' 
SCIENTIFIC SCORE
Possibly Effective
Based on 28 Researches
7.3
USERS' SCORE
Good
Based on 1 Review
8.6
Supplement Facts
Serving Size: 1 Caplet
Amount Per Serving
%DV
Organic ashwagandha powder (root)(0.2% Withanolides, 0.76 mg)
380 mg
*
Organic ashwagandha extract (root)(0.5% Withanolides, 1.4 mg)
280 mg
*
Organic ashwagandha supercriticalCO2 extract (root) (Withania somnifera) (8% Withanolides, 0.8 mg)
10 mg
*
Top Medical Research Studies
9
DHA benefits osteoarthritis treatment
DHA attenuates cartilage degeneration by mediating apoptosis and autophagy in human chondrocytes and rat models of osteoarthritis.
High relevance to OA research
We set out to investigate how docosahexaenoic acid (DHA), a fatty acid known for its health benefits, can affect osteoarthritis (OA), a common degenerative joint disease, particularly among older adults. Using both human chondrocyte models stimulated by IL-1β and rat models created through surgical methods, we aimed to understand DHA's potential to impact chondrocyte behavior and cartilage health.
Our observations revealed that DHA significantly promotes the growth of chondrocytes while reducing cell death, which is a key concern in OA. Notably, we found an increase in autophagosomes—structures that help break down cellular waste—within cells treated with DHA, suggesting enhanced cell health.
In comparing groups, those treated with DHA exhibited healthier cartilage characterized by thickened tissue and a decrease in degeneration when compared to the untreated OA group. We also noted an increase in collagen production, vital for maintaining joint structure. The biochemical analysis indicated that DHA potentially exerts its effects by inhibiting certain pathways associated with cell growth and stress responses, thus enhancing chondrocyte proliferation and survival.
Overall, our findings contribute valuable insights into how DHA can be leveraged as a therapeutic approach for OA, emphasizing its role in protecting and restoring cartilage health.
Our observations revealed that DHA significantly promotes the growth of chondrocytes while reducing cell death, which is a key concern in OA. Notably, we found an increase in autophagosomes—structures that help break down cellular waste—within cells treated with DHA, suggesting enhanced cell health.
In comparing groups, those treated with DHA exhibited healthier cartilage characterized by thickened tissue and a decrease in degeneration when compared to the untreated OA group. We also noted an increase in collagen production, vital for maintaining joint structure. The biochemical analysis indicated that DHA potentially exerts its effects by inhibiting certain pathways associated with cell growth and stress responses, thus enhancing chondrocyte proliferation and survival.
Overall, our findings contribute valuable insights into how DHA can be leveraged as a therapeutic approach for OA, emphasizing its role in protecting and restoring cartilage health.
Read More
9
DHA benefits osteoarthritis treatment
DHA attenuates cartilage degeneration by mediating apoptosis and autophagy in human chondrocytes and rat models of osteoarthritis.
High relevance to OA research
We set out to investigate how docosahexaenoic acid (DHA), a fatty acid known for its health benefits, can affect osteoarthritis (OA), a common degenerative joint disease, particularly among older adults. Using both human chondrocyte models stimulated by IL-1β and rat models created through surgical methods, we aimed to understand DHA's potential to impact chondrocyte behavior and cartilage health.
Our observations revealed that DHA significantly promotes the growth of chondrocytes while reducing cell death, which is a key concern in OA. Notably, we found an increase in autophagosomes—structures that help break down cellular waste—within cells treated with DHA, suggesting enhanced cell health.
In comparing groups, those treated with DHA exhibited healthier cartilage characterized by thickened tissue and a decrease in degeneration when compared to the untreated OA group. We also noted an increase in collagen production, vital for maintaining joint structure. The biochemical analysis indicated that DHA potentially exerts its effects by inhibiting certain pathways associated with cell growth and stress responses, thus enhancing chondrocyte proliferation and survival.
Overall, our findings contribute valuable insights into how DHA can be leveraged as a therapeutic approach for OA, emphasizing its role in protecting and restoring cartilage health.
Our observations revealed that DHA significantly promotes the growth of chondrocytes while reducing cell death, which is a key concern in OA. Notably, we found an increase in autophagosomes—structures that help break down cellular waste—within cells treated with DHA, suggesting enhanced cell health.
In comparing groups, those treated with DHA exhibited healthier cartilage characterized by thickened tissue and a decrease in degeneration when compared to the untreated OA group. We also noted an increase in collagen production, vital for maintaining joint structure. The biochemical analysis indicated that DHA potentially exerts its effects by inhibiting certain pathways associated with cell growth and stress responses, thus enhancing chondrocyte proliferation and survival.
