Medical Researches
Possibly Effective
Based on 16 Researches
We aimed to understand how vitamin K2 influences osteoporosis, especially when combined with another treatment known as recombinant human parathyroid hormone 1-34 (rhPTH (1-34)).
In this study, 77 postmenopausal women with osteoporosis were divided into two groups. One group received vitamin K2 alone, while the other group was treated with a combination of rhPTH (1-34) and vitamin K2. Over the course of the treatment, we looked closely at changes in bone mineral density (BMD), pain levels, and various markers related to bone metabolism, as well as any potential side effects.
Both treatments were effective in improving key parameters like BMD and pain scores. However, the combination therapy significantly outperformed vitamin K2 alone in enhancing BMD and other important markers. Importantly, we found no significant increase in adverse reactions with the combined treatment, which suggests that it is a safe option.
Ultimately, our findings indicate that while vitamin K2 has a positive effect, its benefits were notably enhanced when used alongside rhPTH (1-34). This synergy may offer a promising pathway for more effective osteoporosis management.
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UBIAD1 crucial for bone growthVitamin K converting enzyme UBIAD1 plays an important role in osteogenesis and chondrogenesis in mice.
Vitamin K2's indirect role noted
We explored the role of UBIAD1, an enzyme crucial for converting dietary vitamin K into its active form, MK-4, in the context of bone health and osteoporosis. The study involved a special mouse model where UBIAD1 was intentionally disabled from the first week of life. This allowed us to observe the effects of reduced UBIAD1 activity on bone development.
Our findings revealed that mice lacking UBIAD1 had significantly shorter femurs and lower bone mineral density, indicating a detrimental effect on bone formation. Additionally, we noticed that the production of important proteins involved in forming both bone and cartilage was markedly decreased in these mice. Further experiments on cultured chondrocytes—the cells responsible for cartilage—showed that their differentiation was also impaired without UBIAD1.
These results suggest that UBIAD1 is vital for promoting healthy bone and cartilage growth, underscoring its potential importance in treating osteoporosis. While the study focuses on the enzyme's role, it highlights how vitamin K2 may support bone health through its influence on UBIAD1 activity.
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We explored how vitamin K2 (VK2) affects osteoporosis, particularly in the context of type 2 diabetes. In our research, we created a mouse model of type 2 diabetic osteoporosis by injecting a substance called streptozotocin and feeding them a high-fat, high-sugar diet. Additionally, we simulated this environment in the lab with bone marrow stem cells cultured in high glucose levels.
Our findings revealed that VK2 significantly helped in mitigating bone loss and reducing a type of cell death known as ferroptosis in these conditions. This was evidenced by lower levels of harmful molecules like mitochondrial reactive oxygen species and lipid peroxidation, alongside increased protection from oxidative stress indicated by higher glutathione levels. Notably, VK2 treatment also restored bone mass and boosted essential markers related to bone health in the distal femurs of our models.
Delving into the mechanisms, VK2 appeared to activate a pathway known as AMPK/SIRT1. Crucially, when we used a technique to knock down SIRT1, the beneficial effects of VK2 were diminished in the high-glucose cultured stem cells. Overall, VK2 proves to be a promising agent in combating type 2 diabetic osteoporosis by activating the AMPK/SIRT1 pathway to inhibit ferroptosis and ultimately support bone health.
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Vitamin K2 promotes bone healthVitamin K2 Improves Osteogenic Differentiation by Inhibiting STAT1 via the Bcl-6 and IL-6/JAK in C3H10 T1/2 Clone 8 Cells.
Relevant, but limited osteoporosis context
We aimed to investigate how vitamin K2 (VK2), a small but powerful nutrient, can enhance osteogenic differentiation, which is crucial for bone health and may help counteract osteoporosis. Using C3H10 T1/2 clone 8 cells, we examined the effects of VK2 on various markers associated with bone generation.
Our results showed that VK2 significantly boosted alkaline phosphatase activity and increased levels of key osteogenic indicators such as osteocalcin and RUNX2. We also conducted RNA sequencing to identify how VK2 triggers these changes, uncovering numerous genes that were impacted by its administration.
Notably, we found that VK2 not only elevated signals associated with bone formation but also influenced specific signaling pathways. It seemed to work by reducing the expression of STAT1 through the Bcl-6 and IL-6/JAK signaling pathways. This means that VK2 may enhance bone growth by modulating the intricate network of biological signals involved in bone development.
Overall, our findings suggest that vitamin K2 could play a beneficial role in promoting bone health through its action on crucial biological pathways, hinting at its potential as a supportive treatment for osteoporosis.
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Vitamin K2 improves bone healthEfficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review.
Directly addresses osteoporosis treatment
Our exploration focused on how vitamin K2 supplementation may aid postmenopausal women dealing with osteoporosis, particularly regarding bone mineral density (BMD) and the incidence of fractures over the long term. We meticulously reviewed nine randomized controlled trials with nearly 6,900 participants to gather insightful data on this topic.
The results were promising, revealing that vitamin K2 significantly enhanced lumbar and forearm BMD. Specifically, we observed notable increases in bone density measurements, alongside a reduction in undercarboxylated osteocalcin—a marker associated with bone health, and a significant rise in total osteocalcin.
Although there was an increase in the rate of adverse reactions in the vitamin K2 group, we found no serious side effects stemming from the supplementation. Overall, our study supports the conclusion that vitamin K2 is not only effective but also safe for treating osteoporosis in postmenopausal women. This could provide a welcome option for those looking to improve their bone health.
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