues. I recommend it for anyone with problem skin!
9
Recommended without nausea
2 people found this helpful
I often purchase vitamins from this company, and now zinc for healthy skin and immunity. It’s taken with food and importantly doesn't cause any nausea. This is my second course.
9
No nausea at all
1 people found this helpful
I'm very pleased with this zinc, primarily because it does not cause the common side effect of nausea. It helps symptoms of a cold subside quickly and is worth the investment.
9
No nausea noted
26 people found this helpful
I consume vitamin and mineral complexes with zinc seasonally, twice a year to bolster my immune system and maintain healthy skin. The capsules are stored in a dark glass jar, protected by mica and a paper membrane upon first opening. I experienced no side effects, and there was no sensation of nausea after taking it, which is often an issue with zinc supplements.
9
Highly effective zinc
5 people found this helpful
This zinc is excellent! At 15mg per capsule, made from natural materials, it's well absorbed and causes no nausea. It boosts immunity, essential during pandemics, and has improved my hair, skin, and nails.
9
Limited nausea reported
1 people found this helpful
Great zinc that regulates sugar levels and helps with severe acne. It’s made from natural ingredients that boost the immune system, and I noticed less hair loss as well. Be careful with dosage to avoid nausea and headaches.
7
Zinc treatment reduces nausea risk
Randomized, multicenter, active-controlled open-label study of NPC-25, zinc histidine hydrate, (non-inferiority to NOBELZIN™, zinc acetate dihydrate) for patients with hypozincemia.
We conducted a study to evaluate how effective NPC-25, a new form of zinc, is compared to a well-known treatment, NOBELZIN™, for patients with low zinc levels. Participants in this trial had their zinc levels checked and were grouped to receive either NPC-25 or NOBELZIN™.
For a period of up to 24 weeks, we aimed to maintain their zinc levels within a specific target range while closely monitoring for side effects. One of our main goals was to see if NPC-25 could maintain these target zinc levels similarly to NOBELZIN™.
Our findings revealed that NPC-25 was indeed non-inferior to NOBELZIN™, meaning it worked just as well. Importantly, we also observed that those taking NPC-25 reported fewer digestive issues, like nausea and vomiting. This suggests that while both treatments were effective, NPC-25 might be the gentler option.
7
Zinc treatment in hypozincemia study
Post-marketing surveillance of zinc acetate dihydrate for hypozincemia in Japan.
We explored the impact of zinc acetate dihydrate on several symptoms, including nausea, through a comprehensive study that assessed its safety and effectiveness for treating hypozincemia over a 52-week period. From the data collected, we observed an overall adverse reaction rate of 9.4%, with nausea reported in 1.4% of patients.
Despite nausea being a concern, the benefit of zinc acetate dihydrate for other indications was notable, with an efficacy rate of 83%. For patients experiencing symptoms such as pressure ulcers or stomatitis, the effectiveness was strikingly high. However, the specific effect of zinc on nausea is not definitively isolated within the study results, making it hard to gauge its direct and unique benefits.
In essence, while zinc acetate dihydrate shows promise for a variety of symptoms, including nausea, the evidence does not conclusively highlight its effectiveness for this particular issue on its own. Overall, it appears that zinc treatment can contribute positively to addressing several related health problems.
4
Zinc affects post-op nausea minimally
Comparing the Effect of Zinc-impregnated Pharyngeal Packs with Conventional Methods on the Level of Sore Throat Among Patients Undergoing Septorhinoplasty.
We explored the effectiveness of zinc-impregnated pharyngeal packs in reducing post-operative nausea and sore throat among patients undergoing septorhinoplasty. In this study, we divided 220 patients into four groups, each receiving different types of pharyngeal packs: normal saline-impregnated vibril, normal saline-impregnated gauze, zinc solution-impregnated vibril, and zinc solution-impregnated gauze.
Our findings revealed that there was no significant difference between the groups regarding the occurrence of sore throat shortly after surgery and at various intervals thereafter. However, we did observe that those using zinc solution-impregnated gauze experienced significantly less severity of nausea two hours post-surgery compared to those using normal saline-impregnated gauze. Ultimately, while zinc did not help with sore throat, it showed promise in alleviating nausea.
References
Asaoka D, Ishihara T, Ezoe S, Hamada I, Kitamura M, et al. Randomized, multicenter, active-controlled open-label study of NPC-25, zinc histidine hydrate, (non-inferiority to NOBELZIN™, zinc acetate dihydrate) for patients with hypozincemia. J Trace Elem Med Biol. 2025;87:127558. doi:10.1016/j.jtemb.2024.127558
Ezoe S, Ishihara T, Hosogai T, Kokubo T. Post-marketing surveillance of zinc acetate dihydrate for hypozincemia in Japan. Pharmazie. 2024;79:29. doi:10.1691/ph.2024.3630
Parvizi A, Haddadi S, Akbari M, Akbarpour M, Taghipour Rudsari F, et al. Comparing the Effect of Zinc-impregnated Pharyngeal Packs with Conventional Methods on the Level of Sore Throat Among Patients Undergoing Septorhinoplasty. Anesth Pain Med. 2022;12:e127262. doi:10.5812/aapm-127262
Nuzhat S, Ahmed T, Alam J, Billal SM, Khan AI, et al. New formulation zinc sulphate acceptability and adherence in children with acute diarrhoea: A prospective, open-label, interventional study in Bangladesh. J Paediatr Child Health. 2022;58:1215. doi:10.1111/jpc.15953