Overall, our findings contribute valuable insights into how DHA can be leveraged as a therapeutic approach for OA, emphasizing its role in protecting and restoring cartilage health.
Read More
8
DHA induces apoptosis in RA cells
DHA Induces Cell Death through the Production of ROS and the Upregulation of CHOP in Fibroblast-like Synovial Cells from Human Rheumatoid Arthritis Patients.
High therapeutic relevance for RA
We explored how docosahexaenoic acid (DHA), a marine omega-3 fatty acid, impacts fibroblast-like synovial cells from patients with rheumatoid arthritis (RA). In our investigation, we found that DHA treatment triggered cell death in these cells through a process called apoptosis—a form of programmed cell death— and this effect increased with higher doses of DHA.
DHA not only induced apoptosis but also reduced the levels of proteins associated with inflammation, specifically MMP-9 and IL-1β. Interestingly, we observed that DHA prompted the activation of stress markers in the cells, indicating a response to abnormal stress conditions. Two key players in this process were identified: CHOP and death receptor 5 (DR5). When we reduced the expression of CHOP or DR5, the cells showed improved survival and less apoptosis, highlighting their roles in this pathway.
Additionally, DHA led to an increase in reactive oxygen species (ROS), compounds that can cause damage to cells. By using an antioxidant called Tiron, we discovered that it could prevent the effects of DHA, including the induction of CHOP and DR5, and reduce the cell death triggered by DHA. This protective effect boosted cell viability and diminished markers typically associated with apoptosis.
All of our findings in the lab were corroborated by results from human primary synovial cells from RA patients. This suggests that DHA may hold promise as a therapeutic agent for RA by harnessing oxidative stress and CHOP to promote cell death in the inflamed tissues of the joints.
DHA not only induced apoptosis but also reduced the levels of proteins associated with inflammation, specifically MMP-9 and IL-1β. Interestingly, we observed that DHA prompted the activation of stress markers in the cells, indicating a response to abnormal stress conditions. Two key players in this process were identified: CHOP and death receptor 5 (DR5). When we reduced the expression of CHOP or DR5, the cells showed improved survival and less apoptosis, highlighting their roles in this pathway.
Additionally, DHA led to an increase in reactive oxygen species (ROS), compounds that can cause damage to cells. By using an antioxidant called Tiron, we discovered that it could prevent the effects of DHA, including the induction of CHOP and DR5, and reduce the cell death triggered by DHA. This protective effect boosted cell viability and diminished markers typically associated with apoptosis.
All of our findings in the lab were corroborated by results from human primary synovial cells from RA patients. This suggests that DHA may hold promise as a therapeutic agent for RA by harnessing oxidative stress and CHOP to promote cell death in the inflamed tissues of the joints.
Read More
Most Useful Reviews
9.5
Improved mood drastically
Amazing purchase! I'm on my third bottle and have noticed a significant change in my mood and joint pain. Due to lupus, I often struggle with fatigue and achy joints, but this has helped tremendously! I'm generally in a better mood and mostly pain-free. I even bought a bottle for my grandmother, who is 76 and suffers from arthritis. She's thrilled with her results!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 28 Researches
7.3
- All Researches
9
Docosahexaenoic acid reduces arthritis
Lipid mediators obtained from docosahexaenoic acid by soybean lipoxygenase attenuate RANKL-induced osteoclast differentiation and rheumatoid arthritis.
Moderate relevance of findings
We examined the effects of lipid mediators derived from docosahexaenoic acid (DHA) on arthritis, particularly focusing on rheumatoid arthritis (RA). The study utilized a model involving mice with collagen antibody-induced arthritis (CAIA) and RAW264.7 cells to investigate the role of these mediators in reducing inflammation and joint damage.
The lipid mediators were produced by soybean lipoxygenase from DHA and included substances known for their anti-inflammatory properties. We found that these mediators significantly reduced symptoms in CAIA mice, evidenced by decreased paw swelling and reduced progression of arthritis. In the cellular studies, these mediators inhibited the formation of bone-resorbing cells called osteoclasts, while also downregulating key inflammatory markers.
Following treatment, there were notable improvements in serum cytokine levels, with a decrease in pro-inflammatory cytokines like TNF-α and IL-6, and an increase in the anti-inflammatory cytokine IL-10. Additionally, joint inflammation and damage were reduced, hinting at a complex relationship involving various signaling pathways.
These findings indicate that lipid mediators derived from DHA may offer a promising approach to alleviating symptoms of RA, though the precise individual contributions of DHA alone are difficult to isolate due to the presence of other components in the intervention.
