Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.7
USERS' SCORE
Good
Based on 1 Review
8.6
Top Medical Research Studies
9
To explore vitamin K2's effect on osteoporosis, we conducted a thorough analysis of nine studies involving 6,853 participants.
The findings suggest that vitamin K2 significantly improves bone mineral density (BMD) and reduces certain bone markers.
While there were increased adverse reactions, they were not serious. Overall, this suggests that vitamin K2 can be a beneficial and safe option for postmenopausal women managing osteoporosis.
The findings suggest that vitamin K2 significantly improves bone mineral density (BMD) and reduces certain bone markers.
While there were increased adverse reactions, they were not serious. Overall, this suggests that vitamin K2 can be a beneficial and safe option for postmenopausal women managing osteoporosis.
Read More
8
Vitamin K2 may support bone health
We delved into the effects of vitamin K2 on postmenopausal osteoporosis by reviewing data from 16 randomized controlled trials with over 6,400 participants.
Our analysis revealed that vitamin K2 supplementation positively influences bone mineral density, particularly in the lumbar spine, and can potentially lower fracture rates.
However, while we noted improvements in bone density, the overall difference in fracture incidence was not consistently significant. Importantly, vitamin K2 seems to reduce certain serum markers without increasing adverse reactions, making it a promising option for maintaining bone health in postmenopausal women.
Our analysis revealed that vitamin K2 supplementation positively influences bone mineral density, particularly in the lumbar spine, and can potentially lower fracture rates.
However, while we noted improvements in bone density, the overall difference in fracture incidence was not consistently significant. Importantly, vitamin K2 seems to reduce certain serum markers without increasing adverse reactions, making it a promising option for maintaining bone health in postmenopausal women.
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9
We explored the effects of menaquinone-4 (MK-4), a form of vitamin K, on osteoporosis in ovariectomized mice. In this study, groups of female mice received various treatments for 12 weeks, including MK-4 at different doses.
Our findings revealed that MK-4 significantly boosted bone mineral density and improved bone structure compared to untreated mice. It also promoted bone formation while reducing bone resorption.
Overall, this research highlights the potential of MK-4 as a promising treatment option for osteoporosis.
Our findings revealed that MK-4 significantly boosted bone mineral density and improved bone structure compared to untreated mice. It also promoted bone formation while reducing bone resorption.
Overall, this research highlights the potential of MK-4 as a promising treatment option for osteoporosis.
Read More
Most Useful Reviews
9.5
Supports bones
Very happy with this product. It helps support my bones, which is fantastic for osteoporosis. I will be buying again.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.7
- All Researches
9
To explore vitamin K2's effect on osteoporosis, we conducted a thorough analysis of nine studies involving 6,853 participants.
The findings suggest that vitamin K2 significantly improves bone mineral density (BMD) and reduces certain bone markers.
While there were increased adverse reactions, they were not serious. Overall, this suggests that vitamin K2 can be a beneficial and safe option for postmenopausal women managing osteoporosis.
The findings suggest that vitamin K2 significantly improves bone mineral density (BMD) and reduces certain bone markers.
While there were increased adverse reactions, they were not serious. Overall, this suggests that vitamin K2 can be a beneficial and safe option for postmenopausal women managing osteoporosis.
Read More
9
We explored the effects of menaquinone-4 (MK-4), a form of vitamin K, on osteoporosis in ovariectomized mice. In this study, groups of female mice received various treatments for 12 weeks, including MK-4 at different doses.
Our findings revealed that MK-4 significantly boosted bone mineral density and improved bone structure compared to untreated mice. It also promoted bone formation while reducing bone resorption.
Overall, this research highlights the potential of MK-4 as a promising treatment option for osteoporosis.
Our findings revealed that MK-4 significantly boosted bone mineral density and improved bone structure compared to untreated mice. It also promoted bone formation while reducing bone resorption.
Overall, this research highlights the potential of MK-4 as a promising treatment option for osteoporosis.
Read More
9
We aimed to understand how vitamin K2 influences osteoporosis, especially when combined with another treatment known as recombinant human parathyroid hormone 1-34 (rhPTH (1-34)).
In this study, 77 postmenopausal women with osteoporosis were divided into two groups. One group received vitamin K2 alone, while the other group was treated with a combination of rhPTH (1-34) and vitamin K2. Over the course of the treatment, we looked closely at changes in bone mineral density (BMD), pain levels, and various markers related to bone metabolism, as well as any potential side effects.
Both treatments were effective in improving key parameters like BMD and pain scores. However, the combination therapy significantly outperformed vitamin K2 alone in enhancing BMD and other important markers. Importantly, we found no significant increase in adverse reactions with the combined treatment, which suggests that it is a safe option.
Ultimately, our findings indicate that while vitamin K2 has a positive effect, its benefits were notably enhanced when used alongside rhPTH (1-34). This synergy may offer a promising pathway for more effective osteoporosis management.
In this study, 77 postmenopausal women with osteoporosis were divided into two groups. One group received vitamin K2 alone, while the other group was treated with a combination of rhPTH (1-34) and vitamin K2. Over the course of the treatment, we looked closely at changes in bone mineral density (BMD), pain levels, and various markers related to bone metabolism, as well as any potential side effects.
Both treatments were effective in improving key parameters like BMD and pain scores. However, the combination therapy significantly outperformed vitamin K2 alone in enhancing BMD and other important markers. Importantly, we found no significant increase in adverse reactions with the combined treatment, which suggests that it is a safe option.
Ultimately, our findings indicate that while vitamin K2 has a positive effect, its benefits were notably enhanced when used alongside rhPTH (1-34). This synergy may offer a promising pathway for more effective osteoporosis management.
Read More
9
We explored the role of UBIAD1, an enzyme crucial for converting dietary vitamin K into its active form, MK-4, in the context of bone health and osteoporosis. The study involved a special mouse model where UBIAD1 was intentionally disabled from the first week of life. This allowed us to observe the effects of reduced UBIAD1 activity on bone development.
Our findings revealed that mice lacking UBIAD1 had significantly shorter femurs and lower bone mineral density, indicating a detrimental effect on bone formation. Additionally, we noticed that the production of important proteins involved in forming both bone and cartilage was markedly decreased in these mice. Further experiments on cultured chondrocytes—the cells responsible for cartilage—showed that their differentiation was also impaired without UBIAD1.
These results suggest that UBIAD1 is vital for promoting healthy bone and cartilage growth, underscoring its potential importance in treating osteoporosis. While the study focuses on the enzyme's role, it highlights how vitamin K2 may support bone health through its influence on UBIAD1 activity.
Our findings revealed that mice lacking UBIAD1 had significantly shorter femurs and lower bone mineral density, indicating a detrimental effect on bone formation. Additionally, we noticed that the production of important proteins involved in forming both bone and cartilage was markedly decreased in these mice. Further experiments on cultured chondrocytes—the cells responsible for cartilage—showed that their differentiation was also impaired without UBIAD1.
These results suggest that UBIAD1 is vital for promoting healthy bone and cartilage growth, underscoring its potential importance in treating osteoporosis. While the study focuses on the enzyme's role, it highlights how vitamin K2 may support bone health through its influence on UBIAD1 activity.
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9
We explored how vitamin K2 (VK2) affects osteoporosis, particularly in the context of type 2 diabetes. In our research, we created a mouse model of type 2 diabetic osteoporosis by injecting a substance called streptozotocin and feeding them a high-fat, high-sugar diet. Additionally, we simulated this environment in the lab with bone marrow stem cells cultured in high glucose levels.
Our findings revealed that VK2 significantly helped in mitigating bone loss and reducing a type of cell death known as ferroptosis in these conditions. This was evidenced by lower levels of harmful molecules like mitochondrial reactive oxygen species and lipid peroxidation, alongside increased protection from oxidative stress indicated by higher glutathione levels. Notably, VK2 treatment also restored bone mass and boosted essential markers related to bone health in the distal femurs of our models.
Delving into the mechanisms, VK2 appeared to activate a pathway known as AMPK/SIRT1. Crucially, when we used a technique to knock down SIRT1, the beneficial effects of VK2 were diminished in the high-glucose cultured stem cells. Overall, VK2 proves to be a promising agent in combating type 2 diabetic osteoporosis by activating the AMPK/SIRT1 pathway to inhibit ferroptosis and ultimately support bone health.
Our findings revealed that VK2 significantly helped in mitigating bone loss and reducing a type of cell death known as ferroptosis in these conditions. This was evidenced by lower levels of harmful molecules like mitochondrial reactive oxygen species and lipid peroxidation, alongside increased protection from oxidative stress indicated by higher glutathione levels. Notably, VK2 treatment also restored bone mass and boosted essential markers related to bone health in the distal femurs of our models.