The lipid mediators were produced by soybean lipoxygenase from DHA and included substances known for their anti-inflammatory properties. We found that these mediators significantly reduced symptoms in CAIA mice, evidenced by decreased paw swelling and reduced progression of arthritis. In the cellular studies, these mediators inhibited the formation of bone-resorbing cells called osteoclasts, while also downregulating key inflammatory markers.
Following treatment, there were notable improvements in serum cytokine levels, with a decrease in pro-inflammatory cytokines like TNF-α and IL-6, and an increase in the anti-inflammatory cytokine IL-10. Additionally, joint inflammation and damage were reduced, hinting at a complex relationship involving various signaling pathways.
These findings indicate that lipid mediators derived from DHA may offer a promising approach to alleviating symptoms of RA, though the precise individual contributions of DHA alone are difficult to isolate due to the presence of other components in the intervention.
Read More
9
DHA benefits osteoarthritis treatment
DHA attenuates cartilage degeneration by mediating apoptosis and autophagy in human chondrocytes and rat models of osteoarthritis.
High relevance to OA research
We set out to investigate how docosahexaenoic acid (DHA), a fatty acid known for its health benefits, can affect osteoarthritis (OA), a common degenerative joint disease, particularly among older adults. Using both human chondrocyte models stimulated by IL-1β and rat models created through surgical methods, we aimed to understand DHA's potential to impact chondrocyte behavior and cartilage health.
Our observations revealed that DHA significantly promotes the growth of chondrocytes while reducing cell death, which is a key concern in OA. Notably, we found an increase in autophagosomes—structures that help break down cellular waste—within cells treated with DHA, suggesting enhanced cell health.
In comparing groups, those treated with DHA exhibited healthier cartilage characterized by thickened tissue and a decrease in degeneration when compared to the untreated OA group. We also noted an increase in collagen production, vital for maintaining joint structure. The biochemical analysis indicated that DHA potentially exerts its effects by inhibiting certain pathways associated with cell growth and stress responses, thus enhancing chondrocyte proliferation and survival.
Overall, our findings contribute valuable insights into how DHA can be leveraged as a therapeutic approach for OA, emphasizing its role in protecting and restoring cartilage health.
Our observations revealed that DHA significantly promotes the growth of chondrocytes while reducing cell death, which is a key concern in OA. Notably, we found an increase in autophagosomes—structures that help break down cellular waste—within cells treated with DHA, suggesting enhanced cell health.
In comparing groups, those treated with DHA exhibited healthier cartilage characterized by thickened tissue and a decrease in degeneration when compared to the untreated OA group. We also noted an increase in collagen production, vital for maintaining joint structure. The biochemical analysis indicated that DHA potentially exerts its effects by inhibiting certain pathways associated with cell growth and stress responses, thus enhancing chondrocyte proliferation and survival.
Overall, our findings contribute valuable insights into how DHA can be leveraged as a therapeutic approach for OA, emphasizing its role in protecting and restoring cartilage health.
Read More
9
DHA's ambiguous role in arthritis
Very low calorie ketogenic diet and common rheumatic disorders: A case report.
Mixed effects noted on symptoms
We observed a fascinating case involving a 22-year-old woman with juvenile idiopathic arthritis who was put on a very low calorie ketogenic diet (VLCKD). This diet included high-biological-value protein preparations that featured docosahexaenoic acid (DHA), an omega-3 fatty acid known for its potential health benefits.
The woman saw improvements in her overall weight and health after four months on this diet, including a noticeable reduction in joint pain and headaches. Laboratory tests indicated that her inflammatory markers returned to normal levels, suggesting that the dietary changes—including DHA—might have played a positive role in her experience.
However, it’s essential to note that while DHA is included in the treatment regimen, the isolated effect of DHA on her arthritis symptoms is challenging to determine definitively. This case highlights the potential benefits of dietary interventions for inflammatory conditions but also points to the need for further research to isolate the effects of specific dietary components like DHA.
The woman saw improvements in her overall weight and health after four months on this diet, including a noticeable reduction in joint pain and headaches. Laboratory tests indicated that her inflammatory markers returned to normal levels, suggesting that the dietary changes—including DHA—might have played a positive role in her experience.
However, it’s essential to note that while DHA is included in the treatment regimen, the isolated effect of DHA on her arthritis symptoms is challenging to determine definitively. This case highlights the potential benefits of dietary interventions for inflammatory conditions but also points to the need for further research to isolate the effects of specific dietary components like DHA.
Read More
9
Docosahexaenoic acid reduces arthritis
Lipid mediators obtained from docosahexaenoic acid by soybean lipoxygenase attenuate RANKL-induced osteoclast differentiation and rheumatoid arthritis.