Delving into the mechanisms, VK2 appeared to activate a pathway known as AMPK/SIRT1. Crucially, when we used a technique to knock down SIRT1, the beneficial effects of VK2 were diminished in the high-glucose cultured stem cells. Overall, VK2 proves to be a promising agent in combating type 2 diabetic osteoporosis by activating the AMPK/SIRT1 pathway to inhibit ferroptosis and ultimately support bone health.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Supports bones
Very happy with this product. It helps support my bones, which is fantastic for osteoporosis. I will be buying again.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
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- Wang Q, Yu H, Kong Y. Association of vitamins with bone mineral density and osteoporosis measured by dual-energy x-ray absorptiometry: a cross-sectional study. BMC Musculoskelet Disord. 2024;25:69. doi:10.1186/s12891-024-07173-y
- Öz İ, Kochai A, Avan YL, Keskin D, Çınar BM, et al. The effect of pharmacological treatment in combination with vitamin K on healing in an experimental rat model of osteoporosis. Jt Dis Relat Surg. 2023;34:356. doi:10.52312/jdrs.2023.911
- Moore AE, Dulnoan D, Voong K, Ayis S, Mangelis A, et al. The additive effect of vitamin K supplementation and bisphosphonate on fracture risk in post-menopausal osteoporosis: a randomised placebo controlled trial. Arch Osteoporos. 2023;18:83. doi:10.1007/s11657-023-01288-w
- Li C, Liang C, Kong Z, Su Y, Ren W, et al. Determination of Vitamin K1, MK-4, MK-7, and D Levels in Human Serum of Postmenopausal Osteoporosis Women Based on High Stability LC-MS/MS: MK-7 May Be a New Marker of Bone Metabolism. Ann Nutr Metab. 2023;79:334. doi:10.1159/000531065
- Giordani C, Matacchione G, Giuliani A, Valli D, Scarpa ES, et al. Pro-Osteogenic and Anti-Inflammatory Synergistic Effect of Orthosilicic Acid, Vitamin K2, Curcumin, Polydatin and Quercetin Combination in Young and Senescent Bone Marrow-Derived Mesenchymal Stromal Cells. Int J Mol Sci. 2023;24. doi:10.3390/ijms24108820
- Lee AS, Sung MJ, Son SJ, Han AR, Hong SM, et al. Effect of Menaquinone-4 on Receptor Activator of Nuclear Factor B Ligand-Induced Osteoclast Differentiation and Ovariectomy-Induced Bone Loss. J Med Food. 2023;26:128. doi:10.1089/jmf.2022.K.0078
- Jin C, Tan K, Yao Z, Lin BH, Zhang DP, et al. A Novel Anti-Osteoporosis Mechanism of VK2: Interfering with Ferroptosis via AMPK/SIRT1 Pathway in Type 2 Diabetic Osteoporosis. J Agric Food Chem. 2023;71:2745. doi:10.1021/acs.jafc.2c05632
- Tao X, Xu T, Liu L, Lin X, Zhang Z, et al. Case report: Clinical characteristics and treatment of secondary osteoporosis induced by X-linked congenital adrenal dysplasia. Front Endocrinol (Lausanne). 2022;13:961322. doi:10.3389/fendo.2022.961322
- Ma ML, Ma ZJ, He YL, Sun H, Yang B, et al. Efficacy of vitamin K2 in the prevention and treatment of postmenopausal osteoporosis: A systematic review and meta-analysis of randomized controlled trials. Front Public Health. 2022;10:979649. doi:10.3389/fpubh.2022.979649
- Zhou M, Han S, Zhang W, Wu D. Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review. J Bone Miner Metab. 2022;40:763. doi:10.1007/s00774-022-01342-6
- Zhang W, Li L, Zhou X, Li K, Liu C, et al. Concurrent Treatment with Vitamin K2 and D3 on Spine Fusion in Patients with Osteoporosis-Associated Lumbar Degenerative Disorders. Spine (Phila Pa 1976). 2022;47:352. doi:10.1097/BRS.0000000000004309
- Mandatori D, Penolazzi L, Pelusi L, Lambertini E, Michelucci F, et al. Three-Dimensional Co-Culture System of Human Osteoblasts and Osteoclast Precursors from Osteoporotic Patients as an Innovative Model to Study the Role of Nutrients: Focus on Vitamin K2. Nutrients. 2021;13. doi:10.3390/nu13082823
- Wang H, Zhang N, Li L, Yang P, Ma Y. Menaquinone 4 Reduces Bone Loss in Ovariectomized Mice through Dual Regulation of Bone Remodeling. Nutrients. 2021;13. doi:10.3390/nu13082570
- Wang B, Tang J, Weng S, Chen L, Wu Z, et al. Is vitamin K a treatment choice for atypical femoral fractures in patients with secondary osteoporosis?. J Int Med Res. 2021;49:3000605211001643. doi:10.1177/03000605211001643
- Solmaz I, Ozdemir MA, Unal E, Abdurrezzak U, Muhtaroglu S, et al. Effect of vitamin K2 and vitamin D3 on bone mineral density in children with acute lymphoblastic leukemia: a prospective cohort study. J Pediatr Endocrinol Metab. 2021;34:441. doi:10.1515/jpem-2020-0637
- Zhang Z, Xia K, Gong W, Mai R, Liu P, et al. Efficacy of Recombinant Human Parathyroid Hormone 1-34 and Vitamin K2 Combination Therapy in Postmenopausal Osteoporosis. Horm Metab Res. 2025;57:33. doi:10.1055/a-2371-1642
- Hirashima S, Kiyooka Y, Kaetsu S, Nakagawa K. Vitamin K converting enzyme UBIAD1 plays an important role in osteogenesis and chondrogenesis in mice. Biochem Biophys Res Commun. 2024;702:149635. doi:10.1016/j.bbrc.2024.149635
- Kong M, Gao C, Luan X, Fan C, Hao M, et al. Analyzing the factors associated with efficacy among teriparatide treatment in postmenopausal women with osteoporosis. BMC Musculoskelet Disord. 2024;25:109. doi:10.1186/s12891-024-07227-1
- Skalny AV, Aschner M, Tsatsakis A, Rocha JBT, Santamaria A, et al. Role of vitamins beyond vitamin D in bone health and osteoporosis (Review). Int J Mol Med. 2024;53. doi:10.3892/ijmm.2023.5333
- Cui Y, Zhang W, Yang P, Zhu S, Luo S, et al. Menaquinone-4 prevents medication-related osteonecrosis of the jaw through the SIRT1 signaling-mediated inhibition of cellular metabolic stresses-induced osteoblast apoptosis. Free Radic Biol Med. 2023;206:33. doi:10.1016/j.freeradbiomed.2023.06.022
- Moore AE, Dulnoan D, Voong K, Ayis S, Mangelis A, et al. The additive effect of vitamin K supplementation and bisphosphonate on fracture risk in post-menopausal osteoporosis: a randomised placebo controlled trial. Arch Osteoporos. 2023;18:83. doi:10.1007/s11657-023-01288-w
- Li C, Liang C, Kong Z, Su Y, Ren W, et al. Determination of Vitamin K1, MK-4, MK-7, and D Levels in Human Serum of Postmenopausal Osteoporosis Women Based on High Stability LC-MS/MS: MK-7 May Be a New Marker of Bone Metabolism. Ann Nutr Metab. 2023;79:334. doi:10.1159/000531065
- Giordani C, Matacchione G, Giuliani A, Valli D, Scarpa ES, et al. Pro-Osteogenic and Anti-Inflammatory Synergistic Effect of Orthosilicic Acid, Vitamin K2, Curcumin, Polydatin and Quercetin Combination in Young and Senescent Bone Marrow-Derived Mesenchymal Stromal Cells. Int J Mol Sci. 2023;24. doi:10.3390/ijms24108820
- Jin C, Tan K, Yao Z, Lin BH, Zhang DP, et al. A Novel Anti-Osteoporosis Mechanism of VK2: Interfering with Ferroptosis via AMPK/SIRT1 Pathway in Type 2 Diabetic Osteoporosis. J Agric Food Chem. 2023;71:2745. doi:10.1021/acs.jafc.2c05632
- Tao X, Xu T, Liu L, Lin X, Zhang Z, et al. Case report: Clinical characteristics and treatment of secondary osteoporosis induced by X-linked congenital adrenal dysplasia. Front Endocrinol (Lausanne). 2022;13:961322. doi:10.3389/fendo.2022.961322
- Ma ML, Ma ZJ, He YL, Sun H, Yang B, et al. Efficacy of vitamin K2 in the prevention and treatment of postmenopausal osteoporosis: A systematic review and meta-analysis of randomized controlled trials. Front Public Health. 2022;10:979649. doi:10.3389/fpubh.2022.979649
- Wang H, Li L, Zhang N, Ma Y. Vitamin K2 Improves Osteogenic Differentiation by Inhibiting STAT1 via the Bcl-6 and IL-6/JAK in C3H10 T1/2 Clone 8 Cells. Nutrients. 2022;14. doi:10.3390/nu14142934
- Jadhav N, Ajgaonkar S, Saha P, Gurav P, Pandey A, et al. Molecular Pathways and Roles for Vitamin K2-7 as a Health-Beneficial Nutraceutical: Challenges and Opportunities. Front Pharmacol. 2022;13:896920. doi:10.3389/fphar.2022.896920
- Zhou M, Han S, Zhang W, Wu D. Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review. J Bone Miner Metab. 2022;40:763. doi:10.1007/s00774-022-01342-6
- Zhang W, Li L, Zhou X, Li K, Liu C, et al. Concurrent Treatment with Vitamin K2 and D3 on Spine Fusion in Patients with Osteoporosis-Associated Lumbar Degenerative Disorders. Spine (Phila Pa 1976). 2022;47:352. doi:10.1097/BRS.0000000000004309
- Hu L, Ji J, Li D, Meng J, Yu B. The combined effect of vitamin K and calcium on bone mineral density in humans: a meta-analysis of randomized controlled trials. J Orthop Surg Res. 2021;16:592. doi:10.1186/s13018-021-02728-4