Moderate relevance of findings
We examined the effects of lipid mediators derived from docosahexaenoic acid (DHA) on arthritis, particularly focusing on rheumatoid arthritis (RA). The study utilized a model involving mice with collagen antibody-induced arthritis (CAIA) and RAW264.7 cells to investigate the role of these mediators in reducing inflammation and joint damage.
The lipid mediators were produced by soybean lipoxygenase from DHA and included substances known for their anti-inflammatory properties. We found that these mediators significantly reduced symptoms in CAIA mice, evidenced by decreased paw swelling and reduced progression of arthritis. In the cellular studies, these mediators inhibited the formation of bone-resorbing cells called osteoclasts, while also downregulating key inflammatory markers.
Following treatment, there were notable improvements in serum cytokine levels, with a decrease in pro-inflammatory cytokines like TNF-α and IL-6, and an increase in the anti-inflammatory cytokine IL-10. Additionally, joint inflammation and damage were reduced, hinting at a complex relationship involving various signaling pathways.
These findings indicate that lipid mediators derived from DHA may offer a promising approach to alleviating symptoms of RA, though the precise individual contributions of DHA alone are difficult to isolate due to the presence of other components in the intervention.
The lipid mediators were produced by soybean lipoxygenase from DHA and included substances known for their anti-inflammatory properties. We found that these mediators significantly reduced symptoms in CAIA mice, evidenced by decreased paw swelling and reduced progression of arthritis. In the cellular studies, these mediators inhibited the formation of bone-resorbing cells called osteoclasts, while also downregulating key inflammatory markers.
Following treatment, there were notable improvements in serum cytokine levels, with a decrease in pro-inflammatory cytokines like TNF-α and IL-6, and an increase in the anti-inflammatory cytokine IL-10. Additionally, joint inflammation and damage were reduced, hinting at a complex relationship involving various signaling pathways.
These findings indicate that lipid mediators derived from DHA may offer a promising approach to alleviating symptoms of RA, though the precise individual contributions of DHA alone are difficult to isolate due to the presence of other components in the intervention.
Read More
9
DHA benefits osteoarthritis treatment
DHA attenuates cartilage degeneration by mediating apoptosis and autophagy in human chondrocytes and rat models of osteoarthritis.
High relevance to OA research
We set out to investigate how docosahexaenoic acid (DHA), a fatty acid known for its health benefits, can affect osteoarthritis (OA), a common degenerative joint disease, particularly among older adults. Using both human chondrocyte models stimulated by IL-1β and rat models created through surgical methods, we aimed to understand DHA's potential to impact chondrocyte behavior and cartilage health.
Our observations revealed that DHA significantly promotes the growth of chondrocytes while reducing cell death, which is a key concern in OA. Notably, we found an increase in autophagosomes—structures that help break down cellular waste—within cells treated with DHA, suggesting enhanced cell health.
In comparing groups, those treated with DHA exhibited healthier cartilage characterized by thickened tissue and a decrease in degeneration when compared to the untreated OA group. We also noted an increase in collagen production, vital for maintaining joint structure. The biochemical analysis indicated that DHA potentially exerts its effects by inhibiting certain pathways associated with cell growth and stress responses, thus enhancing chondrocyte proliferation and survival.
Overall, our findings contribute valuable insights into how DHA can be leveraged as a therapeutic approach for OA, emphasizing its role in protecting and restoring cartilage health.
Our observations revealed that DHA significantly promotes the growth of chondrocytes while reducing cell death, which is a key concern in OA. Notably, we found an increase in autophagosomes—structures that help break down cellular waste—within cells treated with DHA, suggesting enhanced cell health.
In comparing groups, those treated with DHA exhibited healthier cartilage characterized by thickened tissue and a decrease in degeneration when compared to the untreated OA group. We also noted an increase in collagen production, vital for maintaining joint structure. The biochemical analysis indicated that DHA potentially exerts its effects by inhibiting certain pathways associated with cell growth and stress responses, thus enhancing chondrocyte proliferation and survival.
Overall, our findings contribute valuable insights into how DHA can be leveraged as a therapeutic approach for OA, emphasizing its role in protecting and restoring cartilage health.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Improved mood drastically
Amazing purchase! I'm on my third bottle and have noticed a significant change in my mood and joint pain. Due to lupus, I often struggle with fatigue and achy joints, but this has helped tremendously! I'm generally in a better mood and mostly pain-free. I even bought a bottle for my grandmother, who is 76 and suffers from arthritis. She's thrilled with her results!
Read More
